LOCUS       NM_172683               7780 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus pogo transposable element with ZNF domain (Pogz),
            transcript variant 1, mRNA.
ACCESSION   NM_172683
VERSION     NM_172683.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7780)
  AUTHORS   Hamada,N., Nishijo,T., Iwamoto,I., Shifman,S. and Nagata,K.I.
  TITLE     Analyses of Conditional Knockout Mice for Pogz, a Gene Responsible
            for Neurodevelopmental Disorders in Excitatory and Inhibitory
            Neurons in the Brain
  JOURNAL   Cells 13 (6), 540 (2024)
   PUBMED   38534384
  REMARK    GeneRIF: Analyses of Conditional Knockout Mice for Pogz, a Gene
            Responsible for Neurodevelopmental Disorders in Excitatory and
            Inhibitory Neurons in the Brain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7780)
  AUTHORS   Sun,X., Zhang,T., Tong,B., Cheng,L., Jiang,W. and Sun,Y.
  TITLE     POGZ suppresses 2C transcriptional program and retrotransposable
            elements
  JOURNAL   Cell Rep 42 (8), 112867 (2023)
   PUBMED   37494184
  REMARK    GeneRIF: POGZ suppresses 2C transcriptional program and
            retrotransposable elements.
REFERENCE   3  (bases 1 to 7780)
  AUTHORS   Conrow-Graham,M., Williams,J.B., Martin,J., Zhong,P., Cao,Q.,
            Rein,B. and Yan,Z.
  TITLE     A convergent mechanism of high risk factors ADNP and POGZ in
            neurodevelopmental disorders
  JOURNAL   Brain 145 (9), 3250-3263 (2022)
   PUBMED   35775424
  REMARK    GeneRIF: A convergent mechanism of high risk factors ADNP and POGZ
            in neurodevelopmental disorders.
REFERENCE   4  (bases 1 to 7780)
  AUTHORS   Heath,J., Cheyou,E.S., Findlay,S., Luo,V.M., Carpio,E.P., Lee,J.,
            Djerir,B., Chen,X., Morin,T., Lebeau,B., Karam,M., Bagci,H.,
            Grapton,D., Ursini-Siegel,J., Cote,J.F., Witcher,M., Richard,S.,
            Marechal,A. and Orthwein,A.
  TITLE     POGZ promotes homology-directed DNA repair in an HP1-dependent
            manner
  JOURNAL   EMBO Rep 23 (1), e51041 (2022)
   PUBMED   34758190
  REMARK    GeneRIF: POGZ promotes homology-directed DNA repair in an
            HP1-dependent manner.
REFERENCE   5  (bases 1 to 7780)
  AUTHORS   Markenscoff-Papadimitriou,E., Binyameen,F., Whalen,S., Price,J.,
            Lim,K., Ypsilanti,A.R., Catta-Preta,R., Pai,E.L., Mu,X., Xu,D.,
            Pollard,K.S., Nord,A.S., State,M.W. and Rubenstein,J.L.
  TITLE     Autism risk gene POGZ promotes chromatin accessibility and
            expression of clustered synaptic genes
  JOURNAL   Cell Rep 37 (10), 110089 (2021)
   PUBMED   34879283
  REMARK    GeneRIF: Autism risk gene POGZ promotes chromatin accessibility and
            expression of clustered synaptic genes.
REFERENCE   6  (bases 1 to 7780)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7780)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (bases 1 to 7780)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 7780)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 7780)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087903.27 and AC087062.25.
            
            On Feb 28, 2019 this sequence version replaced NM_172683.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066108.1, AK035255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               AC087903.27        158979-159282
            305-429             AC087903.27        175492-175616
            430-588             AC087903.27        177585-177743
            589-764             AC087903.27        182338-182513
            765-873             AC087062.25        23847-23955
            874-1164            AC087062.25        25513-25803
            1165-1374           AC087062.25        25883-26092
            1375-1481           AC087062.25        31505-31611
            1482-1819           AC087062.25        32413-32750
            1820-1974           AC087062.25        33698-33852
            1975-2075           AC087062.25        36019-36119
            2076-2222           AC087062.25        36525-36671
            2223-2357           AC087062.25        38061-38195
            2358-2527           AC087062.25        38339-38508
            2528-2668           AC087062.25        38661-38801
            2669-2725           AC087062.25        39356-39412
            2726-2838           AC087062.25        39581-39693
            2839-2863           AC087062.25        39947-39971
            2864-7780           AC087062.25        40086-45002
FEATURES             Location/Qualifiers
     source          1..7780
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..7780
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /note="pogo transposable element with ZNF domain"
                     /db_xref="GeneID:229584"
                     /db_xref="MGI:MGI:2442117"
     exon            1..304
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            305..429
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..4535
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="pogo transposable element with ZNF domain
                     isoform 1"
                     /protein_id="NP_766271.2"
                     /db_xref="CCDS:CCDS17596.1"
                     /db_xref="GeneID:229584"
                     /db_xref="MGI:MGI:2442117"
                     /translation="MADTDLFMECEEEELEPWQKISDVIEDSVVEDYNSVDKTTSVSV
                     SQQPVSAPVPIAAHASVAGHLSTSTTVSNSGAQNSDSTKKTLVTLIANNNAGNTLVQQ
                     GGQPLILTQNPAPGLGTMVTQPVLRPVQVMQNANHVTSSPVASQPIFITTQGFPVRNV
                     RPVQNAMNQVGIVLNVQQGQTVRPITLVPAPGTQFVKPTVGVPQVFSQMTPVRPGSTM
                     PVRPTTNTFTTVIPATLTIRSTVPQSQSQQTKSTPSTSTTPTATQPTSLGQLAGQPPG
                     QSNQTSNPKLAPSFPSPPAVSIASFVTVKRPGVTGENSNEVAKLVNTLNTVPSLGQSP
                     GPVVVSNNSSAQRTSGPESSVKVTSSIPVFDLQDGGRKICPRCNAQFRVTEALRGHMC
                     YCCPEMVEYQKKGKSLDAEPSVPSAAKPSSPEKTAPVTSTPSSTPIPALSPPTKVPEP
                     NENAGDAVQTKLIMLVDDFYYGRDGGKAAQLTSFPKVATSFRCPHCTKRLKNNIRFMN
                     HMKHHVELDQQNGEVDGHTICQHCYRQFSTPFQLQCHLENVHSPYESTTKCKICEWAF
                     ESEPLFLQHMKDTHKPGEMPYVCQVCQYRSSLYSEVDVHFRMIHEDTRHLLCPYCLKV
                     FKNGNAFQQHYMRHQKRNVYHCNKCRLQFLFAKDKIEHKLQHHKTFRKPKQLEGLKPG
                     TKVTIRASRGQPRTVPVSSNDAPSGTLQEAAALTSTDPLPVFLYPPVQRNIQKRAVRK
                     MSVMGRQTCLECSFEIPDFPNHFPTYVHCSLCRYSTCCSRAYANHMINNHVPRKSPKY
                     LALFKNSVSGIKLACTSCTFATSVGDAMAKHLVFNPSHRSSNILPRGLSWMSHLRPGQ
                     ASERVFDWSMKNTYLPPPLVPNKAATVKPVGVTPAEPQELAGPVLQALPSPASTATPP
                     ATPTHPQPSALPPSATEGTECLNVSEQEEGSPVTQDPEPASGGGGGSGVGKKEQLSVK
                     KLRVVLFALCCNTEQAAEHFRNPQRRIRRWLRRFQASQGENLEGKYLSFEAEEKLAEW
                     VLIQREQQLPVNEETLFQKATKIGRSLEGGFKISYEWAVRFMLRHHLTPHARRAVAHT
                     LPKHVAENAGLFIEFVQRQIHNQDLPLSMIVAIDEISLFLDTEVLSSDDRKENALQTV
                     GTGEPWCDVVLAILADGTVLPTLVFFRGQANRFANVPDSILLEAKDSGYSDDEIMELW
                     STRVWKKHTACQHSKSMLVMDCHRTHLSEEVLALLSASSTLPAVVPAGCSSKIQPLDV
                     CIKRTVKNFLHKKWKEQAREMADAACDSDVLLQLVLVWLGEVLGVIGDSPELVQRSFL
                     VASVLPGPDGNVNSPTRNADMQEELIASLEEQLKLNGEQSEEHSASAPRPRSSPEETV
                     EPESLHQLFEGESETESFYGFEEADLDLMEI"
     exon            430..588
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            589..764
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            765..873
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1164
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1374
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1481
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1819
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1974
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2075
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2222
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2357
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2527
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2668
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2725
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2838
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..2863
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..7780
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5069..5074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /note="hexamer: AATGAA"
     polyA_site      5087
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /note="major polyA site"
     regulatory      6507..6512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6529
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /note="major polyA site"
     regulatory      6932..6937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      6956
                     /gene="Pogz"
                     /gene_synonym="9530006B08Rik"
ORIGIN      
        1 ggcgtttctc tcccccgcgc cagctcccat acacggagcc acattccttg gcccccccac
       61 cccctccctc ggggcccccc gcccccctcg ggaaaaaaat ccaccccaat cactcgaacc
      121 cgagggaggc ttcctttcac cctcggggag aggagctttc aacggttccc tcttccccgt
      181 ctcccccccg aaccccggtc ccctcccctg ctcccacccc ctactcccgg cgccgggtgc
      241 aaggtccctt taaggcgacg gcaccttcct cgggtcagac taccggcggc gacgaccacg
      301 ggagcatggc ggacaccgac ctgtttatgg aatgtgagga ggaggaactg gagccatggc
      361 agaaaatcag tgatgtcatt gaggactctg tagttgaaga ttacaattct gtggataaaa
      421 ctacttccgt ttctgtgagc cagcagccag tctcagctcc agtgcccatt gctgcccatg
      481 cttctgttgc tgggcacctc tctacatcca ctactgttag taacagtggg gcacagaaca
      541 gcgacagtac aaagaagact cttgtcacac taattgccaa caacaatgct ggtaatactt
      601 tggtccagca aggtggacag ccactcatcc tcacccaaaa cccagcacca ggtctgggaa
      661 caatggttac tcaaccagta ttgagacctg tccaggtcat gcagaatgcc aatcatgtga
      721 ctagctcccc tgtggcctca caacctatct tcatcactac ccagggattt cctgtaagga
      781 atgttcggcc tgtacaaaat gcaatgaatc aggttgggat tgtgctgaac gtacagcaag
      841 gccaaacagt tagaccaatt acattggtcc cagccccagg tacacagttt gttaagccga
      901 cagttggcgt cccacaagtg ttctctcaga tgacccccgt gaggccaggc tccacaatgc
      961 ctgtgaggcc caccaccaac acctttacca ccgtcatccc agctactctc accatccgaa
     1021 gcactgtccc acagtcccag tcccagcaga ccaagtccac ccccagtacc tccactactc
     1081 ccactgccac acaaccaacc tcactggggc agctagctgg tcagcctcca ggccagtcca
     1141 accagacctc gaatcccaaa ctagctccct ccttcccctc tccacctgca gtgagcattg
     1201 ccagctttgt cactgtgaag cgacctgggg ttacaggtga aaatagcaac gaagtggcca
     1261 aattggtgaa tactcttaac actgtccctt ccctgggcca gagtcctggg cccgtggtgg
     1321 tgtccaacaa cagttctgct caaagaacca gtgggcccga atcttcagtg aaagtgacct
     1381 cttccatccc agtgtttgac ctccaggacg gtggacggaa aatatgtcca cggtgtaatg
     1441 cccagttccg tgttactgaa gctctgagag gtcacatgtg ttactgctgc cctgaaatgg
     1501 ttgagtacca aaagaaaggc aagtccctcg atgcagagcc cagtgtccca tcggcagcaa
     1561 agccctcgtc ccctgagaag acagcccctg ttacttccac accctcctct acaccaattc
     1621 ctgctctctc accacctacc aaagtaccag agccaaatga gaatgctgga gatgctgtcc
     1681 agaccaagct tattatgctg gttgatgatt tctactatgg acgggatggg ggcaaagcag
     1741 cccagctcac gagcttccct aaggttgcca cgtctttccg atgccctcat tgtactaaga
     1801 ggctaaagaa caacattcga ttcatgaacc acatgaagca ccacgtagaa cttgatcaac
     1861 agaatggtga ggtggatggt cacaccatct gccagcactg ttaccgccag ttctccaccc
     1921 ctttccagct ccagtgccac ttggaaaatg ttcatagtcc ctatgaatct actaccaagt
     1981 gcaagatctg tgagtgggcc tttgaaagcg agcccttgtt cctccagcat atgaaggaca
     2041 cccacaagcc tggagagatg ccttatgttt gtcaggtgtg tcagtatcgc tcctccctct
     2101 actctgaagt agatgtccat tttcggatga tccatgaaga tactcggcat ttgctttgcc
     2161 cgtattgcct aaaagtcttc aaaaatggca atgccttcca gcaacactac atgaggcacc
     2221 agaagagaaa tgtttatcac tgcaacaaat gccggctgca gtttctcttt gccaaggaca
     2281 aaattgaaca caagctgcag caccataaaa ccttccgtaa gcctaagcaa ctggaaggct
     2341 tgaaaccagg caccaaggtg acaatccggg cttcccgggg gcagccgaga actgttcctg
     2401 tgtcttcaaa tgatgcacct tctggcacct tgcaggaggc agcagcgctg acctccactg
     2461 accccctacc tgtcttcctt tatccccctg tccagcgcaa tatccagaag agagctgtta
     2521 ggaaaatgag cgtcatgggc cggcagacat gtctggagtg cagctttgag attccagatt
     2581 ttcctaatca tttccctacc tatgtgcatt gttctctctg ccgatacagc acctgctgct
     2641 ctagagctta tgccaatcac atgatcaaca atcatgttcc acggaaaagt cccaagtatt
     2701 tggctttgtt taaaaattct gtaagtggaa tcaagctggc ctgcacttcg tgtacctttg
     2761 ctacctccgt gggagatgcg atggccaagc atttagtgtt caacccctcc cacagatcta
     2821 gcaacatctt accacggggg ctcagttgga tgtctcactt gaggcctggc caggcttctg
     2881 aacgagtgtt cgactggagc atgaagaata catatcttcc acctcccctc gtccctaaca
     2941 aagctgccac tgtgaagcct gtaggagtca ccccagcgga gccccaagag ctggcaggtc
     3001 ctgtgctcca ggcacttcca tccccagcct caactgcaac cccaccagca acccccactc
     3061 acccacagcc ctccgccctg ccaccctcgg ccacagaggg gactgagtgt ctgaatgtca
     3121 gtgaacagga agaaggaagc cctgtcaccc aggatcctga gccagcatca ggtggtggag
     3181 gtggcagtgg ggttggcaag aaagagcagc tgtctgtgaa gaagcttcgg gtagtactgt
     3241 ttgccctgtg ctgcaacact gaacaggcgg ctgaacactt tcgaaacccc cagcggcgaa
     3301 tccgtcgttg gcttcgacgc ttccaggcct ctcagggaga gaacttagag ggcaaatatc
     3361 tcagctttga ggcagaagaa aaactggctg aatgggtgct gatccagaga gagcagcagc
     3421 tccctgtaaa tgaggagacc ttgtttcaga aggccaccaa aattggacgc tctttggaag
     3481 gggggtttaa gatctcctat gagtgggctg tgcgcttcat gcttcggcac cacctcactc
     3541 cccatgcccg gcgagctgtc gcccacacgt taccgaagca tgtagcagaa aatgctggac
     3601 tcttcattga gtttgtgcag cggcagattc acaatcagga cttacctttg tctatgattg
     3661 tggctattga tgagatctct ttgttcctgg acacagaggt gctgagcagt gatgaccgaa
     3721 aggagaacgc tctgcagaca gtgggcacag gggagccttg gtgtgacgtc gtgctggcta
     3781 tcctagcaga tggcactgtc ctccccaccc ttgttttctt ccgaggacaa gcgaatcggt
     3841 tcgctaatgt gccagactct atattactag aggccaaaga cagtggctac agcgacgacg
     3901 aaatcatgga gctttggtca acccgtgtat ggaagaagca cacagcttgt cagcacagca
     3961 aaagcatgtt ggtgatggac tgtcatcgca ctcacttgtc agaagaagta ctggccctgc
     4021 tcagtgcctc tagcactttg cctgcggtag tccccgccgg ttgtagctcc aaaatccagc
     4081 cactagatgt atgcatcaaa cgaactgtta agaacttcct gcacaaaaag tggaaggaac
     4141 aggctcggga aatggctgac gctgcttgtg attctgatgt cttgcttcag ctggtgttgg
     4201 tctggctggg agaggtgctg ggtgtcattg gggactcccc agagctagtt cagcggtcct
     4261 tccttgtggc tagtgttctg ccaggtcccg atggcaacgt taactcaccc acacgcaacg
     4321 ctgacatgca ggaggagctc attgcctccc tagaggagca gctcaagcta aatggagaac
     4381 agtctgagga gcactcagct tctgcccccc gacccaggtc atctcctgaa gagacagtcg
     4441 agcctgaaag ccttcaccag ctttttgagg gggaaagtga gacggagtct ttctatggct
     4501 ttgaggaagc tgaccttgat ctgatggaga tctaggtgct gaggctatgg aagctatgga
     4561 gtcaggaagg aaggtgaggg aggttagagg ggcttagaca agatgggtac cagtggggta
     4621 cttggtttat agtttcaatt ttatgccacc actcccagca ttgactcttc ctgtgaattt
     4681 gtgggttatt aggaacgccg gtagtgatca gttctgagcc gaggagctgg cccattggtt
     4741 actcctaaaa acatgttttt gtgacccttt ttttcttctt taatttaaat cactgtgttt
     4801 gctatttttc tgacaaaatc taggaaaaca atcctttgtg gacagatatt aagttgtttc
     4861 atttccccgt ttacctcaat tgtatcatag tatttctggg ttttgtttgt tttactgtgt
     4921 ggccaatgtc tttgggcatg atactatcta atcattgtta acatgagaac tttgctgcag
     4981 atggaaagaa agaatatgta gctgacaaac tgactattac atatgtggat aagttttttt
     5041 cattgtggtc ttaacacttt tatataaaaa tgaaaatgaa aaatgaatcc cactgaactc
     5101 tttccttctg ctccttccct ccctccccag aggtgctggc ttcttcagca gctctagata
     5161 taaagttgtg ctttaaaacg tgcatgaacc accttgaaac atctagaatg gatagatttt
     5221 tctgtcctca ccaccctcca ccaaaatata acagaaacaa tatttttttg cacttgtaac
     5281 ccttgacccc tttcctgatt tttcacatca tccttcactc tggacaaagg agcacatgtg
     5341 tccctggcaa gcagaggtac tgagtgaggt gatgagtgtt tcaggtggaa gccattccta
     5401 gtctctgtct tcaacaagcc cgatggcgta gtccctttcc tctagaactt tgtcctgtta
     5461 agctcgctga cggcacacct gctcatcaca ggtttaactg gcatgttaag tgttgaacta
     5521 gaaagacaga ctgcttcaac tcctgcttac acgtggcttt cctgttcctc tcatattcag
     5581 agaaacggat gtgaaaagca tagaggtgtg cacagagaaa gacatgaatc tttatttttc
     5641 actgccaact tcaaggaaaa atttttctac agtttgcatg agggattttt ttaagaaaat
     5701 atgtactcat ggtgataaac caaaatgtac tgtaccatag aggagagcaa accttcccca
     5761 cagccacacc gtccttatcc atcccgaggc gttcagagtt tcctcctgtg agccaaggag
     5821 gcagcctgca caagcgtgta agtggttcat ctctaaagtg tacataagtg gagcatttaa
     5881 taaaacaaga ggaaatggat ttataaactt tttctatgtg tccccattga ataggctttc
     5941 atagactggg agatactcaa gacatgcccg cctggtggca caggggtggc gtctgtgacc
     6001 accagtgctt tccctgcaga ttttgttttg tctttttaac tcccagcaca ctataacata
     6061 gtgaacagga ctgatcccag aagtttggcc tgctctaaaa ccatggcatt ggagatctga
     6121 actgaggagc cacctgggct ggtccccagc tttttgcgaa atgccatttt attggtgacg
     6181 gactacactt caaagccaac cttctgcctt tgagaaagct ggagaactgt aaatggtcac
     6241 ttcaatctac agcctaatcc tctttggtcg tctctgcagc agccacagcc ttagcagagc
     6301 tgggttcctg gcctctgcac attgactttg gatgggtcat ttttggttgt tttttgtttt
     6361 ttgttttttt tctttttttt aaagatcatg gtaaccgtga atcagctggg ttttggcaag
     6421 caagttgtct ttgtggactc tgcctgcatg gcttagtagt agaaggaagt ttttttggtt
     6481 ttgttttttt ataattcagt ttaatcaata aacatgtatt tattgacaat tttctgtgtt
     6541 aagtatatca aagttcccaa ttgaacaccc aagattttct ttgcgtgaac ttgtctgcag
     6601 ctgtctgtgc ctcgctggat agtgtcgtgc agaagacccg tgattgtcat ttttagaaat
     6661 caaggttcag tgggacagtg gtggcacaca cctttaatcc cagcactgga gaggcaaaga
     6721 cagatatatc tctgagtttg agactagcct ggttataatg agtacctggt cagccagagt
     6781 tatactgttt tggaaaacac caaaatacaa aaataaatta aatcagggtt taaaaccacc
     6841 ccagggatag gacatgactg acttccagct gaaacagcta cacttagaat tcatttttgt
     6901 ttttgtgtat tgactgttgg cacctcatac cattaaatca tgcacaaagg tcaggacaac
     6961 tcttgagtca tctggggatt aaacttgggc tttcaggtgt gtgaatactg gcacaagtgt
     7021 gggtcttcag tcttcactcg ccaccgtatc tgagacttct gttcttctgt ttgctatgcc
     7081 aagctaccta cctggccctc gagcttacag ggcatctcct gcctctacat accatttggg
     7141 attacaaata cttgagctat tttgtccagc ttttctatgg gttctagaga ttcaaattca
     7201 ggtcttcaca ctcagcaagt gctttagcaa cttgagccac ctcccagccc cacttaagtt
     7261 cttgtaatga ttttatttgg ttatgtgtat ttatacaagt gcaggcgctc atgaggccag
     7321 tcatcagatg tcccctggaa ttgcagtgag atgcttgtga gccacagatt cacatggtac
     7381 tgaggtgcaa actcaagtca agcctgccct cttagatgcc gagcatctct gcaactcccc
     7441 attcaaggtt tcctaatgaa cacatgcttt caaagaacca ggtgctagga ttacaataag
     7501 catcagatgt ttgtactctg aatgtgaggc tacgagtgta ggcgtagggt ctgagcacca
     7561 ccatggtaca gtagctctgg tacatacata cctcatacct gtctttgaaa ttgcatttga
     7621 acaaaagtca ggtttgcagc catcattaac aactcctccc aaacaaaaac aaaaataacc
     7681 tcttacattc ttttaaaatg tagtgcatgg gagaaaaatg agaatattgt atgagcccat
     7741 tgtgttatta aacgtaagtc aaatctacaa aaactatgac
//
