LOCUS       NM_008886               3217 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus PMS1 homolog2, mismatch repair system component
            (Pms2), mRNA.
ACCESSION   NM_008886
VERSION     NM_008886.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3217)
  AUTHORS   Wang,N., Zhang,S., Langfelder,P., Ramanathan,L., Gao,F.,
            Plascencia,M., Vaca,R., Gu,X., Deng,L., Dionisio,L.E., Vu,H.,
            Maciejewski,E., Ernst,J., Prasad,B.C., Vogt,T.F., Horvath,S.,
            Aaronson,J.S., Rosinski,J. and Yang,X.W.
  TITLE     Distinct mismatch-repair complex genes set neuronal CAG-repeat
            expansion rate to drive selective pathogenesis in HD mice
  JOURNAL   Cell (2025) In press
   PUBMED   39938516
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 3217)
  AUTHORS   Palmer,N., Talib,S.Z.A., Goh,C.M.F., Biswas,K., Sharan,S.K. and
            Kaldis,P.
  TITLE     Identification PMS1 and PMS2 as potential meiotic substrates of
            CDK2 activity
  JOURNAL   PLoS One 18 (3), e0283590 (2023)
   PUBMED   36952545
  REMARK    GeneRIF: Identification PMS1 and PMS2 as potential meiotic
            substrates of CDK2 activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3217)
  AUTHORS   Biswas,K., Couillard,M., Cavallone,L., Burkett,S., Stauffer,S.,
            Martin,B.K., Southon,E., Reid,S., Plona,T.M., Baugher,R.N.,
            Mellott,S.D., Pike,K.M., Albaugh,M.E., Maedler-Kron,C., Hamel,N.,
            Tessarollo,L., Marcus,V., Foulkes,W.D. and Sharan,S.K.
  TITLE     A novel mouse model of PMS2 founder mutation that causes mismatch
            repair defect due to aberrant splicing
  JOURNAL   Cell Death Dis 12 (9), 838 (2021)
   PUBMED   34489406
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3217)
  AUTHORS   Goold,R., Hamilton,J., Menneteau,T., Flower,M., Bunting,E.L.,
            Aldous,S.G., Porro,A., Vicente,J.R., Allen,N.D., Wilkinson,H.,
            Bates,G.P., Sartori,A.A., Thalassinos,K., Balmus,G. and
            Tabrizi,S.J.
  TITLE     FAN1 controls mismatch repair complex assembly via MLH1 retention
            to stabilize CAG repeat expansion in Huntington's disease
  JOURNAL   Cell Rep 36 (9), 109649 (2021)
   PUBMED   34469738
REFERENCE   5  (bases 1 to 3217)
  AUTHORS   Girelli Zubani,G., Zivojnovic,M., De Smet,A., Albagli-Curiel,O.,
            Huetz,F., Weill,J.C., Reynaud,C.A. and Storck,S.
  TITLE     Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair
            pathway to generate Ig gene mutations at A-T base pairs
  JOURNAL   J Exp Med 214 (4), 1169-1180 (2017)
   PUBMED   28283534
  REMARK    GeneRIF: Pms2/Mlh1 and multiple uracil glycosylases act jointly,
            each one with a distinct strand bias, to enlarge the immunoglobulin
            gene mutation spectrum from G-C to A-T bases.
REFERENCE   6  (bases 1 to 3217)
  AUTHORS   Mizuta,R., LaSalle,J.M., Cheng,H.L., Shinohara,A., Ogawa,H.,
            Copeland,N., Jenkins,N.A., Lalande,M. and Alt,F.W.
  TITLE     RAB22 and RAB163/mouse BRCA2: proteins that specifically interact
            with the RAD51 protein
  JOURNAL   Proc Natl Acad Sci U S A 94 (13), 6927-6932 (1997)
   PUBMED   9192668
REFERENCE   7  (bases 1 to 3217)
  AUTHORS   Narayanan,L., Fritzell,J.A., Baker,S.M., Liskay,R.M. and
            Glazer,P.M.
  TITLE     Elevated levels of mutation in multiple tissues of mice deficient
            in the DNA mismatch repair gene Pms2
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 3122-3127 (1997)
   PUBMED   9096356
REFERENCE   8  (bases 1 to 3217)
  AUTHORS   Baker,S.M., Bronner,C.E., Zhang,L., Plug,A.W., Robatzek,M.,
            Warren,G., Elliott,E.A., Yu,J., Ashley,T., Arnheim,N., Flavell,R.A.
            and Liskay,R.M.
  TITLE     Male mice defective in the DNA mismatch repair gene PMS2 exhibit
            abnormal chromosome synapsis in meiosis
  JOURNAL   Cell 82 (2), 309-319 (1995)
   PUBMED   7628019
REFERENCE   9  (bases 1 to 3217)
  AUTHORS   Hamilton,S.R., Liu,B., Parsons,R.E., Papadopoulos,N., Jen,J.,
            Powell,S.M., Krush,A.J., Berk,T., Cohen,Z., Tetu,B. et al.
  TITLE     The molecular basis of Turcot's syndrome
  JOURNAL   N Engl J Med 332 (13), 839-847 (1995)
   PUBMED   7661930
REFERENCE   10 (bases 1 to 3217)
  AUTHORS   Nicolaides,N.C., Papadopoulos,N., Liu,B., Wei,Y.F., Carter,K.C.,
            Ruben,S.M., Rosen,C.A., Haseltine,W.A., Fleischmann,R.D.,
            Fraser,C.M. et al.
  TITLE     Mutations of two PMS homologues in hereditary nonpolyposis colon
            cancer
  JOURNAL   Nature 371 (6492), 75-80 (1994)
   PUBMED   8072530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121917.2.
            
            On May 16, 2022 this sequence version replaced NM_008886.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086637.1, AK146365.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC121917.2         171586-171645       c
            61-200              AC121917.2         169605-169744       c
            201-287             AC121917.2         168177-168263       c
            288-390             AC121917.2         167944-168046       c
            391-574             AC121917.2         166862-167045       c
            575-742             AC121917.2         165142-165309       c
            743-840             AC121917.2         163988-164085       c
            841-940             AC121917.2         162057-162156       c
            941-1025            AC121917.2         159565-159649       c
            1026-1181           AC121917.2         158033-158188       c
            1182-2034           AC121917.2         155592-156444       c
            2035-2202           AC121917.2         153399-153566       c
            2203-2303           AC121917.2         152623-152723       c
            2304-2473           AC121917.2         152315-152484       c
            2474-3217           AC121917.2         149906-150649       c
FEATURES             Location/Qualifiers
     source          1..3217
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 82.82 cM"
     gene            1..3217
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /note="PMS1 homolog2, mismatch repair system component"
                     /db_xref="GeneID:18861"
                     /db_xref="MGI:MGI:104288"
     exon            1..60
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..2617
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /note="postmeiotic segregation increased 2; PMS1 protein
                     homolog 2; DNA mismatch repair protein PMS2"
                     /codon_start=1
                     /product="mismatch repair endonuclease PMS2"
                     /protein_id="NP_032912.2"
                     /db_xref="CCDS:CCDS39375.1"
                     /db_xref="GeneID:18861"
                     /db_xref="MGI:MGI:104288"
                     /translation="MEQTEGVSTECAKAIKPIDGKSVHQICSGQVVLSLSTAVKELIE
                     NSVDAGATTIDLRLKDYGVDLIEVSDNGCGVEEENFEGLALKHHTSKIQEFADLTQVE
                     TFGFRGEALSSLCALSDVTISTCHGSASVGTRLVFDHNGKITQKTPYPRPKGTTVSVQ
                     HLFYTLPVRYKEFQRNIKKEYAKMVQVLQAYCIISAGVRVSCTNQLGQGKRQPVVCTS
                     GSSGMKENIGSVFGQKQLQSLIPFVQLPPSDAVCEEYGLSTSRTPQNLFYVSGFISQC
                     THGAGRSATDRQFFFINQRPCDPAKVSKLVNEVYHMYNRHQYPFVVLNVSVDSECVDI
                     NVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDANKLNVNQQPLLDVEGNLVKLHTAEL
                     EKPVPGKQDNSPSLKSTADEKRVASISRLREAFSLHPTKEIKSRGPETAELTRSFPSE
                     KRGVLSSYPSDVISYRGLRGSQDKLVSPTDSPGDCMDREKIEKDSGLSSTSAGSEEGF
                     STPEVASSFSSDYNVSSPEDRPSQETINCGDLDCRPPGTGQSLKPEDHGYQCKALPLA
                     RLSPTNAKRFKTEERPSNVNISQRLPGPQSTSAAEVDVAIKMNKRIVLLEFSLSSLAK
                     RMKQLQHLKAQNKHELSYRKFRAKICPGENQAAEDELRKEISKSMFAEMEILGQFNLG
                     FIVTKLKEDLFLVDQHAADEKYNFEMLQQHTVLQAQRLITPQTLNLTAVNEAVLIENL
                     EIFRKNGFDFVIDEDAPVTERAKLISLPTSKNWTFGPQDIDELIFMLSDSPGVMCRPS
                     RVRQMFASRACRKSVMIGTALNASEMKKLITHMGEMDHPWNCPHGRPTMRHVANLDVI
                     SQN"
     exon            61..200
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            201..287
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            288..390
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            391..574
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..742
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            743..840
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            841..940
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1025
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1181
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..2034
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2202
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2303
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2473
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..3217
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2904
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /note="major polyA site"
     regulatory      3190..3195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
                     /note="hexamer: ATTAAA"
     polyA_site      3217
                     /gene="Pms2"
                     /gene_synonym="Pmsl2"
ORIGIN      
        1 ctcccgcggt gactgtgact ggaggagtcc tgcatccatg gagcaaaccg aaggcgtgag
       61 tacagaatgt gctaaggcca tcaagcctat tgatgggaag tcagtccatc aaatttgttc
      121 tgggcaggtg gtactcagtt taagcaccgc tgtgaaggag ttgatagaaa atagtgtaga
      181 tgctggtgct actactattg atctaaggct taaagactat ggggtggacc tcattgaagt
      241 ttcagacaat ggatgtgggg tagaagaaga aaactttgaa ggtctagctc tgaaacatca
      301 cacatctaag attcaagagt ttgccgacct cacgcaggtt gaaacttttg gctttcgggg
      361 ggaagctctg agctctctgt gtgcactaag tgatgtcact atatctacct gccacgggtc
      421 tgcaagcgtt gggactcgac tggtgtttga ccataatggg aaaatcaccc agaaaactcc
      481 ctacccccga cctaaaggaa ccacagtcag tgtgcagcac ttattttata cactacccgt
      541 gcgttacaaa gagtttcaga ggaacattaa aaaggagtat gccaaaatgg tgcaggtctt
      601 acaggcgtac tgtatcatct cagcaggcgt ccgtgtaagc tgcactaatc agctcggaca
      661 ggggaagcgg cagcctgtgg tgtgcacaag cggcagctct ggcatgaagg aaaatatcgg
      721 gtctgtgttt ggccagaagc agttgcaaag cctcattcct tttgttcagc tgccccctag
      781 tgacgctgtg tgtgaagagt acggcctgag cacttccagg acgccacaaa accttttcta
      841 cgtttcgggc ttcatttcac agtgcacgca cggcgccggg aggagtgcaa cagacaggca
      901 gtttttcttc atcaatcaga ggccctgtga cccagcaaag gtctctaagc ttgtcaatga
      961 ggtttatcac atgtataacc ggcatcagta cccatttgtc gtccttaacg tttccgttga
     1021 ctcagaatgt gtggatatta atgtaactcc agataaaagg caaattctac tacaagaaga
     1081 gaagctattg ctggccgttt taaagacctc cttgatagga atgtttgaca gtgatgcaaa
     1141 caagcttaat gtcaaccagc agccactgct agatgttgaa ggtaacttag taaagctgca
     1201 tactgcagaa ctagaaaagc ctgtgccagg aaagcaagat aactctcctt cactgaagag
     1261 cacagcagac gagaaaaggg tagcatccat ctccaggctg agagaggcct tttctcttca
     1321 tcctactaaa gagatcaagt ctaggggtcc agagactgct gaactgacac ggagttttcc
     1381 aagtgagaaa aggggcgtgt tatcctctta tccttcagac gtcatctctt acagaggcct
     1441 ccgtggctcg caggacaaat tggtgagtcc cacggacagc cctggtgact gtatggacag
     1501 agagaaaata gaaaaagact cagggctcag cagcacctca gctggctctg aggaagggtt
     1561 cagcacccca gaagtggcca gtagctttag cagtgactat aacgtgagct ccccagaaga
     1621 cagaccttct caggaaacca taaactgtgg tgacttggac tgccgtcctc caggtacagg
     1681 acagtccttg aagccagaag accatggata tcaatgcaaa gctctacctc tagctcgtct
     1741 gtcacccaca aatgccaagc gcttcaagac agaggaaaga ccctcaaatg tcaacatttc
     1801 tcaaagattg cctggtcctc agagcacctc agcagctgag gtcgatgtag ccataaaaat
     1861 gaataagaga atcgtgctcc tcgagttctc tctgagttct ctagctaagc gaatgaagca
     1921 gttacagcac ctaaaggcgc agaacaaaca tgaactgagt tacagaaaat ttagggccaa
     1981 gatttgccct ggagaaaacc aagcagcaga agatgaactc agaaaagaga ttagtaaatc
     2041 gatgtttgca gagatggaga tcttgggtca gtttaacctg ggatttatag taaccaaact
     2101 gaaagaggac ctcttcctgg tggaccagca tgctgcggat gagaagtaca actttgagat
     2161 gctgcagcag cacacggtgc tccaggcgca gaggctcatc acaccccaga ctctgaactt
     2221 aactgctgtc aatgaagctg tactgataga aaatctggaa atattcagaa agaatggctt
     2281 tgactttgtc attgatgagg atgctccagt cactgaaagg gctaaattga tttccttacc
     2341 aactagtaaa aactggacct ttggacccca agatatagat gaactgatct ttatgttaag
     2401 tgacagccct ggggtcatgt gccggccctc acgagtcaga cagatgtttg cttccagagc
     2461 ctgtcggaag tcagtgatga ttggaacggc gctcaatgcg agcgagatga agaagctcat
     2521 cacccacatg ggtgagatgg accacccctg gaactgcccc cacggcaggc caaccatgag
     2581 gcacgttgcc aatctggatg tcatctctca gaactgacac accccttgta gcatagagtt
     2641 tattacagat tgttcggttt gcaaagagaa ggttttaagt aatctgatta tcgttgtaca
     2701 aaaattagca tgctgcttta atgtactgga tccatttaaa agcagtgtta aggcaggcat
     2761 gatggagtgt tcctctagct cagctacttg ggagatcccg gtgggaggct catgtgagcc
     2821 caggactttg agaccactcc gagccacatt catgagactc aattcaagga caaaaaaaaa
     2881 aaagatattt ttgaagcctt tttaccatgt ctgcagttac tgttctgcaa tttgactttg
     2941 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtggc aacttttgac
     3001 tttgagccct caatggcgat tgaattctat ttgttttctc acccacccac cctcacccca
     3061 gtgtctgagg cagcgttttg tgaaactcag gcttctcttg actcgttttg tcaccaaggt
     3121 tggcctagaa ctgagcttgc ctccacggcc caagagctgg gatcccaggt gtgtgtcaca
     3181 tatgcccaca ttaaaaaaat atggtctttt ttaatta
//
