LOCUS       NM_011130               1227 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus polymerase (DNA directed), beta (Polb), mRNA.
ACCESSION   NM_011130
VERSION     NM_011130.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1227)
  AUTHORS   Marmolejo-Garza,A., Chatre,L., Croteau,D.L., Herron-Bedoya,A.,
            Luu,M.D.A., Bernay,B., Pontin,J., Bohr,V.A., Boddeke,E. and
            Dolga,A.M.
  TITLE     Nicotinamide riboside modulates the reactive species interactome,
            bioenergetic status and proteomic landscape in a
            brain-region-specific manner
  JOURNAL   Neurobiol Dis 200, 106645 (2024)
   PUBMED   39179121
REFERENCE   2  (bases 1 to 1227)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1227)
  AUTHORS   Chen,S., Zhang,W., Li,X., Cao,Z. and Liu,C.
  TITLE     DNA polymerase beta connects tumorigenicity with the circadian
            clock in liver cancer through the epigenetic demethylation of Per1
  JOURNAL   Cell Death Dis 15 (1), 78 (2024)
   PUBMED   38245510
  REMARK    GeneRIF: DNA polymerase beta connects tumorigenicity with the
            circadian clock in liver cancer through the epigenetic
            demethylation of Per1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1227)
  AUTHORS   Koczor,C.A., Thompson,M.K., Sharma,N., Prakash,A. and Sobol,R.W.
  TITLE     Polbeta/XRCC1 heterodimerization dictates DNA damage recognition
            and basal Polbeta protein levels without interfering with mouse
            viability or fertility
  JOURNAL   DNA Repair (Amst) 123, 103452 (2023)
   PUBMED   36702010
  REMARK    GeneRIF: Polbeta/XRCC1 heterodimerization dictates DNA damage
            recognition and basal Polbeta protein levels without interfering
            with mouse viability or fertility.
REFERENCE   5  (bases 1 to 1227)
  AUTHORS   Huang,M., Wu,T., Liu,R., Wang,M., Shi,M., Xin,J., Shao,S., Zhao,X.,
            Ma,Y., Gu,L., Guo,Z. and Pan,F.
  TITLE     Polbeta modulates the expression of type I interferon via STING
            pathway
  JOURNAL   Biochem Biophys Res Commun 621, 137-143 (2022)
   PUBMED   35834922
  REMARK    GeneRIF: Polbeta modulates the expression of type I interferon via
            STING pathway.
REFERENCE   6  (bases 1 to 1227)
  AUTHORS   Hanley-Hyde,J., Mushinski,J.F., Sadofsky,M., Huppi,K., Krall,M.,
            Kozak,C.A. and Mock,B.
  TITLE     Expression of murine cyclin B1 mRNAs and genetic mapping of related
            genomic sequences
  JOURNAL   Genomics 13 (4), 1018-1030 (1992)
   PUBMED   1387105
REFERENCE   7  (bases 1 to 1227)
  AUTHORS   Messer,A., Plummer,J., Maskin,P., Coffin,J.M. and Frankel,W.N.
  TITLE     Mapping of the motor neuron degeneration (Mnd) gene, a mouse model
            of amyotrophic lateral sclerosis (ALS)
  JOURNAL   Genomics 13 (3), 797-802 (1992)
   PUBMED   1639406
REFERENCE   8  (bases 1 to 1227)
  AUTHORS   Yamaguchi,M., Hayashi,Y., Hirose,F., Shiroki,K. and Matsukage,A.
  TITLE     Activation of the mouse DNA polymerase beta gene promoter by
            adenovirus type 12 E1A proteins
  JOURNAL   Nucleic Acids Res 20 (9), 2321-2325 (1992)
   PUBMED   1534405
REFERENCE   9  (bases 1 to 1227)
  AUTHORS   Hearne,C.M., McAleer,M.A., Love,J.M., Aitman,T.J., Cornall,R.J.,
            Ghosh,S., Knight,A.M., Prins,J.B. and Todd,J.A.
  TITLE     Additional microsatellite markers for mouse genome mapping
  JOURNAL   Mamm Genome 1 (4), 273-282 (1991)
   PUBMED   1794058
REFERENCE   10 (bases 1 to 1227)
  AUTHORS   MacLeod,C.L., Finley,K., Kakuda,D., Kozak,C.A. and Wilkinson,M.F.
  TITLE     Activated T cells express a novel gene on chromosome 8 that is
            closely related to the murine ecotropic retroviral receptor
  JOURNAL   Mol Cell Biol 10 (7), 3663-3674 (1990)
   PUBMED   1694015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV488131.1, AK151436.1 and AV001836.1.
            
            On May 7, 2009 this sequence version replaced NM_011130.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146745.1, BC060998.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AV488131.1         1-21
            22-1212             AK151436.1         7-1197
            1213-1227           AV001836.1         353-367
FEATURES             Location/Qualifiers
     source          1..1227
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 11.42 cM"
     gene            1..1227
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /note="polymerase (DNA directed), beta"
                     /db_xref="GeneID:18970"
                     /db_xref="MGI:MGI:97740"
     exon            1..124
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            125..182
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            183..249
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            250..324
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            325..383
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            384..433
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            434..485
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            486..540
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            541..613
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            614..684
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            685..771
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            772..836
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            837..976
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1227
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1196..1201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1218
                     /gene="Polb"
                     /gene_synonym="A430088C08Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctgcgccctg tcaggcgccg ccattgttcc accggtaaga cccaggtgtg ggtccccggc
       61 gccatgagca aacgcaaggc gccgcaggag accctcaacg gcggcatcac ggacatgctc
      121 gtggaactcg caaactttga gaagaacgtg agccaggcga tccacaagta caatgcgtac
      181 agaaaagcgg catctgtgat agccaagtac ccacacaaaa tcaagagcgg agcggaagct
      241 aagaaactgc caggagtagg aacaaaaatt gctgaaaaga ttgatgaatt tttagcaact
      301 ggaaaattgc gtaaactgga aaagattcgt caagatgata caagttcatc catcaatttc
      361 ctgactcgag ttactggcat tggaccatct gctgcaagga agtttgtaga tgaaggaatt
      421 aagacattag aagatctcag gaaaaatgaa gataaactga accatcatca acgaattggg
      481 ctgaaatatt tcgaggactt tgaaaagaga attcctcgtg aggaaatgct gcagatgcag
      541 gatattgtac ttaatgaaat taaaaaagtg gactctgagt acattgctac agtctgtggc
      601 agtttcagaa gaggcgcaga gtcgagtgga gacatggatg tcctgctgac ccacccaaac
      661 ttcacgtcag aatccagcaa acagccaaag ttgttacatc gtgttgtgga acagttacaa
      721 aaagtccatt tcattacaga tactctgtca aagggtgaaa caaagttcat gggtgtttgc
      781 cagcttccca gcgagaagga tggaaaggaa tatccacaca ggagaatcga tatcaggttg
      841 atccccaaag atcagtacta ctgtggtgtt ctctacttca ctgggagtga catctttaat
      901 aagaacatga gagcgcacgc cctggaaaag ggcttcacaa tcaatgagta caccatccgc
      961 cccctggggg tcactggagt cgctggggag ccccttcctg tggacagtga gcaggacatt
     1021 tttgattaca tccagtggcg ctaccgggag cccaaggata gaagtgaatg atgccctgcc
     1081 agccccaggc acagcccact aggagtccta atttatttct taacctttgc tatgtaaggg
     1141 tttttggtgt tcttaagcga ttgcttcttc tctgtgctta ccatgtacta tagtcaataa
     1201 acttgagcta ttacagaata ttgtctt
//
