LOCUS       NM_027740               2913 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus POC1 centriolar protein B (Poc1b), transcript variant
            1, mRNA.
ACCESSION   NM_027740 XM_356488
VERSION     NM_027740.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2913)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2913)
  AUTHORS   Hua,J., Xu,B., Liu,W., Shi,J., Jiang,H., Zha,X., Zhang,X. and
            Wan,Y.
  TITLE     Homozygous frameshift variant in POC1B causes male infertility with
            oligoasthenoteratozoospermia in human and mice
  JOURNAL   Hum Mol Genet 32 (14), 2307-2317 (2023)
   PUBMED   37070736
  REMARK    GeneRIF: Homozygous frameshift variant in POC1B causes male
            infertility with oligoasthenoteratozoospermia in human and mice.
REFERENCE   3  (bases 1 to 2913)
  AUTHORS   Sha,Y.W., Wang,X., Xu,X., Ding,L., Liu,W.S., Li,P., Su,Z.Y.,
            Chen,J., Mei,L.B., Zheng,L.K., Wang,H.L., Kong,S.B., You,M. and
            Wu,J.F.
  TITLE     Biallelic mutations in PMFBP1 cause acephalic spermatozoa
  JOURNAL   Clin Genet 95 (2), 277-286 (2019)
   PUBMED   30298696
REFERENCE   4  (bases 1 to 2913)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2913)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2913)
  AUTHORS   Hughes,D.S., Keynes,R.J. and Tannahill,D.
  TITLE     Extensive molecular differences between anterior- and
            posterior-half-sclerotomes underlie somite polarity and spinal
            nerve segmentation
  JOURNAL   BMC Dev Biol 9, 30 (2009)
   PUBMED   19463158
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2913)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC144819.1, AK050233.1, BC050888.1 and CO041491.1.
            
            On Jan 13, 2018 this sequence version replaced NM_027740.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090075.1, BC099926.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BC144819.1         1-21
            22-1815             AK050233.1         2-1795
            1816-2172           BC050888.1         1725-2081
            2173-2913           CO041491.1         1-741               c
FEATURES             Location/Qualifiers
     source          1..2913
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 51.06 cM"
     gene            1..2913
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /note="POC1 centriolar protein B"
                     /db_xref="GeneID:382406"
                     /db_xref="MGI:MGI:1918511"
     exon            1..142
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1558
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /note="WD repeat domain 51B; WD repeat-containing protein
                     51B"
                     /codon_start=1
                     /product="POC1 centriolar protein homolog B"
                     /protein_id="NP_082016.1"
                     /db_xref="CCDS:CCDS36045.1"
                     /db_xref="GeneID:382406"
                     /db_xref="MGI:MGI:1918511"
                     /translation="MASGLEDPILERSFKGHKAAITSADFSPNCKQIATASWDTFLML
                     WSLKPHARAYRYVGHKDVVTSLQFSPQGNLLASASRDRTVRLWVLDRKGKSSEFKAHT
                     APVRSVDFSADGQLLVTASEDKSIKVWSMFRQRFLYSLYRHTHWVRCAKFSPDGRLIV
                     SCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPNGTCIASAGSDHAVKIWDIRMN
                     KLLQHYQVHSCGVNCLSFHPLGNSLVTASSDGTVKMLDLIEGRLIYTLQGHTGPVFTV
                     SFSKDGELLTSGGADAQVLIWRTNFIHLHCKDPKRNLKRLHFEASPHLLDIYPRSPHS
                     HEDRKETIEINPKREVMDLQSSSPPVVDVLSFDSTTMTDSTYRAVPGKGEDICRYFLN
                     PLLMPECSSTTVKKRPEDVSDVPSESLRSVPLAVADALEHIMEQLNILTQTVSILEQR
                     LSLTEDKLRDCLENQQKLFSAVQQKS"
     exon            143..227
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /inference="alignment:Splign:2.1.0"
     exon            228..399
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /inference="alignment:Splign:2.1.0"
     exon            400..579
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /inference="alignment:Splign:2.1.0"
     exon            580..687
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /inference="alignment:Splign:2.1.0"
     exon            688..803
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /inference="alignment:Splign:2.1.0"
     exon            804..937
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1006
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1156
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1237
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1453
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..2902
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2874..2879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /note="hexamer: AATAAA"
     polyA_site      2902
                     /gene="Poc1b"
                     /gene_synonym="4933430F16Rik; Wdr51b"
                     /note="major polyA site"
ORIGIN      
        1 gccgccgttg ttgtagtgac cgggaagcgc ccgcactcca gtctgacggt tccgggcgcc
       61 gcacggtccc ccctcgtccc cacccctccc tggtccccca aggccccggg cgccgtccgc
      121 tccccgcatg gcctccggcc tggaggatcc gattctggaa cgttctttta aaggtcacaa
      181 agctgccatc acctccgctg acttcagccc caactgcaaa caaattgcta ctgcttcgtg
      241 ggacaccttt ctcatgctat ggagtttgaa gccacacgct agagcttaca gatacgtggg
      301 ccacaaggat gttgtaacca gcctgcagtt ctcgccacaa ggaaacctat tagcctctgc
      361 ctcgagggac agaactgtta gactgtgggt tcttgatagg aaagggaagt cttcagaatt
      421 taaagcacac acagccccag ttcggagtgt ggacttttcc gctgatggcc agcttttggt
      481 tacagcatct gaagataaat ccattaaagt gtggagtatg ttccgtcagc gcttcctcta
      541 ctccctgtat cgacacacac actgggtacg ctgcgccaaa ttttcacctg acggaaggtt
      601 gatcgtgtca tgtagtgagg ataaaactat taaaatttgg gacactacca ataagcagtg
      661 cgttaataac ttctcagact ctgtaggatt tgcaaatttt gtggatttta accccaacgg
      721 cacatgcatc gcttcagcag gttctgacca tgctgtgaaa atctgggata taagaatgaa
      781 caaattactc cagcactacc aagttcacag ctgcggtgtg aactgtctgt ccttccatcc
      841 tttgggtaac agccttgtca ccgcctcttc tgatggaaca gttaagatgc tggatctcat
      901 agagggaaga ctcatataca cacttcaagg acatacgggg cccgtcttta ccgtttcatt
      961 ttcgaaggac ggagagctgc ttacatcagg cggggcagat gcgcaggtct tgatttggag
     1021 gaccaacttc attcacctgc actgtaaaga tcctaaaaga aacctcaaaa gactgcactt
     1081 tgaggcctcc ccacaccttc ttgacatcta cccacggtca ccgcattccc atgaagacag
     1141 aaaggagact attgaaatta atcccaagcg tgaggtgatg gatttgcaga gctcgtctcc
     1201 ccccgtggtg gatgtccttt ctttcgattc aaccacaatg acggattcca cctatcgagc
     1261 tgtgccaggc aagggtgaag acatctgtag gtatttcttg aaccctttgt taatgccaga
     1321 atgttcatcc acaactgtga aaaagagacc agaagatgta agtgatgtgc cctccgaaag
     1381 cctgaggagc gtcccgctgg cggtggctga cgcactggag cacattatgg aacaactcaa
     1441 catcctaacc cagactgttt caattctgga gcagcgactg tctttgacag aagataagct
     1501 gagagactgc cttgagaatc agcaaaagct tttcagcgct gtccaacaga agagctgagc
     1561 agggagggcc gtgagcgagg tcaggtcagt cgccagaaga cgggctcaca cactctggag
     1621 gtagccgagg ccttccacac ccctgccacg cactaaccga ttcttcagag ggtgagcaac
     1681 gaaaccgaaa aggttccagg cattctcagg gactgactta aacacacaaa tcaatgtcaa
     1741 ggatcaagtt atgctcctcc caggtctaat tgcagtaata aagttatgaa cattttaatc
     1801 accccatttc ccccctcccc catattattt gaaatgtcag cttttattta acatgcagat
     1861 ccccaccagg aaagtaagcg gacctctaga ttttattgtt gcaccatcgc agaatgacca
     1921 tgcccaggca gttcctgaag gtaatgaatg tgtttcttag gtgagcacag ccttgagggg
     1981 aaaccattcg cttgctttca gatagcatct gagatgtaga aaactgagct ggctcgtagt
     2041 tctttcaggt caaaaagagt ctgccttgaa accatgctcc ctccctcagt attgccacag
     2101 caagaatcag ctgcttgtga ttagcaagcg tgctcacgtg acaaggcagg cgttttcctt
     2161 gtctggtggg aactgcatgg gacgtgcgca tctctggtgt tacaggtgaa cacactgagt
     2221 ggtctgggtc atactgaacc tgtggccaca gctcacagag attatgcctg tgtgctttca
     2281 gtacgctaaa aagccaaaat gatgaaaagg atgcacacat gaatcacatg tattattgct
     2341 taaggtgatt ctggtggctg aaataagtgc atttttattt aggaaaaaaa aaagtgcatc
     2401 gtctatttta gtttaatgaa ttgtgatttg aaatgaaaat gggtcaggca ttctaaaaga
     2461 tcttgaacac aagttaagaa cgtttctcta tcttaaacaa aatggaaatc aaagttaaaa
     2521 aaaaaaaaag gcaaattcaa ggcagctggc tctgggcaca cagaacaaag gccggcacgg
     2581 ctgtgtagca ggggcagatg ccatctgtgt acagaaaaat ggagaaacaa tggtgtggga
     2641 atggagaggt tgttctccaa gcggtttcgg ttttgtgcct ctgagctgct tttctcttct
     2701 gtctcctgtg tgttgtaagt gccttctctg tcctgtgagt gtaaccatct tgacattttt
     2761 cccagctcac aaaactaagt ggccatgtat ttttatacct tcattgagaa gacgacataa
     2821 aaaaaaatga aatgtaatgc caacttttgt ttcctctttt ttatgcttca aacaataaag
     2881 acacttctct tttttaaaaa gaaaaaaaaa aaa
//
