LOCUS       NM_028431               1596 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus peptidase (mitochondrial processing) beta (Pmpcb),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_028431 XM_131914 XM_905130 XM_984531
VERSION     NM_028431.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1596)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1596)
  AUTHORS   Cheong,A., Archambault,D., Degani,R., Iverson,E., Tremblay,K.D. and
            Mager,J.
  TITLE     Nuclear-encoded mitochondrial ribosomal proteins are required to
            initiate gastrulation
  JOURNAL   Development 147 (10) (2020)
   PUBMED   32376682
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1596)
  AUTHORS   Pandey,D., Bhunia,A., Oh,Y.J., Chang,F., Bergman,Y., Kim,J.H.,
            Serbo,J., Boronina,T.N., Cole,R.N., Van Eyk,J., Remaley,A.T.,
            Berkowitz,D.E. and Romer,L.H.
  TITLE     OxLDL triggers retrograde translocation of arginase2 in aortic
            endothelial cells via ROCK and mitochondrial processing peptidase
  JOURNAL   Circ Res 115 (4), 450-459 (2014)
   PUBMED   24903103
  REMARK    GeneRIF: OxLDL triggers retrograde translocation of arginase2 in
            aortic endothelial cells via ROCK and mitochondrial processing
            peptidase.
REFERENCE   4  (bases 1 to 1596)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1596)
  AUTHORS   Koppen,M., Bonn,F., Ehses,S. and Langer,T.
  TITLE     Autocatalytic processing of m-AAA protease subunits in mitochondria
  JOURNAL   Mol Biol Cell 20 (19), 4216-4224 (2009)
   PUBMED   19656850
  REMARK    GeneRIF: Data show that Afg3l1 or Afg3l2 are required for
            maturation of newly imported paraplegin subunits after their
            cleavage by MPP.
REFERENCE   6  (bases 1 to 1596)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 1596)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK013995.1.
            
            On Apr 6, 2007 this sequence version replaced NM_028431.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013995.1, AK152673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1596              AK013995.1         2-1597
FEATURES             Location/Qualifiers
     source          1..1596
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 9.97 cM"
     gene            1..1596
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /note="peptidase (mitochondrial processing) beta"
                     /db_xref="GeneID:73078"
                     /db_xref="MGI:MGI:1920328"
     exon            1..117
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /inference="alignment:Splign:2.1.0"
     exon            118..258
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /inference="alignment:Splign:2.1.0"
     exon            259..345
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /inference="alignment:Splign:2.1.0"
     exon            346..475
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /inference="alignment:Splign:2.1.0"
     exon            476..674
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /inference="alignment:Splign:2.1.0"
     exon            675..754
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /inference="alignment:Splign:2.1.0"
     exon            755..867
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1011
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1172
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1258
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1347
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1423
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1596
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1574..1579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /note="hexamer: AATAAA"
     polyA_site      1592
                     /gene="Pmpcb"
                     /gene_synonym="3110004O18Rik; MPP11; MPPB; MPPP52"
                     /note="major polyA site"
ORIGIN      
        1 actttctcca ccgcagagat ggcggcggcc gctctatccc ggacgctgtt gccagaggcc
       61 cggcggcgcc tgtggggatt tacacgaagg cttccgcttc gccgcgccgc tgctcagccg
      121 ttgtactttg gaggggaccg actaagaagc acacaggctg ccccacaggt tgtgctgaat
      181 gtccccgaga cacaagtgac atgtttggaa aatggactca gagtagcttc tgaaaactct
      241 gggctctcaa cgtgcacagt tgggctgtgg atcgatgcgg gaagtcgcta tgagaatgag
      301 aagaacaacg gcaccgccca cttcctggag cacatggcct tcaagggcac taaaaagagg
      361 tcccagttag accttgaact tgagattgag aatatgggcg ctcatcttaa cgcctatacc
      421 tccagagagc agactgtcta ctacgccaaa gcattctcga gagatttgcc cagagctgta
      481 gaaattcttg ctgacataat tcagaacagc acactgggag aagcagagat tgagcgtgag
      541 cggggagtaa tcctgagaga gatgcaggaa gttgaaacca acttgcaaga agttgttttt
      601 gattatcttc atgcgacagc ctatcaaaat actgcacttg gacggacaat tctgggacca
      661 actgaaaata tcaaatctat aaatcgtaag gacctagtgg attacataac cacacactac
      721 aagggaccaa gaattgtact ggctgccgcc ggaggtgttt gccataacga actgctggag
      781 ttagcaaagt tccattttgg tgactctttg tgctcacaca aaggagctat accagctctg
      841 cctccctgca agttcactgg aagtgagatt cgggtgaggg atgacaagat gccattggcg
      901 caccttgcaa tagctgttga agcagttggt tgggcccatc cagacacgat ctgtctcatg
      961 gtcgcaaaca cattgatagg caactgggat cgctcttttg gaggaggaat gaatttatct
     1021 agcaagctgg cccaactcac ttgccatggc aatctctgcc acagcttcca gtccttcaat
     1081 acttcatata cagacacagg attatgggga ctctatatgg tctgtgaaca agccacggtt
     1141 gctgacatgc tgcacgttgt acaaaacgaa tggaagcgtc tgtgtacaga tgtgactgag
     1201 agtgaggttg cacgtgcaaa aaatcttctg aaaacaaaca tgctgctgca gcttgatggg
     1261 tcaactccaa tttgtgaaga cattggtagg cagatgctat gctataatag gagaattcct
     1321 atccccgagc ttgaagcaag aattgatgct gtggatgcgg agacggttcg acgagtgtgc
     1381 accaagtaca ttcatgacaa aagcccagct attgctgctc tgggtcctat tgagcgacta
     1441 ccagatttta accagatttg tagtaacatg cgttggattc gtgactaatt tttgtgatca
     1501 aatactctgc acatatatat ttataaaact aagagactgg aagttttcaa aactgccagt
     1561 gttcaaatga aaaaataaaa atatatttgg aatttt
//
