LOCUS       NP_766462                611 aa            linear   ROD 07-FEB-2025
DEFINITION  podocan precursor [Mus musculus].
ACCESSION   NP_766462 XP_984862
VERSION     NP_766462.2
DBSOURCE    REFSEQ: accession NM_172874.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 611)
  AUTHORS   Teng,H., Zheng,J., Liang,Y., Zhao,J., Yan,Y., Li,S., Li,S. and
            Tong,H.
  TITLE     Podocan promoting skeletal muscle post-injury regeneration by
            inhibiting TGF-beta signaling pathway
  JOURNAL   FASEB J 38 (5), e23502 (2024)
   PUBMED   38430223
  REMARK    GeneRIF: Podocan promoting skeletal muscle post-injury regeneration
            by inhibiting TGF-beta signaling pathway.
REFERENCE   2  (residues 1 to 611)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 611)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (residues 1 to 611)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (residues 1 to 611)
  AUTHORS   Hutter,R., Huang,L., Speidl,W.S., Giannarelli,C., Trubin,P.,
            Bauriedel,G., Klotman,M.E., Fuster,V., Badimon,J.J. and
            Klotman,P.E.
  TITLE     Novel small leucine-rich repeat protein podocan is a negative
            regulator of migration and proliferation of smooth muscle cells,
            modulates neointima formation, and is expressed in human atheroma
  JOURNAL   Circulation 128 (22), 2351-2363 (2013)
   PUBMED   24043300
REFERENCE   6  (residues 1 to 611)
  AUTHORS   Shimizu-Hirota,R., Sasamura,H., Kuroda,M., Kobayashi,E. and
            Saruta,T.
  TITLE     Functional characterization of podocan, a member of a new class in
            the small leucine-rich repeat protein family
  JOURNAL   FEBS Lett 563 (1-3), 69-74 (2004)
   PUBMED   15063725
  REMARK    GeneRIF: Podn was characterized in cultured mouse cells.
REFERENCE   7  (residues 1 to 611)
  AUTHORS   Ross,M.D., Bruggeman,L.A., Hanss,B., Sunamoto,M., Marras,D.,
            Klotman,M.E. and Klotman,P.E.
  TITLE     Podocan, a novel small leucine-rich repeat protein expressed in the
            sclerotic glomerular lesion of experimental HIV-associated
            nephropathy
  JOURNAL   J Biol Chem 278 (35), 33248-33255 (2003)
   PUBMED   12796502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL611936.11.
            
            On or before May 4, 2006 this sequence version replaced
            XP_984862.1, NP_766462.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY313606.1, AK161018.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..611
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.18 cM"
     Protein         1..611
                     /product="podocan precursor"
                     /calculated_mol_wt=66319
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2418
     mat_peptide     24..611
                     /product="Podocan. /id=PRO_0000262525"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
                     /calculated_mol_wt=66319
     Region          68..99
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          80..97
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          98..119
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          101..122
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <108..373
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          122..145
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          123..148
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          148..169
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          149..193
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          170..190
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          193..213
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          194..219
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            215
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          219..239
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          220..240
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          240..261
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          <241..>535
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          241..264
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          264..284
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          265..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            282
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          290..311
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          291..311
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          312..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          312..332
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          335..358
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          336..361
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          361..382
                     /region_name="LRR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          383..403
                     /region_name="LRR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          406..427
                     /region_name="LRR 14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          407..503
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            411
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          432..453
                     /region_name="LRR 15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          477..490
                     /region_name="LRR 16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          503..523
                     /region_name="LRR 17"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          504..524
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          523..583
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          524..545
                     /region_name="LRR 18"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          525..548
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          548..569
                     /region_name="LRR 19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          549..572
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          574..583
                     /region_name="LRR 20"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     Region          585..611
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQ62.1)"
     CDS             1..611
                     /gene="Podn"
                     /gene_synonym="9430070G18; Pcan; SLRR5A"
                     /coded_by="NM_172874.4:268..2103"
                     /db_xref="CCDS:CCDS18445.1"
                     /db_xref="GeneID:242608"
                     /db_xref="MGI:MGI:2674939"
ORIGIN      
        1 magsrglpll llvlqlflgp vlpvrapvfg rsdtptlspe enefveeenq pvlvlsseep
       61 epgpatvdcp rdcacsqegv vdcggidlre fpgdlpehtn hlslqnnqle kiypeelsrl
      121 qrletlnlqn nrltsrglpe eafehltsln ylylannklt laprflpnal isvdfaanyl
      181 tkiygltfgq kpnlrsvylh nnkladaglp dhmfngssnv eililssnfl rhvpkhlppa
      241 lyklhlknnk lekippgafs elsnlrelyl qnnyltdegl dnetfwklss leyldlssnn
      301 lsrvpaglpr slvllhlekn aiqsveadvl tpirnleyll lhsnqlqakg ihplafqglk
      361 klhtvhlynn alervpsglp rrvrtlmilh nqitgigred fattyfleel nlsynritsp
      421 qmhrdafrkl rllrsldlsg nrlqtlppgl pknvhvlkvk rnelaalarg alagmaqlre
      481 lyltgnrlrs ralgprawvd laglqlldia gnqltevpeg lppsleylyl qnnkisavpa
      541 nafdstpnlk giflrfnkla vgsvvesafr rlkhlqvldi egnfefgngs kdkdeeeeee
      601 eeeedeeeet r
//
