LOCUS       NM_026784               1204 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus phosphomevalonate kinase (Pmvk), transcript variant 1,
            mRNA.
ACCESSION   NM_026784 XM_992786 XM_992822
VERSION     NM_026784.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1204)
  AUTHORS   Gamart,J., Barozzi,I., Laurent,F., Reinhardt,R., Martins,L.R.,
            Oberholzer,T., Visel,A., Zeller,R. and Zuniga,A.
  TITLE     SMAD4 target genes are part of a transcriptional network that
            integrates the response to BMP and SHH signaling during early limb
            bud patterning
  JOURNAL   Development 148 (23) (2021)
   PUBMED   34822715
REFERENCE   2  (bases 1 to 1204)
  AUTHORS   Kim,M., Wende,H., Walcher,J., Kuhnemund,J., Cheret,C., Kempa,S.,
            McShane,E., Selbach,M., Lewin,G.R. and Birchmeier,C.
  TITLE     Maf links Neuregulin1 signaling to cholesterol synthesis in
            myelinating Schwann cells
  JOURNAL   Genes Dev 32 (9-10), 645-657 (2018)
   PUBMED   29748249
  REMARK    Erratum:[Genes Dev. 2018 Aug 1;32(15-16):1101. doi:
            10.1101/gad.318477.118. PMID: 30068704]
REFERENCE   3  (bases 1 to 1204)
  AUTHORS   Scortegagna,M., Berthon,A., Settas,N., Giannakou,A., Garcia,G.,
            Li,J.L., James,B., Liddington,R.C., Vilches-Moure,J.G.,
            Stratakis,C.A. and Ronai,Z.A.
  TITLE     The E3 ubiquitin ligase Siah1 regulates adrenal gland organization
            and aldosterone secretion
  JOURNAL   JCI Insight 2 (23), 97128 (2017)
   PUBMED   29212953
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1204)
  AUTHORS   Sisecioglu,M., Budak,H., Geffers,L., Cankaya,M., Ciftci,M.,
            Thaller,C., Eichele,G., Kufrevioglu,O.I. and Ozdemir,H.
  TITLE     A compendium of expression patterns of cholesterol biosynthetic
            enzymes in the mouse embryo
  JOURNAL   J Lipid Res 56 (8), 1551-1559 (2015)
   PUBMED   26108225
REFERENCE   5  (bases 1 to 1204)
  AUTHORS   Cui,X.S., Li,X.Y., Shen,X.H., Bae,Y.J., Kang,J.J. and Kim,N.H.
  TITLE     Transcription profile in mouse four-cell, morula, and blastocyst:
            Genes implicated in compaction and blastocoel formation
  JOURNAL   Mol Reprod Dev 74 (2), 133-143 (2007)
   PUBMED   16998848
  REMARK    Review article
REFERENCE   6  (bases 1 to 1204)
  AUTHORS   Hogenboom,S., Romeijn,G.J., Houten,S.M., Baes,M., Wanders,R.J. and
            Waterham,H.R.
  TITLE     Absence of functional peroxisomes does not lead to deficiency of
            enzymes involved in cholesterol biosynthesis
  JOURNAL   J Lipid Res 43 (1), 90-98 (2002)
   PUBMED   11792727
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY266316.1, AK003607.1, AK150483.1 and AW492322.1.
            
            On Jul 23, 2009 this sequence version replaced NM_026784.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY703869.1, AK150483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               BY266316.1         3-200
            199-691             AK003607.1         2-494
            692-1187            AK150483.1         611-1106
            1188-1204           AW492322.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1204
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.13 cM"
     gene            1..1204
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /note="phosphomevalonate kinase"
                     /db_xref="GeneID:68603"
                     /db_xref="MGI:MGI:1915853"
     exon            1..347
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /inference="alignment:Splign:2.1.0"
     exon            348..411
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /inference="alignment:Splign:2.1.0"
     exon            412..564
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /inference="alignment:Splign:2.1.0"
     exon            565..694
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /inference="alignment:Splign:2.1.0"
     exon            695..1190
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1170..1175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /note="hexamer: AATAAA"
     polyA_site      1190
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgtgct gcgcaggggg gggagggcgg gggggggcgg gaaaggtact tagatactag
       61 gctgcaaggc tctttccctt ccagtttcta cgcccattct ctgcgcgctg gtttcgatgt
      121 gggctgtgta gtgtggagaa ggagtgggat ccctcctcct ttttgcttct actgagcggg
      181 tccacttcgt gcttggctgc atttcagggg tccgaagtgt cagctttagg cctggtgaag
      241 cttggtggca ccatggcccc gctcggagcc tccccgcgtc tggtgctgct gtttagcggg
      301 aagagaaaat ccgggaagga cttcgtgacc gagaggctga agagcagact tggaggtaac
      361 atctgtgctc tcctgcggct ctctggtcca ctcaaggagg agtatgctcg ggagcatggc
      421 ttggacttcc agagacttct ggatgcgagc acctacaagg agacctatcg gagggacatg
      481 atctgttggg gggagcagaa gcgccaggca gacccaggct tcttctgccg gaagattgtg
      541 gaaggcgtgt cccagcctat ctggctggtg agtgacacac ggaggacatc tgacatccag
      601 tggtttcagg aggcctatgg ggctgtgata cagacagtcc gagtagtggc ctcggagcag
      661 agtcgacagc aacggggctg ggtgttcaca ccaggggtgg acgatgctga gtcagagtgt
      721 ggtctggaca actttgggaa ctttgactgg gtcattgaga accacggaga tgagcagtgc
      781 ctggaggatc agctggagca cctgctggga tttattcaag ccaaacttta gtgatgaggc
      841 ttgaggggac gagcagagac tgatgggcct ggcgaacagt ggttctgcca gatgtgggtc
      901 cccagtccca gccgaggtca gcaaacagac agacagtctg gcttgccaga ggtctgggca
      961 ggatgctcgt gagtagtggg caaataaaga aacctctggt gttgtgtttt ccctggagag
     1021 gacactctgc ctctttaggg cacttatagg gcaaaggcag gcgcatgagt tttgcctgag
     1081 gcaggaacat tgccacaccc atgatgggca ggctgcagag ctgtgatggt ggtgtttccc
     1141 tgtgtgtacg ctctcagccc tggagtccta ataaacttac ttggatcaca aaaaaaaaaa
     1201 aaaa
//
