LOCUS       NM_001369189            4320 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus PNN interacting serine/arginine-rich (Pnisr),
            transcript variant 2, mRNA.
ACCESSION   NM_001369189
VERSION     NM_001369189.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4320)
  AUTHORS   Cibi,D.M., Mia,M.M., Guna Shekeran,S., Yun,L.S., Sandireddy,R.,
            Gupta,P., Hota,M., Sun,L., Ghosh,S. and Singh,M.K.
  TITLE     Neural crest-specific deletion of Rbfox2 in mice leads to
            craniofacial abnormalities including cleft palate
  JOURNAL   Elife 8, e45418 (2019)
   PUBMED   31241461
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4320)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   3  (bases 1 to 4320)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772187.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.133267.1, AK017507.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AL772187.6         131117-131208
            93-191              AL772187.6         137416-137514
            192-380             AL772187.6         140249-140437
            381-604             AL772187.6         142153-142376
            605-776             AL772187.6         143889-144060
            777-967             AL772187.6         145056-145246
            968-1105            AL772187.6         148946-149083
            1106-1205           AL772187.6         152585-152684
            1206-1259           AL772187.6         153421-153474
            1260-1430           AL772187.6         154507-154677
            1431-4320           AL772187.6         156655-159544
FEATURES             Location/Qualifiers
     source          1..4320
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 9.06 cM"
     gene            1..4320
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /note="PNN interacting serine/arginine-rich"
                     /db_xref="GeneID:66625"
                     /db_xref="MGI:MGI:1913875"
     exon            1..92
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /inference="alignment:Splign:2.1.0"
     exon            93..191
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..2521
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /note="isoform 2 is encoded by transcript variant 2;
                     SRrp130; splicing factor, arginine/serine-rich 130;
                     serine/arginine-rich-splicing regulatory protein 130;
                     arginine/serine-rich protein PNISR; serine/arginine-rich
                     splicing factor 18; splicing factor, arginine/serine-rich
                     18"
                     /codon_start=1
                     /product="arginine/serine-rich protein PNISR isoform 2"
                     /protein_id="NP_001356118.1"
                     /db_xref="CCDS:CCDS89720.1"
                     /db_xref="GeneID:66625"
                     /db_xref="MGI:MGI:1913875"
                     /translation="MWDQGGQPWQQWPLNQQQWMQSFQHQQDPSQIDWAALAQAWIAQ
                     REASGQQSIVEQPPGMMPNGQDMSAMESGPNNHGNFQGDSNFNRMWQPEWGMHQQPPH
                     PPPEQPWMPPAPGPMDIVPPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGP
                     VNQFDYQHGAAFGPPQGGFHPPYWQPGPPGPPAPTQNRRERPPSFRDRQRSPIALPVK
                     QEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEG
                     GDGPRLPQRSKFDSDEEDEDAENLEAVSSGKVTRSPSPAPQEEHSEPEMTEEEKEYQM
                     MLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYG
                     SGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLQDKQIEEEKQQTER
                     VTKEMNEFIHREQNSLSLLEASEADRDAVNDKKRTPNEAPSVLEPKREHKGKEKERGS
                     RSGSSSSGSSSSGSRTSSSSSSVSSSSYSSSSGSSCTSSRSSSPKRRKRPSRSRSPPA
                     KARRSRSRSYSRRVKVDSSRTRGKLRDRRRSNRSSIERERRRNRSPSRDRRRSRSRSR
                     DRRTNRSSRSRSRDRRKIEDPRGNLSGNSHKHKGEAKEQDRKKERSRSVDKDRRKKDK
                     ERDRELDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFCRSGSISVKVIRHDSRQDS
                     KKNATKDSKRHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSLEKSQRSGKKASRKH
                     KSKSRSR"
     exon            192..380
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /inference="alignment:Splign:2.1.0"
     exon            381..604
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /inference="alignment:Splign:2.1.0"
     exon            605..776
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /inference="alignment:Splign:2.1.0"
     exon            777..967
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1105
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1205
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1259
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1430
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..4320
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3072..3077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /note="hexamer: AATAAA"
     polyA_site      3101
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /note="major polyA site"
     regulatory      4026..4031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /note="hexamer: AATAAA"
     polyA_site      4047
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
     regulatory      4298..4303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
                     /note="hexamer: AATAAA"
     polyA_site      4311
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
     polyA_site      4320
                     /gene="Pnisr"
                     /gene_synonym="5730406M06Rik; Pinsr; Sfrs18; Srsf18"
ORIGIN      
        1 atcttgtctt gttcatgaag aagtagaagc atcgaaaggt tggagagaat tacaggaacg
       61 gtggcgacag cggtattccg gaaccggagc gggagcttaa aggatgtggg atcaaggagg
      121 gcagccgtgg cagcaatggc ccttgaacca gcaacagtgg atgcagtcat ttcagcacca
      181 gcaagatcca agccagattg actgggctgc tttggcccag gcttggattg cacaaagaga
      241 agcctcagga cagcaaagca tcgtagaaca acctccagga atgatgccaa atggacagga
      301 tatgtctgca atggagtctg gtccaaataa tcatgggaat tttcaagggg attcaaattt
      361 taacagaatg tggcaaccag aatggggaat gcatcagcag cccccacacc cccctccaga
      421 gcagccatgg atgccaccag caccaggccc aatggacatt gttcctcctt ctgaagacag
      481 caacagtcag gacagtgggg agtttgcccc tgacaacagg catatattta accagaacaa
      541 tcacaacttt ggtggaccac ctgataactt tgcagtgggg ccggtgaacc agtttgacta
      601 tcagcatggg gctgcttttg gtccaccaca aggtggattt catcctcctt attggcaacc
      661 aggacctcca ggacctccag cacctacaca gaaccgaaga gagcggccac catcattcag
      721 ggaccgacag cgttcaccta ttgcacttcc agtgaagcag gagcctccac aaattgatgc
      781 agtaaaacgc aggactcttc cagcctggat tcgtgaaggc cttgagaaga tggaacgtga
      841 aaagcagaag aagttagaga aagagagaat ggaacagcag cgttcacagt tgtcaaaaaa
      901 agaaaagaag gccactgaag atgcggaagg aggggatggg cctcgcttac cccaaagaag
      961 taaatttgat agtgatgaag aggacgaaga tgctgaaaac ctggaggctg tgagcagtgg
     1021 caaagtcact agaagtccat ctccagctcc ccaagaagag cacagtgaac cagagatgac
     1081 ggaagaggag aaggagtacc aaatgatgtt gctgacaaag atgcttctaa ctgaaattct
     1141 cctggacgtc acagatgaag aaatttatta cgtggctaaa gatgcgcatc ggaaagcaac
     1201 gaaagctcct gcaaagcagc tggcacagtc cagtgcactg gcctccctca ccggcctcgg
     1261 cggactgggt ggctatggat caggcgacag tgaagatgag aggagtgaca gaggttctga
     1321 gtcatctgac actgatgatg aagagttacg gcaccgaatc cggcaaaaac aagaagcttt
     1381 ttggagaaaa gagaaagaac agcagctgtt acaagataaa cagatagaag aagaaaagca
     1441 gcaaacagaa agggttacaa aagagatgaa tgaatttatt cacagagagc aaaatagttt
     1501 atcacttcta gaagcaagtg aagccgaccg tgatgcggtc aatgacaaga aaagaactcc
     1561 aaacgaagct ccgtcagtgt tagagcccaa aagagagcat aaagggaagg agaaggagcg
     1621 ggggagtagg tcaggcagct ccagtagcgg cagctccagt agcggcagca ggacgagcag
     1681 cagtagcagc tccgtctcca gttcttccta cagctccagc tcaggcagca gctgcacgtc
     1741 ctctcgctcc tcatctccta agcggagaaa gagacccagt aggagcaggt ctcccccagc
     1801 gaaagctaga cgcagcagga gcaggagcta ctcgcgcaga gtgaaagtag acagcagcag
     1861 gaccaggggg aagctgagag ataggcggag atctaataga agtagcattg aaagagaaag
     1921 acgaagaaac cggagccctt ccagagacag acgtagaagc agaagtcgct caagggatag
     1981 acgaaccaat cgttccagtc gcagtaggag tcgagatagg cgtaaaattg aggatccacg
     2041 tggaaatctt agtgggaaca gtcataagca taaaggtgag gctaaagaac aagacaggaa
     2101 aaaggagagg agtcgaagtg tagataaaga caggagaaag aaagacaagg aaagggaccg
     2161 tgaactggat aaaagaaaag aaaaacagaa aagggaagaa aaagatttta aattcagtag
     2221 tcaggatgat cggttaaaaa ggaagcgaga aagtgagaga actttctgta ggagtggttc
     2281 tatatctgtt aaagtcataa gacatgactc tagacaggat agtaagaaaa atgctaccaa
     2341 agatagtaaa aggcattcag gttctgattc tagtggaagg agcagttccg aatcccccgg
     2401 aagtagcaaa gaaaagaagg ctaagaagcc taaacatagt cgatcgcgct ccctggagaa
     2461 atctcaaagg tctggtaaga aggcaagccg caaacacaag tctaagtccc gatcaaggta
     2521 gtatactttt taaagtattt tgtctgattt tttttttaag ttttttgaat ttattcaaag
     2581 ttgaaagtgt cctttctctc tctctctctc tcttttataa actcagtttg gtatttatta
     2641 aatattttta aataatgtta gaaatcctgt ataaaagtat ttatttatat tgcagatttt
     2701 aagtataaat acatttttat ttttaaattt tgtcttttcc cttttttttt ctttcagatc
     2761 aacaacccct ccccgtcgta agcgctgagg aatgatgtgg caagaatgcc atgatgctgt
     2821 ttttaaaaat tccatgagtt taagggcttg tctcattata gaggcacatt gtggctgtgt
     2881 aggtgaaacc agattttttt tttttattgt gtaaataggt gtcttttttc caaatgctgc
     2941 tccaagttac ttaataggat ttctttgtat tacatttttt ttcaagaaat agtacttaat
     3001 aagactataa atatgccatt tctctttcag ctgtaatgtt ctcaaaatat tcttgaatgt
     3061 actgtgatgt caataaaact atttagttca tttttgttaa actcttgcac cttaatttta
     3121 tgattttaat ctaaggaacg tacttttata aaaaggcagc tgaagttttg tataacaggt
     3181 ttttaaagtt actcccatct tctccaagaa tagtttgtca aagtttgtaa attgtgccca
     3241 tggacttttg tcaaattcca attttaaggg ttcgggaaag ggccagaaaa tgaccttact
     3301 tttctttgaa gccatctgat cagctttcta accttttttg ggggggaggg gaggcattca
     3361 agtaatatat tctctgtatg aaatgttatt cacgcctgta aaatgaaatt gctggaaaca
     3421 atcaggccat tacaccagta gagttatttg taatgactat ttgacactaa tagtctggaa
     3481 ctatatagtc actcctgttc tacatgccta acaccttggg gttacccgtt aagaaatagg
     3541 atgtaggatt caatatattt taaaaatata atatgacctc agcttaatgg tggaatattg
     3601 tgttatgcag gattgtgtca attgcataac attaaaatgg tctgattttc tcagtttcca
     3661 aaacccatgg ctagtgaacg gtctagcgtg agtccccgct tgatgagtag taggcatttc
     3721 gccaagtgtt cagctgcttc aggtctgagt ttttaagacg atacacttac acattgatag
     3781 ttgatctctg gaaacagtgc ttttcatatt gtaactgaaa gagaagcaca gtgcagaaca
     3841 cagaaggcag agtattatgc tttcttacca gcaatagttc atttgaaaat aatgccaggt
     3901 ttttgccaag atcagtgttt ccttgaaatg aagacagaaa tagatttgtt tgtgcattct
     3961 tgtacctcga catagcatct taattttgag cagttacgca tttatctaaa ggaaataaat
     4021 ctgtgaataa atgcatgttt accaaaatgg ctgtttacag tgcatttagt tacaatattt
     4081 ataaagttgc catttcacag aataagtagt ttggagttct atacaattta gtcatcagta
     4141 atatctggag acaaaatgtg caatattttt tatgtaggtg agctaacaca gtgtatctaa
     4201 ttgaagaatt ctgattaatt tgtaatagat aagttgtata aaattttcat accttaaagt
     4261 gttttagatt actcttcaag tgaagtatta ttttcaaaat aaaattctac tgaaaaattc
//
