LOCUS       NM_175498               4518 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus paraneoplastic antigen MA2 (Pnma2), mRNA.
ACCESSION   NM_175498
VERSION     NM_175498.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4518)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4518)
  AUTHORS   Pinson,M.R., Chung,D.D., Mahnke,A.H., Salem,N.A., Osorio,D.,
            Nair,V., Payne,E.A., Del Real,J.J., Cai,J.J. and Miranda,R.C.
  TITLE     Gag-like proteins: Novel mediators of prenatal alcohol exposure in
            neural development
  JOURNAL   Alcohol Clin Exp Res 46 (4), 556-569 (2022)
   PUBMED   35187673
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY122944.1, AK043718.1, BB266086.2, AK084459.1 and BB493058.1.
            
            On Mar 7, 2008 this sequence version replaced NM_175498.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220357.1, AK043718.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BY122944.1         40-91
            53-1743             AK043718.1         1-1691
            1744-2306           BB266086.2         88-650
            2307-4509           AK084459.1         496-2698
            4510-4518           BB493058.1         314-322
FEATURES             Location/Qualifiers
     source          1..4518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.6 cM"
     gene            1..4518
                     /gene="Pnma2"
                     /gene_synonym="A830049P17Rik; mKIAA0883"
                     /note="paraneoplastic antigen MA2"
                     /db_xref="GeneID:239157"
                     /db_xref="MGI:MGI:2444129"
     exon            1..86
                     /gene="Pnma2"
                     /gene_synonym="A830049P17Rik; mKIAA0883"
                     /inference="alignment:Splign:2.1.0"
     exon            87..215
                     /gene="Pnma2"
                     /gene_synonym="A830049P17Rik; mKIAA0883"
                     /inference="alignment:Splign:2.1.0"
     exon            216..4518
                     /gene="Pnma2"
                     /gene_synonym="A830049P17Rik; mKIAA0883"
                     /inference="alignment:Splign:2.1.0"
     CDS             586..1683
                     /gene="Pnma2"
                     /gene_synonym="A830049P17Rik; mKIAA0883"
                     /codon_start=1
                     /product="paraneoplastic antigen Ma2 homolog"
                     /protein_id="NP_780707.1"
                     /db_xref="CCDS:CCDS27226.1"
                     /db_xref="GeneID:239157"
                     /db_xref="MGI:MGI:2444129"
                     /translation="MAVALLEEWCKIMGVDVQKSLLVVDIPVDCGEPEIQTVLQEALK
                     CVGSYRLLGKIFQKQDNTSVVLVELMEDTDMSVVPSEVQGKGGVWKVIFKTPNQDTEF
                     LQRLNLFLEKEGQTVAGMFRALKHEGVSPATPPCTSPELLAHLTGQAMVHGQRPLLPV
                     KYCKMRIFSGSTAAAPEEEPFEVWLEQATEIAKEWPIPEAEKKRWVAESLRGPALDLM
                     HIVQADNPSISVGECLEAFKQVFGSTESRRTSQVKYLRTYQQEGEKISAYVLRLETLL
                     RRAVEKRAIPRNIADQVRLEQVMAGANLGNVLWCRLQELKDQGPLPTFLQLMKVIREE
                     EEEEDAYFEQESREEPGEREGSGCWNNSRNN"
     regulatory      1985..1990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pnma2"
                     /gene_synonym="A830049P17Rik; mKIAA0883"
                     /note="hexamer: AATACA"
     polyA_site      2013
                     /gene="Pnma2"
                     /gene_synonym="A830049P17Rik; mKIAA0883"
     regulatory      4494..4499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pnma2"
                     /gene_synonym="A830049P17Rik; mKIAA0883"
                     /note="hexamer: AATAAA"
     polyA_site      4514
                     /gene="Pnma2"
                     /gene_synonym="A830049P17Rik; mKIAA0883"
                     /note="major polyA site"
ORIGIN      
        1 ggagcctgcg ccccggaagt aaagcggaca ctccacccgc taatggacgc gcggcagccg
       61 cccgacagac ctctctcggc gccaggggca gcttgactcg actgaaattg agacacatac
      121 atcctattgt atagagatgt gtgacatctt cctgatctgg aagctgagta cttggctcct
      181 tggttcttga aaaacattct ggaacacatg aacaggagtc cttgccatct cactgtgtga
      241 ctccccagag ttgggtgcta gagtggaagc cacctccccc attgactaga gagaggcgaa
      301 gtgacagaaa ccaggagatg gtgggaaaag cgattgttcc aggtgcctcc cgatgacaag
      361 agtcagcacc acgcagttac aacaaccagc cctcggaagc agcagcgacc ccactgcaga
      421 gcaacagccc accctacgta cgctgcagga cccgtcagcc ttgctgtggg tctgaagaca
      481 gacagggagt gtctggttct tgtgactggg taaagggaca gagcatttgg cccaagaggc
      541 tttgagacct cttggagacc aagtccagaa gcatatcctg ggacaatggc ggtggccctg
      601 ctggaggagt ggtgtaagat catgggtgta gacgtccaga agtcactgct ggtggttgac
      661 attccggtgg actgtggtga acctgagatc cagacagtcc tccaggaggc tctgaagtgt
      721 gtcggcagct accggctact aggcaagata ttccagaagc aggacaacac cagtgttgtc
      781 ttagtggaac ttatggagga cacagatatg tctgtggtcc ccagtgaggt acagggcaag
      841 ggaggtgtct ggaaagtgat cttcaagacc cctaatcagg acactgagtt tctccaaaga
      901 ctgaacctct ttctagaaaa agaagggcag acggtcgcag ggatgttccg agcccttaag
      961 catgagggag tgtctccagc caccccaccc tgcacgtccc ctgagttatt ggcccatttg
     1021 acggggcagg caatggttca cggccagagg cctctgttgc ctgtgaagta ctgtaagatg
     1081 agaatattct ctgggagcac agcagctgcc ccagaggagg agccctttga ggtctggttg
     1141 gaacaggcca ctgagatagc caaggaatgg cccatccctg aagcagaaaa gaaaaggtgg
     1201 gtggcagaga gcctccgtgg ccctgccctg gacctcatgc acatagtaca ggcagacaac
     1261 ccttccatca gtgtggggga atgtctggag gcctttaagc aggtgtttgg gagcacggag
     1321 agccgtagaa cctcacaggt aaaataccta agaacctatc agcaagaagg ggagaaaatc
     1381 tcagcctacg tgctccggct ggaaactctg ctccggagag ctgtggaaaa aagggccatc
     1441 ccccggaaca ttgctgacca ggtacgcctg gagcaggtca tggctggtgc caacctcggc
     1501 aacgttctgt ggtgcaggct acaggagctg aaagatcagg gcccactccc cacctttttg
     1561 cagctgatga aggtgatacg tgaggaagaa gaagaagaag acgcctactt tgaacaagag
     1621 agcagggagg agccggggga aagggagggc tctggctgct ggaacaattc aagaaacaac
     1681 tgagagatat ccccactccg tccctgatct ggtgggcgat gcttgacaag agacgatgct
     1741 tgacaaggct aaccccatta cagtggattc ttcttaagtg caggactgaa gctaaacatt
     1801 aggactgaag gtttttgtct tttctttctt ttcttttgtt ttgatagggt ctcaccttat
     1861 agcccaagtt ggccttgaac tgacattctt cctgcctcaa cctcccaaat tgagagttct
     1921 gggattagag gaacatccca ccactagttc cccatctcgg tttttctttc tgagaaaaaa
     1981 aaaaaataca agactaagtt ccaataccta aaacttctga actttagttt cctttaagta
     2041 caccagggtt ggccagacag ctcggttgat caagttactt accattctct tcagagggag
     2101 caataatgtg aacaggagat aggaattggc caggcagggg ctggagggat gctcagccat
     2161 taagcacatt tgctattctt ttggaggagt tcagatcgca gcacccatgt agtggttcac
     2221 aattctctat aacggggatc caacaccttc ttctggtctc tttgggtact ttgcatatgt
     2281 ggtacacatg catacatgca gaccatacac ataaaataaa aacaaataaa tctttaagaa
     2341 gaaaagaacc tggctaggca gtttccaggc attccaaaag tgtccctggt cttctggtgc
     2401 atgaacctca caaggagctc tgatttccca ttgtcccctt cctgaaggtt acacttgagg
     2461 gtgggacctt cagtcagaca ctaatccatt tgtggatagt gttagaatta ggtccataga
     2521 tttttcatga taaaatggct tatatctgtt ccccagtttt agcctaatct cctatatgat
     2581 tttaggggta gctcatcaga gggggaaatt tacagtagcc ttgatcagga cttttctgag
     2641 tctcattaag agaaaaccat tgccttctgg tcagaaaaat ggaatctacc tcttgcctag
     2701 gccgagacct accattgcaa gctaaccaaa acataagcgt taatcaagtc gggcaggtcc
     2761 atcaccaggc taatggactg cccattagga aggcagattc acctaactct atgctaatga
     2821 gatggaagga ataattatcc ctttaatgaa gtaatgtcct tttccttccc agagtccctg
     2881 ctatctgtac agtcactaca gaactaccat gaaaagtaat tttcactttt tctttttctt
     2941 tttgctggcc caggcctaag cgcacattct ttagtacttt gagctgtttc actctctcca
     3001 tgtggctgca tgctaaccct ctacccactc aaaagaaagc gtggctttct ctcttctttt
     3061 tctctatatc cctcttccag gtatgtttga tccccataag ccatagggta gaaggagaga
     3121 accaattcct gcaagctgtc attttacaca cacacacatg tacaaataat gtaattttta
     3181 aaaccacaac aagtagacca atgtttactc atacctttga aaaatggact gaccttattt
     3241 aaaaaaaaaa ttatacaaaa cacatatatc ctacttaatg tgtgcaacaa cctactcttt
     3301 atagggtgtg tgtgtgtgtg cgcttgcatg catgtatgtg tgtgtggagg aggggtgggg
     3361 cttgtggtac acttcataaa gggaaagatg caaaggtcaa ctaagttaaa tggcctcagc
     3421 accaaaatgc tcagaagtga aaccagagca gaggcccaga acaagacttt agggatccac
     3481 cctctgtgcg tcgctcaaat gtgttttctt agttctgtag aggactgatt ttaagcacta
     3541 gtgttttaaa ctccttacat ctcagacacc cagcaggtag tatcaagtgt gctaatgacc
     3601 aagtctcagt atctccgtgt tcaccaagct tgcttttgtt tccaaactga cccaggactg
     3661 cagaacaaag ctccctgctg gcaatggtga gcctattcca aaagccctgt aattgtgcac
     3721 agacttgaaa agccatagcg ccttgtgagt atgtgtgcca ggtcaagagt actagggcac
     3781 cataaacaaa cactgcttag ttgcctgcca ggcagagctc gggcacagtt agtgtgcagc
     3841 ctgtggtaga tccctgtgtg gttagcaagc tgcttggttt ctctgaacat ccgtttcctt
     3901 atctaaaaat gggctgccat taggatcaag tggcacaatg ctttttaagg gcttggagta
     3961 acgtttggaa cttagaagcc cctccatata ctgaggatct ttgtattttt gtgatagttg
     4021 tcagctcaat gcatgttctc ttgattgttt ccattgtatg gaaacaagtc acaaagtaac
     4081 agacttacat tccagtcggg atgctcctgc agtgaggaag aactttggct tggaagtaag
     4141 tgtgcactag ctggccgtcc acatttgtgg taagtattcc agaagtagtt ggtgactgtt
     4201 aatcgacttg actttggaat gatgacctgt tcttccgggt tgtgggttag tttaactgaa
     4261 gaataagaag ttctaagaaa ggtggtttgt ttgtttattt aagtcatcat ctgtgatggt
     4321 ttatctttcg gaaatatatt tctcaacact gtccagccac agtgatgtca gtgatgggat
     4381 tgtccttgac cactctagcc tgactccacg tggcattatg ttcctgggaa tagctttgcc
     4441 gttgtactta ccaacagaat acagagttaa atgttaccac tgcgaagtta ccaaataaat
     4501 ctgagctagt gaaatcgt
//
