LOCUS       NM_001163689            2635 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus patatin-like phospholipase domain containing 2
            (Pnpla2), transcript variant 1, mRNA.
ACCESSION   NM_001163689
VERSION     NM_001163689.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2635)
  AUTHORS   Chen,H., Liu,C., Cui,S., Xia,Y., Zhang,K., Cheng,H., Peng,J.,
            Yu,X., Li,L., Yu,H., Zhang,J., Zheng,J.S. and Zhang,B.
  TITLE     Intermittent fasting triggers interorgan communication to suppress
            hair follicle regeneration
  JOURNAL   Cell 188 (1), 157-174 (2025)
   PUBMED   39674178
REFERENCE   2  (bases 1 to 2635)
  AUTHORS   Yang,H., Zingaro,V.A., Lincoff,J., Tom,H., Oikawa,S.,
            Oses-Prieto,J.A., Edmondson,Q., Seiple,I., Shah,H., Kajimura,S.,
            Burlingame,A.L., Grabe,M. and Ruggero,D.
  TITLE     Remodelling of the translatome controls diet and its impact on
            tumorigenesis
  JOURNAL   Nature 633 (8028), 189-197 (2024)
   PUBMED   39143206
REFERENCE   3  (bases 1 to 2635)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   4  (bases 1 to 2635)
  AUTHORS   Farley,A., Gao,Y., Sun,Y., Zohrabian,S., Pu,W.T. and Lin,Z.
  TITLE     Activation of VGLL4 Suppresses Cardiomyocyte Maturational
            Hypertrophic Growth
  JOURNAL   Cells 13 (16), 1342 (2024)
   PUBMED   39195232
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2635)
  AUTHORS   Sciarretta,F., Ninni,A., Zaccaria,F., Chiurchiu,V., Bertola,A.,
            Karlinsey,K., Jia,W., Ceci,V., Di Biagio,C., Xu,Z., Gaudioso,F.,
            Tortolici,F., Tiberi,M., Zhang,J., Carotti,S., Boudina,S.,
            Grumati,P., Zhou,B., Brestoff,J.R., Ivanov,S., Aquilano,K. and
            Lettieri-Barbato,D.
  TITLE     Lipid-associated macrophages reshape BAT cell identity in obesity
  JOURNAL   Cell Rep 43 (7), 114447 (2024)
   PUBMED   38963761
REFERENCE   6  (bases 1 to 2635)
  AUTHORS   Kralisch,S., Klein,J., Lossner,U., Bluher,M., Paschke,R.,
            Stumvoll,M. and Fasshauer,M.
  TITLE     Isoproterenol, TNFalpha, and insulin downregulate adipose
            triglyceride lipase in 3T3-L1 adipocytes
  JOURNAL   Mol Cell Endocrinol 240 (1-2), 43-49 (2005)
   PUBMED   16009485
  REMARK    GeneRIF: Adipose triglyceride lipase (desnutrin) is downregulated
            by isoproterenol, TNFalpha, and insulin.
REFERENCE   7  (bases 1 to 2635)
  AUTHORS   Zimmermann,R., Strauss,J.G., Haemmerle,G., Schoiswohl,G.,
            Birner-Gruenberger,R., Riederer,M., Lass,A., Neuberger,G.,
            Eisenhaber,F., Hermetter,A. and Zechner,R.
  TITLE     Fat mobilization in adipose tissue is promoted by adipose
            triglyceride lipase
  JOURNAL   Science 306 (5700), 1383-1386 (2004)
   PUBMED   15550674
  REMARK    GeneRIF: reported that adipose triglyceride lipase (ATGL),
            catalyzes the initial step in triglyceride hydrolysis; ATGL and
            hormone-sensitive lipase (HSL) coordinately catabolize stored
            triglycerides in adipose tissue [ATGL]
REFERENCE   8  (bases 1 to 2635)
  AUTHORS   Villena,J.A., Roy,S., Sarkadi-Nagy,E., Kim,K.H. and Sul,H.S.
  TITLE     Desnutrin, an adipocyte gene encoding a novel patatin
            domain-containing protein, is induced by fasting and
            glucocorticoids: ectopic expression of desnutrin increases
            triglyceride hydrolysis
  JOURNAL   J Biol Chem 279 (45), 47066-47075 (2004)
   PUBMED   15337759
  REMARK    GeneRIF: desnutrin may have a role in the pathophysiology of
            obesity
REFERENCE   9  (bases 1 to 2635)
  AUTHORS   Vogel,S., Piantedosi,R., O'Byrne,S.M., Kako,Y., Quadro,L.,
            Gottesman,M.E., Goldberg,I.J. and Blaner,W.S.
  TITLE     Retinol-binding protein-deficient mice: biochemical basis for
            impaired vision
  JOURNAL   Biochemistry 41 (51), 15360-15368 (2002)
   PUBMED   12484775
REFERENCE   10 (bases 1 to 2635)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB574719.1, AK031609.1 and AK076464.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076464.1, AK031609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BB574719.1         1-42
            43-2005             AK031609.1         1-1963
            2006-2635           AK076464.1         1791-2420
FEATURES             Location/Qualifiers
     source          1..2635
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.81 cM"
     gene            1..2635
                     /gene="Pnpla2"
                     /gene_synonym="0610039C21Rik; 1110001C14Rik; Atgl;
                     TTS-2.2"
                     /note="patatin-like phospholipase domain containing 2"
                     /db_xref="GeneID:66853"
                     /db_xref="MGI:MGI:1914103"
     exon            1..286
                     /gene="Pnpla2"
                     /gene_synonym="0610039C21Rik; 1110001C14Rik; Atgl;
                     TTS-2.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1560
                     /gene="Pnpla2"
                     /gene_synonym="0610039C21Rik; 1110001C14Rik; Atgl;
                     TTS-2.2"
                     /EC_number="3.1.1.3"
                     /EC_number="3.1.1.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     patatin-like phospholipase domain-containing protein 2;
                     transport-secretion protein; desnutrin; triglyceride
                     hydrolase; adipose triglyceride lipase; iPLA2-zeta;
                     calcium-independent phospholipase A2-zeta"
                     /codon_start=1
                     /product="patatin-like phospholipase domain-containing
                     protein 2 isoform 1"
                     /protein_id="NP_001157161.1"
                     /db_xref="CCDS:CCDS52445.1"
                     /db_xref="GeneID:66853"
                     /db_xref="MGI:MGI:1914103"
                     /translation="MFPRETKWNISFAGCGFLGVYHIGVASCLREHAPFLVANATHIY
                     GASAGALTATALVTGACLGEAGANIIEVSKEARKRFLGPLHPSFNLVKTIRGCLLKTL
                     PADCHERANGRLGISLTRVSDGENVIISHFSSKDELIQANVCSTFIPVYCGLIPPTLQ
                     GVRYVDGGISDNLPLYELKNTITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRN
                     LYRLSKALFPPEPMVLREMCKQGYRDGLRFLRRNGLLNQPNPLLALPPVVPQEEDAEE
                     AAVVEERAGEEDQLQPYRKDRILEHLPARLNEALLEACVEPKDLMTTLSNMLPVRLAT
                     AMMVPYTLPLESAVSFTIRLLEWLPDVPEDIRWMKEQTGSICQYLVMRAKRKLGDHLP
                     SRLSEQVELRRAQSLPSVPLSCATYSEALPNWVRNNLSLGDALAKWEECQRQLLLGLF
                     CTNVAFPPDALRMRAPASPTAADPATPQDPPGLPPC"
     exon            287..519
                     /gene="Pnpla2"
                     /gene_synonym="0610039C21Rik; 1110001C14Rik; Atgl;
                     TTS-2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            520..585
                     /gene="Pnpla2"
                     /gene_synonym="0610039C21Rik; 1110001C14Rik; Atgl;
                     TTS-2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..795
                     /gene="Pnpla2"
                     /gene_synonym="0610039C21Rik; 1110001C14Rik; Atgl;
                     TTS-2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..856
                     /gene="Pnpla2"
                     /gene_synonym="0610039C21Rik; 1110001C14Rik; Atgl;
                     TTS-2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1024
                     /gene="Pnpla2"
                     /gene_synonym="0610039C21Rik; 1110001C14Rik; Atgl;
                     TTS-2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1157
                     /gene="Pnpla2"
                     /gene_synonym="0610039C21Rik; 1110001C14Rik; Atgl;
                     TTS-2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1280
                     /gene="Pnpla2"
                     /gene_synonym="0610039C21Rik; 1110001C14Rik; Atgl;
                     TTS-2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..2635
                     /gene="Pnpla2"
                     /gene_synonym="0610039C21Rik; 1110001C14Rik; Atgl;
                     TTS-2.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1962..1967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pnpla2"
                     /gene_synonym="0610039C21Rik; 1110001C14Rik; Atgl;
                     TTS-2.2"
                     /note="hexamer: AATAAA"
     polyA_site      1979
                     /gene="Pnpla2"
                     /gene_synonym="0610039C21Rik; 1110001C14Rik; Atgl;
                     TTS-2.2"
                     /note="major polyA site"
ORIGIN      
        1 tcctcctctg cctcccggca cagcgtctcc gcctccgccg gcggagaccc caaggtatcg
       61 agactgcggg acccactgcc cgcaggacat cgagtcacga tgttcccgag ggagaccaag
      121 tggaacatct cattcgctgg ctgcggcttc ctcggggtct accacattgg cgtggcctcc
      181 tgcctccgtg agcacgcgcc cttcctggtg gccaacgcca ctcacatcta cggagcctcg
      241 gcaggggcgc tcaccgccac agcgctggtc actggggcct gcctgggtga agcaggtgcc
      301 aacattattg aggtgtccaa ggaggcccgg aagcggttcc tgggtcctct gcatccctcc
      361 ttcaacctgg tgaagaccat ccgtggctgt ctactaaaga ccctgcctgc tgattgccat
      421 gagcgcgcca atggacgcct gggcatctcc ctgactcgtg tttcagacgg agagaacgtc
      481 atcatatccc actttagctc caaggatgag ctcatccagg ccaatgtctg cagcacattt
      541 atcccggtgt actgtggcct cattcctcct accctccaag gggtgcgcta tgtggatggc
      601 ggcatttcag acaacttgcc actttatgag ctgaagaata ccatcacagt gtccccattc
      661 tcaggcgaga gtgacatctg ccctcaggac agctccacca acatccacga gcttcgcgtc
      721 accaacacca gcatccagtt caaccttcgc aatctctacc gcctctcgaa ggctctcttc
      781 ccgccagagc ccatggtcct ccgagagatg tgcaaacagg gctacagaga tggacttcga
      841 ttccttagga ggaatggcct actgaaccaa cccaaccctt tgctggcact gcccccagtt
      901 gtcccccagg aagaggatgc agaggaagct gctgtggtgg aggagagggc tggagaggag
      961 gatcaattgc agccttatag aaaagatcga attctagagc acctgcctgc cagactcaat
     1021 gaggccctgc tggaggcctg tgtggaacca aaggacctga tgaccaccct ttccaacatg
     1081 ctaccagtgc gcctggcaac ggccatgatg gtgccctata ctctgccgct ggagagtgca
     1141 gtgtccttca ccatccgctt gttggagtgg ctgcctgatg tccctgaaga tatccggtgg
     1201 atgaaagagc agacgggtag catctgccag tatctggtga tgagggccaa gaggaaattg
     1261 ggtgaccatc tgccttccag actgtctgag caggtggaac tgcgacgtgc ccagtctctg
     1321 ccctctgtgc cactgtcttg cgccacctac agtgaggccc tacccaactg ggtacgaaac
     1381 aacctctcac tgggggacgc gctggccaag tgggaagaat gccagcgtca gctactgctg
     1441 ggtctcttct gcaccaatgt ggccttcccg ccggatgcct tgcgcatgcg cgcacctgcc
     1501 agccccactg ccgcagatcc tgccacccca caggatccac ctggcctccc gccttgctga
     1561 gaatcaccat tcccacatcg cccggctacc agccaagctc caagttgtcc tgccccacta
     1621 agaggagccc cggggtggaa caagatcctg tctgccccgg ctctccccct tacatgctgt
     1681 ggaatgagga cataggaccc tgcacagctg caagtgggct ttcgatgtga aacctttcac
     1741 cagccactca ctatgctact cctggtgggg agggatgggg agtcgccctc ccccggagcc
     1801 cacagagccc tcccccgtca cgtcacctgt gccttactcc tgcccaccac cttttcagtg
     1861 cagggtcagt cttaagaact ccacatctgc tgctgctccc tggtgtccaa gtttccttgc
     1921 agagtgtgtg aagaattatt tatttttgcc aaagcagatc taataaaagc cacagctcag
     1981 cttctgcctt cctcacttct gcatgttacc cttgcctccg actgtggtca gcagacagag
     2041 ctttctccca gtgaactggt gtctcagtag ctaacagttg ggcttcacgg ggttctctga
     2101 gtcctggcag ctggggaccg tctcctaagg tcagtcctct ggcaaggaca catgtaagct
     2161 gctctgttct ctctgaggct tgctgcctgt ctcttgggcc agcagatatg tttgggagtt
     2221 tgagcccctt agtatcgata aaaaaactaa agtggtgggt tagagttgct cagccgttga
     2281 acagctgtct aatatgcacc aggtccggat tccatctcaa gcactagggg gaaaatgttt
     2341 acaaaaggtg tcacccacac atccgctcct catgtgacac agcgagtgag ggcgtggatc
     2401 cctgtgaagg gcgaagcttc tggaactgcg gtctggggac ccgggaagat tggttcctga
     2461 cccatactgg ggcatcttgc ccagaacttt gtgcttggct cctctttctt ggttgtcaca
     2521 tgctccactg ccaggtgcat atgccctttc ctgtactgta accatacctg cttcccgcca
     2581 gaaccttggg agagatcaga agtactgagg caaagtagag ttcaccatgg tttcc
//
