LOCUS       NM_011128               1593 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus pancreatic lipase-related protein 2 (Pnliprp2), mRNA.
ACCESSION   NM_011128
VERSION     NM_011128.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1593)
  AUTHORS   Tao,H.P., Lu,T.F., Li,S., Jia,G.X., Zhang,X.N., Yang,Q.E. and
            Hou,Y.P.
  TITLE     Pancreatic lipase-related protein 2 is selectively expressed by
            peritubular myoid cells in the murine testis and sustains long-term
            spermatogenesis
  JOURNAL   Cell Mol Life Sci 80 (8), 217 (2023)
   PUBMED   37468762
  REMARK    GeneRIF: Pancreatic lipase-related protein 2 is selectively
            expressed by peritubular myoid cells in the murine testis and
            sustains long-term spermatogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1593)
  AUTHORS   Kuge,H., Miyamoto,I., Yagyu,K.I. and Honke,K.
  TITLE     PLRP2 selectively localizes synaptic membrane proteins via
            acyl-chain remodeling of phospholipids
  JOURNAL   J Lipid Res 61 (12), 1747-1763 (2020)
   PUBMED   32963038
  REMARK    GeneRIF: PLRP2 selectively localizes synaptic membrane proteins via
            acyl-chain remodeling of phospholipids.
REFERENCE   3  (bases 1 to 1593)
  AUTHORS   Ge,W., Gao,Y., Zhao,Y., Yang,Y., Sun,Q., Yang,X., Xu,X. and
            Zhang,J.
  TITLE     Decreased T-cell mediated hepatic injury in concanavalin A-treated
            PLRP2-deficient mice
  JOURNAL   Int Immunopharmacol 85, 106604 (2020)
   PUBMED   32428799
  REMARK    GeneRIF: Decreased T-cell mediated hepatic injury in concanavalin
            A-treated PLRP2-deficient mice.
REFERENCE   4  (bases 1 to 1593)
  AUTHORS   Gao,Y., Lu,W., Sun,Q., Yang,X., Liu,J., Ge,W., Yang,Y., Zhao,Y.,
            Xu,X. and Zhang,J.
  TITLE     Pancreatic lipase-related protein 2 is responsible for the
            increased hepatic retinyl ester hydrolase activity in vitamin
            A-deficient mice
  JOURNAL   FEBS J 286 (21), 4232-4244 (2019)
   PUBMED   31199585
  REMARK    GeneRIF: Our results indicate that Plrp2 can be activated in the
            liver and is responsible for the increased RE hydrolases (REH)
            activity in the liver of mice fed vitamin A-deficient diet (VAD)
REFERENCE   5  (bases 1 to 1593)
  AUTHORS   Chang,I., Bramall,A.N., Baynash,A.G., Rattner,A., Rakheja,D.,
            Post,M., Joza,S., McKerlie,C., Stewart,D.J., McInnes,R.R. and
            Yanagisawa,M.
  TITLE     Endothelin-2 deficiency causes growth retardation, hypothermia, and
            emphysema in mice
  JOURNAL   J Clin Invest 123 (6), 2643-2653 (2013)
   PUBMED   23676500
REFERENCE   6  (bases 1 to 1593)
  AUTHORS   Li,X., Lindquist,S., Lowe,M., Noppa,L. and Hernell,O.
  TITLE     Bile salt-stimulated lipase and pancreatic lipase-related protein 2
            are the dominating lipases in neonatal fat digestion in mice and
            rats
  JOURNAL   Pediatr Res 62 (5), 537-541 (2007)
   PUBMED   17805199
  REMARK    GeneRIF: BSSL and PLRP2 responsible for fat digestion as long as
            milk is the main food. Milk-borne BSSL is able to compensate for a
            slower ontogeny of pancreatic BSSL expression in the mouse.
REFERENCE   7  (bases 1 to 1593)
  AUTHORS   Brown,A.C., Olver,W.I., Donnelly,C.J., May,M.E., Naggert,J.K.,
            Shaffer,D.J. and Roopenian,D.C.
  TITLE     Searching QTL by gene expression: analysis of diabesity
  JOURNAL   BMC Genet 6, 12 (2005)
   PUBMED   15760467
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1593)
  AUTHORS   D'Agostino,D. and Lowe,M.E.
  TITLE     Pancreatic lipase-related protein 2 is the major colipase-dependent
            pancreatic lipase in suckling mice
  JOURNAL   J Nutr 134 (1), 132-134 (2004)
   PUBMED   14704305
  REMARK    GeneRIF: study concluded that pancreatic lipase-related protein 2
            is the major colipase-dependent lipase in the pancreas of newborn
            mice
REFERENCE   9  (bases 1 to 1593)
  AUTHORS   Lowe,M.E., Kaplan,M.H., Jackson-Grusby,L., D'Agostino,D. and
            Grusby,M.J.
  TITLE     Decreased neonatal dietary fat absorption and T cell cytotoxicity
            in pancreatic lipase-related protein 2-deficient mice
  JOURNAL   J Biol Chem 273 (47), 31215-31221 (1998)
   PUBMED   9813028
REFERENCE   10 (bases 1 to 1593)
  AUTHORS   Grusby,M.J., Nabavi,N., Wong,H., Dick,R.F., Bluestone,J.A.,
            Schotz,M.C. and Glimcher,L.H.
  TITLE     Cloning of an interleukin-4 inducible gene from cytotoxic T
            lymphocytes and its identification as a lipase
  JOURNAL   Cell 60 (3), 451-459 (1990)
   PUBMED   2302735
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008021.1, AK131882.1 and BC094923.1.
            
            On Nov 15, 2007 this sequence version replaced NM_011128.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094923.1, AK008021.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AK008021.1         6-20
            16-1557             AK131882.1         2-1543
            1558-1593           BC094923.1         1517-1552
FEATURES             Location/Qualifiers
     source          1..1593
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 54.5 cM"
     gene            1..1593
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /note="pancreatic lipase-related protein 2"
                     /db_xref="GeneID:18947"
                     /db_xref="MGI:MGI:1336202"
     exon            1..154
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1515
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /EC_number="3.1.1.3"
                     /EC_number="3.1.1.26"
                     /note="galactolipase; PL-RP2; cytotoxic T-lymphocyte
                     lipase; triacylglycerol lipase"
                     /codon_start=1
                     /product="pancreatic lipase-related protein 2 precursor"
                     /protein_id="NP_035258.2"
                     /db_xref="CCDS:CCDS38030.1"
                     /db_xref="GeneID:18947"
                     /db_xref="MGI:MGI:1336202"
                     /translation="MPMDVRGCLFPSVQMLLCWLVSLLLATVGGKEVCYGHLGCFSND
                     KPWAGMIQRPSKIFPWSPEDIDTRFLLYTNENPNNYQIISATDPATINASNFQLDRKT
                     RFIIHGFIDKGEEGWLLDMCKKMFQVEKVNCICVDWKRGSRTEYTQASYNTRVVGAEI
                     AFLVQVLSTEMGYSPENVHLIGHSLGSHVAGEAGRRLEGHVGRITGLDPAEPCFQGLP
                     EEVRLDPSDAMFVDVIHTDSAPIIPYLGFGMSQKVGHLDFFPNGGKEMPGCQKNILST
                     IVDINGIWEGTRNFAACNHLRSYKYYASSILNPDGFLGYPCSSYEKFQHNDCFPCPEQ
                     GCPKMGHYADQFEGKTATVEQTFFLNTGDSGNFTRWRYKVSVTLSGAKKLSGYILVAL
                     YGCNGNSKQYEVFKGSLQPEARYIRDIDVDVNVGEIQKVKFLWNNKVINLFRPTMGAS
                     QITVQRGKDGKEFNFCSSNTVHEDVLQSLYPC"
     exon            155..309
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            310..435
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            436..570
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..682
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            683..802
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            803..922
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1041
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1171
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1283
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1451
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1568
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1540..1545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /note="hexamer: AATAAA"
     polyA_site      1558
                     /gene="Pnliprp2"
                     /gene_synonym="PLRP2"
                     /note="major polyA site"
ORIGIN      
        1 tccccagtgc actccagaac caactgcctc tttgggtcca gcctctgctg gcctcatccc
       61 tatcctatgc ctatggatgt ccgtggatgt ctgtttccat ccgtgcagat gttgctctgc
      121 tggctcgtca gccttctgct ggccacagtc ggagggaaag aggtttgcta tggacacctt
      181 ggatgctttt ccaatgacaa gccctgggca gggatgattc agcggccttc gaagatattc
      241 ccttggtccc cagaggacat tgatacccgc tttcttctgt acacaaacga gaatccaaac
      301 aactaccaaa taatctctgc caccgaccca gccaccatca atgcttccaa cttccaactg
      361 gaccgcaaga cacgtttcat tatccatgga ttcatagaca agggagaaga aggctggttg
      421 ctggacatgt gcaagaaaat gtttcaagtg gagaaagtga actgtatttg cgttgactgg
      481 aagcgcggat ccaggactga atacacccaa gcctcctaca acactcgggt cgtgggcgct
      541 gagattgcct tcttggtgca agtgttgtcg acagagatgg ggtacagccc agagaacgtg
      601 cacctcatcg gccacagctt gggctcacat gtggctgggg aagcaggcag gaggctggag
      661 ggccatgtgg gcaggatcac agggctggac cctgcagagc cctgtttcca aggcctgccc
      721 gaggaagttc ggttggaccc atcggatgcc atgtttgtag acgtgatcca cactgacagt
      781 gcccccataa tcccctatct aggtttcgga atgagccaaa aggtcggcca tctggatttc
      841 tttcccaacg gagggaagga aatgccggga tgtcagaaaa acatcctttc caccattgtt
      901 gatatcaatg gaatatggga aggaactcga aacttcgcag cctgcaacca cctacggagc
      961 tacaagtact atgccagcag catcctcaac cctgacggct tcctggggta cccctgttcc
     1021 tcctatgaga agttccagca caatgactgc ttcccttgtc cagaacaagg gtgtcccaaa
     1081 atggggcact atgctgatca atttgagggg aaaactgcta ctgtggaaca aacctttttc
     1141 ctgaatacag gagacagtgg taactttact cgttggagat acaaagtatc agtcacacta
     1201 tcaggagcaa agaagctgag tgggtacatc ttggtcgctc tgtacggatg taacggaaac
     1261 tcaaagcagt atgaagtttt caaaggatcc ctccaaccag aagcaagata tattcgtgac
     1321 attgatgtgg acgtcaacgt tggagaaatc cagaaggtta agttcctctg gaacaacaag
     1381 gtgataaatc tcttccggcc cactatggga gcttcacaaa tcacagtgca acgcggtaaa
     1441 gacgggaaag agttcaactt ctgtagcagc aacactgtgc atgaagatgt tctgcagtct
     1501 ctgtaccctt gttaatggtg tgcccgtgcc tcttcccata ataaacgttc ctgatgcact
     1561 tggtctgaaa aaaaaaaaaa aaaaaaaaaa aaa
//
