LOCUS       NM_027354               1707 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus POC1 centriolar protein A (Poc1a), mRNA.
ACCESSION   NM_027354 XM_135092
VERSION     NM_027354.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1707)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1707)
  AUTHORS   Geister,K.A., Brinkmeier,M.L., Cheung,L.Y., Wendt,J., Oatley,M.J.,
            Burgess,D.L., Kozloff,K.M., Cavalcoli,J.D., Oatley,J.M. and
            Camper,S.A.
  TITLE     LINE-1 Mediated Insertion into Poc1a (Protein of Centriole 1 A)
            Causes Growth Insufficiency and Male Infertility in Mice
  JOURNAL   PLoS Genet 11 (10), e1005569 (2015)
   PUBMED   26496357
  REMARK    GeneRIF: Spermatogonial stem cell transplantation studies revealed
            that Poc1a is essential for normal function of both Sertoli cells
            and germ cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1707)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1707)
  AUTHORS   Cha,K.B., Karolyi,I.J., Hunt,A., Wenglikowski,A.M., Wilkinson,J.E.,
            Dolan,D.F., Dootz,G., Finnegan,A.A., Seasholtz,A.F.,
            Hankenson,K.D., Siracusa,L.D. and Camper,S.A.
  TITLE     Skeletal dysplasia and male infertility locus on mouse chromosome 9
  JOURNAL   Genomics 83 (6), 951-960 (2004)
   PUBMED   15177549
REFERENCE   5  (bases 1 to 1707)
  AUTHORS   Pang,A.L., Taylor,H.C., Johnson,W., Alexander,S., Chen,Y., Su,Y.A.,
            Li,X., Ravindranath,N., Dym,M., Rennert,O.M. and Chan,W.Y.
  TITLE     Identification of differentially expressed genes in mouse
            spermatogenesis
  JOURNAL   J Androl 24 (6), 899-911 (2003)
   PUBMED   14581517
REFERENCE   6  (bases 1 to 1707)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 1707)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD549942.1, CA557124.1, AK011064.1, BE981233.1 and BB234823.1.
            
            On Sep 1, 2009 this sequence version replaced NM_027354.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154163.1, BC034901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               CD549942.1         1-383
            384-901             CA557124.1         34-551
            902-1353            AK011064.1         580-1031
            1354-1695           BE981233.1         15-356              c
            1696-1707           BB234823.1         162-173
FEATURES             Location/Qualifiers
     source          1..1707
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.46 cM"
     gene            1..1707
                     /gene="Poc1a"
                     /gene_synonym="2510040D07Rik; cha; Wdr51a"
                     /note="POC1 centriolar protein A"
                     /db_xref="GeneID:70235"
                     /db_xref="MGI:MGI:1917485"
     exon            1..396
                     /gene="Poc1a"
                     /gene_synonym="2510040D07Rik; cha; Wdr51a"
                     /inference="alignment:Splign:2.1.0"
     CDS             379..1596
                     /gene="Poc1a"
                     /gene_synonym="2510040D07Rik; cha; Wdr51a"
                     /note="WD repeat domain 51A; WD repeat-containing protein
                     51A"
                     /codon_start=1
                     /product="POC1 centriolar protein homolog A"
                     /protein_id="NP_081630.2"
                     /db_xref="CCDS:CCDS23474.1"
                     /db_xref="GeneID:70235"
                     /db_xref="MGI:MGI:1917485"
                     /translation="MAAPSQEDPSLERHFKGHRDAVTCVDFSLNTKHLASGSMDSTLM
                     IWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH
                     TATVRSVHFCSDGQSLVTASDDKTVKVWSTHRQRFLFSLTQHINWVRCAKFSPDGRLI
                     VSASDDKTVKLWDKTSRECIHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDART
                     HRLLQHYQLHSAAVNALSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT
                     VAFSRTGEYFASGGSDEQVMVWKSNFDIVDYGDMKARRPPPLTSSSGTLPKMDLPVPP
                     GRDRSLESVQGEPQESISMPQTLTSTLEHIVGQLDILTQTVSILEQRLTLTEDRLKQC
                     LENQQLIMQRTPP"
     exon            397..481
                     /gene="Poc1a"
                     /gene_synonym="2510040D07Rik; cha; Wdr51a"
                     /inference="alignment:Splign:2.1.0"
     exon            482..653
                     /gene="Poc1a"
                     /gene_synonym="2510040D07Rik; cha; Wdr51a"
                     /inference="alignment:Splign:2.1.0"
     exon            654..833
                     /gene="Poc1a"
                     /gene_synonym="2510040D07Rik; cha; Wdr51a"
                     /inference="alignment:Splign:2.1.0"
     exon            834..941
                     /gene="Poc1a"
                     /gene_synonym="2510040D07Rik; cha; Wdr51a"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1057
                     /gene="Poc1a"
                     /gene_synonym="2510040D07Rik; cha; Wdr51a"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1191
                     /gene="Poc1a"
                     /gene_synonym="2510040D07Rik; cha; Wdr51a"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1260
                     /gene="Poc1a"
                     /gene_synonym="2510040D07Rik; cha; Wdr51a"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1353
                     /gene="Poc1a"
                     /gene_synonym="2510040D07Rik; cha; Wdr51a"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1497
                     /gene="Poc1a"
                     /gene_synonym="2510040D07Rik; cha; Wdr51a"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1707
                     /gene="Poc1a"
                     /gene_synonym="2510040D07Rik; cha; Wdr51a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1674..1679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Poc1a"
                     /gene_synonym="2510040D07Rik; cha; Wdr51a"
                     /note="hexamer: AATAAA"
     polyA_site      1693
                     /gene="Poc1a"
                     /gene_synonym="2510040D07Rik; cha; Wdr51a"
                     /note="major polyA site"
ORIGIN      
        1 cttcatttcc ccgatggctg cgcgctccgt tacctgagct agagctgaag ggccgaaacc
       61 ttcatctaag attttttttt ttaagttctt aggaggaaag tgtgacagcg aactgaggct
      121 tttggctgct cggcgggtca cctcatctgg aagagcggga ggacaagagc ttgacgccta
      181 tcgaacgacc cgacttccgg tcggcggaca aaaacctagg gcgcttctcc tttaattgcg
      241 gtgggcggga cgcggcgacg ccaccggcgt tgctattggt ggcgattggg ggcgcggaaa
      301 ctgaactggc acaactgccg acccagctat ctctggcact tggggcacag ctggtcctac
      361 cagcccgcta gccccgctat ggctgctccc agccaggagg acccctcact ggagagacat
      421 tttaagggcc accgagatgc agtcacctgt gtggacttca gtctcaacac caagcacttg
      481 gccagtggct ccatggactc aaccctcatg atctggcaca tgaagcccca gtcacgtgcc
      541 taccgcttca cgggccacaa ggacgctgtg acctgtgtga atttctcccc atcgggacac
      601 cttcttgcct caggctcccg agacaagact gttcgcatct gggtacccaa tgtcaaaggt
      661 gagtcaactg tatttcgtgc acacacggcc acagtgagga gtgtccactt ctgcagcgat
      721 ggccagtcac ttgtgacagc ctctgatgac aagacagtca aagtgtggtc aactcatcgc
      781 cagagattcc tgttttccct gacccagcac atcaactggg tccgctgtgc caagttctcc
      841 cctgacgggc ggctcatcgt gtctgccagt gatgacaaga ctgtcaagct gtgggacaag
      901 accagccggg aatgtatcca ctcatactgt gagcacggcg gttttgtcac ctacgtggac
      961 ttccacccca gtggtacctg cattgctgct gccggcatgg acaacacggt gaaggtgtgg
     1021 gatgcgcgga ctcatcggct gttgcagcat tatcagttac acagtgcagc cgtgaatgcc
     1081 ctctccttcc acccatcggg aaactacctc atcacagcct ccagtgactc aacgctgaag
     1141 atcctggacc tgatggaggg ccggctgctc tatacgctcc atgggcacca ggggcctgct
     1201 accaccgttg ccttttcaag aacgggggag tatttcgctt ctggaggctc cgatgagcag
     1261 gtgatggtct ggaagagtaa ctttgacatt gttgattatg gagacatgaa ggcacggagg
     1321 cccccacccc taaccagctc ttctggaact ctgccaaaaa tggatttgcc tgtcccacca
     1381 ggcagagaca ggagtctgga gtcagttcaa ggcgagcccc aggagtccat cagcatgcct
     1441 cagacactga ccagcaccct ggagcacatc gtgggccagc tggacatcct cacgcagaca
     1501 gtgtccattc tggaacagcg actgacacta acagaagaca ggctgaagca gtgcctggag
     1561 aaccagcagc taatcatgca gagaacgcca ccgtgatgag gggagcaagg atcaggagct
     1621 cagtgattgg ggggacagca ggccagggat ttgtatgggg acttgagtaa ataaataaag
     1681 ggatcccacc tgagagagcc acatctt
//
