LOCUS       NM_181579               3909 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus premature ovarian failure 1B (Pof1b), mRNA.
ACCESSION   NM_181579
VERSION     NM_181579.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3909)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3909)
  AUTHORS   Rizzolio,F., Bione,S., Villa,A., Berti,E., Cassetti,A., Bulfone,A.,
            Tribioli,C. and Toniolo,D.
  TITLE     Spatial and temporal expression of POF1B, a gene expressed in
            epithelia
  JOURNAL   Gene Expr Patterns 7 (4), 529-534 (2007)
   PUBMED   17123869
  REMARK    GeneRIF: The data show that during mouse development Pof1b
            expression is activated in the external layers of the epidermis
            just prior to formation of the epidermal permeability barrier.
REFERENCE   3  (bases 1 to 3909)
  AUTHORS   Bione,S., Rizzolio,F., Sala,C., Ricotti,R., Goegan,M.,
            Manzini,M.C., Battaglia,R., Marozzi,A., Vegetti,W., Dalpra,L.,
            Crosignani,P.G., Ginelli,E., Nappi,R., Bernabini,S., Bruni,V.,
            Torricelli,F., Zuffardi,O. and Toniolo,D.
  TITLE     Mutation analysis of two candidate genes for premature ovarian
            failure, DACH2 and POF1B
  JOURNAL   Hum Reprod 19 (12), 2759-2766 (2004)
   PUBMED   15459172
REFERENCE   4  (bases 1 to 3909)
  AUTHORS   Bione,S. and Toniolo,D.
  TITLE     X chromosome genes and premature ovarian failure
  JOURNAL   Semin Reprod Med 18 (1), 51-57 (2000)
   PUBMED   11299520
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137653.1, AK086511.1 and AF408412.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137653.1, AK036922.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1032              AK137653.1         2-1033
            1033-1402           AK086511.1         1034-1403
            1403-2689           AK137653.1         1402-2688
            2690-3909           AF408412.1         884-2103
FEATURES             Location/Qualifiers
     source          1..3909
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 48.76 cM"
     gene            1..3909
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /note="premature ovarian failure 1B"
                     /db_xref="GeneID:69693"
                     /db_xref="MGI:MGI:1916943"
     exon            1..64
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            65..402
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1881
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /codon_start=1
                     /product="protein POF1B"
                     /protein_id="NP_853557.1"
                     /db_xref="CCDS:CCDS30362.1"
                     /db_xref="GeneID:69693"
                     /db_xref="MGI:MGI:1916943"
                     /translation="MMSSSYWSETSSSSCGTQQPTEVLQCQPQHYHYYHQPSQAQQPP
                     EKNVVYERVRTYSGPMNKVVQALDPLGSREVLSPLKPASSYQSLVWSDHSQELYSPTL
                     KISTCAPSTLHITQNAEQELHSPTVKVTTYPQTTIRRYIVQNPEQEPLSPFLRGSQFF
                     PGNNVIYEKTIRKVEKLNTDQECCPQIQCHHHVIQQPQIIHSPHCQQSHSSHQIQCIT
                     ENDSNIGHELCHGGPSQIHEQVIIQDDGPEKLDPKYFGELLADLSRKNTDLYHCLLEH
                     LERIGGSKQDFESTDTSEDIESLIPKGLSEFTKQQIRYILQMRGMSDKSLRLVLSTFS
                     NIREELGHLQNDLTSLENDKIRLEKDLAFKENQMKEYEELLASVRANNRQQQQGLQDS
                     SAKCQSLEENNLSLRHTLSDLEYRLKELEYCKRNLEQENKNLRIQVSETCTGPTLQAK
                     MDEIGNHYMEMVKNLRLDKDREISKLRSQLNQYQKDVSKREGSCSDFQFKLHELTSLL
                     EEKDSLIKRQSEELSKLRQEIYSSHNQPSCGGRTTITTKKYRTQYPILGLLYDDYEYI
                     PPGSDTQTIVIEKTEDKWTCP"
     exon            403..477
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            478..558
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            559..660
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            661..834
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            835..965
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            966..993
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1068
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1161
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1275
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1428
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1548
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1677
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1760
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1875
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..3890
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3871..3876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3890
                     /gene="Pof1b"
                     /gene_synonym="2310066B14Rik"
                     /note="major polyA site"
ORIGIN      
        1 gccagacctg ctcctgctgc tgttcgggta actcatcttt tactggtacc accagggata
       61 caagggagag cacctgggaa aactctgggg aaactgtttc tgaccaccat cgagaagatg
      121 atgagctcaa gctattggag tgagaccagc agcagcagct gcgggaccca gcagcccaca
      181 gaggtcctgc agtgccagcc tcagcattac cactattacc atcagccaag tcaagcccag
      241 cagcctccag aaaaaaatgt agtgtatgaa cgagtgagga cctacagtgg gccaatgaac
      301 aaggtggtgc aggccttgga cccgctcggc tcacgggaag tgctctcccc tctcaaacct
      361 gcctcctcct accaaagttt ggtttggagc gaccattccc aggagctcta ttctccaact
      421 ctgaaaatat ctacttgtgc accaagcact ctccacataa cacaaaatgc tgaacaggaa
      481 ctccattctc caacagtgaa agttactaca tatccacaaa ccaccattag gagatacata
      541 gtacaaaacc ctgaacagga accattgtct cctttcctaa gaggaagtca attcttccca
      601 ggaaacaatg taatttatga aaaaacaata agaaaagtgg agaagctcaa cacagatcaa
      661 gaatgttgtc ctcaaattca gtgccatcat catgtcatcc agcaacccca gatcatccac
      721 tcgccacatt gtcaacagtc ccattctagc catcaaatcc agtgtataac agaaaatgat
      781 tcaaatattg ggcatgaact ctgtcatggc gggccaagcc aaatacacga acaggtgata
      841 attcaggatg atggccctga aaaattggat cccaaatatt ttggagagtt gcttgctgat
      901 ctaagtcgca agaatacaga cctatatcac tgcttattag aacatttgga gcgaattgga
      961 ggaagcaaac aagattttga gtccacagat acatcagaag acattgagtc attgattccc
     1021 aaaggactgt cagagtttac aaaacagcaa attcgttata ttctgcagat gaggggtatg
     1081 tctgataagt ccctgagact agtgctgtcc acgtttagca acatacggga ggaacttgga
     1141 catcttcaaa atgatttgac atcactggaa aatgacaaga taagacttga aaaggacttg
     1201 gcattcaaag aaaatcaaat gaaagagtat gaagaactct tggcatcagt gagagcaaat
     1261 aatcgccaac agcaacaagg acttcaagac tcaagcgcaa aatgtcagtc attggaagaa
     1321 aataaccttt ctcttcgaca tacactgtca gacttggaat acagactgaa agaacttgag
     1381 tattgtaaac gcaatttaga gcaagagaat aaaaacctta gaatacaggt gtctgagact
     1441 tgcacaggcc ctacactaca ggctaaaatg gatgagattg gcaatcatta tatggagatg
     1501 gtaaaaaact tgagacttga taaagataga gaaatcagca agctaaggtc ccaattaaac
     1561 cagtaccaaa aagatgtttc aaaaagagaa ggaagttgta gtgatttcca attcaaactt
     1621 catgaattga caagtttgct ggaagagaag gattctctaa taaagcgtca atcagaggaa
     1681 ctctcaaagt tgagacaaga aatatattca tcccataacc aaccctcttg tggtggaagg
     1741 actacaatca ccacaaaaaa gtacagaaca cagtatccaa tcctaggtct cctgtacgat
     1801 gactatgaat atataccacc aggtagtgac acacaaacga ttgtgatcga gaaaactgaa
     1861 gacaaatgga cttgtccatg aatggaccca ttctacaata ctacaaccca aaggaaattt
     1921 tctttgtctg catcagtatt ttaattgtta tttttctatt gctaatgtgc aatcaaattg
     1981 tgaatcatgt tactacgcca tggatctagt gggacgattt aattctagag atgagttccc
     2041 cctcattcag gagaactgag tctttaaaaa aaacacacac acattgatgt atttgaaatt
     2101 taacaccgtg caaatgagag aaaaaaaatg acctttgtgt ttaaaccctg gttgcagaca
     2161 gtgtagaacc taacctgtta tttttatata gggtgcttcc tatatgttga acttattcat
     2221 acaatagagc ctttacaagt tattctatta tgttaatgtg caacttagct ataggattca
     2281 gtcctgtttt tcagcaaaac agaggcaatt aaattttaaa aaataggcta actagaacat
     2341 aaaatataca gccttacttt tctcacatta agcttgtgac taataggagt acagcagtgc
     2401 taacatatct tggaaacagc taagtcaaag gtggaggtta attttgttaa tcatggaaat
     2461 gagctaatat cttttaaata aatgcattaa ttgaattata catagttcta agtacatgtc
     2521 agtgcctggg aaaatctgtt ctttcaaaac atattttctg caagtggtcc aattcacttt
     2581 gtaaaaaacg caatactgta ctgtagtagt gggcataaga atgtagaatt tttcatagtg
     2641 atatacagac ataacattgc tatattgcat agtcataaaa tctttaacaa aaatagcagt
     2701 aaaagatact tgatagctgt atcttggaga atattttata gtagagtctt tgatgtagtt
     2761 agaaatttgt tacttgaatt gtaatggcgt tacaaagtga tacaagtatt tgtttattat
     2821 attataaata aggaagtttc ataatataac ccaatcaaaa ggtacaaaac attgctcatc
     2881 aaattaggat taaggtaaca aatatattca gtttacatgt ttagttcata gttttgtact
     2941 aaaatatcta cagaaacctt tataaaattc ttcaatgctt tataagcata ttctaattat
     3001 tctaagaagc agttagtata agcatggctg tggcactata tgcactagaa ctatgagtta
     3061 gaaatattta aaaggtcttg atatgaaatt gagtcttatt tatattctta taacacttaa
     3121 gataaacatt aagttctcta acatgaataa aatttctatt ttatcaatat tttatgatat
     3181 aaaatgttaa tgtttcatat ttttacaatt cccctctatt ttctggacag acaagttctc
     3241 tcctctgata gatacccata tatgcaatta tggcaaaagt gtattgtttt tgtctattac
     3301 aaaagttaca atggaatgct ttaattacct tgacagaaaa atgccataat tacagtttga
     3361 aaatgagaat gtctttttca aaattacaga aaactaataa tatccagaat taaagagcaa
     3421 ttaagaagac agtctgtttg atctaagata gtgatttaga gtcatataaa tgtttcccat
     3481 ttttttttta ccaacgtttt aagatcaata gaaataagag gaataaaagt gatattaaat
     3541 tatacattta gttctggaga tgggttcccc cagtcattca ggagacctga gtctgttttt
     3601 tatacattga tatatttgat atagcaacac gcaaatgaga gggggaaaaa cctttgtgtt
     3661 tgaactctaa ttgcaggcag tgtagaacct aacctgctat tagggtgctt cctatgttca
     3721 tcaattctgt gtagttactc aatgaaaact ctagtgtcat caggtgaaga tgtccattca
     3781 tctcatttct atctctatat gttttcactt cagatttgtc aaataaaatg gaaactggag
     3841 agtgtcatac aaaatattct tatgtatcta aataaaatat gttaagcatc aaaaaaaaaa
     3901 aaaaaaaaa
//
