LOCUS       NM_008891               3469 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus pinin (Pnn), mRNA.
ACCESSION   NM_008891
VERSION     NM_008891.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3469)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3469)
  AUTHORS   Blazquez,L., Emmett,W., Faraway,R., Pineda,J.M.B., Bajew,S.,
            Gohr,A., Haberman,N., Sibley,C.R., Bradley,R.K., Irimia,M. and
            Ule,J.
  TITLE     Exon Junction Complex Shapes the Transcriptome by Repressing
            Recursive Splicing
  JOURNAL   Mol Cell 72 (3), 496-509 (2018)
   PUBMED   30388411
REFERENCE   3  (bases 1 to 3469)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3469)
  AUTHORS   Joo,J.H., Ryu,D., Peng,Q. and Sugrue,S.P.
  TITLE     Role of Pnn in alternative splicing of a specific subset of lncRNAs
            of the corneal epithelium
  JOURNAL   Mol Vis 20, 1629-1642 (2014)
   PUBMED   25489234
  REMARK    GeneRIF: Pnn has an important role in alternative splicing of a
            specific subset of lncRNAs of the corneal epithelium.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3469)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 3469)
  AUTHORS   Leu,S. and Ouyang,P.
  TITLE     Spatial and temporal expression profile of pinin during mouse
            development
  JOURNAL   Gene Expr Patterns 6 (6), 620-631 (2006)
   PUBMED   16427813
  REMARK    GeneRIF: Spatial and temporal expression profile of pinin during
            mouse development.
REFERENCE   7  (bases 1 to 3469)
  AUTHORS   Gotter,A.L.
  TITLE     Tipin, a novel timeless-interacting protein, is developmentally
            co-expressed with timeless and disrupts its self-association
  JOURNAL   J Mol Biol 331 (1), 167-176 (2003)
   PUBMED   12875843
REFERENCE   8  (bases 1 to 3469)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (bases 1 to 3469)
  AUTHORS   Ouyang,P., Zhen,Y.Y. and Sugrue,S.P.
  TITLE     Cloning and analysis of cDNA encoding murine pinin
  JOURNAL   Gene 197 (1-2), 115-120 (1997)
   PUBMED   9332356
REFERENCE   10 (bases 1 to 3469)
  AUTHORS   Ouyang,P. and Sugrue,S.P.
  TITLE     Characterization of pinin, a novel protein associated with the
            desmosome-intermediate filament complex
  JOURNAL   J Cell Biol 135 (4), 1027-1042 (1996)
   PUBMED   8922384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY775218.1, AK030978.1 and CJ318297.1.
            
            On Aug 17, 2006 this sequence version replaced NM_008891.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.255467.1, AK030978.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                BY775218.1         2-74
            74-3355             AK030978.1         3-3284
            3356-3469           CJ318297.1         308-421
FEATURES             Location/Qualifiers
     source          1..3469
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 26.0 cM"
     gene            1..3469
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /note="pinin"
                     /db_xref="GeneID:18949"
                     /db_xref="MGI:MGI:1100514"
     exon            1..197
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2265
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /codon_start=1
                     /product="pinin"
                     /protein_id="NP_032917.2"
                     /db_xref="CCDS:CCDS25933.1"
                     /db_xref="GeneID:18949"
                     /db_xref="MGI:MGI:1100514"
                     /translation="MAVAVRALQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARL
                     LALSGPGGGRGRGSLLLRRGFSDSGGGPPAKQRDLEGAVSRLGGERRTRRESRQESDP
                     EDDDVKKPALQSSVVATSKERTRRDLIQDQNMDEKGKQRNRRIFGLLMGTLQKFKQES
                     TVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQL
                     QEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEGRRIEFAE
                     QINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVAQREEELEETGNQHNDVEVEEA
                     GEEEEKEAGIVHSDAEKEQEEEEQKQEMEVKTEEEAEVREGEKQQDSQPEEVMDVLEM
                     VESVKHVIAEQEVMETNQVESIEPSENETSKELEPEMEFDVEPDKECKSLSPGKENIN
                     SQEVEKESEEKEEKEEKEPEPQPEPVAQPQPPPQPLPQSQPHSQPHSQPQPVLQSQPL
                     CQPETLPLAVLQPPPQVIQEQGNLLPERKDFPLESIKLPEVSVEPVLTVHSENKSKNK
                     TRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSG
                     SSSRDSSSSTSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSR
                     DTKGSKDKSSRPDRKRSISESSRSGKRSSRSERDRKSDRKDKRR"
     exon            198..269
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /inference="alignment:Splign:2.1.0"
     exon            270..338
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /inference="alignment:Splign:2.1.0"
     exon            339..411
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /inference="alignment:Splign:2.1.0"
     exon            412..506
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /inference="alignment:Splign:2.1.0"
     exon            507..582
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /inference="alignment:Splign:2.1.0"
     exon            583..738
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /inference="alignment:Splign:2.1.0"
     exon            739..877
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /inference="alignment:Splign:2.1.0"
     exon            878..3469
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2625..2630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /note="hexamer: AATAAA"
     polyA_site      2646
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /note="major polyA site"
     regulatory      3287..3292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /note="hexamer: AATAAA"
     polyA_site      3308
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /note="major polyA site"
     regulatory      3429..3434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /note="hexamer: AGTAAA"
     polyA_site      3454
                     /gene="Pnn"
                     /gene_synonym="D12Ertd512e"
                     /note="major polyA site"
ORIGIN      
        1 gtcagtcctt ccgcgtggag cggcgggcgc ggtgcggcgc tgcgcggcct ggagagcggt
       61 cgcgaagcct gctgcagaga gaagatggcg gtcgccgtga gagctttgca ggagcagcta
      121 gagaaggcca aagagagcct caagaatgtg gacgagaata tccgcaagct caccgggcgg
      181 gacccgaatg atgtgaggcc catccaagcc agattgctgg ccctttctgg tcctggtgga
      241 ggtagaggac gaggtagctt attgctaagg cgtggattct cagatagtgg aggaggaccc
      301 ccagccaaac aaagagacct ggaaggggca gtcagtaggc tgggtgggga gcgtcggaca
      361 agaagagaat cacgccagga gagcgaccca gaagacgatg atgttaaaaa gccagcactg
      421 caatcttccg ttgtagctac ctccaaagag cgcacgcgca gagaccttat ccaggatcaa
      481 aacatggatg agaaggggaa gcaaaggaac cgacgaatat ttggcttgtt gatgggcact
      541 cttcagaaat ttaaacaaga atctactgtt gctactgaac ggcaaaaaag acgccaagaa
      601 attgaacaaa aacttgaagt tcaggctgaa gaagagagaa agcaggttga aaacgagagg
      661 cgagaactgt ttgaggagag acgtgctaag cagacggagc tgcggcttct ggagcagaag
      721 gttgagcttg cgcagctgca agaagaatgg aatgaacata atgccaagat aattaagtat
      781 ataaggacca agacaaagcc ccatttgttc tatattcctg gaagaatgtg tccagctacc
      841 caaaagctaa tagaagagtc acagagaaag atgaatgctt tatttgaagg tagacgcatc
      901 gaatttgcag aacaaataaa taaaatggag gctaggccta gaagacaatc aatgaaggaa
      961 aaagagcatc aggtggtgcg taatgaagaa cagaaggcgg aacaagaaga gggtaaggtg
     1021 gctcagcgag aggaagagtt ggaggagaca ggtaatcagc acaatgatgt agaagtagag
     1081 gaggcaggag aggaagagga gaaggaagca ggtatagttc atagtgatgc agagaaagaa
     1141 caggaggagg aggaacaaaa gcaggaaatg gaggttaaga ctgaggagga ggctgaggta
     1201 agagaaggtg agaagcagca ggatagtcag ccagaagaag tgatggatgt gctagagatg
     1261 gtggaaagtg tcaaacacgt aattgctgag caggaagtaa tggaaactaa ccaagttgaa
     1321 agtatagagc cttcagaaaa tgaaactagc aaagaattgg agccagagat ggaatttgat
     1381 gttgagccag ataaagaatg taaatctctt tctcctggaa aagagaatat taattctcag
     1441 gaagtggaaa aggagtctga ggagaaagag gaaaaagaag agaaagaacc tgagccccaa
     1501 cctgagcctg tggctcagcc tcagccccca cctcagcccc tgccccagag ccagccccat
     1561 tctcagcccc actcccagcc ccagcctgta ctccagtccc agcctctctg tcagcctgag
     1621 actttgccat tagctgtttt gcagcctcca cctcaggtta ttcaggagca agggaatcta
     1681 ctacctgagc ggaaggattt tcctctagag tctataaaac tccctgaggt gtctgtagag
     1741 ccagtcttga cagtacattc agaaaacaaa agcaagaata agactaggag caggagcagg
     1801 gggcgagcaa ggaataaaac aagcaagagt agaagtcgga gcagcagcag cagtagttcc
     1861 agtagcagct ctactagtag cagcagcggg agcagctcca gcagtggcag cagcagtagt
     1921 cgaagcagct ccagcagcag ctccagcacg agtgggagca gcagcagaga cagcagcagc
     1981 agcactagca gtagcagtga gagtaggagt cgcagtaggg gccgaggaca taaccgagat
     2041 aggaagcaca gaaggagcgt ggaccggaag cgaagggata cttcaggact agaaagaagt
     2101 cacaagtctt caaaaggtgg tagtagtaga gatacaaaag gatcaaagga taagagttcc
     2161 cgccctgaca gaaaaaggtc tatatcagag agtagtcgat caggcaaaag atcttcaaga
     2221 agtgaaagag accgaaaatc agacaggaaa gacaaaaggc gttaatgaag aagccaggct
     2281 tgcttagcct attctttgca gcagaagatg tcttgatgag taaaaggatt accttgtaaa
     2341 gaggatgctg ccttaagaat tgcatgttgt aaaaattctt tttggagaat acagactgtt
     2401 tgtttaccag acattcttgt actttttgca taattttgta agagttattt atcaaaatta
     2461 tgtgaggttc caaaatatgt aaaaatgata ataataaaaa aagattaaca tcctttgtca
     2521 tcttttttaa ctaccctatt actgttcagt cagaatccgt atattttaat aggtaaatct
     2581 ttaaattgtt ccttatgttc tgtatcatac attgcttttg tagaaataaa tatgcatctt
     2641 tcattatttt tgggatgtcc ttgttgacac ttgtataata aatatcttta tatcattttc
     2701 agtttttgtc acaagatact gaacatgatt aggatgtttt tgaaggtttc atcactttga
     2761 tttgcctgaa aacagttgcc aggtttttac agctttgaca gggaatagtt cttttaaaac
     2821 atttatttcc tatcttacag tttttaatct aagcattttt ctgtttttca ttaaaaccat
     2881 tcagttggta gataacttca accgtacgat ttggttgtca tttcacgatt atagaacaac
     2941 attctcttgt cctctcagct ccttgtgtga taacaactta gagtgtaatc tgttatagtt
     3001 atcacctccc gggtggtggg ggtcgggtaa aaatctcttc taaacttggt ttttgaatct
     3061 gtggtcttgt cttttctgtt ggctataact gaaacatgcc aatctgtgtt ttcaagaatt
     3121 tttgtttaag gaagtattgt atggaagttt acacaatgaa ggaagttcat ctagacttga
     3181 atatgtaaac aagataacac acaagtgtac caagtgatta ttaactttgt tgtttataaa
     3241 tttgtatgga cctggagtat ctgttgccca ttactatata tgtgcaaata aatgtgactt
     3301 agacttgtga ctgtttaaaa ttagtacttg tattaaagtt ttgatgcata tgagagcatt
     3361 taaatgacag tggctatttt aacattgtag ttttagcctg atattaaata ttcagtatat
     3421 tgtctataag taaatggttt cagtgaaaaa tgaacaaata tcttcattt
//
