LOCUS       NP_076134                502 aa            linear   ROD 31-AUG-2024
DEFINITION  protein O-glucosyltransferase 2 precursor [Mus musculus].
ACCESSION   NP_076134
VERSION     NP_076134.1
DBSOURCE    REFSEQ: accession NM_023645.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 502)
  AUTHORS   Neupane,S., Williamson,D.B., Roth,R.A., Halabi,C.M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     Poglut2/3 double knockout in mice results in neonatal lethality
            with reduced levels of fibrillin in lung tissues
  JOURNAL   J Biol Chem 300 (7), 107445 (2024)
   PUBMED   38844137
  REMARK    GeneRIF: Poglut2/3 double knockout in mice results in neonatal
            lethality with reduced levels of fibrillin in lung tissues.
REFERENCE   2  (residues 1 to 502)
  AUTHORS   Takeuchi,H., Fernandez-Valdivia,R.C., Caswell,D.S., Nita-Lazar,A.,
            Rana,N.A., Garner,T.P., Weldeghiorghis,T.K., Macnaughtan,M.A.,
            Jafar-Nejad,H. and Haltiwanger,R.S.
  TITLE     Rumi functions as both a protein O-glucosyltransferase and a
            protein O-xylosyltransferase
  JOURNAL   Proc Natl Acad Sci U S A 108 (40), 16600-16605 (2011)
   PUBMED   21949356
REFERENCE   3  (residues 1 to 502)
  AUTHORS   Fernandez-Valdivia,R., Takeuchi,H., Samarghandi,A., Lopez,M.,
            Leonardi,J., Haltiwanger,R.S. and Jafar-Nejad,H.
  TITLE     Regulation of mammalian Notch signaling and embryonic development
            by the protein O-glucosyltransferase Rumi
  JOURNAL   Development 138 (10), 1925-1934 (2011)
   PUBMED   21490058
REFERENCE   4  (residues 1 to 502)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   5  (residues 1 to 502)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   6  (residues 1 to 502)
  AUTHORS   Kimata,Y., Ooboki,K., Nomura-Furuwatari,C., Hosoda,A., Tsuru,A. and
            Kohno,K.
  TITLE     Identification of a novel mammalian endoplasmic reticulum-resident
            KDEL protein using an EST database motif search
  JOURNAL   Gene 261 (2), 321-327 (2000)
   PUBMED   11167020
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK035899.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035899.1, AK170300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 23.54 cM"
     Protein         1..502
                     /product="protein O-glucosyltransferase 2 precursor"
                     /EC_number="2.4.2.26"
                     /note="KDEL containing protein 1; endoplasmic
                     reticulum-resident KDEL protein; KDEL motif-containing
                     protein 1; KDEL (Lys-Asp-Glu-Leu) containing 1; protein
                     O-xylosyltransferase POGLUT2; ERp58; ER protein 58;
                     endoplasmic reticulum resident protein 58"
                     /calculated_mol_wt=56020
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1983
     mat_peptide     20..502
                     /product="Protein O-glucosyltransferase 2.
                     /id=PRO_0000247164"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHP7.1)"
                     /calculated_mol_wt=56020
     Region          24..130
                     /region_name="Filamin"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHP7.1)"
     Region          29..129
                     /region_name="IG_FLMN"
                     /note="Filamin-type immunoglobulin domains; smart00557"
                     /db_xref="CDD:214720"
     Region          151..484
                     /region_name="Glyco_transf_90"
                     /note="Glycosyl transferase family 90; pfam05686"
                     /db_xref="CDD:310354"
     Site            152
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JHP7.1)"
     Site            302
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JHP7.1)"
     Site            414
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9JHP7.1)"
     Region          499..502
                     /region_name="Prevents secretion from ER.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU10138"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHP7.1)"
     CDS             1..502
                     /gene="Poglut2"
                     /gene_synonym="1810049A15Rik; 5730416C13Rik; EP58; Kdel1;
                     Kdelc1"
                     /coded_by="NM_023645.3:275..1783"
                     /db_xref="CCDS:CCDS14929.1"
                     /db_xref="GeneID:72050"
                     /db_xref="MGI:MGI:1919300"
ORIGIN      
        1 mfsisllscl flgtvpalaq tggerrlspe kseiwgpglk ahvvlparyf yiravdtsge
       61 qftsspgekv fqvkisapde qftrvgvqvl drkdgsfivr yrmyasyrnl kievkhhgqh
      121 vaespyvlrg pvyhencdcp ledsaawlre mncsetisqi qkdlahfptv dpekiaaeip
      181 krfgqrqslc hytlkdnkvy ikthgehvgf rifmdaills ltrkvrmpdv effvnlgdwp
      241 lekkksnsni qpifswcgst esrdivmpty dltdsvletm grvsldmmsv qantgppwes
      301 knstavwrgr dsrkerlelv klsrkhpeli daaftnffff khdeslygpi vkhisffdff
      361 khkyqinidg tvaayrlpyl lvgdsvvlkq dsiyyehfyn elqpwkhyip vksnlsdlle
      421 klkwakehda eakkiakagq efarnnlmgd difcyyfklf qgyanlqvse pqiregmkrv
      481 epqseddlfp ctchrrkakd el
//
