LOCUS       NM_026925               1498 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus pancreatic lipase (Pnlip), mRNA.
ACCESSION   NM_026925
VERSION     NM_026925.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1498)
  AUTHORS   Zhu,G., Wilhelm,S.J., George,L.G., Cassidy,B.M., Zino,S.,
            Luke,C.J., Hanna,M., Stone,S., Phan,N., Matiwala,N.,
            Ballentine,S.J., Lowe,M.E. and Xiao,X.
  TITLE     Preclinical mouse model of a misfolded PNLIP variant develops
            chronic pancreatitis
  JOURNAL   Gut 72 (7), 1340-1354 (2023)
   PUBMED   36631248
  REMARK    GeneRIF: Preclinical mouse model of a misfolded PNLIP variant
            develops chronic pancreatitis.
REFERENCE   2  (bases 1 to 1498)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1498)
  AUTHORS   Heymans,C., Delcorte,O., Spourquet,C., Villacorte-Tabelin,M.,
            Dupasquier,S., Achouri,Y., Mahibullah,S., Lemoine,P., Balda,M.S.,
            Matter,K. and Pierreux,C.E.
  TITLE     Spatio-temporal expression pattern and role of the tight junction
            protein MarvelD3 in pancreas development and function
  JOURNAL   Sci Rep 11 (1), 14519 (2021)
   PUBMED   34267243
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1498)
  AUTHORS   Padgett,L.R., Robertson,M.A., Anderson-Baucum,E.K., Connors,C.T.,
            Wu,W., Mirmira,R.G. and Mastracci,T.L.
  TITLE     Deoxyhypusine synthase, an essential enzyme for hypusine
            biosynthesis, is required for proper exocrine pancreas development
  JOURNAL   FASEB J 35 (5), e21473 (2021)
   PUBMED   33811703
REFERENCE   5  (bases 1 to 1498)
  AUTHORS   de Oliveira,C., Khatua,B., Noel,P., Kostenko,S., Bag,A.,
            Balakrishnan,B., Patel,K.S., Guerra,A.A., Martinez,M.N.,
            Trivedi,S., McCullough,A., Lam-Himlin,D.M., Navina,S., Faigel,D.O.,
            Fukami,N., Pannala,R., Phillips,A.E., Papachristou,G.I.,
            Kershaw,E.E., Lowe,M.E. and Singh,V.P.
  TITLE     Pancreatic triglyceride lipase mediates lipotoxic systemic
            inflammation
  JOURNAL   J Clin Invest 130 (4), 1931-1947 (2020)
   PUBMED   31917686
  REMARK    GeneRIF: Pancreatic triglyceride lipase mediates lipotoxic systemic
            inflammation.
REFERENCE   6  (bases 1 to 1498)
  AUTHORS   Tabor,D.E., Xia,Y.R., Mehrabian,M., Edwards,P.A. and Lusis,A.J.
  TITLE     A cluster of stearoyl CoA desaturase genes, Scd1 and Scd2, on mouse
            chromosome 19
  JOURNAL   Mamm Genome 9 (4), 341-342 (1998)
   PUBMED   9530639
REFERENCE   7  (bases 1 to 1498)
  AUTHORS   Welch,C.L., Xia,Y.R., Edwards,P.A., Lusis,A.J. and Ericsson,J.
  TITLE     Assignment of Gpam to distal mouse chromosome 19 by linkage
            analysis
  JOURNAL   Mamm Genome 9 (1), 93 (1998)
   PUBMED   9434961
REFERENCE   8  (bases 1 to 1498)
  AUTHORS   Roghani,A., Welch,C., Xia,Y., Liu,Y., Peter,D., Finn,J.P.,
            Edwards,R.H. and Lusis,A.J.
  TITLE     Assignment of the mouse vesicular monoamine transporter genes,
            Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis
  JOURNAL   Mamm Genome 7 (5), 393-394 (1996)
   PUBMED   8661734
REFERENCE   9  (bases 1 to 1498)
  AUTHORS   Warden,C.H., Davis,R.C., Yoon,M.Y., Hui,D.Y., Svenson,K., Xia,Y.R.,
            Diep,A., He,K.Y. and Lusis,A.J.
  TITLE     Chromosomal localization of lipolytic enzymes in the mouse:
            pancreatic lipase, colipase, hormone-sensitive lipase, hepatic
            lipase, and carboxyl ester lipase
  JOURNAL   J Lipid Res 34 (8), 1451-1455 (1993)
   PUBMED   8105016
REFERENCE   10 (bases 1 to 1498)
  AUTHORS   Grusby,M.J., Nabavi,N., Wong,H., Dick,R.F., Bluestone,J.A.,
            Schotz,M.C. and Glimcher,L.H.
  TITLE     Cloning of an interleukin-4 inducible gene from cytotoxic T
            lymphocytes and its identification as a lipase
  JOURNAL   Cell 60 (3), 451-459 (1990)
   PUBMED   2302735
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC061061.1 and AV049089.1.
            
            On Jul 24, 2018 this sequence version replaced NM_026925.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061061.1, SRR5189682.81375.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1487              BC061061.1         1-1487
            1488-1498           AV049089.1         297-307
FEATURES             Location/Qualifiers
     source          1..1498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 54.46 cM"
     gene            1..1498
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /note="pancreatic lipase"
                     /db_xref="GeneID:69060"
                     /db_xref="MGI:MGI:97722"
     exon            1..28
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1426
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /EC_number="3.1.1.3"
                     /note="pancreatic triglyceride lipase; pancreatic
                     triacylglycerol lipase"
                     /codon_start=1
                     /product="pancreatic triacylglycerol lipase precursor"
                     /protein_id="NP_081201.2"
                     /db_xref="CCDS:CCDS29930.1"
                     /db_xref="GeneID:69060"
                     /db_xref="MGI:MGI:97722"
                     /translation="MLMLWTFAVLLGAVAGREVCFDKLGCFSDDAPWSGTLDRPLKAL
                     PWSPAQINTRFLLYTNENPDNYQLITSDASNIRNSNFRTNRKTRIIIHGFIDKGEENW
                     LSDMCKNMFRVESVNCICVDWKGGSRTTYTQATQNVRVVGAEVALLVNVLQSDLGYSL
                     NNVHLIGHSLGSHIAGEAGKRTFGAIGRITGLDPAEPYFQGTPEEVRLDPTDAQFVDA
                     IHTDAGPIIPNLGFGMSQTVGHLDFFPNGGIEMPGCQKNILSQIVDIDGIWEGTRNFA
                     ACNHLRSYKFYTDSIVNPTGFAGFSCSSYSLFTANKCFPCGSGGCPQMGHYADRYPGK
                     TSRLYQTFYLNTGDKSNFARWRYQVTVTLSGQKVTGHILVSLFGNGGNSKQYEVFKGS
                     LQPGTSHVNEFDSDVDVGDLQKVKFIWYNNVINPTLPKVGASRITVERNDGRVFNFCS
                     QETVREDVLLTLSPC"
     exon            29..74
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            75..229
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            230..352
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            353..487
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            488..599
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            600..719
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            720..839
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            840..958
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1088
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1197
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1362
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1498
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1465..1470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /note="hexamer: AATAAA"
     polyA_site      1487
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /note="major polyA site"
ORIGIN      
        1 gtccgtagaa cctgacggat ccgccacgat gctaatgctg tggacatttg cagtgctgct
       61 gggagcagta gctggaaggg aagtttgctt cgacaaactc ggctgcttca gtgatgatgc
      121 cccctggtca ggaactctag acagacccct gaaagcactg ccctggagcc cagcacagat
      181 caacacccgc tttctcctct acaccaacga gaatccagac aactaccagc taattacttc
      241 agatgcatca aacatcagaa actccaattt ccgaacaaac agaaaaaccc gtatcattat
      301 ccacggcttc atcgacaagg gagaagaaaa ctggctatct gacatgtgca agaacatgtt
      361 ccgagtggag agtgtgaact gcatctgtgt ggactggaaa ggcggttccc gaacgacata
      421 tacccaggct acccagaacg tccgggtcgt gggggcagaa gtggcattgt tggttaacgt
      481 tctgcagtct gatctgggat actcacttaa caatgtccac ctgattggcc acagcctggg
      541 ttcccacatt gctggggagg ctggaaagag gacctttgga gccattggaa ggatcacagg
      601 gttggacccc gctgagcctt acttccaggg cacccctgaa gaagtccgac tggaccccac
      661 cgatgctcag tttgtggacg caattcacac agacgccggg cccattatcc ccaacttagg
      721 atttggaatg agccagactg tgggtcactt agatttcttt ccaaacggag gaatcgaaat
      781 gccaggatgc cagaagaata ttctttccca aattgttgac atcgacggga tctgggaagg
      841 aactcgaaac tttgctgcct gtaaccactt aagaagctac aagttttaca ccgacagcat
      901 cgtcaaccca actggctttg ctgggttctc ctgtagctct tacagtcttt tcacggcaaa
      961 taagtgcttc ccatgtggga gtggaggatg cccccagatg ggtcattacg ctgacagata
     1021 tcctgggaaa acaagcagac tctaccagac attttacctc aacaccggtg ataagagcaa
     1081 cttcgcacgt tggcggtacc aggtgactgt caccctgtct ggacagaagg tcactgggca
     1141 cattctagtt tctttgtttg gaaatggagg aaactctaaa cagtatgaag ttttcaaggg
     1201 ctctctgcag ccaggtactt ctcacgtcaa tgaattcgac tctgatgtgg atgttggaga
     1261 tttgcagaag gttaaattta tttggtacaa caatgtgatc aacccaactc tacccaaagt
     1321 gggagcatca aggatcacag tggaaagaaa tgatggcaga gtgttcaact tctgtagtca
     1381 agagacagtg agggaagacg tcctgctcac actgtctcca tgttaggagg ctgctgctgt
     1441 gtgaccacca agtcccactg ttgtaataaa gtctagtatt aaagcaatat tttctgtt
//
