LOCUS       NM_153556               3077 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus PMS1 homolog 1, mismatch repair system component
            (Pms1), mRNA.
ACCESSION   NM_153556
VERSION     NM_153556.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3077)
  AUTHORS   Wang,N., Zhang,S., Langfelder,P., Ramanathan,L., Gao,F.,
            Plascencia,M., Vaca,R., Gu,X., Deng,L., Dionisio,L.E., Vu,H.,
            Maciejewski,E., Ernst,J., Prasad,B.C., Vogt,T.F., Horvath,S.,
            Aaronson,J.S., Rosinski,J. and Yang,X.W.
  TITLE     Distinct mismatch-repair complex genes set neuronal CAG-repeat
            expansion rate to drive selective pathogenesis in HD mice
  JOURNAL   Cell (2025) In press
   PUBMED   39938516
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 3077)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3077)
  AUTHORS   Palmer,N., Talib,S.Z.A., Goh,C.M.F., Biswas,K., Sharan,S.K. and
            Kaldis,P.
  TITLE     Identification PMS1 and PMS2 as potential meiotic substrates of
            CDK2 activity
  JOURNAL   PLoS One 18 (3), e0283590 (2023)
   PUBMED   36952545
  REMARK    GeneRIF: Identification PMS1 and PMS2 as potential meiotic
            substrates of CDK2 activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3077)
  AUTHORS   Duroc,Y., Kumar,R., Ranjha,L., Adam,C., Guerois,R., Md Muntaz,K.,
            Marsolier-Kergoat,M.C., Dingli,F., Laureau,R., Loew,D.,
            Llorente,B., Charbonnier,J.B., Cejka,P. and Borde,V.
  TITLE     Concerted action of the MutLbeta heterodimer and Mer3 helicase
            regulates the global extent of meiotic gene conversion
  JOURNAL   Elife 6, e21900 (2017)
   PUBMED   28051769
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3077)
  AUTHORS   Fischer,J.M., Dudley,S., Miller,A.J. and Liskay,R.M.
  TITLE     An intact Pms2 ATPase domain is not essential for male fertility
  JOURNAL   DNA Repair (Amst) 39, 46-51 (2016)
   PUBMED   26753533
REFERENCE   6  (bases 1 to 3077)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (bases 1 to 3077)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 3077)
  AUTHORS   Peltomaki,P.
  TITLE     DNA mismatch repair and cancer
  JOURNAL   Mutat Res 488 (1), 77-85 (2001)
   PUBMED   11223406
  REMARK    Review article
REFERENCE   9  (bases 1 to 3077)
  AUTHORS   Prolla,T.A., Baker,S.M., Harris,A.C., Tsao,J.L., Yao,X.,
            Bronner,C.E., Zheng,B., Gordon,M., Reneker,J., Arnheim,N.,
            Shibata,D., Bradley,A. and Liskay,R.M.
  TITLE     Tumour susceptibility and spontaneous mutation in mice deficient in
            Mlh1, Pms1 and Pms2 DNA mismatch repair
  JOURNAL   Nat Genet 18 (3), 276-279 (1998)
   PUBMED   9500552
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ056105.1 and BC028939.1.
            
            On Aug 27, 2015 this sequence version replaced NM_153556.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028939.1, ERR3363660.2875363.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                CJ056105.1         1-32
            33-3077             BC028939.1         1-3045
FEATURES             Location/Qualifiers
     source          1..3077
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.99 cM"
     gene            1..3077
                     /gene="Pms1"
                     /note="PMS1 homolog 1, mismatch repair system component"
                     /db_xref="GeneID:227099"
                     /db_xref="MGI:MGI:1202302"
     exon            1..143
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            144..295
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..2917
                     /gene="Pms1"
                     /note="postmeiotic segregation increased 1"
                     /codon_start=1
                     /product="PMS1 protein homolog 1"
                     /protein_id="NP_705784.1"
                     /db_xref="CCDS:CCDS14951.1"
                     /db_xref="GeneID:227099"
                     /db_xref="MGI:MGI:1202302"
                     /translation="MKQLPAATVRLLSSSQTITSVVSVVKELIENSLDAGATSIEVKL
                     ENYGFDKIEIRDNGEGIKAVDVPVMAVKYYTSKISSHEDLGNLTTYGFRGEALGSICN
                     VAEVVVTTRTSADDFSTQYVLDGSGHILSQKPSHLGQGTTVTALKLFKNLPVRKQFYS
                     TAKKCKDELKNVQDLLISYGVLKPDVRITFVHNKAVIWQKSRVPDHRMALMSVLGTAV
                     MGNMESVEQHCEQSQIYLSGFFPKHDADHNSTSLSTPERSFIFINSRPVHQKDILKLI
                     RRYYNLKCLKESTRLYPIFFLKIDVPSAEVDINLTPDKSQVLLQNKESVLIALENLMM
                     TCYGPLPTTESSENNRVDISSANMVVSQTAETDVLFNKMESFGNNYPNADTSAIHFQK
                     DESRKNIDHHLNEQINIGNYFDGHFSGDINKDTFQNIPMNNLSSETNQSNHSETHSVG
                     SMEHIQGENGRNGTGGSGGDGRETLPEKALEICADDWSKGNLCNSMGENIEPVKILVP
                     QKSLSCKVTSSHPRLEPETLSDGPCSRTSDVIHNRSGRLTAYDLISSRAVKKPMSASA
                     LFIQDHRTQFLTENPKTGLEDATEQIKARWETLSEEEKHKYEEKAKKDLERYNNQMKK
                     AIEQETQVSLKDGRKKRATSSWGWTQKHKVKDSSNQPKLDELFQSQNEKKKSENIKIT
                     EIPFSMENLKANLKKQKEVDLEEKDEIYLIHSLKFPDSWLVTSRADVMLLNPYRVEEA
                     LLFKRLLENHKLLAEPLEKPIILTESLLNGSHYLEVLYKMSTVEERGSGSAYLCDPRL
                     TANGFKIRLTPGVSSTENYLEIEGMAQCLPFYGIMDLKEILNAIVNKNAKEIYECRPR
                     KVINYLEGEAVRLSRQLPMYLPREDVQDLIYRMKHQFGKEIKGCVHGRPFFHHLTHLP
                     GTS"
     exon            296..478
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..581
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..745
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..862
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..985
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1129
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1980
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2460
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2591
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2752
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..3064
                     /gene="Pms1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3046..3051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pms1"
                     /note="hexamer: AATAAT"
     polyA_site      3064
                     /gene="Pms1"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcgggc cttagaggag cgcgagcgcg ggtcctgctg agcgcagccg tgcttcggtc
       61 cgaaggacgt ccagcgaagt aggccgtgca actcagggtt tgctgagtgc ttgccgctgt
      121 gggtggtgaa tgcgcgctag aagctactca ggtgcaagct aggatgaaac agttgcctgc
      181 agcaacagtt cgcctcctgt ccagttctca gacaatcacg tcagtggtca gcgttgtgaa
      241 agagctcatt gaaaactcct tggatgccgg agccaccagc attgaagtta aactggagaa
      301 ctatggattt gataaaattg agattcggga caatggtgag ggcatcaagg ctgtagatgt
      361 ccctgtaatg gcagtgaagt actacacctc gaagatcagc agtcatgaag accttggaaa
      421 tctgacaact tatggttttc gtggtgaagc cttggggtca atatgtaatg ttgcggaggt
      481 ggtagttaca acaaggacat ctgctgatga ctttagcact cagtatgttt tagatggcag
      541 tggccacata ctttctcaga agccttcaca tcttggtcaa ggtacaactg taactgctct
      601 aaagttgttt aagaatctgc ctgtaagaaa acaattttac tcaacagcta aaaagtgtaa
      661 agatgaacta aaaaatgtac aggaccttct cataagctac ggtgtcctga aacctgatgt
      721 gaggattact tttgtacata ataaggcagt tatttggcag aaaagcagag ttccagatca
      781 caggatggct ctaatgtcgg ttctgggaac tgctgtcatg ggcaacatgg aatctgttga
      841 gcagcactgt gaacagtcgc agatttacct aagtggattc ttcccaaagc acgatgcaga
      901 ccacaattcc acaagtcttt caaccccaga gagaagtttc atctttatta atagtcggcc
      961 agtacatcaa aaagatatac taaagttaat tcgacgctat tataatctga agtgcctaaa
     1021 ggagtctacc cgcttgtatc ccattttctt tctgaaaatt gatgttccat cagctgaggt
     1081 ggatataaat ctaacaccag ataaaagtca agtgttatta cagaataagg aatctgtttt
     1141 aattgctctt gaaaatctga tgatgacctg ttacggacca ctacccacta cagagtcttc
     1201 tgaaaataac agagtagata tttcctcagc caacatggtt gttagtcaaa cagccgaaac
     1261 agatgtgctt tttaataaaa tggaatcatt tggaaataat tatccaaatg ctgatacttc
     1321 ggctattcac ttccaaaagg atgaatctag aaaaaacatt gatcatcatt taaatgaaca
     1381 gataaatata ggcaattatt ttgatggtca ttttagtggt gacattaata aggacacatt
     1441 tcaaaatatt cctatgaata atttatcatc agagactaat cagagtaatc acagtgaaac
     1501 tcattctgta ggttctatgg agcacatcca aggagaaaat ggcaggaatg gtacaggagg
     1561 aagtggggga gatgggagag aaacacttcc tgagaaagct ctggaaatct gtgcagacga
     1621 ttggagcaaa ggaaatttgt gtaattcaat gggagagaat atcgaacctg tgaaaatttt
     1681 agtgccacaa aagagcttat catgtaaagt gaccagtagt cacccacgcc ttgaaccaga
     1741 gactctcagt gatggtcctt gtagcagaac atcagatgta atccataaca gatctggacg
     1801 gcttacagcc tatgacttaa ttagcagtcg agcagtcaag aagcccatgt cagccagtgc
     1861 cctgttcatt caagaccacc gcactcagtt cctcacagag aatcccaaga ctggtttgga
     1921 ggatgcgaca gaacaaatca aagcacgatg ggagacactg agtgaagagg aaaagcacaa
     1981 atacgaggaa aaggctaaaa aagacttgga acgatacaat aaccaaatga agaaagctat
     2041 tgaacaggag acacaagtat cattgaaaga cggcaggaaa aaaagggcca ccagttcgtg
     2101 gggctggaca cagaaacata aggtgaaaga ctcatctaat cagccaaaac ttgatgagct
     2161 ctttcagtcc cagaatgaaa agaagaagag tgaaaatatt aaaataacag agattccctt
     2221 ttctatggaa aacttaaaag cgaacttgaa gaaacaaaag gaagttgact tagaggagaa
     2281 ggatgagatt tacctgatcc acagtctcaa gtttcctgat tcgtggctgg tcacgtccag
     2341 agccgatgtc atgttactga acccatacag agtggaggaa gccctgctat ttaaaagact
     2401 tcttgagaat cataaactcc ttgcagaacc actggaaaag ccaattatat taacagagag
     2461 tcttcttaat gggtctcatt atctagaggt tttatataaa atgtcaacag ttgaagaaag
     2521 aggcagtgga tcagcttacc tgtgtgaccc tcgtcttaca gcaaatggct tcaagatcag
     2581 attgacacca ggagtttcca gtactgagaa ctacttggaa atagaaggaa tggctcagtg
     2641 tctcccattc tatggaataa tggatttaaa ggaaattctt aatgctatag taaacaaaaa
     2701 tgcaaaggag atttatgaat gtagacctcg aaaagtaata aattatctgg agggagaagc
     2761 cgtccgtcta tccagacagc tacccatgta cttaccaaga gaggatgtcc aagatcttat
     2821 ctatagaatg aagcaccagt tcggaaaaga aattaaaggc tgtgttcatg gccgcccatt
     2881 ttttcatcat ttgacccatc ttccaggaac ttcatgatta agcttatgac cattagttac
     2941 tatggaaact gatgtggttc ttaacccact ttgtcctatc atgtatcaaa gtgattattt
     3001 gtatactgga aaaggttttt tacagctata aaatatgtat aaataaataa tatggactat
     3061 aaaaaaaaaa aaaaaaa
//
