LOCUS       NM_172874               3032 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus podocan (Podn), transcript variant 2, mRNA.
ACCESSION   NM_172874 XM_979768
VERSION     NM_172874.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3032)
  AUTHORS   Teng,H., Zheng,J., Liang,Y., Zhao,J., Yan,Y., Li,S., Li,S. and
            Tong,H.
  TITLE     Podocan promoting skeletal muscle post-injury regeneration by
            inhibiting TGF-beta signaling pathway
  JOURNAL   FASEB J 38 (5), e23502 (2024)
   PUBMED   38430223
  REMARK    GeneRIF: Podocan promoting skeletal muscle post-injury regeneration
            by inhibiting TGF-beta signaling pathway.
REFERENCE   2  (bases 1 to 3032)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3032)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3032)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3032)
  AUTHORS   Hutter,R., Huang,L., Speidl,W.S., Giannarelli,C., Trubin,P.,
            Bauriedel,G., Klotman,M.E., Fuster,V., Badimon,J.J. and
            Klotman,P.E.
  TITLE     Novel small leucine-rich repeat protein podocan is a negative
            regulator of migration and proliferation of smooth muscle cells,
            modulates neointima formation, and is expressed in human atheroma
  JOURNAL   Circulation 128 (22), 2351-2363 (2013)
   PUBMED   24043300
REFERENCE   6  (bases 1 to 3032)
  AUTHORS   Shimizu-Hirota,R., Sasamura,H., Kuroda,M., Kobayashi,E. and
            Saruta,T.
  TITLE     Functional characterization of podocan, a member of a new class in
            the small leucine-rich repeat protein family
  JOURNAL   FEBS Lett 563 (1-3), 69-74 (2004)
   PUBMED   15063725
  REMARK    GeneRIF: Podn was characterized in cultured mouse cells.
REFERENCE   7  (bases 1 to 3032)
  AUTHORS   Ross,M.D., Bruggeman,L.A., Hanss,B., Sunamoto,M., Marras,D.,
            Klotman,M.E. and Klotman,P.E.
  TITLE     Podocan, a novel small leucine-rich repeat protein expressed in the
            sclerotic glomerular lesion of experimental HIV-associated
            nephropathy
  JOURNAL   J Biol Chem 278 (35), 33248-33255 (2003)
   PUBMED   12796502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL611936.11.
            
            On Dec 13, 2019 this sequence version replaced NM_172874.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY313606.1, AK161018.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AL611936.11        157846-157930       c
            86-201              AL611936.11        155914-156029       c
            202-262             AL611936.11        154584-154644       c
            263-582             AL611936.11        152952-153271       c
            583-676             AL611936.11        151492-151585       c
            677-741             AL611936.11        150253-150317       c
            742-851             AL611936.11        149279-149388       c
            852-1008            AL611936.11        148457-148613       c
            1009-1124           AL611936.11        148039-148154       c
            1125-1782           AL611936.11        147130-147787       c
            1783-1931           AL611936.11        144770-144918       c
            1932-2129           AL611936.11        143683-143880       c
            2130-3032           AL611936.11        140769-141671       c
FEATURES             Location/Qualifiers
     source          1..3032
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.18 cM"
     gene            1..3032
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /note="podocan"
                     /db_xref="GeneID:242608"
                     /db_xref="MGI:MGI:2674939"
     exon            1..85
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /inference="alignment:Splign:2.1.0"
     exon            86..201
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /inference="alignment:Splign:2.1.0"
     exon            202..262
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /inference="alignment:Splign:2.1.0"
     exon            263..582
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..2103
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /codon_start=1
                     /product="podocan precursor"
                     /protein_id="NP_766462.2"
                     /db_xref="CCDS:CCDS18445.1"
                     /db_xref="GeneID:242608"
                     /db_xref="MGI:MGI:2674939"
                     /translation="MAGSRGLPLLLLVLQLFLGPVLPVRAPVFGRSDTPTLSPEENEF
                     VEEENQPVLVLSSEEPEPGPATVDCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHL
                     SLQNNQLEKIYPEELSRLQRLETLNLQNNRLTSRGLPEEAFEHLTSLNYLYLANNKLT
                     LAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDHMFNGSS
                     NVEILILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSNLRELYLQNNYLT
                     DEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIQSVEADVLTPIR
                     NLEYLLLHSNQLQAKGIHPLAFQGLKKLHTVHLYNNALERVPSGLPRRVRTLMILHNQ
                     ITGIGREDFATTYFLEELNLSYNRITSPQMHRDAFRKLRLLRSLDLSGNRLQTLPPGL
                     PKNVHVLKVKRNELAALARGALAGMAQLRELYLTGNRLRSRALGPRAWVDLAGLQLLD
                     IAGNQLTEVPEGLPPSLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVE
                     SAFRRLKHLQVLDIEGNFEFGNGSKDKDEEEEEEEEEEDEEEETR"
     exon            583..676
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /inference="alignment:Splign:2.1.0"
     exon            677..741
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /inference="alignment:Splign:2.1.0"
     exon            742..851
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1008
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1124
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1782
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1931
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2129
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..3032
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3006..3011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /note="hexamer: TATAAA"
     polyA_site      3032
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /note="major polyA site"
ORIGIN      
        1 gacttgaatg acaggagccg gcgcccgcgg agcgcagcgg acacccgcga gcctgttccg
       61 cccacggcgc ggcgcgcagc ggcaggtgct ggcaagggcc agtggcatca gatcccccag
      121 agctggggtt acaggtggtt gtgagtcatc ccagagagtg ctgggctcag tcttctgtga
      181 gcagagcact gctcttaaca gataagcttg tggactttta tggagacaag ccaaaggtga
      241 gagaagaaag ccagcctgtc cagcaccatg gctggcagca ggggcctgcc actcctactg
      301 ctggtgcttc agctcttcct gggccctgtg ctgcctgtga gggcacctgt gtttggccga
      361 agtgacaccc ccaccctgag ccccgaggag aatgaatttg tggaggaaga gaatcagcca
      421 gtgctggttc tgagctccga ggagccagag cctggcccag ccactgtcga ctgtccccga
      481 gattgtgcct gttcccagga aggtgtagtg gactgtggtg gcattgacct gcgtgagttt
      541 ccaggcgacc tgcccgagca caccaaccat ctctccttgc agaacaacca gctggagaag
      601 atctaccccg aggagctgtc ccggctgcag cggctggaga cgctgaacct gcagaacaac
      661 cgcctgacat cccgagggct cccagaggag gcatttgagc atcttactag cctcaattac
      721 ctgtacctgg ccaacaacaa gctgacactg gcaccccgat tcctgccaaa cgccctgatc
      781 agtgtggact ttgctgccaa ttatctcact aagatctatg gactcacctt tggccaaaag
      841 ccaaatctga ggtctgtgta cctgcataac aacaagctag cagatgccgg gctgccggac
      901 cacatgttca atggctccag caacgtcgag atcctaatcc tgtccagcaa cttcctgcgc
      961 cacgtgccca agcacctgcc acccgctctg tacaagctgc acctcaagaa caataagcta
     1021 gagaagatcc cccctggggc cttcagtgag ctgagcaacc tacgggaact ctacctgcag
     1081 aacaactacc tgaccgacga gggtctggac aacgagacct tctggaagct gtccagcctg
     1141 gagtacctgg acttgtccag caacaacctg tcgagggtcc cagcgggtct tccccgcagc
     1201 ctggtcctgc tgcacctgga gaaaaatgcc atccagagcg tagaagctga tgtgctgaca
     1261 cccatccgca acctggagta cctgctgcta catagcaacc agctgcaggc caagggtatc
     1321 cacccactgg ccttccaggg cctcaagaag ctccacacag tgcatctata caacaacgcg
     1381 ctggaacgtg tgcccagcgg cctgccccgc cgagtgcgca ccctcatgat cctgcacaac
     1441 cagattacag gcataggccg tgaggacttc gctaccacct acttcctgga agagctcaac
     1501 ctcagctaca accgcatcac cagcccacag atgcaccgag atgccttccg caagctacgc
     1561 ctgctgcgtt cacttgactt gtctggcaac cgtctgcaaa cactgcctcc aggcctgccg
     1621 aaaaacgtac acgtgctcaa ggtcaagcgg aatgagctgg ctgccctggc acgtggggca
     1681 ctagctggca tggcccagct tcgggaactc tacctcacag gcaaccgact gcgaagccgg
     1741 gccctgggac cccgtgcctg ggtggacctt gctggtctgc agctgctgga catcgctggg
     1801 aatcagctca cagaggtccc tgaggggctc cccccatctc tggagtatct gtacctgcag
     1861 aataacaaga ttagtgccgt tcctgccaac gcctttgact ccactcccaa ccttaagggg
     1921 atctttctca ggttcaacaa gctggctgtg ggctccgtgg tggaaagcgc cttccggagg
     1981 ctgaaacacc tgcaggtctt ggacattgaa ggcaactttg agtttggtaa tggttccaag
     2041 gacaaagatg aggaagagga agaagaggag gaagaggaag atgaggaaga ggaaactaga
     2101 taggacaaag tgacatggat gaaacccagg acgatggact accggactcc tttctgcagc
     2161 ccaggcctgt gccccatgag cgcccccttc tgacacaccc aacgctgagc ccaagaggca
     2221 cccgaaagtc acacgggctg aacacagtct cgtgtcccac cccttccagc aatgtgtcac
     2281 acagtcagac acgtgcagat accacttcac caccacgccc ccagtttggc cacgtagata
     2341 gccagctgca tatgaccttc caaactggct ctctgcacaa tctcacactg acacacacac
     2401 acacacacac acacacacac acacacacac acacacacac acaccctcac ctctgagtcc
     2461 acactggcct ggtagactca ggcagctacc ctctccccta ttcacttaca cagagtgacc
     2521 tatgctacca aaagctcttg cttccagaca gctctggttg gaaacagttg gccatgtgcc
     2581 ttgtcctctg gtccctccct tggagacgca gggttgtctc cttgctctgt ggccgggtgc
     2641 ttttcactct ttgagacgca aaagctggct tttgttttgt gccttcccta tggggacttg
     2701 aaccttctgc cttcgaccac agcctcacct cctcccccca ggtgctgggc actcctactg
     2761 ctgggagtcc ctttttgttg tgccctggca ggtcacaggc actttcagag aacagcctca
     2821 agaaggcttg gaagagaaag aggcagcagt gcgtggtggg ggtggggtgg ggtggtggca
     2881 gctgcgttgg tcttcagttc tgcagggaag ttctgggtac ctttggtttt gtttaaggag
     2941 aaaaaaaaat atatatgaag ataaaaatct caaagctgat ttttttcctg ttacagaaaa
     3001 actaatataa agtattatcc ctgcccttgc aa
//
