LOCUS       NM_013723               5330 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus podocalyxin-like (Podxl), mRNA.
ACCESSION   NM_013723
VERSION     NM_013723.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5330)
  AUTHORS   Arriagada,C., Lin,E., Schonning,M. and Astrof,S.
  TITLE     Mesodermal fibronectin controls cell shape, polarity, and
            mechanotransduction in the second heart field during cardiac
            outflow tract development
  JOURNAL   Dev Cell 60 (1), 62-84 (2025)
   PUBMED   39413783
REFERENCE   2  (bases 1 to 5330)
  AUTHORS   Weberling,A., Siriwardena,D., Penfold,C., Christodoulou,N.,
            Boroviak,T.E. and Zernicka-Goetz,M.
  TITLE     Primitive to visceral endoderm maturation is essential for mouse
            epiblast survival beyond implantation
  JOURNAL   iScience 28 (1), 111671 (2024)
   PUBMED   39868030
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5330)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5330)
  AUTHORS   Tarnick,J., Elhendawi,M., Holland,I., Chang,Z. and Davies,J.A.
  TITLE     Innervation of the developing kidney in vivo and in vitro
  JOURNAL   Biol Open 12 (8) (2023)
   PUBMED   37439314
REFERENCE   5  (bases 1 to 5330)
  AUTHORS   Barlow,H.R., Ahuja,N., Bierschenk,T., Htike,Y., Fassetta,L.,
            Azizoglu,D.B., Flores,J., Gao,N., De la,O. S, Sneddon,J.B.,
            Marciano,D.K. and Cleaver,O.
  TITLE     Rab11 is essential to pancreas morphogenesis, lumen formation and
            endocrine mass
  JOURNAL   Dev Biol 499, 59-74 (2023)
   PUBMED   37172642
REFERENCE   6  (bases 1 to 5330)
  AUTHORS   Anisimov,S.V., Tarasov,K.V., Riordon,D., Wobus,A.M. and
            Boheler,K.R.
  TITLE     SAGE identification of differentiation responsive genes in P19
            embryonic cells induced to form cardiomyocytes in vitro
  JOURNAL   Mech Dev 117 (1-2), 25-74 (2002)
   PUBMED   12204248
REFERENCE   7  (bases 1 to 5330)
  AUTHORS   Li,J., Li,Y., Brophy,P.D. and Kershawt,D.B.
  TITLE     Gene structure and alternative splicing of murine podocalyxin: a
            member of the CD34 sialomucin family
  JOURNAL   DNA Seq 12 (5-6), 407-412 (2001)
   PUBMED   11913788
REFERENCE   8  (bases 1 to 5330)
  AUTHORS   Doyonnas,R., Kershaw,D.B., Duhme,C., Merkens,H., Chelliah,S.,
            Graf,T. and McNagny,K.M.
  TITLE     Anuria, omphalocele, and perinatal lethality in mice lacking the
            CD34-related protein podocalyxin
  JOURNAL   J Exp Med 194 (1), 13-27 (2001)
   PUBMED   11435469
  REMARK    GeneRIF: Podocalyxin is required for normal kidney function
REFERENCE   9  (bases 1 to 5330)
  AUTHORS   Huttenhofer,A., Kiefmann,M., Meier-Ewert,S., O'Brien,J.,
            Lehrach,H., Bachellerie,J.P. and Brosius,J.
  TITLE     RNomics: an experimental approach that identifies 201 candidates
            for novel, small, non-messenger RNAs in mouse
  JOURNAL   EMBO J 20 (11), 2943-2953 (2001)
   PUBMED   11387227
REFERENCE   10 (bases 1 to 5330)
  AUTHORS   Hara,T., Nakano,Y., Tanaka,M., Tamura,K., Sekiguchi,T.,
            Minehata,K., Copeland,N.G., Jenkins,N.A., Okabe,M., Kogo,H.,
            Mukouyama,Y. and Miyajima,A.
  TITLE     Identification of podocalyxin-like protein 1 as a novel cell
            surface marker for hemangioblasts in the murine
            aorta-gonad-mesonephros region
  JOURNAL   Immunity 11 (5), 567-578 (1999)
   PUBMED   10591182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY137094.1 and AF290209.1.
            
            On Jan 4, 2008 this sequence version replaced NM_013723.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF290209.1, BC054530.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               BY137094.1         2-102
            102-5330            AF290209.1         1-5229
FEATURES             Location/Qualifiers
     source          1..5330
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.57 cM"
     gene            1..5330
                     /gene="Podxl"
                     /gene_synonym="Ly102; PC; PCLP-1; Pclp1; Podxl1"
                     /note="podocalyxin-like"
                     /db_xref="GeneID:27205"
                     /db_xref="MGI:MGI:1351317"
     exon            1..359
                     /gene="Podxl"
                     /gene_synonym="Ly102; PC; PCLP-1; Pclp1; Podxl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..1801
                     /gene="Podxl"
                     /gene_synonym="Ly102; PC; PCLP-1; Pclp1; Podxl1"
                     /note="podocalyxin-like protein 1"
                     /codon_start=1
                     /product="podocalyxin precursor"
                     /protein_id="NP_038751.2"
                     /db_xref="CCDS:CCDS19983.1"
                     /db_xref="GeneID:27205"
                     /db_xref="MGI:MGI:1351317"
                     /translation="MPPTTALSALLLLLLSPASHSHNGNETSTSAIKSSTVQSHQSAT
                     TSTEVTTGHPVASTLASTQPSNPTPFTTSTQSPSMPTSTPNPTSNQSGGNLTSSVSEV
                     DKTKTSSPSSTAFTSSSGQTASSGGKSGDSFTTAPTTTLGLINVSSQPTDLNTTSKLL
                     STPTTDNTTSPQQPVDSSPSTASHPVGQHTPAAVPSSSGSTPSTDNSTLTWKPTTHKP
                     LGTSEATQPLTSQTPGITTLPVSTLQQSMASTVGTTTEEFTHLISNGTPVAPPGPSTP
                     SPIWAFGNYQLNCEPPIRPDEELLILNLTRASLCERSPLDEKEKLVELLCHSVKASFK
                     PAEDLCTLHVAPILDNQAVAVKRIIIETKLSPKAVYELLKDRWDDLTEAGVSDMKLGK
                     EGPPEVNEDRFSLPLIITIVCMASFLLLVAALYGCCHQRISQRKDQQRLTEELQTVEN
                     GYHDNPTLEVMETPSEMQEKKVVNLNGELGDSWIVPLDNLTKDDLDEEEDTHL"
     exon            360..938
                     /gene="Podxl"
                     /gene_synonym="Ly102; PC; PCLP-1; Pclp1; Podxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1147
                     /gene="Podxl"
                     /gene_synonym="Ly102; PC; PCLP-1; Pclp1; Podxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1219
                     /gene="Podxl"
                     /gene_synonym="Ly102; PC; PCLP-1; Pclp1; Podxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1373
                     /gene="Podxl"
                     /gene_synonym="Ly102; PC; PCLP-1; Pclp1; Podxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1435
                     /gene="Podxl"
                     /gene_synonym="Ly102; PC; PCLP-1; Pclp1; Podxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1603
                     /gene="Podxl"
                     /gene_synonym="Ly102; PC; PCLP-1; Pclp1; Podxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..5330
                     /gene="Podxl"
                     /gene_synonym="Ly102; PC; PCLP-1; Pclp1; Podxl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5310..5315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Podxl"
                     /gene_synonym="Ly102; PC; PCLP-1; Pclp1; Podxl1"
                     /note="hexamer: AATAAA"
     polyA_site      5330
                     /gene="Podxl"
                     /gene_synonym="Ly102; PC; PCLP-1; Pclp1; Podxl1"
                     /note="major polyA site"
ORIGIN      
        1 gggggcggag gccagcgcgg acgggacggg gcgggagtct tcgcagcaac gtgcgcgggg
       61 ccgcagcggc gcagacaccg cccgggccgc agacaccttc gctcgtcgct gctggctccg
      121 tgtcccagcc cagctctgcg gtaggcagga ggagcggccg gatcgcgact ccggagttcg
      181 cggccgtcgc caggcctccc ggagcggcgc cgacgctccc gctgtccgga cgcgcgaccc
      241 tgcgccagcg ccgcagccac ctgctcggag tccccgggcg agcacaacca tgcctcccac
      301 tacggcgctc tccgcgctgc tgctgctgct actgtcgcct gcatctcact cccataatgg
      361 aaatgagact agcacatctg ctatcaaatc tagcactgtc cagagccacc aaagtgccac
      421 aacatcaaca gaagtcacaa ctggtcaccc agtggcatct acacttgctt caacccagcc
      481 aagcaaccct acaccattca caacctcaac ccaatctcca tctatgccga cctccacccc
      541 aaaccccacg agcaatcaaa gcggtggcaa tctgacttcc agtgtctccg aggtggacaa
      601 gactaaaaca agctctccca gtagcacggc cttcaccagt agcagtggac aaacagcctc
      661 ctctggaggc aagagcggtg acagttttac cacagcccca acaaccactt tggggctaat
      721 caacgtctct tctcagccta ctgaccttaa taccacctca aagcttcttt ctacccccac
      781 aacagacaac acaacaagcc ctcagcagcc tgtggattct tcaccgagca cagcgagcca
      841 tcctgtgggg cagcataccc ctgctgctgt tcccagcagc tctggctcca cgcccagcac
      901 tgacaactct acactgacat ggaagcccac tacacacaaa ccattgggca cctctgaagc
      961 cactcagccc ctcaccagcc agacaccagg catcactaca ttgcccgtct ccacactgca
     1021 acagtctatg gcgtctacag tgggaactac gactgaagag ttcacacacc tcatctctaa
     1081 tgggactccc gtggcccctc caggccccag cacaccctct cccatctggg cctttggaaa
     1141 ttaccagcta aactgtgaac ctcccataag gccagatgag gaactcctta ttctgaacct
     1201 cacaagagcc agcctttgcg aaaggagccc tctggatgag aaagagaaac tcgtggaact
     1261 gctgtgtcac tcagtcaaag cgtccttcaa gccagctgag gatttgtgca ctctacatgt
     1321 ggcccctatt ctagataacc aggcggtggc agtgaagaga atcattatcg agacgaagct
     1381 ttctcctaag gccgtgtatg agctactgaa ggacagatgg gatgacctga cagaggccgg
     1441 agtcagtgac atgaagctgg ggaaggaagg gcctccagag gtcaatgagg accgcttcag
     1501 cctgccgctc atcatcacca tcgtctgcat ggcatccttc ctgctccttg ttgctgccct
     1561 ctacggctgc tgtcaccagc ggatctccca gaggaaggac cagcaacggc tcacagagga
     1621 gctgcagaca gtggagaatg gttaccatga caacccaacc ttggaagtga tggagactcc
     1681 ttctgagatg caggagaaga aggtggtcaa ccttaatggg gagctggggg acagttggat
     1741 cgtccctctg gacaacttga ccaaggatga cctagatgag gaggaagaca cacacctctg
     1801 atctgtctgc tggccacccc aactgcactg cagagctcca gaccacccaa agtgccattt
     1861 ggacagggag ggggaaatct tcccacctga agacagaaag actggggagg gagaatggac
     1921 tccgaaggtt gtctccctcc tcacaatccc tacagggcct taattttcct tttcaagttc
     1981 aacaaagtca cattctgtct agttccctca tgtaaaataa cctacttgtg cctgagccca
     2041 gagcaggaag gcaggaggaa gatggagaac gccatgcgag tctctggagc tcctccagga
     2101 acggcaccct ctcatctcat aactgaggcc ttaagaggtc aggtgacttg cacggggcca
     2161 cacagccctt tggtgacaaa ggttgtttcc ctcagtctgg tgcttaattg catccagaca
     2221 cactactgtg ttcatctgtg cccattcccc aaggcacaag acacttgcag gtgggcaggc
     2281 tggaaaagaa aaccaagcct ctatggtctc aaggacaggt ccccaatttc catctcctat
     2341 aacatggcct cggctagctt gttgtatccc acctctcatg agttagtctt tagtcccatt
     2401 atttcccagg gcatggcttt gaacttcttg ttctacattc tgatttcctt gcctttctta
     2461 gtgggattgg gactaaactc acaggcctca ctatctaatg gagtctgcct aaggggtggg
     2521 tgggcaggca aaggcatctc atgctctgat ggcttcccca atagcttcct catggcagct
     2581 gattctgtac tgagactggc ctatcattta agacactccc tagaagacac ttctcaaaaa
     2641 tctcctctgg ccgtctgctt ctgctccttt tttgttgttc actgctcagc tgagtgggtg
     2701 actcctcaaa acctagtgtc acatagcagt tgtctaggaa cagatatgtc ctggggtccc
     2761 aactggtccc tgattggcaa atgtgtctca gtagacaatc gatctaacct accaggcatt
     2821 attattattc cacaggaagc tcagggactt ttcaagttgc tgagagcttg ggttggtgtg
     2881 ctgtggtgtg ttgtgtgtgt gtgcgccagc tccttactgc caaaggccaa agctcagatc
     2941 gtggagactg tgagctaatt ccatcggttt gcaccctcct ttgccacatg gagaaaggcc
     3001 cagattgtgc agttttaaga taccttggcc tactctccca gcacggagcc aggcttttgt
     3061 gtctggtgtg ctttgtggca ttccagctgt cccatttctg atggcctctc agggaacata
     3121 aaaccatgcc tagtacctag cacaggattt gtccaggctc agcggtgtca ggcagccatg
     3181 tccaaggttg cgagggccca gcatagtgat gatgggtttc ctgagaaagg ggaaggggcc
     3241 ctgtgtggag ctttgaatta ggcccatggt ttgtattctt gtggtataag ttcccaggac
     3301 tgtctggttt ggagcagctt atttgaaagg ggagctaggg gggcagacag gtgtcctctg
     3361 cctgagtcca tctttaccac tgtctctctg agatacagac tagagagaaa gaaaaggctg
     3421 acagaagtca gggaaggctc ctagtgagtt tcacaggagc ttgaaaaaaa ggctaagaag
     3481 aactcaacaa gccccttggc atgcttctct aaggtttgca ggggagtgtg gggaacagtg
     3541 ccaactgggg gggggggggg aattaggtct gtttgatccc tgcattaggt tctgccaccc
     3601 agtgggttca ttctgtcatg gtccgagagg cagacaggat ttcttcttct caatggggca
     3661 aggccatttg acagaccgca aatgcttttt ctgcaaactg gtcacagatt tcaaccctac
     3721 agtctgtcag ctatgattgt aatattagac aacagatagt gtgtctgggc tggaggaaca
     3781 gccatggctc tgaccagact ggcccagtgt tccttcttgt gcactcaaat tgtgtagcct
     3841 tttattacct ggccttcact tgctcttacg gctgggacat ctgttcagca agacatgctg
     3901 ctagcatcta taaaagtcat cttcctgtgg ttatgaccgg gtttttagag ctgttaactc
     3961 agaatctcag gcccagtcag agaaaaggga gaggaaggga actttagagc cagctgtacc
     4021 aaagagaaac cagagctctt catttcagtg gcaaatggtt ctcccctagc tgcaaacccc
     4081 aagggcccga tggctgtgcc tgagcacacc cagcagctct tgtgctccca cgtgcatgtc
     4141 aagagaggca ggtgagcatg gggcactgag cagtctgccc ggcagaaaag gacccagact
     4201 catctaggac actcacttct atcttccctg atagagtgag ccagcccact ctatcagtgt
     4261 ttgagttcta ttggtctttg cctatttttt ggacaataca ctggtgaaac tttggagagt
     4321 aagttgaagt tgacaagatc tatgcatatt tttgacaatg taaatacaag agccacatgt
     4381 ttatttacct tgtactactt tcagagagta aacttggggt aaagatttga tagctatgag
     4441 agatagctaa gcctccctcc ccacttctga acaagaatgt aaatgtctat ttagtagaga
     4501 tgactttttt aaaaatgaag aaagtaacaa gacaggctgg taacaaacgt atttgccttg
     4561 gagatagtgg atttacacct cccctgccaa gtcgcagtcc tactgcagtt caggctggag
     4621 ttgagaatgg tctgtgatgg tcacggggaa aggtttggag atacagtcta gtctccctac
     4681 aggaaatcac atctgaagac acaaagagtc tccccaggga cagggacaag aggaaaacac
     4741 gcatcccaca ctgcccaccc tgtgctgcgt gtttctcaag aacagggaat taaggactgc
     4801 aacttctagg tacaaggtta taggagaccg ccagccttcc tcacgatgac cctggagggg
     4861 ctgggagaac acaagggaca atagcagcca tatttggggc tctggaatca tgtggtccga
     4921 ggtgtaaata agcattctag gggcttgggt ttttgttttt gttttcctgt caggaattaa
     4981 ttttgaaaac tccttgagga atgtccagca gaatgaggct caaagggact gcatagatga
     5041 aggcagaggg ggagaagccc tgtgtagaac agcctgtgtc accgtcaggt gtctgatgct
     5101 tccctcggtc tgccgcaaac ccaccactgg ccaggatcac tgttttgtgg gggcctttct
     5161 gtttgtgaat gtcaaccagc ttgcccagga gattggggga gtgtatgttg tagtggacag
     5221 gggtctaaag tacactggaa tttattgaga gattatagtt aactattgca ttttcttata
     5281 aagtctattt tggaaaattg tacactgtca ataaaaatgc ttttgtgtaa
//
