LOCUS       NM_018874               1619 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus pancreatic lipase related protein 1 (Pnliprp1), mRNA.
ACCESSION   NM_018874
VERSION     NM_018874.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1619)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   2  (bases 1 to 1619)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1619)
  AUTHORS   Hale,M.A., Swift,G.H., Hoang,C.Q., Deering,T.G., Masui,T.,
            Lee,Y.K., Xue,J. and MacDonald,R.J.
  TITLE     The nuclear hormone receptor family member NR5A2 controls aspects
            of multipotent progenitor cell formation and acinar differentiation
            during pancreatic organogenesis
  JOURNAL   Development 141 (16), 3123-3133 (2014)
   PUBMED   25063451
REFERENCE   4  (bases 1 to 1619)
  AUTHORS   Ren,J., Chen,Z., Zhang,W., Li,L., Sun,R., Deng,C., Fei,Z.,
            Sheng,Z., Wang,L., Sun,X., Wang,Z. and Fei,J.
  TITLE     Increased fat mass and insulin resistance in mice lacking
            pancreatic lipase-related protein 1
  JOURNAL   J Nutr Biochem 22 (7), 691-698 (2011)
   PUBMED   21115337
  REMARK    GeneRIF: We propose that PLRP1 may function as a metabolic
            inhibitor in vivo of pancreatic triglyceride
            lipase-colipase-mediated dietary triglyceride digestion.
REFERENCE   5  (bases 1 to 1619)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   6  (bases 1 to 1619)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   7  (bases 1 to 1619)
  AUTHORS   Roghani,A., Welch,C., Xia,Y., Liu,Y., Peter,D., Finn,J.P.,
            Edwards,R.H. and Lusis,A.J.
  TITLE     Assignment of the mouse vesicular monoamine transporter genes,
            Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis
  JOURNAL   Mamm Genome 7 (5), 393-394 (1996)
   PUBMED   8661734
REFERENCE   8  (bases 1 to 1619)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
REFERENCE   9  (bases 1 to 1619)
  AUTHORS   Warden,C.H., Davis,R.C., Yoon,M.Y., Hui,D.Y., Svenson,K., Xia,Y.R.,
            Diep,A., He,K.Y. and Lusis,A.J.
  TITLE     Chromosomal localization of lipolytic enzymes in the mouse:
            pancreatic lipase, colipase, hormone-sensitive lipase, hepatic
            lipase, and carboxyl ester lipase
  JOURNAL   J Lipid Res 34 (8), 1451-1455 (1993)
   PUBMED   8105016
REFERENCE   10 (bases 1 to 1619)
  AUTHORS   Grusby,M.J., Nabavi,N., Wong,H., Dick,R.F., Bluestone,J.A.,
            Schotz,M.C. and Glimcher,L.H.
  TITLE     Cloning of an interleukin-4 inducible gene from cytotoxic T
            lymphocytes and its identification as a lipase
  JOURNAL   Cell 60 (3), 451-459 (1990)
   PUBMED   2302735
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF061274.1.
            
            On Apr 5, 2007 this sequence version replaced NM_018874.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF061274.1, BC090985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1619              AF061274.1         2-1620
FEATURES             Location/Qualifiers
     source          1..1619
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="Swiss Webster"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 54.49 cM"
     gene            1..1619
                     /gene="Pnliprp1"
                     /gene_synonym="Plrp1"
                     /note="pancreatic lipase related protein 1"
                     /db_xref="GeneID:18946"
                     /db_xref="MGI:MGI:97723"
     exon            1..156
                     /gene="Pnliprp1"
                     /gene_synonym="Plrp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1578
                     /gene="Pnliprp1"
                     /gene_synonym="Plrp1"
                     /EC_number="3.1.1.3"
                     /note="PL-RP1; inactive pancreatic lipase-related protein
                     1"
                     /codon_start=1
                     /product="inactive pancreatic lipase-related protein 1
                     precursor"
                     /protein_id="NP_061362.1"
                     /db_xref="CCDS:CCDS29931.1"
                     /db_xref="GeneID:18946"
                     /db_xref="MGI:MGI:97723"
                     /translation="MLILWTIPLFLLGAAQGKEVCYDNLGCFSDAEPWAGTAIRPLKL
                     LPWSPEKINTRFLLYTNENPTAFQTLQLSDPSTIEASNFQVARKTRFIIHGFIDKGEE
                     NWVVDMCKNMFQVEEVNCICVDWKRGSQTTYTQAANNVRVVGAQVAQMIDILVRNFNY
                     SASKVHLIGHSLGAHVAGEAGSRTPGLGRITGLDPVEANFEGTPEEVRLDPSDADFVD
                     VIHTDAAPLIPFLGFGTNQMVGHFDFFPNGGQYMPGCKKNALSQIVDIDGIWSGTRDF
                     VACNHLRSYKYYLESILNPDGFAAYPCASYRDFESNKCFPCPDQGCPQMGHYADKFAN
                     NTSVEPQKFFLNTGEAKNFARWRYRVSLTFSGRTVTGQVKVSLFGSNGNTRQCDIFRG
                     IIKPGATHSNEFDAKLDVGTIEKVKFLWNNHVVNPSFPKVGAAKITVQKGEERTEHNF
                     CSEETVREDILLTLLPCKTSDTM"
     exon            157..205
                     /gene="Pnliprp1"
                     /gene_synonym="Plrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..360
                     /gene="Pnliprp1"
                     /gene_synonym="Plrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            361..486
                     /gene="Pnliprp1"
                     /gene_synonym="Plrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..621
                     /gene="Pnliprp1"
                     /gene_synonym="Plrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            622..730
                     /gene="Pnliprp1"
                     /gene_synonym="Plrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..850
                     /gene="Pnliprp1"
                     /gene_synonym="Plrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..970
                     /gene="Pnliprp1"
                     /gene_synonym="Plrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1089
                     /gene="Pnliprp1"
                     /gene_synonym="Plrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1219
                     /gene="Pnliprp1"
                     /gene_synonym="Plrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1328
                     /gene="Pnliprp1"
                     /gene_synonym="Plrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1496
                     /gene="Pnliprp1"
                     /gene_synonym="Plrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1619
                     /gene="Pnliprp1"
                     /gene_synonym="Plrp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atagctctca tggcacactg tttgcttgga ctgcagtcca aacgataagg ctggagcata
       61 aaaaggtccc ggtgggtccc aggacagcag gcacctggct cctgtgatca cagcagccac
      121 ctttgcatct gcatttccag ccactaaaag gcagagatgc tgattctctg gacaatccct
      181 cttttcctac tgggagcagc tcaggggaaa gaggtttgct atgacaacct tggatgcttt
      241 tctgatgctg agccctgggc agggacagct atcaggcccc taaaacttct cccttggagc
      301 cctgagaaga tcaacactcg cttcctgctc tacaccaatg agaacccaac tgctttccag
      361 actcttcagc tttctgaccc atcgaccatt gaggcctcca attttcaagt tgccaggaag
      421 actcggttca tcatccatgg cttcatagac aaaggagagg agaactgggt ggttgacatg
      481 tgcaagaaca tgttccaagt ggaggaggtg aactgcatct gcgtggactg gaagagaggc
      541 tctcagacta cctacacgca ggctgccaac aatgtgcgag tagtgggtgc ccaggtggct
      601 cagatgattg acatccttgt gagaaacttc aactactctg cttccaaagt ccacctcatt
      661 ggccacagcc taggagccca cgtggcaggg gaagcaggaa gtcggactcc aggtcttggc
      721 aggattacag gactggatcc tgtagaagca aattttgagg gaacccctga agaggtccgg
      781 ctcgacccct cggatgctga ctttgttgat gtgattcaca cagatgcagc tcccttgatc
      841 ccattcttgg gctttggaac aaaccaaatg gtggggcact ttgacttctt ccccaacgga
      901 ggacagtaca tgcccgggtg caagaagaac gctctgtcac agattgtgga catcgatggc
      961 atctggtcag gaacccggga ctttgtggct tgtaaccacc tgagaagcta caagtactac
     1021 ttagagagca tccttaaccc agatgggttt gctgcatacc cctgcgcttc ctacagggac
     1081 tttgagtcta acaaatgctt cccctgccca gatcaaggct gcccacagat gggtcactat
     1141 gctgataagt ttgccaacaa tacaagtgtg gagccacaga agttcttcct gaacacagga
     1201 gaagccaaga actttgcacg ctggaggtac cgtgtttcct tgacattctc tggaaggacg
     1261 gtcacaggcc aagtcaaagt gtctctgttt ggaagtaacg gcaatactcg ccagtgtgat
     1321 atcttcaggg gaattatcaa gcccggtgct acgcattcca atgagtttga tgccaagctt
     1381 gatgtgggaa caattgagaa agtcaagttt ctttggaata accacgtggt aaacccaagt
     1441 ttccccaaag tgggcgcagc caagatcact gtgcaaaagg gggaggagcg gacagagcac
     1501 aacttctgta gtgaagagac cgtgagagaa gacatcctgc tcactctctt gccttgtaaa
     1561 acctcagaca caatgtgacc tcttggtaac accaataaaa tcatcagctg cacctaccc
//
