LOCUS       NM_212445               3644 bp    mRNA    linear   ROD 31-AUG-2024
DEFINITION  Mus musculus protein O-glucosyltransferase 3 (Poglut3), mRNA.
ACCESSION   NM_212445 XM_110668
VERSION     NM_212445.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3644)
  AUTHORS   Neupane,S., Williamson,D.B., Roth,R.A., Halabi,C.M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     Poglut2/3 double knockout in mice results in neonatal lethality
            with reduced levels of fibrillin in lung tissues
  JOURNAL   J Biol Chem 300 (7), 107445 (2024)
   PUBMED   38844137
  REMARK    GeneRIF: Poglut2/3 double knockout in mice results in neonatal
            lethality with reduced levels of fibrillin in lung tissues.
REFERENCE   2  (bases 1 to 3644)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3644)
  AUTHORS   Takeuchi,H., Fernandez-Valdivia,R.C., Caswell,D.S., Nita-Lazar,A.,
            Rana,N.A., Garner,T.P., Weldeghiorghis,T.K., Macnaughtan,M.A.,
            Jafar-Nejad,H. and Haltiwanger,R.S.
  TITLE     Rumi functions as both a protein O-glucosyltransferase and a
            protein O-xylosyltransferase
  JOURNAL   Proc Natl Acad Sci U S A 108 (40), 16600-16605 (2011)
   PUBMED   21949356
REFERENCE   4  (bases 1 to 3644)
  AUTHORS   Fernandez-Valdivia,R., Takeuchi,H., Samarghandi,A., Lopez,M.,
            Leonardi,J., Haltiwanger,R.S. and Jafar-Nejad,H.
  TITLE     Regulation of mammalian Notch signaling and embryonic development
            by the protein O-glucosyltransferase Rumi
  JOURNAL   Development 138 (10), 1925-1934 (2011)
   PUBMED   21490058
REFERENCE   5  (bases 1 to 3644)
  AUTHORS   Chiellini,C., Costa,M., Novelli,S.E., Amri,E.Z., Benzi,L.,
            Bertacca,A., Cohen,P., Del Prato,S., Friedman,J.M. and Maffei,M.
  TITLE     Identification of cathepsin K as a novel marker of adiposity in
            white adipose tissue
  JOURNAL   J Cell Physiol 195 (2), 309-321 (2003)
   PUBMED   12652657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079869.22, AK075811.1, AK019513.1, AK020078.1 and AK076412.1.
            
            On Nov 22, 2004 this sequence version replaced NM_212445.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075811.1, SRR7345562.1558172.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC079869.22        150822-151012       c
            192-1845            AK075811.1         1-1654
            1846-2465           AK019513.1         594-1213
            2466-3416           AK020078.1         6-956
            3417-3644           AK076412.1         1236-1463
FEATURES             Location/Qualifiers
     source          1..3644
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.12 cM"
     gene            1..3644
                     /gene="Poglut3"
                     /gene_synonym="2010004J24Rik; 4833410J10Rik; Kdelc2"
                     /note="protein O-glucosyltransferase 3"
                     /db_xref="GeneID:68304"
                     /db_xref="MGI:MGI:1923765"
     exon            1..264
                     /gene="Poglut3"
                     /gene_synonym="2010004J24Rik; 4833410J10Rik; Kdelc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1589
                     /gene="Poglut3"
                     /gene_synonym="2010004J24Rik; 4833410J10Rik; Kdelc2"
                     /EC_number="2.4.2.26"
                     /note="KDEL motif-containing protein 2; protein
                     O-xylosyltransferase POGLUT3; KDEL (Lys-Asp-Glu-Leu)
                     containing 2"
                     /codon_start=1
                     /product="protein O-glucosyltransferase 3 precursor"
                     /protein_id="NP_997610.1"
                     /db_xref="CCDS:CCDS23182.1"
                     /db_xref="GeneID:68304"
                     /db_xref="MGI:MGI:1923765"
                     /translation="MQALPLGLQLALLVAAGAGARVSAPRSLAWGPGLQAAAVLPVRY
                     FFLQSVDSDGRNFTSSPPGQTQFKVVVKSLSPKELVRIYVPKPLDRNDGTFLVRYRMH
                     ETAHKGLKIEILHGSEHVAHSPYILKGPVYHEYCDCPEDDPQVWQETLSCPASEPQIE
                     QDFVSFPSINLQQMLKEVPTRFGDERGAVVHYTILNNHIYRRSLGKYTDFKMFSDEIL
                     LSLARKVTLPDLEFYINLGDWPLEHRKVNDTPGPIPIISWCGSLDSRDIILPTYDVTH
                     STLEAMRGVTNDLLSVQGNTGPSWINKTEKAFFRGRDSREERLQLVLLSKENPQLLDA
                     GITGYFFFQEKEKELGKAKLMGFFDFFKYKYQVNVDGTVAAYRYPYLMLGDSLVLKQE
                     SPYYEHFYVALKPWKHYVPIKRNLGDLLEKVKWAKENDEEAKKIAKEGQLTARDLLQP
                     PRLYCYYYRVLQKYAERQASKPMIRDGMELVPQPDDGTSICQCHRRRPEREEL"
     exon            265..462
                     /gene="Poglut3"
                     /gene_synonym="2010004J24Rik; 4833410J10Rik; Kdelc2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..749
                     /gene="Poglut3"
                     /gene_synonym="2010004J24Rik; 4833410J10Rik; Kdelc2"
                     /inference="alignment:Splign:2.1.0"
     exon            750..966
                     /gene="Poglut3"
                     /gene_synonym="2010004J24Rik; 4833410J10Rik; Kdelc2"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1163
                     /gene="Poglut3"
                     /gene_synonym="2010004J24Rik; 4833410J10Rik; Kdelc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1358
                     /gene="Poglut3"
                     /gene_synonym="2010004J24Rik; 4833410J10Rik; Kdelc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1463
                     /gene="Poglut3"
                     /gene_synonym="2010004J24Rik; 4833410J10Rik; Kdelc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..3644
                     /gene="Poglut3"
                     /gene_synonym="2010004J24Rik; 4833410J10Rik; Kdelc2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1912
                     /gene="Poglut3"
                     /gene_synonym="2010004J24Rik; 4833410J10Rik; Kdelc2"
                     /note="major polyA site"
     regulatory      3501..3506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Poglut3"
                     /gene_synonym="2010004J24Rik; 4833410J10Rik; Kdelc2"
                     /note="hexamer: ATTATA"
     polyA_site      3521
                     /gene="Poglut3"
                     /gene_synonym="2010004J24Rik; 4833410J10Rik; Kdelc2"
     regulatory      3524..3529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Poglut3"
                     /gene_synonym="2010004J24Rik; 4833410J10Rik; Kdelc2"
                     /note="hexamer: AATAAA"
     polyA_site      3550
                     /gene="Poglut3"
                     /gene_synonym="2010004J24Rik; 4833410J10Rik; Kdelc2"
                     /note="major polyA site"
ORIGIN      
        1 agaggcccgc cctcgggtgt cccctcggcc cggcgctcca gctcctccct ggccagcgga
       61 gctgagagcc ggcgaccatg caggccctgc cgctggggct gcagctcgcc ctgctggtgg
      121 cggcgggggc cggggcgcgc gtgagcgcac cgcggagcct ggcgtggggc cctgggttgc
      181 aggccgccgc cgtcctgccc gtgcgctact tcttcctgca gtcggtggac tcggacggcc
      241 ggaacttcac tagctcgccg ccaggtcaaa cacagttcaa agtagtggta aaatcccttt
      301 cacctaaaga gctggtccgt atttatgtcc ctaaaccttt ggacagaaat gatggaacgt
      361 ttttggtgag atacaggatg cacgagacgg cccataaagg gctcaagata gagatccttc
      421 atggcagtga acatgtggct cactctccct atattttaaa aggacccgtg taccacgagt
      481 actgtgactg cccggaagat gaccctcagg tctggcagga aaccctgtct tgtccagcca
      541 gtgaaccaca gatcgagcag gattttgttt ccttccccag cattaatctc cagcagatgc
      601 tgaaggaggt ccccacaaga tttggggacg agcggggtgc tgttgttcat tacacaattc
      661 tcaataacca catctaccgg agatctttgg ggaaatacac agacttcaaa atgttctctg
      721 atgaaatttt gctgtcactg gcaagaaagg tcaccctccc agatttagaa ttttatatca
      781 accttggaga ttggcccttg gagcatcgaa aagtcaatga caccccaggc cctataccta
      841 tcatttcctg gtgtggctcc ttggactcaa gagacattat ccttccaaca tatgatgtca
      901 cccactccac actcgaagca atgaggggtg tcacaaatga tctcctctcc gttcagggaa
      961 acacagggcc ttcatggatc aataaaacag agaaagcttt cttccgaggt agagatagcc
     1021 gggaggagag gctgcagttg gtacttctgt ccaaagaaaa tccacagctg ctagatgcag
     1081 gaattacagg atatttcttt ttccaagaga aagaaaaaga gcttggaaaa gccaagttga
     1141 tgggtttctt tgatttcttt aagtacaagt accaagtgaa cgtggacggg actgtggccg
     1201 cctacaggta tccgtacctc atgctgggcg acagcctggt cctcaagcag gagtcaccat
     1261 actacgaaca tttctatgtg gcactaaagc cttggaaaca ctacgttccc attaagagaa
     1321 acctcggtga tttactagag aaagtgaaat gggccaagga aaatgatgaa gaagcaaaga
     1381 agattgcgaa agaagggcag ttaactgcca gggacctgct ccagccgccc aggctttact
     1441 gctactatta cagagtactg cagaaatatg ccgagcgcca ggccagcaag cccatgattc
     1501 gtgatggaat ggagcttgtt ccccagccgg atgatggcac atccatctgc cagtgccacc
     1561 ggaggaggcc tgagagggaa gagctttgag gagacccagc tccatactcc tttgtatgcc
     1621 agctgcatct ttaagacttg tgaaagatgc taagctgtga aggaccagag aaaccaggcc
     1681 tggtgggtta ggctcacacc cgcaatcctg gcacaatgga agcagaacaa gaggatttca
     1741 ttagtgcaaa gcctacctga gatttgtggt gacttccagg ccagcccagc ttacccagtt
     1801 ggatcttatc aaaagaccag aacaaaaaag aaatgtagag aaatgctaag cttttaatcc
     1861 cacactcgag agcctaagtc aggaagatca tgaatttcag tattatgaaa tatctttgga
     1921 gttgcttgtt tgtgcaccct agtggataaa aggctcataa atcactggga atccgtgggt
     1981 ggcacgctca ggtgcactgg cttgcttctg tctttatcca agataaaagt cgaattcact
     2041 tacttttata ttcaattatg aagggcaaag tgtttgggga ggctcgactg tctcctccct
     2101 gtgttgtttc tcctcttggt ttttttggtt ttttggtttt tttttttttg tttgtttgtt
     2161 tttttgtttg tttgtttttt ggtttttcaa gacagggttt ctctgtatag ccctggctgt
     2221 cctggaactc actctgtaga ccaggctggc ctcaaactca gaaatctgcc tgtctctgcc
     2281 tcccaagtgc tgggattaaa ggcgtgcgcc accaccgccc ggcaagaatt tgtatcttta
     2341 actagatctt agaaatatca gcatgacaaa tatcccatat ggacatgaga agaaagactg
     2401 cctccctcgc ttctacctct ttaaccacag gttcagaaag aaaaaggtat tttgttagag
     2461 acacattaat ttttttaaat tgatgtcgtt tgaggctgaa tagtcctagc agaactagga
     2521 gaaaaagaag ttgaaacaaa ctaggcagtt tctattgact tgtccgattc tcattttgaa
     2581 cagtcacacc ttggaacatt gcactggaca cagagtcttt gacacacaaa cctgcagggg
     2641 acattttaca tccaaaccgt aacaagtcta tcaagaaatc taggttaact ccacttgacc
     2701 gtagcctttg aaatgagttt tacatggctt tatggttcat taacttgcac ataccttagg
     2761 ggaaccagct ggtttattaa gctccaattc cttcccttcc aacttaacca attgtccata
     2821 tagtccatta gccactttta atactgaagt atttatcaaa atatatctgg cttcagggcc
     2881 catgagttaa gaataaggag aaacccccag agagggactg gagggagaaa ggggacagtg
     2941 atataattat accttaattt caatagaaga aagttttata tgactttcaa aaaagggagg
     3001 gatgtaaggc tataaagata taggtgtgtt tatttgaata aactgtcaac aatgtttatg
     3061 gcttgaaaca ctggccgtca cccatcggtt gtgagcgcat tgcttgcata gctactgaca
     3121 ttgctcgcat agctactgac gagtggagga attgagcacc accatcaaca agaagaaacc
     3181 agttttaatt atgcgggaat gaaagctttc catgaccaaa ggcacaggac agaacgtgaa
     3241 gacatttcct aaaagaaagg gttggttggg aagagtacag agagaggggg atttttattt
     3301 tcgctttata ccattttata atatccaaat tggttttaaa ctatggatat agaatcaagc
     3361 tgtaaaataa gtgttaacat gctaaaaaat aaataaataa atgcacagag gagacgataa
     3421 gaaggggaaa gaaacagata tttatgtttt ccacaatgcc atattaagaa tccatgtcta
     3481 gaatgttgtc ctgtggtttt attatatact cttttttttt ttaaataaag cacattttta
     3541 taataagaaa gggaactcca tgtactttaa gattcatacc acctgcaccc tgatatgtct
     3601 ctaaggcttg cttatttctt aaaaaaatat attttctgtg tctg
//
