LOCUS       NM_001034866            1689 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus poly(A)-specific ribonuclease (PARN)-like domain
            containing 1 (Pnldc1), mRNA.
ACCESSION   NM_001034866 XM_139740 XM_910801
VERSION     NM_001034866.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1689)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1689)
  AUTHORS   Gainetdinov,I., Colpan,C., Cecchini,K., Arif,A., Jouravleva,K.,
            Albosta,P., Vega-Badillo,J., Lee,Y., Ozata,D.M. and Zamore,P.D.
  TITLE     Terminal modification, sequence, length, and PIWI-protein identity
            determine piRNA stability
  JOURNAL   Mol Cell 81 (23), 4826-4842 (2021)
   PUBMED   34626567
REFERENCE   3  (bases 1 to 1689)
  AUTHORS   Sun,Y.H., Zhu,J., Xie,L.H., Li,Z., Meduri,R., Zhu,X., Song,C.,
            Chen,C., Ricci,E.P., Weng,Z. and Li,X.Z.
  TITLE     Ribosomes guide pachytene piRNA formation on long intergenic piRNA
            precursors
  JOURNAL   Nat Cell Biol 22 (2), 200-212 (2020)
   PUBMED   32015435
  REMARK    Erratum:[Nat Cell Biol. 2020 Mar;22(3):353. doi:
            10.1038/s41556-020-0482-3.. PMID: 32066908]
REFERENCE   4  (bases 1 to 1689)
  AUTHORS   Gainetdinov,I., Colpan,C., Arif,A., Cecchini,K. and Zamore,P.D.
  TITLE     A Single Mechanism of Biogenesis, Initiated and Directed by PIWI
            Proteins, Explains piRNA Production in Most Animals
  JOURNAL   Mol Cell 71 (5), 775-790 (2018)
   PUBMED   30193099
REFERENCE   5  (bases 1 to 1689)
  AUTHORS   Nishimura,T., Nagamori,I., Nakatani,T., Izumi,N., Tomari,Y.,
            Kuramochi-Miyagawa,S. and Nakano,T.
  TITLE     PNLDC1, mouse pre-piRNA Trimmer, is required for meiotic and
            post-meiotic male germ cell development
  JOURNAL   EMBO Rep 19 (3) (2018)
   PUBMED   29444933
  REMARK    GeneRIF: PNLDC1-mediated piRNA trimming is indispensable for the
            function of piRNAs throughout mouse spermatogenesis.
REFERENCE   6  (bases 1 to 1689)
  AUTHORS   Zhang,Y., Guo,R., Cui,Y., Zhu,Z., Zhang,Y., Wu,H., Zheng,B.,
            Yue,Q., Bai,S., Zeng,W., Guo,X., Zhou,Z., Shen,B., Zheng,K.,
            Liu,M., Ye,L. and Sha,J.
  TITLE     An essential role for PNLDC1 in piRNA 3' end trimming and male
            fertility in mice
  JOURNAL   Cell Res 27 (11), 1392-1396 (2017)
   PUBMED   28994417
  REMARK    GeneRIF: PNLDC1/PARN-1 has a conserved role in 3' trimming during
            piRNA maturation.
REFERENCE   7  (bases 1 to 1689)
  AUTHORS   Ding,D., Liu,J., Dong,K., Midic,U., Hess,R.A., Xie,H.,
            Demireva,E.Y. and Chen,C.
  TITLE     PNLDC1 is essential for piRNA 3' end trimming and transposon
            silencing during spermatogenesis in mice
  JOURNAL   Nat Commun 8 (1), 819 (2017)
   PUBMED   29018194
  REMARK    GeneRIF: PNLDC1 is a regulator of piRNA biogenesis, transposon
            silencing and spermatogenesis, protecting the germline genome in
            mice.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1689)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1689)
  AUTHORS   Anastasakis,D., Skeparnias,I., Shaukat,A.N., Grafanaki,K.,
            Kanellou,A., Taraviras,S., Papachristou,D.J., Papakyriakou,A. and
            Stathopoulos,C.
  TITLE     Mammalian PNLDC1 is a novel poly(A) specific exonuclease with
            discrete expression during early development
  JOURNAL   Nucleic Acids Res 44 (18), 8908-8920 (2016)
   PUBMED   27515512
REFERENCE   10 (bases 1 to 1689)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158033.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XM_910801.3, XM_139740.8.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158033.1, SRR5189676.127671.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1689
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.71 cM"
     gene            1..1689
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /note="poly(A)-specific ribonuclease (PARN)-like domain
                     containing 1"
                     /db_xref="GeneID:240023"
                     /db_xref="MGI:MGI:2685159"
     exon            1..165
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1685
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /EC_number="3.1.13.4"
                     /note="PARN-like domain-containing protein 1;
                     poly(A)-specific ribonuclease domain-containing protein 1;
                     poly(A)-specific ribonuclease PARN-like domain-containing
                     protein 1"
                     /codon_start=1
                     /product="poly(A)-specific ribonuclease PNLDC1"
                     /protein_id="NP_001030038.1"
                     /db_xref="CCDS:CCDS49948.1"
                     /db_xref="GeneID:240023"
                     /db_xref="MGI:MGI:2685159"
                     /translation="MDVGADEFEQSLPLLQELVAGADFVGLDIEFTGLRSNLSRPQQI
                     SLFDLPSEWYLKTRQSVQQFTICQIGLSMFSSIEGESNKYVAHSCNFFLFPTTFGILD
                     SEFSFQASSVQFLNQYGFDYNKFLKNGIPYMNEEQEKKIKHSILRGNWRVRSSLDKDQ
                     IKVVIDKVTQWLDLAEEGDQMTLPGIAGFQAFEVQLVLRQALPNIWTVLKEEWVIVKK
                     VSQPQRWYLEHASCDQVSCWKEQILLSARGFSVFFQMLVKAQKPLVGHNMMMDLLHLH
                     EKFFRPLPESYDQFKQNIHSLFPVLIDTKNVTKDIWKELRFPRVSNLLEVYEVLSSNL
                     NPTKDSGPVIIHARQCKKYAETKCPHEAAYDAFLCGSVLLKVAHLLLQRVHGNGAVHE
                     PAFPQYLDVLAPYVNQVNLIRAGVPKINFSGPDYPSIRPPVLILTVKRWPGVSEQQVY
                     REFQNLCKFDVRRFTRSQFLLLTNKFKDARSVLKEYRNHPTLQVSLYRSWRHSPNITC
                     LLQVCSIVTTWAMIAFLLGRPMP"
     exon            166..223
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            224..297
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            298..337
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            338..461
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            462..550
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            551..651
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            652..728
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            729..872
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            873..942
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1028
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1084
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1149
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1203
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1246
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1346
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1522
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1621
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1689
                     /gene="Pnldc1"
                     /gene_synonym="Gm313"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgacacgtg cacgagcttt aaggccctgc gcagcggaaa cgcgtgggca gcacgtggcc
       61 gcatccggcg cgccctggga ctagcggcta tggacgtggg cgcggacgaa tttgagcaga
      121 gccttccact cctgcaggag cttgtcgcgg gtgcggactt cgtgggtctg gatatagagt
      181 tcacaggtct gcgttcaaac ttgtctcggc cccaacagat cagtcttttt gacttgccat
      241 ctgagtggta tctgaagacc cggcagagtg ttcagcagtt tacaatctgt cagattggat
      301 tgtccatgtt ttccagcatc gaaggagagt caaacaagta tgtagcacac tcctgcaatt
      361 tctttctctt ccctacaaca tttgggatcc tggactcaga gttctctttc caggcatcta
      421 gtgtgcagtt tctgaatcag tatggcttcg actataacaa gttcctcaaa aatggaatcc
      481 catacatgaa tgaagagcag gagaagaaaa tcaagcacag tatcctaaga gggaactgga
      541 gagtccgaag ctctctggat aaagaccaaa tcaaggtggt gattgataag gtgacccagt
      601 ggctggacct ggctgaggaa ggtgaccaga tgactctgcc tggcatcgct gggttccaag
      661 cctttgaggt ccaactggtg ctgaggcagg ccctccccaa catctggaca gtgctgaaag
      721 aggagtgggt gattgtgaag aaggtgagcc agccacaacg ctggtacctt gagcacgcct
      781 cttgtgacca agtcagctgt tggaaggaac agattcttct ctctgcaaga ggcttctctg
      841 tctttttcca gatgttggtg aaagcccaga agcccttggt aggacataac atgatgatgg
      901 acctactgca tctccatgag aagttcttcc gacctcttcc agaaagctat gatcagttta
      961 agcagaacat ccatagcctg tttcctgtcc tcattgacac taagaacgtg acaaaggaca
     1021 tctggaagga actgcgtttc ccacgggtct ccaacctctt ggaagtgtac gaagtgctga
     1081 gcagtaactt gaatcccact aaggattctg gaccggtgat tattcacgca agacagtgta
     1141 aaaaatacgc tgagaccaag tgccctcacg aagcagccta tgacgctttc ctctgcgggt
     1201 cagttctttt gaaagtggct cacttgctcc tgcagagggt gcatggcaac ggtgctgtgc
     1261 acgagcctgc cttcccccaa taccttgatg tgctggcgcc ttacgtgaac caagtgaacc
     1321 ttatccgagc tggggttccg aaaattaatt tttctggtcc cgattacccc agcatccgcc
     1381 ctcctgtact catcctcacc gtcaagaggt ggcctggggt gagcgagcag caggtctacc
     1441 gtgagttcca gaatctctgc aagttcgatg tcaggcggtt cactcgaagc cagttcctgc
     1501 tcctgaccaa taagtttaag gatgcccgca gtgtcttgaa ggagtacagg aaccacccaa
     1561 ccctgcaggt ctccttgtac cggtcctgga gacattcccc caacatcacc tgcctgttac
     1621 aggtctgcag catagtcacc acctgggcca tgattgcatt tctcctggga agacccatgc
     1681 cctgagagc
//
