LOCUS       NM_080463               8313 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus protein O-fucosyltransferase 1 (Pofut1), mRNA.
ACCESSION   NM_080463
VERSION     NM_080463.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8313)
  AUTHORS   He,S., Luo,Y., Ma,W., Wang,X., Yan,C., Hao,W., Fang,Y., Su,H.,
            Lai,B., Liu,J., Xiong,Y., Bai,T., Ren,X., Liu,E., Han,H., Wu,Y.,
            Yuan,Z. and Wang,Y.
  TITLE     Endothelial POFUT1 controls injury-induced liver fibrosis by
            repressing fibrinogen synthesis
  JOURNAL   J Hepatol 81 (1), 135-148 (2024)
   PUBMED   38460791
  REMARK    GeneRIF: Endothelial POFUT1 controls injury-induced liver fibrosis
            by repressing fibrinogen synthesis.
REFERENCE   2  (bases 1 to 8313)
  AUTHORS   Nauman,M., Varshney,S., Choi,J., Augenlicht,L.H. and Stanley,P.
  TITLE     EOGT enables residual Notch signaling in mouse intestinal cells
            lacking POFUT1
  JOURNAL   Sci Rep 13 (1), 17473 (2023)
   PUBMED   37838775
  REMARK    GeneRIF: EOGT enables residual Notch signaling in mouse intestinal
            cells lacking POFUT1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8313)
  AUTHORS   Tanwar,A. and Stanley,P.
  TITLE     Synergistic regulation of Notch signaling by different O-glycans
            promotes hematopoiesis
  JOURNAL   Front Immunol 14, 1097332 (2023)
   PUBMED   37795096
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8313)
  AUTHORS   Liang,C., Li,Y., Qin,H., Ramzan,M.N., Wang,H., Liu,S. and Yan,Q.
  TITLE     Role of poFUT1 and O-fucosylation in placental angiogenesisdagger
  JOURNAL   Biol Reprod 108 (4), 553-563 (2023)
   PUBMED   36723873
  REMARK    GeneRIF: Role of poFUT1 and O-fucosylation in placental
            angiogenesisdagger.
REFERENCE   5  (bases 1 to 8313)
  AUTHORS   Serra,C.F.H., Liu,H., Qian,J., Mori,M., Lu,J. and Cardoso,W.V.
  TITLE     Prominin 1 and Notch regulate ciliary length and dynamics in
            multiciliated cells of the airway epithelium
  JOURNAL   iScience 25 (8), 104751 (2022)
   PUBMED   35942101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8313)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   7  (bases 1 to 8313)
  AUTHORS   Buono,K.D., Robinson,G.W., Martin,C., Shi,S., Stanley,P.,
            Tanigaki,K., Honjo,T. and Hennighausen,L.
  TITLE     The canonical Notch/RBP-J signaling pathway controls the balance of
            cell lineages in mammary epithelium during pregnancy
  JOURNAL   Dev Biol 293 (2), 565-580 (2006)
   PUBMED   16581056
REFERENCE   8  (bases 1 to 8313)
  AUTHORS   Shi,S., Stahl,M., Lu,L. and Stanley,P.
  TITLE     Canonical Notch signaling is dispensable for early cell fate
            specifications in mammals
  JOURNAL   Mol Cell Biol 25 (21), 9503-9508 (2005)
   PUBMED   16227600
REFERENCE   9  (bases 1 to 8313)
  AUTHORS   Shi,S. and Stanley,P.
  TITLE     Protein O-fucosyltransferase 1 is an essential component of Notch
            signaling pathways
  JOURNAL   Proc Natl Acad Sci U S A 100 (9), 5234-5239 (2003)
   PUBMED   12697902
REFERENCE   10 (bases 1 to 8313)
  AUTHORS   Wang,Y., Shao,L., Shi,S., Harris,R.J., Spellman,M.W., Stanley,P.
            and Haltiwanger,R.S.
  TITLE     Modification of epidermal growth factor-like repeats with O-fucose.
            Molecular cloning and expression of a novel GDP-fucose protein
            O-fucosyltransferase
  JOURNAL   J Biol Chem 276 (43), 40338-40345 (2001)
   PUBMED   11524432
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807380.6.
            
            On Nov 3, 2022 this sequence version replaced NM_080463.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132301.1, AK081059.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AL807380.6         96311-96521
            212-333             AL807380.6         98434-98555
            334-516             AL807380.6         103245-103427
            517-629             AL807380.6         104477-104589
            630-822             AL807380.6         114396-114588
            823-1065            AL807380.6         115994-116236
            1066-8313           AL807380.6         120491-127738
FEATURES             Location/Qualifiers
     source          1..8313
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..8313
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
                     /note="protein O-fucosyltransferase 1"
                     /db_xref="GeneID:140484"
                     /db_xref="MGI:MGI:2153207"
     exon            1..211
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1254
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
                     /EC_number="2.4.1.221"
                     /note="GDP-fucose protein O-fucosyltransferase 1;
                     peptide-O-fucosyltransferase 1"
                     /codon_start=1
                     /product="GDP-fucose protein O-fucosyltransferase 1
                     precursor"
                     /protein_id="NP_536711.3"
                     /db_xref="CCDS:CCDS16909.1"
                     /db_xref="GeneID:140484"
                     /db_xref="MGI:MGI:2153207"
                     /translation="MGAAAWAPPHLLLRASFLLLLLLLPLRGRSAGSWDLAGYLLYCP
                     CMGRFGNQADHFLGSLAFAKLLNRTLAVPPWIEYQHHKPPFTNLHVSYQKYFKLEPLQ
                     AYHRVVSLEDFMENLAPSHWPPEKRVAYCFEVAAQRSPDKKTCPMKEGNPFGPFWDQF
                     HVSFNKSELFTGISFSASYKEQWTQRFPAKEHPVLALPGAPAQFPVLEEHRELQKYMV
                     WSDEMVRTGEALISAHLVRPYVGIHLRIGSDWKNACAMLKDGTAGSHFMASPQCVGYS
                     RSTATPLTMTMCLPDLKEIQRAVTLWVRALNARSVYIATDSESYVSEIQQLFKDKVRV
                     VSLKPEVAQIDLYILGQADHFIGNCVSSFTAFVKRERDLHGRQSSFFGMDRPSQLRDE
                     F"
     exon            212..333
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            334..516
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..629
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..822
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1065
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..8313
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5601..5606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
                     /note="hexamer: ATTAAA"
     polyA_site      5624
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
                     /note="major polyA site"
     regulatory      6380..6385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
                     /note="hexamer: ATTAAA"
     polyA_site      6400
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
     regulatory      7757..7762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
                     /note="hexamer: AGTAAA"
     polyA_site      7776
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
     regulatory      8125..8130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
                     /note="hexamer: AGTAAA"
     polyA_site      8146
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
     regulatory      8289..8294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
                     /note="hexamer: ATTAAA"
     polyA_site      8313
                     /gene="Pofut1"
                     /gene_synonym="O-FucT-1"
ORIGIN      
        1 actcgcgcct cttcttccct cccaccccct ccccgcctcc gggccgtggc actctggggc
       61 tctgccgtcg acatgggcgc cgccgcgtgg gcaccgccac acctgctgct gcgggcgtct
      121 ttcctgcttc tgctgctgtt gctgccgctc cgcgggcggt cagcgggctc ctgggacctg
      181 gccggttacc tgctctactg tccctgcatg gggcgctttg ggaaccaggc tgatcacttc
      241 ttgggctccc tggcatttgc gaagctgctg aaccgcacct tggctgtacc tccatggatt
      301 gaataccaac atcacaagcc tcctttcacc aacctccatg tgtcctacca aaagtacttc
      361 aaactggagc ctctccaagc ctaccatcgg gttgtcagcc tggaggactt catggaaaat
      421 ctggcaccct cccactggcc ccctgagaag cgagtggcat actgctttga ggtggcagcc
      481 cagcgaagtc ctgataagaa gacatgtccc atgaaggaag gaaatccttt tgggccattc
      541 tgggaccagt ttcatgtgag tttcaataag tcagaactgt tcacaggcat ttccttcagc
      601 gcctcctaca aagaacaatg gacccagaga tttcctgcaa aagagcatcc tgtgctcgca
      661 ctgcctgggg ccccagcaca gttccctgtc ctggaggaac acagggagct ccagaagtac
      721 atggtgtggt cagatgagat ggtgaggacg ggagaggccc tgatcagtgc ccacctcgtc
      781 cggccctatg tgggcattca tctgcgcatt ggctccgact ggaagaatgc ctgtgccatg
      841 ctgaaggatg gaactgcagg gtcacacttc atggcttccc ctcagtgtgt gggctatagc
      901 cgcagcacag cgacccctct caccatgacc atgtgcctcc ctgacctgaa ggaaatccag
      961 cgggctgtga cgctttgggt gagagcactg aatgccagat cggtctacat cgccacagac
     1021 tctgagagct acgtgtcaga gatccagcag ctcttcaaag acaaggtgag ggtggtgagc
     1081 ctgaaacccg aggtggccca gatcgacctg tacatcctcg gccaggctga ccacttcatt
     1141 ggaaactgtg tctcctcgtt cactgccttc gtgaagcggg agcgggacct ccatgggagg
     1201 cagtcgtcct tctttggcat ggacagaccc tcccagcttc gggatgaatt ttgatcccat
     1261 ctgaagcccc cacctcccac cctcaaccag gcttggctgc taaggatgct cctgggatta
     1321 cacatccctt ttcttttctg ccagaggtgg agaacagtac caaggacgtc ctggaagaga
     1381 aggcattcca tcccaggcat tggctcccat ggtccccagc cagggctgct ctgggctgca
     1441 tgatcatgca catacaaagc agcccacctc cagcctgggc acaccctgat atatacacat
     1501 acatacacat aatatatatc atatatatat atatatatgt gtgtgtgtat gtatatatat
     1561 atatatatat atatatatat catatatatt ttccccccct tggttgaggg tttgggggag
     1621 gagcaaaggg gtaaggttaa gatctaatct catatagccc aggctggcct tgaactcctg
     1681 gtccttctgc ctctacctcc taagtgctga gattaggagt gtctaccaca acactcactt
     1741 gatctctgta gttttgatgc aaagccatgc atgactacct gaaaactccc ctttgttttt
     1801 aaaaatcagt ggagtccatt agcacaaaag cctaaagtga ccttataaat gaaatgcaga
     1861 caaagccaag aagcaagtgg gcctattggc tgctcttctg ggggtcccct aaagggccct
     1921 cagactttcc actgccaggc ccagccactg ccatccctgg gctcctctgt tgtgaacaca
     1981 gcaggcagga gttagcagtg ctctgaggac aggtatgtgc tcccaccatg ggtggcagtg
     2041 tccgggcctc agcagtatca ctgcacaagt gaggctggca gggtgcactg aaagctgctg
     2101 tctctaagac cctcccagcc tctgctctgt ggtctcagcc ctcactgcag ctgtccccta
     2161 aggactactc accaagcctc tgacatgtcc gtgcacagag gccatgtgaa gccccaggtt
     2221 gggagcagtc tttgtccctc cagccagtgt ggtgaggtcc tcctgatgct gctgctctca
     2281 ttcataagaa gtgaactcta ggtgacgggc caagtggtcc tagattctgc cttgcacagg
     2341 gacatttaga ggctggagcc ccagtgggtg accatgcaga ccaccctgac gggcacagca
     2401 tttctgaaga gcaggtgctg ggctctcgtc tgtggcaagc actgtactct ttgaccccgt
     2461 ttctcccctg taagtgctga gtctggtggg ttctaagctt cacgtcagct catgagtgtt
     2521 gtaaacctgg gctagaacaa gactcccatg tggccattgc cgagtgtaac tgttgcttac
     2581 tgccaggcgc tgtgctgggg cctgaagggc atcctcttac ttagtttgcc cctggtttta
     2641 tccttttctt tctgaccaaa aaaaaaagtg actgtttaga gacattttct cccaggcagg
     2701 gctgcatagc tgtgggtggt aagccagacc cactggactc tgtgtgttgc ttcccaggac
     2761 acattgtgca ctaaaggaca ctaggaaaat gatgagccac ccgactgcct ctgcatactg
     2821 ctgttggctt ctgctgccag ccctattagg aagcgacata aaaaacagga agctctgggt
     2881 agttacagta cctgttttcc ttcaggaagt gttcactgat ggcctactgt gtgctaggaa
     2941 ggagggtggc agcagagaaa gcttaagacc caggattgct gtggaaggga agagctgtga
     3001 agaatgccaa ggggaggggc tcagggaaac tgttttaaag gaatcacctt agggagtgga
     3061 ggaggacttg ctcagctgag gaggctgcac actccctgca gcaagcatgg cacgtgccaa
     3121 ggcactaagg caggaaggga cagcaaggga acatctggag atgaggtgcc aagatgacgt
     3181 cccagagggg agctggtgct gcctgtgggt gagaggctag gccattgtgc tggaggtggg
     3241 agaagaaatc acattctgag tatatcaagt tatttttgta tttcagtctc tttttttaaa
     3301 ggcaccagcc tacatggttg tgcagtatat tccatttaat gtcttgggtt ttgtttttgt
     3361 ttttttttta ctacataacc acacatccta tttttcctgt gtgaacatag ctgaatagat
     3421 gcttttaatt atgtaagctt ccactgagga gtgtttcata gtttgtgact caccttctat
     3481 gagatcaatc cccagctgtt actattggat tttatcccca aggtttcttt gtgtacccct
     3541 tgctgtctta gaactactca ctctttagac caggctggcc tctagttctc agagatcacc
     3601 aacctctata agaaaattca actgtgctca aaaattgtga ctttaaaaaa ctgagctcac
     3661 ggtattaaca atttacttca gcagctagtt catttactcc ccactcctaa tcggtctgga
     3721 gactggcttc cttttgtact ctggggtagg gtcttctgtg ggccagtctg gcctggaact
     3781 cttgatgtag cccagactta tcatatatgt attcctagtc ctcctgtctc agcctcacaa
     3841 gtgcggtgat tgcagctgtg agctgtctca cattggttcc tcctgagcca ttaaatgact
     3901 ctgcatggat gcccaggaaa gtgctaactg aagctgcagt gtgcccgggt ggggcagggg
     3961 gagccccagg aggaggctga gccccggtgg gcctcttctc tccatgtttc ctttccaact
     4021 tctaggtgct gaggcagtgg ctatcttctt tatggagtcc tgcaggacaa gcaatccaag
     4081 tggctggggc tgaatcgccc caggaccgtg ctttttacaa gctcttgtaa aagacccaag
     4141 gcctgcagtg tggcatcacc caggggagcc accttaaatg caaaatccca gttgaacctt
     4201 ttagatccag cctgtaatct cagctagttt ggaggttgag acaggacagt cgcattctag
     4261 gtctacctag caacttaggg gagactgtct caaaataata aggcttgaaa aaggtggggt
     4321 gttgttcagt tggccgaatg cttggtcacc ataacacagc cctcaggagt acaggggaac
     4381 gtatccctgt tacacaggat gcagtgtctt ggccacacta gcctgacaac aaagcggggc
     4441 cttgtgcaca agtgtttgga ttctgttctg gctggttttt gtcaacttga cacaaactag
     4501 agtcatctga gaagagagaa cctcagtgga gaaaatgccc ctgtcagact gtcctgtagg
     4561 caggcccatg gggcattttc ttgactgaca gttcattttg aagggcctag cccactgtgg
     4621 gtaaggctgc ctctgaacag aaagtcctgg gatggataag ggaggctggg tgtggtgtca
     4681 cttttaatcc cagttctagg caggcagatc tctgtgttca aggccagcca gggctctggg
     4741 gtctggagca aagcagtagc agtgttcctc cataatctgt tccagtccct gtcttggcct
     4801 ctacagtgag ataaagcctt tcccccatgt tgctccagtc gtggtaccca ccacagcaac
     4861 ggaaagcaaa ctcagacccc aagcccgggg tctttcccaa agcatgatcc agtctcggac
     4921 tctccgtttc acagttgaag aggagacagt ggtgaagtgg aaatgtctag ttctttggaa
     4981 agtcagttat gtcaaatgat gttttgctgg ggcacacagg tgaaaggaca tcttggtaaa
     5041 gcaaatgtga aagacttcct gaagcagaca caggtgagag gacgcttgaa gaagtataaa
     5101 tctgacccca cagacagtgg gagatgagca ctgagcattg gtttggtttg ctgtgccttg
     5161 ctattcttct ctaaagacac acatgtgttg gttcaccttg catagtgttg tttagctcaa
     5221 cttgtggtaa ggctgtcttt tagaaaagct cacccaaaga ctattcgtga ggttcctgca
     5281 gcagcttgcg acttccacgc ctcaccttga gcagatgggc aagcctggtc aattcttcag
     5341 gattgggctg tagctgcctg gtgtctgctt gctgagaaga ctggactgca gtgactgctt
     5401 tgtgcctggt gtctgccagc ccagaggact gctctgcagc tgctgctgag ttttatttgc
     5461 tgtttgctgc gggactgaac tgttgagaaa gaagatcagg ctcacctgca aggaactgtt
     5521 gctgaagtgc ttcctttata tcctaataac tcttccatta cccgtgccgg ggggtgggct
     5581 agaagagaga ttgaaccctt attaaaagta ggttttgcaa aaaatgcatg ccttcatagt
     5641 ggttcagatt aggacagagc ttggtcacca acaagttctt tggctctcac tagccccgcc
     5701 cccccccccc cagctttact ctcagaagcc taatcctctg gaggcaggag gggcttcctc
     5761 cccactagac tgagctctca gcttcctgtt ggctctctgg caacagctgg gagagatggt
     5821 ctcaccctga gcaaacagtg tggggaaacc acaaggaaac ttctggaagg cagtgcccag
     5881 cagggctgac ccactcctag gactgcttca acccctactg aggccctgca agtctcccca
     5941 ggcatttcag acagggtcct ttatttctct ggcagcctgt gcccactgct cacagttgga
     6001 gaaggagctt cagagagggt gagcggcctc gtggactggc cgtgttctgt tatcactaaa
     6061 catcttcagt gtgttggctc caactgcaat ttcagttctg gtgatgtccc ggcagggtgg
     6121 agcggagtga tgtcacatgc aggcttaaca ggttgggcgg cgttaatatg gacaatttaa
     6181 aaaatattat cattgtgtgt gtatgatggg gttagccagc atgtgtaaag gctagagaac
     6241 agctttgtgg agtcatagtt ctttggccct taggtgggtt acagggatta aagtcaggtt
     6301 tcaggcttgg gggacaagtg cctttcctta cctgctgagc catcttactg tcaccaagta
     6361 tactctttat gccattacaa ttaaatttct tctggctgga gaaatgggtc cataggtaaa
     6421 attcttgctg tgcaagtatg aggatctaag gtttggcctc ccagaaccca cacaaaaaag
     6481 ctgaaagact ggagagatgg cttagcagtt aagagcagta aacctgctat tcctgtagtc
     6541 ttgggttcag ttctcaggat ccacaggtaa ctcacaacca tctataactc cagttctaga
     6601 gaatccaaag tcctcttctg tctccatggg cactaggctc acatgtggta cagtcatata
     6661 tgcaggcgct tgttcaataa gcgatgatga tgatgataaa gccaggaaga atagtgcaca
     6721 cctgtaatcc cagcacagtg caggggcggc agagacagga aggaccctgg gctcatttgt
     6781 caggcaatct agtttaattg gtaagaggct cagtgagaga ccctatctca acaagcttgg
     6841 ggttggggag atacctctgt gagtaagttt gcttgcagtg caagtctgat gacctgactt
     6901 gggatcccca gagcacacct acaagctaga cacaacagca cttgtttgta gttccattat
     6961 gccctctaag gaatggagaa ttgctcttag actaactagc ctggcatatg catttgagaa
     7021 tgaaaggaga gaccctgcct caaacaaggc caagtttatc ctctgacatg ctaacacata
     7081 cacttagaca tatcacaaac acattataca tacataacac accctttatc catacacaca
     7141 cgtatacaca acacacatac aaatacaatg catatatata tatagagaga gagagagatg
     7201 cagtatacac actaattgta catacacaac atatataaaa cacattatac acatacagat
     7261 atgcacacaa atcaggaaga aattaaggaa gattactaac atcaacctct ggcttacaca
     7321 cacactcaca cacataccag gtgtactata aaaattgtca tttaaaacag ggagtggtat
     7381 aatcccgtgg ggcacctgga aaacagaggt ccctgaatct tttttatatg ccagcctgat
     7441 ttgcatagca agttccaggc tagccagaac tacataatga gaacttgtct caacatttta
     7501 aaaataaaaa agtggtgaac acagaggcac tgcggctctc tgggaggccc ccgagcagtg
     7561 agcccaggct gaggggactt ccctgagcag tgagaatatt ggaggtcctc ctagcctagg
     7621 ccttcaaaag caccccagtg agggcgcttg gcaaatgtcc agtgtcattt ataggaattt
     7681 gtgtcttttt gttcttgtgg cgtgttcagc cagaggagaa agcctctcct tgcttcagga
     7741 tggacccaaa ttcatgagta aacaacagga atcctatgtt gttgctgctg tttttaatgt
     7801 tacacatatg ggtgttttgc ttgcacgtat gtctgtacat catatgcatg gctactgcgc
     7861 acaaagacaa gaagttgttg tatcccctag aactgagtta taagaggatg ttagccacca
     7921 tgtggatgct gaatatcaaa ctaggtcctc tgaaagagaa gcctgtggtc cgtttaagtg
     7981 ctgagccatc tctccagccc cagagaagca cagtggtgga gagacaggga aaaggaaggg
     8041 agatgggact gaggaggagt tcagtcttat cttcactttg tatgaccctg atggcagcaa
     8101 tgagccagtg cccacccgcc ttgaagtaaa gttgccttcc tctgtcctct gtcctctcct
     8161 ctctccttat gggatgatgg gggaatactt ggggttaggg ggaccccaac agggcatgac
     8221 catgaacagg taactaaaaa aaacaaaaca aaacaaaaca ggtaactaat tctacattgt
     8281 cagatttaat taaaatccct gcttggaaac tgg
//
