LOCUS       NP_598782                261 aa            linear   ROD 30-APR-2024
DEFINITION  pyridoxine-5'-phosphate oxidase [Mus musculus].
ACCESSION   NP_598782
VERSION     NP_598782.1
DBSOURCE    REFSEQ: accession NM_134021.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 261)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 261)
  AUTHORS   Chen,C.C., Li,B., Millman,S.E., Chen,C., Li,X., Morris,J.P. 4th,
            Mayle,A., Ho,Y.J., Loizou,E., Liu,H., Qin,W., Shah,H., Violante,S.,
            Cross,J.R., Lowe,S.W. and Zhang,L.
  TITLE     Vitamin B6 Addiction in Acute Myeloid Leukemia
  JOURNAL   Cancer Cell 37 (1), 71-84 (2020)
   PUBMED   31935373
REFERENCE   3  (residues 1 to 261)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 261)
  AUTHORS   Kang,J.H., Hong,M.L., Kim,D.W., Park,J., Kang,T.C., Won,M.H.,
            Baek,N.I., Moon,B.J., Choi,S.Y. and Kwon,O.S.
  TITLE     Genomic organization, tissue distribution and deletion mutation of
            human pyridoxine 5'-phosphate oxidase
  JOURNAL   Eur J Biochem 271 (12), 2452-2461 (2004)
   PUBMED   15182361
REFERENCE   5  (residues 1 to 261)
  AUTHORS   Ngo,E.O., LePage,G.R., Thanassi,J.W., Meisler,N. and Nutter,L.M.
  TITLE     Absence of pyridoxine-5'-phosphate oxidase (PNPO) activity in
            neoplastic cells: isolation, characterization, and expression of
            PNPO cDNA
  JOURNAL   Biochemistry 37 (21), 7741-7748 (1998)
   PUBMED   9601034
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK164667.1, CK625276.1, AL596384.17 and AI464320.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026564.1, AK154004.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..261
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 60.17 cM"
     Protein         1..261
                     /product="pyridoxine-5'-phosphate oxidase"
                     /EC_number="1.4.3.5"
                     /note="pyridoxamine-phosphate oxidase"
                     /calculated_mol_wt=29983
     Region          57..261
                     /region_name="pdxH"
                     /note="pyridoxamine-phosphate oxidase; TIGR00558"
                     /db_xref="CDD:273138"
     Site            238
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9NVS9; propagated from
                     UniProtKB/Swiss-Prot (Q91XF0.1)"
     Site            241
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q91XF0.1)"
     CDS             1..261
                     /gene="Pnpo"
                     /coded_by="NM_134021.2:152..937"
                     /db_xref="CCDS:CCDS25308.1"
                     /db_xref="GeneID:103711"
                     /db_xref="MGI:MGI:2144151"
ORIGIN      
        1 mtcgllsvtv tfrrpakwtg ylrhlccrga vmdlgpmrks yrgdreafee thltsldpmk
       61 qfaswfdeav qcpdigeana mcvatctrdg kpsarmlllk gfgkdgfrff tnyesrkgke
      121 ldsnpfaslv fyweplnrqv rvegpvkklp ekeaenyfhs rpkssqigav vsrqssvipd
      181 reylrkknee lgqlyqdqev pkpeywggyi lypqvmefwq gqtnrlhdri vfrrglatgd
      241 splgpmthhg eedwvyerla p
//
