LOCUS       NM_001310640             992 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus phosphomevalonate kinase (Pmvk), transcript variant 3,
            mRNA.
ACCESSION   NM_001310640 XM_011240212
VERSION     NM_001310640.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 992)
  AUTHORS   Gamart,J., Barozzi,I., Laurent,F., Reinhardt,R., Martins,L.R.,
            Oberholzer,T., Visel,A., Zeller,R. and Zuniga,A.
  TITLE     SMAD4 target genes are part of a transcriptional network that
            integrates the response to BMP and SHH signaling during early limb
            bud patterning
  JOURNAL   Development 148 (23) (2021)
   PUBMED   34822715
REFERENCE   2  (bases 1 to 992)
  AUTHORS   Kim,M., Wende,H., Walcher,J., Kuhnemund,J., Cheret,C., Kempa,S.,
            McShane,E., Selbach,M., Lewin,G.R. and Birchmeier,C.
  TITLE     Maf links Neuregulin1 signaling to cholesterol synthesis in
            myelinating Schwann cells
  JOURNAL   Genes Dev 32 (9-10), 645-657 (2018)
   PUBMED   29748249
  REMARK    Erratum:[Genes Dev. 2018 Aug 1;32(15-16):1101. doi:
            10.1101/gad.318477.118.. PMID: 30068704]
REFERENCE   3  (bases 1 to 992)
  AUTHORS   Scortegagna,M., Berthon,A., Settas,N., Giannakou,A., Garcia,G.,
            Li,J.L., James,B., Liddington,R.C., Vilches-Moure,J.G.,
            Stratakis,C.A. and Ronai,Z.A.
  TITLE     The E3 ubiquitin ligase Siah1 regulates adrenal gland organization
            and aldosterone secretion
  JOURNAL   JCI Insight 2 (23), 97128 (2017)
   PUBMED   29212953
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 992)
  AUTHORS   Sisecioglu,M., Budak,H., Geffers,L., Cankaya,M., Ciftci,M.,
            Thaller,C., Eichele,G., Kufrevioglu,O.I. and Ozdemir,H.
  TITLE     A compendium of expression patterns of cholesterol biosynthetic
            enzymes in the mouse embryo
  JOURNAL   J Lipid Res 56 (8), 1551-1559 (2015)
   PUBMED   26108225
REFERENCE   5  (bases 1 to 992)
  AUTHORS   Cui,X.S., Li,X.Y., Shen,X.H., Bae,Y.J., Kang,J.J. and Kim,N.H.
  TITLE     Transcription profile in mouse four-cell, morula, and blastocyst:
            Genes implicated in compaction and blastocoel formation
  JOURNAL   Mol Reprod Dev 74 (2), 133-143 (2007)
   PUBMED   16998848
  REMARK    Review article
REFERENCE   6  (bases 1 to 992)
  AUTHORS   Hogenboom,S., Romeijn,G.J., Houten,S.M., Baes,M., Wanders,R.J. and
            Waterham,H.R.
  TITLE     Absence of functional peroxisomes does not lead to deficiency of
            enzymes involved in cholesterol biosynthesis
  JOURNAL   J Lipid Res 43 (1), 90-98 (2002)
   PUBMED   11792727
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC028659.1.
            
            On Jul 16, 2015 this sequence version replaced XM_011240212.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start site compared to variant 1. The encoded isoform
            (3) has a shorter N-terminus than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028659.1, BU524619.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-992               BC028659.1         1-992
FEATURES             Location/Qualifiers
     source          1..992
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.13 cM"
     gene            1..992
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /note="phosphomevalonate kinase"
                     /db_xref="GeneID:68603"
                     /db_xref="MGI:MGI:1915853"
     exon            1..199
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /inference="alignment:Splign:2.1.0"
     exon            200..352
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..619
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /EC_number="2.7.4.2"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="phosphomevalonate kinase isoform 3"
                     /protein_id="NP_001297569.1"
                     /db_xref="CCDS:CCDS79953.1"
                     /db_xref="GeneID:68603"
                     /db_xref="MGI:MGI:1915853"
                     /translation="MICWGEQKRQADPGFFCRKIVEGVSQPIWLVSDTRRTSDIQWFQ
                     EAYGAVIQTVRVVASEQSRQQRGWVFTPGVDDAESECGLDNFGNFDWVIENHGDEQCL
                     EDQLEHLLGFIQAKL"
     exon            353..482
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /inference="alignment:Splign:2.1.0"
     exon            483..978
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      958..963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /note="hexamer: AATAAA"
     polyA_site      978
                     /gene="Pmvk"
                     /gene_synonym="1110011E12Rik; 2900002L22Rik; PMK; PMKA;
                     PMKASE"
                     /note="major polyA site"
ORIGIN      
        1 gcaccggtct caagcctggc tgcagccctg cttcctgacc ctcatactaa ctggattagc
       61 ttaacacaag caaaatgcta gcagtatttg cttaatgctg ccaggaagcc tctgctgacg
      121 cacggagagg acctggagag tggcctcgga ggcagttggt gagagacagc agggacttgg
      181 tgatgtggga ggggcaaagg agcatggctt ggacttccag agacttctgg atgcgagcac
      241 ctacaaggag acctatcgga gggacatgat ctgttggggg gagcagaagc gccaggcaga
      301 cccaggcttc ttctgccgga agattgtgga aggcgtgtcc cagcctatct ggctggtgag
      361 tgacacacgg aggacatctg acatccagtg gtttcaggag gcctatgggg ctgtgataca
      421 gacagtccga gtagtggcct cggagcagag tcgacagcaa cggggctggg tgttcacacc
      481 aggggtggac gatgctgagt cagagtgtgg tctggacaac tttgggaact ttgactgggt
      541 cattgagaac cacggagatg agcagtgcct ggaggatcag ctggagcacc tgctgggatt
      601 tattcaagcc aaactttagt gatgaggctt gaggggacga gcagagactg atgggcctgg
      661 cgaacagtgg ttctgccaga tgtgggtccc cagtcccagc cgaggtcagc aaacagacag
      721 acagtctggc ttgccagagg tctgggcagg atgctcgtga gtagtgggca aataaagaaa
      781 cctctggtgt tgtgttttcc ctggagagga cactctgcct ctttagggca cttatagggc
      841 aaaggcaggc gcatgagttt tgcctgaggc aggaacattg ccacacccat gatgggcagg
      901 ctgcagagct gtgatggtgg tgtttccctg tgtgtacgct ctcagccctg gagtcctaat
      961 aaacttactt ggatcacaaa aaaaaaaaaa aa
//
