LOCUS       NP_705784                917 aa            linear   ROD 04-MAR-2025
DEFINITION  PMS1 protein homolog 1 [Mus musculus].
ACCESSION   NP_705784
VERSION     NP_705784.1
DBSOURCE    REFSEQ: accession NM_153556.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 917)
  AUTHORS   Wang,N., Zhang,S., Langfelder,P., Ramanathan,L., Gao,F.,
            Plascencia,M., Vaca,R., Gu,X., Deng,L., Dionisio,L.E., Vu,H.,
            Maciejewski,E., Ernst,J., Prasad,B.C., Vogt,T.F., Horvath,S.,
            Aaronson,J.S., Rosinski,J. and Yang,X.W.
  TITLE     Distinct mismatch-repair complex genes set neuronal CAG-repeat
            expansion rate to drive selective pathogenesis in HD mice
  JOURNAL   Cell (2025) In press
   PUBMED   39938516
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (residues 1 to 917)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 917)
  AUTHORS   Palmer,N., Talib,S.Z.A., Goh,C.M.F., Biswas,K., Sharan,S.K. and
            Kaldis,P.
  TITLE     Identification PMS1 and PMS2 as potential meiotic substrates of
            CDK2 activity
  JOURNAL   PLoS One 18 (3), e0283590 (2023)
   PUBMED   36952545
  REMARK    GeneRIF: Identification PMS1 and PMS2 as potential meiotic
            substrates of CDK2 activity.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 917)
  AUTHORS   Duroc,Y., Kumar,R., Ranjha,L., Adam,C., Guerois,R., Md Muntaz,K.,
            Marsolier-Kergoat,M.C., Dingli,F., Laureau,R., Loew,D.,
            Llorente,B., Charbonnier,J.B., Cejka,P. and Borde,V.
  TITLE     Concerted action of the MutLbeta heterodimer and Mer3 helicase
            regulates the global extent of meiotic gene conversion
  JOURNAL   Elife 6, e21900 (2017)
   PUBMED   28051769
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 917)
  AUTHORS   Fischer,J.M., Dudley,S., Miller,A.J. and Liskay,R.M.
  TITLE     An intact Pms2 ATPase domain is not essential for male fertility
  JOURNAL   DNA Repair (Amst) 39, 46-51 (2016)
   PUBMED   26753533
REFERENCE   6  (residues 1 to 917)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (residues 1 to 917)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (residues 1 to 917)
  AUTHORS   Peltomaki,P.
  TITLE     DNA mismatch repair and cancer
  JOURNAL   Mutat Res 488 (1), 77-85 (2001)
   PUBMED   11223406
  REMARK    Review article
REFERENCE   9  (residues 1 to 917)
  AUTHORS   Prolla,T.A., Baker,S.M., Harris,A.C., Tsao,J.L., Yao,X.,
            Bronner,C.E., Zheng,B., Gordon,M., Reneker,J., Arnheim,N.,
            Shibata,D., Bradley,A. and Liskay,R.M.
  TITLE     Tumour susceptibility and spontaneous mutation in mice deficient in
            Mlh1, Pms1 and Pms2 DNA mismatch repair
  JOURNAL   Nat Genet 18 (3), 276-279 (1998)
   PUBMED   9500552
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ056105.1 and BC028939.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028939.1, ERR3363660.2875363.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..917
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.99 cM"
     Protein         1..917
                     /product="PMS1 protein homolog 1"
                     /note="postmeiotic segregation increased 1"
                     /calculated_mol_wt=103464
     Region          1..318
                     /region_name="mutl"
                     /note="DNA mismatch repair protein MutL; TIGR00585"
                     /db_xref="CDD:273155"
     Region          558..629
                     /region_name="HMG-box_SF"
                     /note="high mobility group (HMG)-box domain superfamily;
                     cl00082"
                     /db_xref="CDD:469606"
     Region          <559..708
                     /region_name="NHP6B"
                     /note="Chromatin-associated proteins containing the HMG
                     domain [Chromatin structure and dynamics]; COG5648"
                     /db_xref="CDD:227935"
     Site            order(560,562..566,569..570,577,589..590,593,596..597,604,
                     608,611,615,618)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438801"
     CDS             1..917
                     /gene="Pms1"
                     /coded_by="NM_153556.2:164..2917"
                     /db_xref="CCDS:CCDS14951.1"
                     /db_xref="GeneID:227099"
                     /db_xref="MGI:MGI:1202302"
ORIGIN      
        1 mkqlpaatvr llsssqtits vvsvvkelie nsldagatsi evklenygfd kieirdngeg
       61 ikavdvpvma vkyytskiss hedlgnltty gfrgealgsi cnvaevvvtt rtsaddfstq
      121 yvldgsghil sqkpshlgqg ttvtalklfk nlpvrkqfys takkckdelk nvqdllisyg
      181 vlkpdvritf vhnkaviwqk srvpdhrmal msvlgtavmg nmesveqhce qsqiylsgff
      241 pkhdadhnst slstpersfi finsrpvhqk dilklirryy nlkclkestr lypifflkid
      301 vpsaevdinl tpdksqvllq nkesvliale nlmmtcygpl pttessennr vdissanmvv
      361 sqtaetdvlf nkmesfgnny pnadtsaihf qkdesrknid hhlneqinig nyfdghfsgd
      421 inkdtfqnip mnnlssetnq snhsethsvg smehiqgeng rngtggsggd gretlpekal
      481 eicaddwskg nlcnsmgeni epvkilvpqk slsckvtssh prlepetlsd gpcsrtsdvi
      541 hnrsgrltay dlissravkk pmsasalfiq dhrtqflten pktgledate qikarwetls
      601 eeekhkyeek akkdlerynn qmkkaieqet qvslkdgrkk ratsswgwtq khkvkdssnq
      661 pkldelfqsq nekkksenik iteipfsmen lkanlkkqke vdleekdeiy lihslkfpds
      721 wlvtsradvm llnpyrveea llfkrllenh kllaeplekp iiltesllng shylevlykm
      781 stveergsgs aylcdprlta ngfkirltpg vsstenylei egmaqclpfy gimdlkeiln
      841 aivnknakei yecrprkvin ylegeavrls rqlpmylpre dvqdliyrmk hqfgkeikgc
      901 vhgrpffhhl thlpgts
//
