LOCUS       NM_001122818            4454 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Mus musculus patatin-like phospholipase domain containing 6
            (Pnpla6), transcript variant 1, mRNA.
ACCESSION   NM_001122818
VERSION     NM_001122818.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4454)
  AUTHORS   Liu,J., He,Y., Lwin,C., Han,M., Guan,B., Naik,A., Bender,C.,
            Moore,N., Huryn,L.A., Sergeev,Y.V., Qian,H., Zeng,Y., Dong,L.,
            Liu,P., Lei,J., Haugen,C.J., Prasov,L., Shi,R., Dollfus,H.,
            Aristodemou,P., Laich,Y., Nemeth,A.H., Taylor,J., Downes,S.,
            Krawczynski,M.R., Meunier,I., Strassberg,M., Tenney,J., Gao,J.,
            Shear,M.A., Moore,A.T., Duncan,J.L., Menendez,B., Hull,S.,
            Vincent,A.L., Siskind,C.E., Traboulsi,E.I., Blackstone,C.,
            Sisk,R.A., Miraldi Utz,V., Webster,A.R., Michaelides,M., Arno,G.,
            Synofzik,M. and Hufnagel,R.B.
  TITLE     Neuropathy target esterase activity defines phenotypes among PNPLA6
            disorders
  JOURNAL   Brain 147 (6), 2085-2097 (2024)
   PUBMED   38735647
  REMARK    GeneRIF: Neuropathy target esterase activity defines phenotypes
            among PNPLA6 disorders.
REFERENCE   2  (bases 1 to 4454)
  AUTHORS   McFerrin,J., Patton,B.L., Sunderhaus,E.R. and Kretzschmar,D.
  TITLE     NTE/PNPLA6 is expressed in mature Schwann cells and is required for
            glial ensheathment of Remak fibers
  JOURNAL   Glia 65 (5), 804-816 (2017)
   PUBMED   28206686
REFERENCE   3  (bases 1 to 4454)
  AUTHORS   Pamies,D., Reig,J.A., Vilanova,E. and Sogorb,M.A.
  TITLE     Expression of Neuropathy Target Esterase in mouse embryonic stem
            cells during differentiation
  JOURNAL   Arch Toxicol 84 (6), 481-491 (2010)
   PUBMED   20112100
  REMARK    GeneRIF: the expression of CaMKIIalpha and pCREB exhibits a
            significant increase in cortex and hippocampus after treatment with
            PFOS, compared with the control.
REFERENCE   4  (bases 1 to 4454)
  AUTHORS   Read,D.J., Li,Y., Chao,M.V., Cavanagh,J.B. and Glynn,P.
  TITLE     Neuropathy target esterase is required for adult vertebrate axon
            maintenance
  JOURNAL   J Neurosci 29 (37), 11594-11600 (2009)
   PUBMED   19759306
REFERENCE   5  (bases 1 to 4454)
  AUTHORS   Rosenbluth,J., Schiff,R., Lam,P., Nuriel,T. and Chao,M.V.
  TITLE     Spongiform pathology in mouse CNS lacking 'neuropathy target
            esterase' and cellular prion protein
  JOURNAL   Neurobiol Dis 35 (3), 433-437 (2009)
   PUBMED   19524041
  REMARK    GeneRIF: We conclude that spongiform pathology in conditional NTE
            knockout mice is not mediated by PrPc, and that tubulovesicular
            inclusions can be seen in spongiform encephalopathy of other
            etiologies and are not pathognomonic of prion disease
REFERENCE   6  (bases 1 to 4454)
  AUTHORS   Quistad,G.B., Barlow,C., Winrow,C.J., Sparks,S.E. and Casida,J.E.
  TITLE     Evidence that mouse brain neuropathy target esterase is a
            lysophospholipase
  JOURNAL   Proc Natl Acad Sci U S A 100 (13), 7983-7987 (2003)
   PUBMED   12805562
  REMARK    GeneRIF: mouse brain neuropathy target esterase is a
            lysophospholipase
REFERENCE   7  (bases 1 to 4454)
  AUTHORS   Winrow,C.J., Hemming,M.L., Allen,D.M., Quistad,G.B., Casida,J.E.
            and Barlow,C.
  TITLE     Loss of neuropathy target esterase in mice links organophosphate
            exposure to hyperactivity
  JOURNAL   Nat Genet 33 (4), 477-485 (2003)
   PUBMED   12640454
  REMARK    GeneRIF: NTE has a role in neural development and in the
            neurodegeneration induced by organophosphate compounds in mice
REFERENCE   8  (bases 1 to 4454)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4454)
  AUTHORS   Falardeau,J.L., Kennedy,J.C., Acierno,J.S. Jr., Sun,M., Stahl,S.,
            Goldin,E. and Slaugenhaupt,S.A.
  TITLE     Cloning and characterization of the mouse Mcoln1 gene reveals an
            alternatively spliced transcript not seen in humans
  JOURNAL   BMC Genomics 3, 3 (2002)
   PUBMED   11897010
REFERENCE   10 (bases 1 to 4454)
  AUTHORS   Moser,M., Stempfl,T., Li,Y., Glynn,P., Buttner,R. and
            Kretzschmar,D.
  TITLE     Cloning and expression of the murine sws/NTE gene
  JOURNAL   Mech Dev 90 (2), 279-282 (2000)
   PUBMED   10640712
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC170806.2.
            
            On Mar 17, 2020 this sequence version replaced NM_001122818.2.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056999.1, SRR9219382.188743.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AC170806.2         41852-41997
            147-205             AC170806.2         42951-43009
            206-274             AC170806.2         43122-43190
            275-362             AC170806.2         43518-43605
            363-445             AC170806.2         43766-43848
            446-543             AC170806.2         43999-44096
            544-684             AC170806.2         47716-47856
            685-844             AC170806.2         47949-48108
            845-925             AC170806.2         48542-48622
            926-1054            AC170806.2         48718-48846
            1055-1135           AC170806.2         49029-49109
            1136-1301           AC170806.2         49200-49365
            1302-1385           AC170806.2         49699-49782
            1386-1495           AC170806.2         50199-50308
            1496-1651           AC170806.2         50452-50607
            1652-1729           AC170806.2         50693-50770
            1730-1935           AC170806.2         57403-57608
            1936-2067           AC170806.2         57870-58001
            2068-2191           AC170806.2         58079-58202
            2192-2305           AC170806.2         58444-58557
            2306-2381           AC170806.2         58793-58868
            2382-2522           AC170806.2         60971-61111
            2523-2586           AC170806.2         61273-61336
            2587-2755           AC170806.2         61903-62071
            2756-2938           AC170806.2         62261-62443
            2939-3057           AC170806.2         62984-63102
            3058-3214           AC170806.2         63304-63460
            3215-3331           AC170806.2         63690-63806
            3332-3401           AC170806.2         63892-63961
            3402-3518           AC170806.2         64410-64526
            3519-3820           AC170806.2         67732-68033
            3821-3937           AC170806.2         68739-68855
            3938-4034           AC170806.2         69286-69382
            4035-4144           AC170806.2         69508-69617
            4145-4454           AC170806.2         70395-70704
FEATURES             Location/Qualifiers
     source          1..4454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 1.92 cM"
     gene            1..4454
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /note="patatin-like phospholipase domain containing 6"
                     /db_xref="GeneID:50767"
                     /db_xref="MGI:MGI:1354723"
     exon            1..146
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            147..205
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..4219
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /EC_number="3.1.1.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuropathy target esterase; patatin-like phospholipase
                     domain-containing protein 6; Swiss-cheese"
                     /codon_start=1
                     /product="patatin-like phospholipase domain-containing
                     protein 6 isoform 1"
                     /protein_id="NP_001116290.2"
                     /db_xref="CCDS:CCDS85487.1"
                     /db_xref="GeneID:50767"
                     /db_xref="MGI:MGI:1354723"
                     /translation="MEESLQPKDCRLQDLLPSPKQSMEAPLQTGMVLGVMIGAGVAVL
                     VTAVLILLVVRRLRVQKTPAPEGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVS
                     TTSRPRMKKKLKMLNIAKKILRIQKETPTLQRKEPPPSVLEADLTEGDLANSHLPSEV
                     LYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCL
                     PGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFS
                     AVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTR
                     TSPVRGSKRVVSTSGTEDTSKETSGRPLDSIGAPLPGPAGDPVKPTSLEAPPAPLLSR
                     CISMPVDISGLQGGPRSDFDMAYERGRISVSLQEEASGGPQTASPRELREQPAGACEY
                     SYCEDESATGGCPFGPYQGRQTSSIFEAAKRELAKLMRIEDPSLLNSRVLLHHAKAGT
                     IIARQGDQDVSLHFVLWGCLHVYQRMIDKAEEVCLFVAQPGELVGQLAVLTGEPLIFT
                     LRAQRDCTFLRISKSHFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAG
                     RALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRATT
                     VHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPGSGLSVP
                     QHSELTNPASNLSTVAILPVCAEVPMMAFTLELQHALQAIGPTLLLNSDVIRALLGAS
                     ALDSIQEFRLSGWLAQQEDAHRIVLYQTDTSLTPWTVRCLRQADCILIVGLGDQEPTV
                     GQLEQMLENTAVRALKQLVLLHREEGPGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRR
                     SPAKLHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEE
                     AGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSM
                     FTGSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSG
                     YLPPLCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSG
                     WWLLWKRLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPSIDCFKTM
                     DFGKFDQIYDVGYQYGKAVFGGWTRGEVIEKMLTDRRSTDLNESRRADILAFPSSGFT
                     DLAEIVSRIEPPTSYVSDGCADGEESDCLTEYEEDAGPDCSRDEGGSPEGASPSTASE
                     VEEEKSTLRQRRFLPQETPSSVADA"
     exon            206..274
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            275..362
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            363..445
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            446..543
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            544..684
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            685..844
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            845..925
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1054
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1135
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1301
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1385
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1495
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1651
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1729
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1935
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2067
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2191
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2305
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2381
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2522
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2586
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2755
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2938
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3057
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3214
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3331
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            3332..3401
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            3402..3518
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..3820
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            3821..3937
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            3938..4034
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            4035..4144
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
     exon            4145..4454
                     /gene="Pnpla6"
                     /gene_synonym="MSws; Nte"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaaactag gggtgttggc cgaagctggg tggacctggt tgcagctcct gaatggtacg
       61 agtttccatc gaccgagcaa aggtgtccct tcgaggactg ttagagagct tcagctttgc
      121 cccggatcga tttgtcctga ttccggtacc cctctagacg ctctcacccc aaccccggcg
      181 aatggaggag tcactccagc caaaggactg caggctacaa gacctgctac ctagtccgaa
      241 acaatcgatg gaggccccac tgcaaaccgg aatggtgctg ggcgtgatga tcggggccgg
      301 agtggcggtg ctggtcaccg ccgtgctcat cctcttggtg gtgcgaaggc tgcgggtgca
      361 gaaaactcca gccccggagg gtccccggta tcggttccgg aagcgggaca aagtgctttt
      421 ctatggccgg aagattatgc ggaaggtgtc acagtccact tcttccctgg tggacacatc
      481 agtctccacc acttcccggc cccgcatgaa gaagaaactg aagatgctta acattgccaa
      541 gaagatctta cgtatccaaa aggagactcc gaccctacaa cggaaggagc ccccaccttc
      601 agtgctggag gctgacctca cagagggaga cctggccaat tcccacctac cctctgaggt
      661 actctacatg cttaagaatg ttcgggtgct aggtcacttt gagaagccgc tcttcctgga
      721 gctctgccgg cacatggtct tccagcgtct cgggcagggg gactatgttt ttcggcccgg
      781 tcaaccagat gccagcatct atgtggttca agatgggctg ctggagctct gcctaccagg
      841 gcctgatggg aaggagtgtg tggtgaagga ggtggttcct ggagacagcg tcaacagcct
      901 tctgagcatc cttgatgtca tcacgggtca ccagcatccc cagcggactg tgtcagccag
      961 ggctgcacgg gactccacag tgctgagact cccagtagaa gccttctctg ctgtcttcac
     1021 caagtaccct gagagtttgg tgcgagtggt acagatcatc atggtaaggc tgcagagagt
     1081 caccttcctg gcgcttcaca attacctggg tctgaccaat gaactcttca gtcatgagat
     1141 ccagccccta cgccttttcc ccagccccgg cctcccgacc cgaaccagcc ctgtccgtgg
     1201 ctctaaacgg gtagtcagca cctcaggtac tgaggacacc tcaaaggaga cctctggccg
     1261 gcccctggac tccattggag ctcctctgcc tggacctgca ggggatcccg tgaagcccac
     1321 atccttagaa gcacccccag ccccgttact gagccgctgc atctccatgc cagtagacat
     1381 ctcaggcttg caaggtggcc ctcgttctga ttttgacatg gcctatgaac gtggacggat
     1441 atctgtttct cttcaagaag aggcatctgg gggacctcag acagcatccc ctagggagct
     1501 ccgggagcag ccagcgggtg cctgtgaata tagctactgt gaggatgagt cagccacagg
     1561 cggatgtccc tttgggccct accagggccg ccagacaagc agcatctttg aggctgcaaa
     1621 gagagagcta gccaagctga tgcggattga ggacccctct ctactgaaca gcagagtctt
     1681 gctacatcat gccaaagccg gcaccatcat agcccgccaa ggggaccagg atgtgagcct
     1741 gcactttgtg ctctggggct gcctgcacgt gtaccagcgc atgattgaca aggctgagga
     1801 agtgtgccta tttgtggcac agccagggga gctggtgggg caactggcgg tgctcactgg
     1861 ggaacctctc atcttcacac tacgtgccca gagagactgc accttcctgc ggatctccaa
     1921 atcccacttc tatgagatca tgcgtgcaca acccagtgtg gtactgagtg cagctcacac
     1981 ggtggctgct agaatgtccc ccttcgtgcg ccagatggac tttgccattg actggacagc
     2041 tgtggaggct ggtcgtgcgc tctacaggca gggagaccgc tccgactgca cctacattgt
     2101 actcaatgga cgtctccgta gtgtcatcca acgaggcagt ggcaagaagg agctagttgg
     2161 ggagtatggt cgaggggatc tcattggcgt ggtggaggca ctgacccggc agccacgagc
     2221 caccactgta cacgcagtgc gagacactga gctggccaag cttcccgagg gcaccttagg
     2281 ccacatcaaa cgtcggtacc cacaggttgt gacccgcctt attcatctgc taagccagaa
     2341 aattctaggc aatctgcagc agttgcaagg accctttcca ggctccgggc tcagtgttcc
     2401 gcagcactcg gaactgacca acccagccag caatctgtct actgtagcta tcctccctgt
     2461 gtgtgctgag gtgcccatga tggcctttac tctggaactg cagcatgctc tgcaagctat
     2521 tggtcccacg ctcctcctta acagtgacgt catccgggca ctcctggggg cttcagcact
     2581 ggatagcatt caagaattcc ggctgtcagg gtggttggcc cagcaggaag atgcccatcg
     2641 cattgtgctc taccaaactg acacatccct gacgccttgg accgtccgtt gtctgcgcca
     2701 ggccgactgc atcctcattg tgggcctggg ggaccaggaa cccactgttg gccagctgga
     2761 gcaaatgtta gagaacactg ctgtccgtgc cttgaagcaa ctggttttgc tgcaccggga
     2821 ggaaggccct ggtcccacgc gcactgtaga gtggctcaac atgcgcagct ggtgctcagg
     2881 gcacctgcac ctgcgctgtc ctcgccgcct cttctcacgg cgcagcccag cgaaacttca
     2941 tgagctgtat gagaaggttt tctccaggcg tgcagaccgt cacagcgact tctcccgctt
     3001 ggcacgagta ctcacaggaa acactattgc tctggtgctg ggtgggggcg gagccagagg
     3061 ctgctcgcat attggggtgc tgaaggcatt agaggaggca ggagtcccag tcgaccttgt
     3121 gggaggcaca tccataggtt ccttcattgg ggccttgtat gccgaggaac gcagcgccag
     3181 ccgaactaaa caacgagccc gggagtgggc caagagcatg acttctgtac tggagcctgt
     3241 attggacctc acatatcctg tcacctccat gtttactggc tcagccttta acagaagtat
     3301 ccaccgtgtc ttccaggata agcagattga ggacctgtgg ctgccttact tcaatgtgac
     3361 cacagacatc actgcctctg ccatgcgcgt ccacaaagat ggctccctgt ggcggtatgt
     3421 acgtgccagc atgacgctct cgggctacct acccccgctg tgcgacccaa aggatgggca
     3481 cctgctcatg gatggtggct acatcaacaa cctgccagcg gatattgccc gaagcatggg
     3541 agccaaaacg gtcattgcca tcgacgttgg aagccaggat gagacagatc tcagcaccta
     3601 tggggacagc ctgtctggct ggtggttgct gtggaaaagg ctaaacccct gggcagacaa
     3661 ggtaaaggtt ccagacatgg ctgagatcca gtcccgcttg gcgtacgtgt cctgtgtgcg
     3721 gcagctagaa gtcgtcaagt ccagctccta ttgcgagtac cttcgtccat ccattgactg
     3781 cttcaagacc atggactttg gaaagtttga ccagatctat gatgtgggtt accagtatgg
     3841 gaaggctgtc tttggaggct ggacccgtgg tgaagtcatt gagaaaatgc tcacagaccg
     3901 gagatctaca gaccttaatg agagtcgccg tgcagatata cttgccttcc caagttctgg
     3961 gttcactgac ttggctgaga ttgtgtcccg gatcgagcca ccaacaagct acgtctctga
     4021 tggctgtgct gatggggagg agtcggattg cttgacagag tatgaggaag atgcaggacc
     4081 agactgctca agagatgaag ggggctcccc tgagggtgcc agccctagca ctgcctcaga
     4141 ggtggaagaa gagaagtcca cactccggca acgacgcttt ctgcctcagg agactcccag
     4201 ctcagtcgca gatgcctgag gatcttgaca gggaagccct gttcctagac tgggttatgg
     4261 gtgagcttgt gggggagctc acactattat tcccactgct gctatacttc aacactccct
     4321 gggcccttcc cccttggctc caaggaccac acactggact gacttgccct gtccctaagg
     4381 ggagggcaga actgcactga taacctttga ccaactatgt gaccttcccc caaataaact
     4441 cttacccctt tcga
//
