LOCUS       NM_025443               1578 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus partner of NOB1 homolog (Pno1), mRNA.
ACCESSION   NM_025443
VERSION     NM_025443.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1578)
  AUTHORS   Wang,X., Wu,T., Hu,Y., Marcinkiewicz,M., Qi,S.,
            Valderrama-Carvajal,H., Luo,H. and Wu,J.
  TITLE     Pno1 tissue-specific expression and its functions related to the
            immune responses and proteasome activities
  JOURNAL   PLoS One 7 (9), e46093 (2012)
   PUBMED   23029399
  REMARK    GeneRIF: Pno1 gene knockout is Lethal in Embryos.
REFERENCE   2  (bases 1 to 1578)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   3  (bases 1 to 1578)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1578)
  AUTHORS   Zhou,G.J., Zhang,Y., Wang,J., Guo,J.H., Ni,J., Zhong,Z.M.,
            Wang,L.Q., Dang,Y.J., Dai,J.F. and Yu,L.
  TITLE     Cloning and characterization of a novel human RNA binding protein
            gene PNO1
  JOURNAL   DNA Seq 15 (3), 219-224 (2004)
   PUBMED   15497447
REFERENCE   5  (bases 1 to 1578)
  AUTHORS   Abidari,J.M., Gonzales,E.T., Inoue,K., Lupski,J.R., Karsenty,G. and
            Katsanis,N.
  TITLE     Identification of novel genes expressed during metanephric
            induction through single-cell library screening
  JOURNAL   Kidney Int 57 (6), 2221-2228 (2000)
   PUBMED   10844592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY034432.1, AK007324.1 and AI837771.1.
            
            On Sep 7, 2006 this sequence version replaced NM_025443.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020037.1, AK146152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               BY034432.1         2-142
            142-1474            AK007324.1         107-1439
            1475-1578           AI837771.1         1-104               c
FEATURES             Location/Qualifiers
     source          1..1578
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 9.79 cM"
     gene            1..1578
                     /gene="Pno1"
                     /gene_synonym="1810003N24Rik; Emi3; Imi3"
                     /note="partner of NOB1 homolog"
                     /db_xref="GeneID:66249"
                     /db_xref="MGI:MGI:1913499"
     exon            1..277
                     /gene="Pno1"
                     /gene_synonym="1810003N24Rik; Emi3; Imi3"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..829
                     /gene="Pno1"
                     /gene_synonym="1810003N24Rik; Emi3; Imi3"
                     /note="expressed during mesenchymal induction 3; induced
                     during mesenchymal induction 3"
                     /codon_start=1
                     /product="RNA-binding protein PNO1"
                     /protein_id="NP_079719.1"
                     /db_xref="CCDS:CCDS24449.1"
                     /db_xref="GeneID:66249"
                     /db_xref="MGI:MGI:1913499"
                     /translation="METQSTGTEDGFTPVTHRGGRRAKKRQAEQSSAAGQDGEAGRMD
                     TEEARPAKRPVFPPLSGDQLLTGKEETRKIPVPGNRYTPLKENWMKIFTPIVEHLGLQ
                     IRFNLKSRNVEIRTCKDTKDVSALTKAADFVKAFVLGFQVEDALALIRLDDLFLESFE
                     ITDVKPLKGDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVHVHILGSFQNIKMAR
                     TAICNLILGNPPSKVYGNIRAVASRSADRF"
     exon            278..427
                     /gene="Pno1"
                     /gene_synonym="1810003N24Rik; Emi3; Imi3"
                     /inference="alignment:Splign:2.1.0"
     exon            428..511
                     /gene="Pno1"
                     /gene_synonym="1810003N24Rik; Emi3; Imi3"
                     /inference="alignment:Splign:2.1.0"
     exon            512..572
                     /gene="Pno1"
                     /gene_synonym="1810003N24Rik; Emi3; Imi3"
                     /inference="alignment:Splign:2.1.0"
     exon            573..690
                     /gene="Pno1"
                     /gene_synonym="1810003N24Rik; Emi3; Imi3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..761
                     /gene="Pno1"
                     /gene_synonym="1810003N24Rik; Emi3; Imi3"
                     /inference="alignment:Splign:2.1.0"
     exon            762..1565
                     /gene="Pno1"
                     /gene_synonym="1810003N24Rik; Emi3; Imi3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1542..1547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pno1"
                     /gene_synonym="1810003N24Rik; Emi3; Imi3"
                     /note="hexamer: AGTAAA"
     polyA_site      1565
                     /gene="Pno1"
                     /gene_synonym="1810003N24Rik; Emi3; Imi3"
                     /note="major polyA site"
ORIGIN      
        1 gattggtgga ggctggcgca tgcgctgtac aaccacgcac gtgttcctct agtcgtactt
       61 gccgggattg atcttggccg agatggagac gcaaagcacc ggaacggagg acggctttac
      121 tcccgtcacg cacagagggg gccgccgggc gaagaaacga caggctgagc agtcgtcagc
      181 ggcgggacag gatggagaag ccggacgcat ggacacggag gaggcgcggc cggcgaagag
      241 gccggtcttc ccgccgctct ccggggatca gctcctgact gggaaagaag aaacgaggaa
      301 aattcccgtc ccaggtaaca gatacacacc gttgaaagaa aactggatga agatatttac
      361 tccgattgta gaacatttgg gacttcagat acgctttaac ctgaaatcaa ggaatgtaga
      421 aatcaggact tgtaaagaca ccaaggatgt cagtgccctg acaaaagcgg ccgactttgt
      481 gaaagccttt gttcttggct ttcaggtgga ggatgcactt gcccttatcc gactagatga
      541 cctcttccta gagtcttttg aaataactga tgttaagccc ctaaaaggag accacctgtc
      601 aagggcaata ggaagaattg ctggcaaagg aggaaaaacc aaatttacca tagagaacgt
      661 aacacggaca cggattgtcc tggcagatgt gcacgttcac attcttggct ctttccaaaa
      721 tatcaagatg gcaagaacag ctatttgcaa cctcatccta ggaaatcctc catcaaaggt
      781 gtatggcaat atccgagctg tggccagcag atcagcagat cggttctgat tttccatgaa
      841 cccttgagat gttcacataa aaccatggga agaatttccc agccacttag agctcaggtt
      901 tcttctcagc tctcagccag agcagaagca taaaaggaag gtttaacagg acttgtactc
      961 agctgcttct aggataattt aaatatgata taatactgaa aagtacagca gtttataagt
     1021 gtaagtaagc cacacgggca gatgcacagg ttacaaccct atcaattaga ggtaactgct
     1081 tgcttacaac tctttggtta cagatttaca gctaaactta taaactttat ataaactgaa
     1141 atttttaatt aaaaatgaat cacaattctt ggtgccaggc actgtgacta tttcagggtt
     1201 gagtcatggc agaaacttgc actattgaac tatatgtgct catctttgca cttcctgtac
     1261 aatttataaa atgaaagtcc tgcatcacgt ggctaataaa tgttattttt caaataatta
     1321 aagatgttaa aatatttctc atgtgcagta aaagtaaaaa tgtaaaagaa ttctcccaag
     1381 aaaactgttc tccaaacagc atattctact agtgtctgtg tgtatgaatt tgattatttc
     1441 ttaaattgtt ttagaacaca tttcattaaa catgtaactt agatactaca ttctcatgtt
     1501 tctcaaaagc cttaaccaaa atattgtaat gattggaggt cagtaaattc aagcaataac
     1561 taaaaaaaaa aaaaaaaa
//
