LOCUS       NM_027438               2360 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus paraneoplastic antigen MA1 (Pnma1), mRNA.
ACCESSION   NM_027438 XM_127024
VERSION     NM_027438.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2360)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2360)
  AUTHORS   Chen,H.L. and D'Mello,S.R.
  TITLE     Induction of neuronal cell death by paraneoplastic Ma1 antigen
  JOURNAL   J Neurosci Res 88 (16), 3508-3519 (2010)
   PUBMED   20936693
  REMARK    GeneRIF: PNMA1 functions to promote neuronal death.  PNMA1-mediated
            apoptosis can be prevented by Bcl2. Although the detailed mechanism
            remains to be delineated, it is likely to involve association of
            proteins with PNMA1 through its BH3-like sequence.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK136933.1 and BM939442.1.
            
            On May 24, 2007 this sequence version replaced NM_027438.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK136933.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2356              AK136933.1         3-2358
            2357-2360           BM939442.1         310-313
FEATURES             Location/Qualifiers
     source          1..2360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.07 cM"
     gene            1..2360
                     /gene="Pnma1"
                     /gene_synonym="5730402C15Rik"
                     /note="paraneoplastic antigen MA1"
                     /db_xref="GeneID:70481"
                     /db_xref="MGI:MGI:2180564"
     exon            1..2359
                     /gene="Pnma1"
                     /gene_synonym="5730402C15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             563..1624
                     /gene="Pnma1"
                     /gene_synonym="5730402C15Rik"
                     /codon_start=1
                     /product="paraneoplastic antigen Ma1 homolog"
                     /protein_id="NP_081714.2"
                     /db_xref="CCDS:CCDS26040.1"
                     /db_xref="GeneID:70481"
                     /db_xref="MGI:MGI:2180564"
                     /translation="MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDETEIEETLQAAMP
                     QVSYRVLGRMFWREENAKAALLELTGAVDYSLIPREMPGKGGLWKVVFKPPTSDAVFL
                     ERLHLFLAREGWTVQDVARVLGFQNPAPAPGPEMPAEMLNYILDNVIQPLVESIWYKK
                     LTLFSGKDIPGPGEETFDSWLEHSNEIIEEWQVSDIEKRRRLMESLRGPAADVIRILK
                     TNNAAITTAECLKALEQVFGSVESSRDAQVRFLNTYQNPGEKLSSYVIRLEPLLQKVV
                     DKGVIDKDNVNQARLEQVIAGANHSGALRRQLWLAGAEEGPAPNLFQLLVQIREEEAK
                     KEEEEAEAALLQLGLEGHF"
     regulatory      2338..2343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pnma1"
                     /gene_synonym="5730402C15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2359
                     /gene="Pnma1"
                     /gene_synonym="5730402C15Rik"
                     /note="major polyA site"
ORIGIN      
        1 agctgcacgc cggccgttgc gggagcgcgc ggacataagc gctaggcaga gctgcctcca
       61 gccgagtttc tcccccatcc cgtgcttcct gccgcttggg ttcccggtgc tcggagtgcc
      121 gcctctcccc acgtagccaa gccacggcct cgcgtgaccc tcagcccgcc ggcgtgccgg
      181 ggagaggtgg gaggagctgc cacgccccgc gaccgcaccc agccatctcc cgcccggagt
      241 catcagtctt gagcccacct tgctccctct ctttaagcgg tgacgccaga cacagctgca
      301 gccagttcag ccctccctgc ccggaccaaa gggggcgaca ttcgagtgat aggcggagtg
      361 tcccgtggct cccgaccctg acttgggacc cggaagggac aagaaggaac tctggtgtct
      421 tttggtaatt gtggttgcct gaagcttgtc gccccctggc ctaccggggg aggagagcat
      481 gttgtattgt cctaggccct atagcctcgt gagccagtcc aagcagtgtc tgtagaactg
      541 gcacttttaa tagttgggtg aaatggctat gacactattg gaagactggt gcaggggaat
      601 ggatgtgaac tctcagagag ctctgttggt ctgggggatc cctgtgaact gtgatgagac
      661 cgaaattgaa gagaccctcc aagctgcgat gccccaggta tcctatcgag tgctggggag
      721 aatgttctgg agggaagaaa atgctaaagc agccttgtta gagctcactg gggcagtgga
      781 ttactccctg atacccaggg agatgccagg caaaggaggg ctctggaaag tggtgtttaa
      841 accccccact tccgacgcag tttttttgga aaggctgcac ctctttctag ctagggaagg
      901 gtggaccgtg caagatgttg ctcgtgtgct tgggtttcag aaccctgctc cagctccagg
      961 cccggaaatg ccagcagaga tgctcaacta tattttggat aatgttattc aacctcttgt
     1021 tgagtccata tggtataaga agctgacgtt attctccggg aaggacattc ccgggcctgg
     1081 cgaggaaacc tttgattcct ggctggagca ctcaaatgaa atcatagagg aatggcaggt
     1141 gtcggatata gaaaagagac ggcggttgat ggagagtttg agaggccccg ctgctgacgt
     1201 catccgcatc ctcaagacca acaacgccgc cataacgacc gcagaatgcc tgaaggctct
     1261 tgagcaggtc tttgggagtg tggagagctc tagagatgca caggtcagat ttctgaacac
     1321 ttaccagaac ccaggagaaa agttatcttc gtatgttatc cgtctggagc ctctgctgca
     1381 aaaggtagta gacaaggggg tcattgataa agataacgtg aaccaggctc gcttggagca
     1441 ggtcatcgct ggggctaacc acagtggggc cctccgaagg cagttgtggc tggccggggc
     1501 tgaggaaggg cctgcaccca acctcttcca gttactggtg cagattcgag aggaggaagc
     1561 caagaaggag gaggaggagg ccgaggccgc cctcttgcag ctaggcctgg aggggcactt
     1621 ctgagtccta ggactggcca ggctgctttt gatatacctg tgacgtttta gtaagcctgc
     1681 cactcaaagc aagcacccag cctcctcctg gcttggtttt gtttcctgag ggatgggatg
     1741 gggaagtcag gcccgcatat tcctgtaaca ttcacagaag tgtgtgattg tcaggagctg
     1801 caacggtaaa ggtggtcctt actgcctaaa gtgaatgctt gatgccagcc ctcctggcga
     1861 catctctgac agctgtgcac aaacgtgaag ctgtgacact tcctgtcaag gtggttgcga
     1921 agctgcaggt tctgatgcta accgcgcacc aggttcacag actgtacagt acaaactctt
     1981 gtgtttgtta ctaacactgt ggatggtttt actgtaaatt gttcccaatt tgtatcgatg
     2041 gaaagaatgt gattctatta gaagatatta ctcatcttga aaaatgcgga tttctaattc
     2101 ctcacggctc aacgctggaa tcagtttccc tgaaaaggat cctcggacta aaagtggcat
     2161 gttagaaaaa accaggcctt taccgagctg cacaatcagt tcctcacggt ggaagacaga
     2221 agtcctaggg ggagtggccg tggccagtct acacttcccc cacttcaaag actagtcatt
     2281 taataattgg tcagcgctaa gggttctaag tttgaagtta ttgaatagat gtatacaaat
     2341 aaaaatttga aaattctcaa
//
