LOCUS       NM_026383               1907 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus proline-rich nuclear receptor coactivator 2 (Pnrc2),
            mRNA.
ACCESSION   NM_026383
VERSION     NM_026383.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1907)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1907)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   3  (bases 1 to 1907)
  AUTHORS   Cho,H., Kim,K.M., Han,S., Choe,J., Park,S.G., Choi,S.S. and
            Kim,Y.K.
  TITLE     Staufen1-mediated mRNA decay functions in adipogenesis
  JOURNAL   Mol Cell 46 (4), 495-506 (2012)
   PUBMED   22503102
REFERENCE   4  (bases 1 to 1907)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1907)
  AUTHORS   Zhou,D., Shen,R., Ye,J.J., Li,Y., Tsark,W., Isbell,D., Tso,P. and
            Chen,S.
  TITLE     Nuclear receptor coactivator PNRC2 regulates energy expenditure and
            adiposity
  JOURNAL   J Biol Chem 283 (1), 541-553 (2008)
   PUBMED   17971453
  REMARK    GeneRIF: Study provides evidence that PNRC2 plays one or more
            important roles in controlling the energy balance between energy
            storage and energy expenditure. PNRC2 may be a new target in the
            treatment of obesity and related metabolic diseases.
REFERENCE   6  (bases 1 to 1907)
  AUTHORS   Teuscher,C., Doerge,R.W., Fillmore,P.D. and Blankenhorn,E.P.
  TITLE     eae36, a locus on mouse chromosome 4, controls susceptibility to
            experimental allergic encephalomyelitis in older mice and mice
            immunized in the winter
  JOURNAL   Genetics 172 (2), 1147-1153 (2006)
   PUBMED   16299394
REFERENCE   7  (bases 1 to 1907)
  AUTHORS   Zhou,D., Masri,S., Ye,J.J. and Chen,S.
  TITLE     Transcriptional regulation of the mouse PNRC2 promoter by the
            nuclear factor Y (NFY) and E2F1
  JOURNAL   Gene 361, 89-100 (2005)
   PUBMED   16181749
  REMARK    GeneRIF: The finding that the PNRC2 promoter is activated by NFY
            and repressed by E2F1 indicates that in addition to functioning as
            nuclear receptor coactivator, PNRC2 may also play a role in the
            cell cycle.
REFERENCE   8  (bases 1 to 1907)
  AUTHORS   Zhou,D. and Chen,S.
  TITLE     PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors
            through an SH3-binding motif
  JOURNAL   Nucleic Acids Res 29 (19), 3939-3948 (2001)
   PUBMED   11574675
REFERENCE   9  (bases 1 to 1907)
  AUTHORS   Peters,L.L., Weier,H.U., Walensky,L.D., Snyder,S.H., Parra,M.,
            Mohandas,N. and Conboy,J.G.
  TITLE     Four paralogous protein 4.1 genes map to distinct chromosomes in
            mouse and human
  JOURNAL   Genomics 54 (2), 348-350 (1998)
   PUBMED   9828140
REFERENCE   10 (bases 1 to 1907)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672076.10, AK012073.1 and AK011192.1.
            
            On Jul 30, 2009 this sequence version replaced NM_026383.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011192.1, BC006598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AL672076.10        52939-52957         c
            20-1345             AK012073.1         4-1329
            1346-1592           AK011192.1         1324-1570
            1593-1907           AK011192.1         1572-1886
FEATURES             Location/Qualifiers
     source          1..1907
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.01 cM"
     gene            1..1907
                     /gene="Pnrc2"
                     /gene_synonym="0610011E17Rik; D4Bwg0593e"
                     /note="proline-rich nuclear receptor coactivator 2"
                     /db_xref="GeneID:52830"
                     /db_xref="MGI:MGI:106512"
     exon            1..173
                     /gene="Pnrc2"
                     /gene_synonym="0610011E17Rik; D4Bwg0593e"
                     /inference="alignment:Splign:2.1.0"
     exon            174..378
                     /gene="Pnrc2"
                     /gene_synonym="0610011E17Rik; D4Bwg0593e"
                     /inference="alignment:Splign:2.1.0"
     exon            379..1907
                     /gene="Pnrc2"
                     /gene_synonym="0610011E17Rik; D4Bwg0593e"
                     /inference="alignment:Splign:2.1.0"
     CDS             397..819
                     /gene="Pnrc2"
                     /gene_synonym="0610011E17Rik; D4Bwg0593e"
                     /codon_start=1
                     /product="proline-rich nuclear receptor coactivator 2"
                     /protein_id="NP_080659.1"
                     /db_xref="CCDS:CCDS18792.1"
                     /db_xref="GeneID:52830"
                     /db_xref="MGI:MGI:106512"
                     /translation="MGGGERYNIPDPQSRNASKNQEQQNRQKSKDQNSSQTKIAHKKK
                     ERGHGYNPAAAAWQAMQNGGKTKSLSNNSNWNAGLSSPSLLFKSQASQNYAGAKFSEP
                     PSPSVLPKPPSHWVHVSLNPSDKETMTFQLKTLLKVQV"
     regulatory      1884..1889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pnrc2"
                     /gene_synonym="0610011E17Rik; D4Bwg0593e"
                     /note="hexamer: AATAAA"
     polyA_site      1907
                     /gene="Pnrc2"
                     /gene_synonym="0610011E17Rik; D4Bwg0593e"
                     /note="major polyA site"
ORIGIN      
        1 gcgcttgcag cggcctccat tttgtcggga aaggcagtag gaggttggtc cccagacgga
       61 gttgtgatcc gtgactcgtt cgtgggctgt tagatccgtg catcgtttct ccctgtagag
      121 ggaaggaggc ttggaggtcg agagggagcc gccgccgccg ccgctcgaag tcgctaggac
      181 ttctctcaaa cttgtgtgct gaggagactc gatgtggacc tcagctccta ggctgaaatc
      241 agcagactgg ctcatgaaaa cttgtgtact gagacaaagg aaaggatcta gcagaaagca
      301 acgtctctta tcctgggctt ggcagcaagg aagaggacaa gtagtggaaa tccttcaatc
      361 tgaaaagcaa actgaaaggt gacaaagaag ctgaagatgg gtggcggaga gaggtataac
      421 attccagacc ctcaatctag aaatgctagt aagaaccaag aacagcaaaa tagacagaag
      481 agcaaggatc agaattcttc ccagacgaag attgctcata agaaaaagga acgaggacat
      541 gggtacaatc cagcagcagc agcatggcag gccatgcaaa atgggggaaa gaccaagagc
      601 ctttctaaca actccaactg gaatgctggt ttatcaagtc ctagcttgct ttttaagtct
      661 caagctagtc agaactatgc tggagccaaa tttagtgaac caccatcacc aagtgttctc
      721 cccaagccac caagccactg ggttcatgtt tccttgaacc cttcagataa ggaaacgatg
      781 acatttcaac ttaaaacctt acttaaggta caggtataaa gttagtaggt gttaacttta
      841 aattgtgacg cttacacatg acatctgatt tatgtgctgt acacactata cagtgtcgat
      901 gcaatttcaa caatttaagt gactaattga ttctacttgg taaattcaag tttagatctg
      961 ggaaatagta accttaactt ttttattgtt tgatgggaaa aattaagatt tatgggttaa
     1021 cacacaactt ctgaagaagt cagacagtgc atttagcata tacaaggttg cacagttcag
     1081 tttcatggtc tagggtcatc caaactatct tgggcatttt tcaaaagata gcggcgcagc
     1141 acatgtccca gtggtcattt cttaaatgca gtggataagt acccagagat gtaccaagtc
     1201 tattctaaaa acagacagtg ctgactagca ccccacaaag ctgctaaagt gatcctggcc
     1261 tcacctatat acaaagcctg tttgaagtag ggagttgtgt ttgtgacatt taaagtcatg
     1321 taaatacatg taataagctt gtaacatatg taatgttttc ttagccttta ttctacaaaa
     1381 ataagactat ttttagtgtg aatttgatga atgtaagacc atgaactgtt ttttttttaa
     1441 aaatcttatg gcctaatttt gaaggtctcc aatttttaaa ggttgccctt gtgcttaagt
     1501 gccagagtga atcaatgtaa ctgatgtgtg aaatctgttg tattaagttt ttataattga
     1561 aaagatttaa gctacatttc ctgttttttt ttaaagagat ataaagatgt aggacaaaac
     1621 ttcctcccca accatcttaa acccaaagac tcattttggc tttatcaacc ctaagtcacc
     1681 cctgcctgat tatgtgcaac ccctcatttt cattggcaaa gggaaaaagt ctcttgtgtt
     1741 attaaaccca gtaacaatta cttctcaatc tttatgagca gaagagctaa attgtgtttt
     1801 ctcaattaag ttcagagcaa gagttcaagt caaacattga gtatcctaaa ggacaagttc
     1861 acaaaactat aatctgactg aaaaataaaa ttcataaata aaccttt
//
