LOCUS       NM_023645               2324 bp    mRNA    linear   ROD 31-AUG-2024
DEFINITION  Mus musculus protein O-glucosyltransferase 2 (Poglut2), mRNA.
ACCESSION   NM_023645
VERSION     NM_023645.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2324)
  AUTHORS   Neupane,S., Williamson,D.B., Roth,R.A., Halabi,C.M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     Poglut2/3 double knockout in mice results in neonatal lethality
            with reduced levels of fibrillin in lung tissues
  JOURNAL   J Biol Chem 300 (7), 107445 (2024)
   PUBMED   38844137
  REMARK    GeneRIF: Poglut2/3 double knockout in mice results in neonatal
            lethality with reduced levels of fibrillin in lung tissues.
REFERENCE   2  (bases 1 to 2324)
  AUTHORS   Takeuchi,H., Fernandez-Valdivia,R.C., Caswell,D.S., Nita-Lazar,A.,
            Rana,N.A., Garner,T.P., Weldeghiorghis,T.K., Macnaughtan,M.A.,
            Jafar-Nejad,H. and Haltiwanger,R.S.
  TITLE     Rumi functions as both a protein O-glucosyltransferase and a
            protein O-xylosyltransferase
  JOURNAL   Proc Natl Acad Sci U S A 108 (40), 16600-16605 (2011)
   PUBMED   21949356
REFERENCE   3  (bases 1 to 2324)
  AUTHORS   Fernandez-Valdivia,R., Takeuchi,H., Samarghandi,A., Lopez,M.,
            Leonardi,J., Haltiwanger,R.S. and Jafar-Nejad,H.
  TITLE     Regulation of mammalian Notch signaling and embryonic development
            by the protein O-glucosyltransferase Rumi
  JOURNAL   Development 138 (10), 1925-1934 (2011)
   PUBMED   21490058
REFERENCE   4  (bases 1 to 2324)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   5  (bases 1 to 2324)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   6  (bases 1 to 2324)
  AUTHORS   Kimata,Y., Ooboki,K., Nomura-Furuwatari,C., Hosoda,A., Tsuru,A. and
            Kohno,K.
  TITLE     Identification of a novel mammalian endoplasmic reticulum-resident
            KDEL protein using an EST database motif search
  JOURNAL   Gene 261 (2), 321-327 (2000)
   PUBMED   11167020
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK035899.1.
            
            On Apr 5, 2007 this sequence version replaced NM_023645.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035899.1, AK170300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2324              AK035899.1         2-2325
FEATURES             Location/Qualifiers
     source          1..2324
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 23.54 cM"
     gene            1..2324
                     /gene="Poglut2"
                     /gene_synonym="1810049A15Rik; 5730416C13Rik; EP58; Kdel1;
                     Kdelc1"
                     /note="protein O-glucosyltransferase 2"
                     /db_xref="GeneID:72050"
                     /db_xref="MGI:MGI:1919300"
     exon            1..456
                     /gene="Poglut2"
                     /gene_synonym="1810049A15Rik; 5730416C13Rik; EP58; Kdel1;
                     Kdelc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1783
                     /gene="Poglut2"
                     /gene_synonym="1810049A15Rik; 5730416C13Rik; EP58; Kdel1;
                     Kdelc1"
                     /EC_number="2.4.2.26"
                     /note="KDEL containing protein 1; endoplasmic
                     reticulum-resident KDEL protein; KDEL motif-containing
                     protein 1; KDEL (Lys-Asp-Glu-Leu) containing 1; protein
                     O-xylosyltransferase POGLUT2; ERp58; ER protein 58;
                     endoplasmic reticulum resident protein 58"
                     /codon_start=1
                     /product="protein O-glucosyltransferase 2 precursor"
                     /protein_id="NP_076134.1"
                     /db_xref="CCDS:CCDS14929.1"
                     /db_xref="GeneID:72050"
                     /db_xref="MGI:MGI:1919300"
                     /translation="MFSISLLSCLFLGTVPALAQTGGERRLSPEKSEIWGPGLKAHVV
                     LPARYFYIRAVDTSGEQFTSSPGEKVFQVKISAPDEQFTRVGVQVLDRKDGSFIVRYR
                     MYASYRNLKIEVKHHGQHVAESPYVLRGPVYHENCDCPLEDSAAWLREMNCSETISQI
                     QKDLAHFPTVDPEKIAAEIPKRFGQRQSLCHYTLKDNKVYIKTHGEHVGFRIFMDAIL
                     LSLTRKVRMPDVEFFVNLGDWPLEKKKSNSNIQPIFSWCGSTESRDIVMPTYDLTDSV
                     LETMGRVSLDMMSVQANTGPPWESKNSTAVWRGRDSRKERLELVKLSRKHPELIDAAF
                     TNFFFFKHDESLYGPIVKHISFFDFFKHKYQINIDGTVAAYRLPYLLVGDSVVLKQDS
                     IYYEHFYNELQPWKHYIPVKSNLSDLLEKLKWAKEHDAEAKKIAKAGQEFARNNLMGD
                     DIFCYYFKLFQGYANLQVSEPQIREGMKRVEPQSEDDLFPCTCHRRKAKDEL"
     exon            457..662
                     /gene="Poglut2"
                     /gene_synonym="1810049A15Rik; 5730416C13Rik; EP58; Kdel1;
                     Kdelc1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..868
                     /gene="Poglut2"
                     /gene_synonym="1810049A15Rik; 5730416C13Rik; EP58; Kdel1;
                     Kdelc1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..946
                     /gene="Poglut2"
                     /gene_synonym="1810049A15Rik; 5730416C13Rik; EP58; Kdel1;
                     Kdelc1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1119
                     /gene="Poglut2"
                     /gene_synonym="1810049A15Rik; 5730416C13Rik; EP58; Kdel1;
                     Kdelc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1357
                     /gene="Poglut2"
                     /gene_synonym="1810049A15Rik; 5730416C13Rik; EP58; Kdel1;
                     Kdelc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1567
                     /gene="Poglut2"
                     /gene_synonym="1810049A15Rik; 5730416C13Rik; EP58; Kdel1;
                     Kdelc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1657
                     /gene="Poglut2"
                     /gene_synonym="1810049A15Rik; 5730416C13Rik; EP58; Kdel1;
                     Kdelc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1765
                     /gene="Poglut2"
                     /gene_synonym="1810049A15Rik; 5730416C13Rik; EP58; Kdel1;
                     Kdelc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..2324
                     /gene="Poglut2"
                     /gene_synonym="1810049A15Rik; 5730416C13Rik; EP58; Kdel1;
                     Kdelc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1964..1969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Poglut2"
                     /gene_synonym="1810049A15Rik; 5730416C13Rik; EP58; Kdel1;
                     Kdelc1"
                     /note="hexamer: AATAAA"
     polyA_site      1985
                     /gene="Poglut2"
                     /gene_synonym="1810049A15Rik; 5730416C13Rik; EP58; Kdel1;
                     Kdelc1"
                     /note="major polyA site"
ORIGIN      
        1 acaagtttgt cattgtccgg agaaagtgga gcctgcggtt cttaaccagg ttcagcagaa
       61 cgtgtggcat ccttctcctg gacatgccac cgctcgggtt gtgacattct tgggcacagc
      121 atagtcccac gcgcggaccc cgcacgtcaa gcgacacttt agggactttg actgctgcta
      181 ggactgacca ccgtcctcct acctacccag gctagctccg tccacttagc acgtttgcat
      241 ttattcgtgg atcttccaag actcggtctt gtaaatgttc agcatttcgc tgctttcctg
      301 cctttttctg gggactgtgc cagcacttgc ccagaccggc ggagagagga ggctgagccc
      361 agagaagagc gaaatatggg gacccgggct aaaagcacac gtggtccttc ctgcccgcta
      421 tttctacatt cgggcggtgg atacctcagg ggaacagttt acatcttctc caggtgaaaa
      481 ggtgttccag gttaaaatct cagcacccga tgagcagttc acgagagttg gtgtccaggt
      541 tttagatcga aaggacggtt ccttcatagt aagatacaga atgtatgcca gctacagaaa
      601 tctgaagata gaggttaaac accatgggca acatgttgcc gagtctcctt atgttttaag
      661 aggaccagtt taccatgaga actgtgactg tcctttggaa gacagtgcag cctggctacg
      721 ggagatgaac tgttcggaaa caatctctca gattcagaaa gatctggcac atttccctac
      781 tgttgatcct gaaaagattg cagcagaaat cccaaaacga tttgggcaga ggcaaagcct
      841 gtgtcactat accttaaagg acaataaggt ttatatcaag actcatggtg agcacgttgg
      901 ctttaggatt ttcatggatg caatactact ttcattgact agaaaggtga ggatgccaga
      961 tgtggaattt tttgttaatt tgggagactg gcctttggaa aaaaagaaat ccaactccaa
     1021 cattcagccg atcttttcct ggtgtggctc cacagagtcc agggatattg tgatgcctac
     1081 ctacgacctg actgactctg ttctagaaac catgggccga gtaagtctgg atatgatgtc
     1141 ggtgcaagct aacacagggc ctccctggga aagtaagaat tccacagctg tctggagggg
     1201 ccgagacagc cgcaaagaga gactagagct ggtgaagctt agcagaaaac acccagagct
     1261 catcgatgct gctttcacaa attttttctt ctttaaacat gacgaaagcc tgtatgggcc
     1321 catcgtgaaa cacatttcat tttttgattt cttcaagcac aagtatcaga taaatattga
     1381 tggcactgtg gcagcgtacc gattgcccta cctgctggtg ggtgacagtg tcgttctgaa
     1441 gcaggactcc atctactatg aacactttta caatgagctg cagccctgga aacattacat
     1501 tccagtcaaa agtaacctaa gcgatctgct agaaaagctc aagtgggcaa aagagcatga
     1561 tgcagaggcc aagaagatag caaaagcagg acaagaattt gcgagaaata atctaatggg
     1621 tgatgatata ttctgttatt acttcaaact gttccagggc tatgcaaatt tacaagtgag
     1681 cgagccccaa attcgagagg gtatgaagag ggtagagcca caatccgagg atgacctctt
     1741 cccttgcacg tgccatagga gaaaggccaa agatgaactc tgagaagcaa aatatcttct
     1801 gttcaaatca tggtgctctg aggacacttt actataaagg ttatttttaa gtatgtttca
     1861 cagacaatgt caaatttacg tgtgcccatt cactttctca cagtatttcg tcttatgcag
     1921 tgttcccatg actgtctttt acatcacatt ttaaaatttt tataataaaa ctgcctttat
     1981 tttaagggtc tgttttgtta cagttattac ctatgagcag aagaaatagg cgagtttggg
     2041 tccttgattc tggtgagtgc tctgattcaa acaggcctcc aaaagcaaaa caaaactcag
     2101 ccaattgtgg tggttcatgc ctataatcct agcacttcag aggttaagac aagaagattc
     2161 tgtgagttca aggccagtct gagctacata gtaagttgga agacaataag actctgtttt
     2221 aaaatgcaaa tgactctgtc tgttttaagc tctttttctt ttggaataac tactcattga
     2281 gtctcagtca aacctcattc taataaaaca tgctagagct gcct
//
