LOCUS       NP_081201                465 aa            linear   ROD 28-APR-2025
DEFINITION  pancreatic triacylglycerol lipase precursor [Mus musculus].
ACCESSION   NP_081201
VERSION     NP_081201.2
DBSOURCE    REFSEQ: accession NM_026925.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 465)
  AUTHORS   Zhu,G., Wilhelm,S.J., George,L.G., Cassidy,B.M., Zino,S.,
            Luke,C.J., Hanna,M., Stone,S., Phan,N., Matiwala,N.,
            Ballentine,S.J., Lowe,M.E. and Xiao,X.
  TITLE     Preclinical mouse model of a misfolded PNLIP variant develops
            chronic pancreatitis
  JOURNAL   Gut 72 (7), 1340-1354 (2023)
   PUBMED   36631248
  REMARK    GeneRIF: Preclinical mouse model of a misfolded PNLIP variant
            develops chronic pancreatitis.
REFERENCE   2  (residues 1 to 465)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 465)
  AUTHORS   Heymans,C., Delcorte,O., Spourquet,C., Villacorte-Tabelin,M.,
            Dupasquier,S., Achouri,Y., Mahibullah,S., Lemoine,P., Balda,M.S.,
            Matter,K. and Pierreux,C.E.
  TITLE     Spatio-temporal expression pattern and role of the tight junction
            protein MarvelD3 in pancreas development and function
  JOURNAL   Sci Rep 11 (1), 14519 (2021)
   PUBMED   34267243
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 465)
  AUTHORS   Padgett,L.R., Robertson,M.A., Anderson-Baucum,E.K., Connors,C.T.,
            Wu,W., Mirmira,R.G. and Mastracci,T.L.
  TITLE     Deoxyhypusine synthase, an essential enzyme for hypusine
            biosynthesis, is required for proper exocrine pancreas development
  JOURNAL   FASEB J 35 (5), e21473 (2021)
   PUBMED   33811703
REFERENCE   5  (residues 1 to 465)
  AUTHORS   de Oliveira,C., Khatua,B., Noel,P., Kostenko,S., Bag,A.,
            Balakrishnan,B., Patel,K.S., Guerra,A.A., Martinez,M.N.,
            Trivedi,S., McCullough,A., Lam-Himlin,D.M., Navina,S., Faigel,D.O.,
            Fukami,N., Pannala,R., Phillips,A.E., Papachristou,G.I.,
            Kershaw,E.E., Lowe,M.E. and Singh,V.P.
  TITLE     Pancreatic triglyceride lipase mediates lipotoxic systemic
            inflammation
  JOURNAL   J Clin Invest 130 (4), 1931-1947 (2020)
   PUBMED   31917686
  REMARK    GeneRIF: Pancreatic triglyceride lipase mediates lipotoxic systemic
            inflammation.
REFERENCE   6  (residues 1 to 465)
  AUTHORS   Tabor,D.E., Xia,Y.R., Mehrabian,M., Edwards,P.A. and Lusis,A.J.
  TITLE     A cluster of stearoyl CoA desaturase genes, Scd1 and Scd2, on mouse
            chromosome 19
  JOURNAL   Mamm Genome 9 (4), 341-342 (1998)
   PUBMED   9530639
REFERENCE   7  (residues 1 to 465)
  AUTHORS   Welch,C.L., Xia,Y.R., Edwards,P.A., Lusis,A.J. and Ericsson,J.
  TITLE     Assignment of Gpam to distal mouse chromosome 19 by linkage
            analysis
  JOURNAL   Mamm Genome 9 (1), 93 (1998)
   PUBMED   9434961
REFERENCE   8  (residues 1 to 465)
  AUTHORS   Roghani,A., Welch,C., Xia,Y., Liu,Y., Peter,D., Finn,J.P.,
            Edwards,R.H. and Lusis,A.J.
  TITLE     Assignment of the mouse vesicular monoamine transporter genes,
            Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis
  JOURNAL   Mamm Genome 7 (5), 393-394 (1996)
   PUBMED   8661734
REFERENCE   9  (residues 1 to 465)
  AUTHORS   Warden,C.H., Davis,R.C., Yoon,M.Y., Hui,D.Y., Svenson,K., Xia,Y.R.,
            Diep,A., He,K.Y. and Lusis,A.J.
  TITLE     Chromosomal localization of lipolytic enzymes in the mouse:
            pancreatic lipase, colipase, hormone-sensitive lipase, hepatic
            lipase, and carboxyl ester lipase
  JOURNAL   J Lipid Res 34 (8), 1451-1455 (1993)
   PUBMED   8105016
REFERENCE   10 (residues 1 to 465)
  AUTHORS   Grusby,M.J., Nabavi,N., Wong,H., Dick,R.F., Bluestone,J.A.,
            Schotz,M.C. and Glimcher,L.H.
  TITLE     Cloning of an interleukin-4 inducible gene from cytotoxic T
            lymphocytes and its identification as a lipase
  JOURNAL   Cell 60 (3), 451-459 (1990)
   PUBMED   2302735
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC061061.1 and AV049089.1.
            
            On Oct 15, 2003 this sequence version replaced NP_081201.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061061.1, SRR5189682.81375.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 54.46 cM"
     Protein         1..465
                     /product="pancreatic triacylglycerol lipase precursor"
                     /EC_number="3.1.1.3"
                     /note="pancreatic triglyceride lipase; pancreatic
                     triacylglycerol lipase"
                     /calculated_mol_wt=49753
     sig_peptide     1..16
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1693
     mat_peptide     17..465
                     /product="Pancreatic triacylglycerol lipase.
                     /id=PRO_0000401139"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P8U6.1)"
                     /calculated_mol_wt=49753
     Region          18..352
                     /region_name="Lipase"
                     /note="pfam00151"
                     /db_xref="CDD:395099"
     Region          355..465
                     /region_name="PLAT_PL"
                     /note="PLAT/LH2 domain of pancreatic triglyceride lipase.
                     Lipases hydrolyze phospholipids and triglycerides to
                     generate fatty acids for energy production or for storage
                     and to release inositol phosphates that act as second
                     messengers. The central role of...; cd01759"
                     /db_xref="CDD:238857"
     CDS             1..465
                     /gene="Pnlip"
                     /gene_synonym="1810007A24Rik; PL; PTL"
                     /coded_by="NM_026925.4:29..1426"
                     /db_xref="CCDS:CCDS29930.1"
                     /db_xref="GeneID:69060"
                     /db_xref="MGI:MGI:97722"
ORIGIN      
        1 mlmlwtfavl lgavagrevc fdklgcfsdd apwsgtldrp lkalpwspaq intrfllytn
       61 enpdnyqlit sdasnirnsn frtnrktrii ihgfidkgee nwlsdmcknm frvesvncic
      121 vdwkggsrtt ytqatqnvrv vgaevallvn vlqsdlgysl nnvhlighsl gshiageagk
      181 rtfgaigrit gldpaepyfq gtpeevrldp tdaqfvdaih tdagpiipnl gfgmsqtvgh
      241 ldffpnggie mpgcqknils qivdidgiwe gtrnfaacnh lrsykfytds ivnptgfagf
      301 scssyslfta nkcfpcgsgg cpqmghyadr ypgktsrlyq tfylntgdks nfarwryqvt
      361 vtlsgqkvtg hilvslfgng gnskqyevfk gslqpgtshv nefdsdvdvg dlqkvkfiwy
      421 nnvinptlpk vgasritver ndgrvfnfcs qetvredvll tlspc
//
