LOCUS       NM_008890                980 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus phenylethanolamine-N-methyltransferase (Pnmt), mRNA.
ACCESSION   NM_008890
VERSION     NM_008890.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 980)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 980)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 980)
  AUTHORS   Wang,Q., Wang,Y., Kuo,H.C., Xie,P., Kuang,X., Hirokawa,K.E.,
            Naeemi,M., Yao,S., Mallory,M., Ouellette,B., Lesnar,P., Li,Y.,
            Ye,M., Chen,C., Xiong,W., Ahmadinia,L., El-Hifnawi,L., Cetin,A.,
            Sorensen,S.A., Harris,J.A., Zeng,H. and Koch,C.
  TITLE     Regional and cell-type-specific afferent and efferent projections
            of the mouse claustrum
  JOURNAL   Cell Rep 42 (2), 112118 (2023)
   PUBMED   36774552
REFERENCE   4  (bases 1 to 980)
  AUTHORS   Ren,H., Pu,Z., Sun,T., Chen,T., Liu,L., Liu,Z., O'Shea,C.,
            Pavlovic,D., Tan,X. and Lei,M.
  TITLE     High-Resolution 3D Heart Models of Cardiomyocyte Subpopulations in
            Cleared Murine Heart
  JOURNAL   Front Physiol 13, 779514 (2022)
   PUBMED   35665220
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 980)
  AUTHORS   Bonthuis,P.J., Steinwand,S., Stacher Horndli,C.N., Emery,J.,
            Huang,W.C., Kravitz,S., Ferris,E. and Gregg,C.
  TITLE     Noncanonical genomic imprinting in the monoamine system determines
            naturalistic foraging and brain-adrenal axis functions
  JOURNAL   Cell Rep 38 (10), 110500 (2022)
   PUBMED   35263575
REFERENCE   6  (bases 1 to 980)
  AUTHORS   Cole,T.J., Blendy,J.A., Monaghan,A.P., Krieglstein,K., Schmid,W.,
            Aguzzi,A., Fantuzzi,G., Hummler,E., Unsicker,K. and Schutz,G.
  TITLE     Targeted disruption of the glucocorticoid receptor gene blocks
            adrenergic chromaffin cell development and severely retards lung
            maturation
  JOURNAL   Genes Dev 9 (13), 1608-1621 (1995)
   PUBMED   7628695
REFERENCE   7  (bases 1 to 980)
  AUTHORS   Suh,Y.H., Chun,Y.S., Lee,I.S., Kim,S.S., Choi,W., Chong,Y.H.,
            Hong,L., Kim,S.H., Park,C.W. and Kim,C.G.
  TITLE     Complete nucleotide sequence and tissue-specific expression of the
            rat phenylethanolamine N-methyltransferase gene
  JOURNAL   J Neurochem 63 (5), 1603-1608 (1994)
   PUBMED   7931317
REFERENCE   8  (bases 1 to 980)
  AUTHORS   Morita,S., Kobayashi,K., Hidaka,H. and Nagatsu,T.
  TITLE     Organization and complete nucleotide sequence of the gene encoding
            mouse phenylethanolamine N-methyltransferase
  JOURNAL   Brain Res Mol Brain Res 13 (4), 313-319 (1992)
   PUBMED   1320721
REFERENCE   9  (bases 1 to 980)
  AUTHORS   Kobayashi,K., Sasaoka,T., Morita,S., Nagatsu,I., Iguchi,A.,
            Kurosawa,Y., Fujita,K., Nomura,T., Kimura,M., Katsuki,M. et al.
  TITLE     Genetic alteration of catecholamine specificity in transgenic mice
  JOURNAL   Proc Natl Acad Sci U S A 89 (5), 1631-1635 (1992)
   PUBMED   1542654
REFERENCE   10 (bases 1 to 980)
  AUTHORS   Yamada,K., Sakai,M., Okamura,H., Ibata,Y. and Nagatsu,I.
  TITLE     Detection of tyrosine hydroxylase and
            phenylethanolamine-N-methyltransferase messenger RNAs in the mouse
            adrenal gland and the brain by in situ hybridization
  JOURNAL   Histochemistry 97 (3), 201-206 (1992)
   PUBMED   1348741
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591390.8.
            
            On Jun 19, 2019 this sequence version replaced NM_008890.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136691.1, BC119079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AL591390.8         118703-118946       c
            245-452             AL591390.8         118025-118232       c
            453-980             AL591390.8         117389-117916       c
FEATURES             Location/Qualifiers
     source          1..980
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.75 cM"
     gene            1..980
                     /gene="Pnmt"
                     /gene_synonym="Pent"
                     /note="phenylethanolamine-N-methyltransferase"
                     /db_xref="GeneID:18948"
                     /db_xref="MGI:MGI:97724"
     exon            1..244
                     /gene="Pnmt"
                     /gene_synonym="Pent"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..897
                     /gene="Pnmt"
                     /gene_synonym="Pent"
                     /EC_number="2.1.1.28"
                     /note="PNMTase; noradrenaline N-methyltransferase"
                     /codon_start=1
                     /product="phenylethanolamine N-methyltransferase"
                     /protein_id="NP_032916.1"
                     /db_xref="CCDS:CCDS25347.1"
                     /db_xref="GeneID:18948"
                     /db_xref="MGI:MGI:97724"
                     /translation="MNGGSDLKHATGSGSDPKHAAEMDPDSDAGQVAVALAYQRFEPR
                     AYLRNNYAPPRGDLSNPDGVGPWKLRCMAQVFATGEVSGRVLIDIGSGPTIYQLLSAC
                     AHFEDITMTDFLEVNRQELGLWLREEPGAFDWSVYSQHACLIEDKGESWQEKERQLRA
                     RVKRVLPIDVHKPQPLGTPSLVPLPADALVSAFCLEAVSPDLTSFQRALHHITTLLRP
                     GGHLLLIGALEESWYLAGEARLSVVPVSEEEVREALVLGGYEVRELRTYIMPAHLCTG
                     VDDVKGIFFAWAQKMEVQV"
     exon            245..452
                     /gene="Pnmt"
                     /gene_synonym="Pent"
                     /inference="alignment:Splign:2.1.0"
     exon            453..980
                     /gene="Pnmt"
                     /gene_synonym="Pent"
                     /inference="alignment:Splign:2.1.0"
     regulatory      960..965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pnmt"
                     /gene_synonym="Pent"
                     /note="hexamer: AATAAA"
     polyA_site      980
                     /gene="Pnmt"
                     /gene_synonym="Pent"
                     /note="major polyA site"
ORIGIN      
        1 aacagaagca tgaacggtgg ctcagacctg aagcacgcta cagggagtgg ctcagacccg
       61 aagcacgctg cagagatgga ccctgactcc gacgctggcc aggtagctgt cgccttggct
      121 taccagcgct tcgagccccg cgcctatctc cgcaacaact acgcgcctcc tcgtggagac
      181 ctgagcaacc ctgatggcgt cgggccttgg aagctgcgct gcatggcaca agtctttgct
      241 accggtgagg tgtcgggacg ggttctcatt gatattggct ccggccccac catatatcag
      301 ctgctcagtg cctgtgccca ctttgaggac atcaccatga cagacttctt ggaagtcaac
      361 cgtcaggagc tgggactctg gctgcgagag gagccaggag cctttgactg gagtgtgtat
      421 agtcagcatg cctgcctcat tgaggacaag ggtgagtcct ggcaggagaa agaacgccag
      481 cttcgagcga gggtgaagcg agtcctgcct atcgatgtgc acaagcccca gcccctggga
      541 actcccagtc tggtccctct gcctgccgac gccttggtct ctgccttctg cctggaggct
      601 gtgagcccag atcttactag cttccagcgg gctttgcatc acatcaccac actgctgagg
      661 cccgggggtc atctcctcct cattggggcc ctggaggagt cctggtacct tgctggggag
      721 gccaggctgt ctgtggtgcc agtgtctgag gaggaggtga gggaggccct ggtccttggt
      781 ggttacgagg tccgagagct tcgcacctac atcatgcctg cccacctctg cacgggggta
      841 gatgatgtca aaggcatctt ctttgcctgg gcccagaaga tggaggtgca ggtgtgaggg
      901 ccccaaaaat gccaggtgtc ctgtgcctcc caaagtcctt atcacctgaa gtggaaccta
      961 ataaagtgac agttcccggc
//
