LOCUS       NM_173180               3125 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus peptidase (mitochondrial processing) alpha (Pmpca),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_173180
VERSION     NM_173180.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3125)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3125)
  AUTHORS   Pandey,D., Bhunia,A., Oh,Y.J., Chang,F., Bergman,Y., Kim,J.H.,
            Serbo,J., Boronina,T.N., Cole,R.N., Van Eyk,J., Remaley,A.T.,
            Berkowitz,D.E. and Romer,L.H.
  TITLE     OxLDL triggers retrograde translocation of arginase2 in aortic
            endothelial cells via ROCK and mitochondrial processing peptidase
  JOURNAL   Circ Res 115 (4), 450-459 (2014)
   PUBMED   24903103
  REMARK    GeneRIF: OxLDL triggers retrograde translocation of arginase2 in
            aortic endothelial cells via ROCK and mitochondrial processing
            peptidase.
REFERENCE   3  (bases 1 to 3125)
  AUTHORS   Koppen,M., Bonn,F., Ehses,S. and Langer,T.
  TITLE     Autocatalytic processing of m-AAA protease subunits in mitochondria
  JOURNAL   Mol Biol Cell 20 (19), 4216-4224 (2009)
   PUBMED   19656850
  REMARK    GeneRIF: Data show that Afg3l1 or Afg3l2 are required for
            maturation of newly imported paraplegin subunits after their
            cleavage by MPP.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732541.11.
            
            On Nov 17, 2006 this sequence version replaced NM_173180.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004549.1, AK167975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AL732541.11        136893-136977       c
            86-288              AL732541.11        136187-136389       c
            289-368             AL732541.11        136015-136094       c
            369-451             AL732541.11        135748-135830       c
            452-546             AL732541.11        135147-135241       c
            547-647             AL732541.11        134359-134459       c
            648-911             AL732541.11        133650-133913       c
            912-1004            AL732541.11        133327-133419       c
            1005-1123           AL732541.11        133121-133239       c
            1124-1214           AL732541.11        132938-133028       c
            1215-1277           AL732541.11        132745-132807       c
            1278-1422           AL732541.11        131156-131300       c
            1423-3125           AL732541.11        129204-130906       c
FEATURES             Location/Qualifiers
     source          1..3125
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 18.88 cM"
     gene            1..3125
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /note="peptidase (mitochondrial processing) alpha"
                     /db_xref="GeneID:66865"
                     /db_xref="MGI:MGI:1918568"
     exon            1..85
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /inference="alignment:Splign:2.1.0"
     exon            86..288
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /inference="alignment:Splign:2.1.0"
     exon            289..368
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /inference="alignment:Splign:2.1.0"
     exon            369..451
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /inference="alignment:Splign:2.1.0"
     exon            452..546
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /inference="alignment:Splign:2.1.0"
     exon            547..647
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /inference="alignment:Splign:2.1.0"
     exon            648..911
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1004
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1123
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1214
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1277
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1422
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..3125
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1706..1711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /note="hexamer: AATGAA"
     polyA_site      1730
                     /gene="Pmpca"
                     /gene_synonym="1200002L24Rik; 4933435E07Rik; Alpha-MPP;
                     P-55"
                     /note="major polyA site"
ORIGIN      
        1 agaagcgcgg cggcgcgatg gcgacggcag tgtgggcggc tgcgcggctg cttcggggat
       61 ctgcggtgct gtgcgcgcgg cccaggtttg gatctcctgc acacagacgg ttcagcagtg
      121 gtgccaccta ccccaacatc cccctctctt ctcccttgcc tggagtaccc aagcctattt
      181 ttgcaacagt tgatggacag gaaaagtttg aaaccaaagt taccactctg gacaatgggc
      241 ttcgtgtggc atctcaaaat aagtttggac aattctgtac cgtaggaatt cttattaatt
      301 caggatcacg atatgaagcg aaatatctta gtggaatagc tcattttttg gaaaaattgg
      361 cattttcgtc cactgctcga tttgacagca aagacgaaat cctgcttacg ctggaaaaac
      421 atggtggtat ctgtgactgc cagacctcaa gagacaccac catgtatgct gtgtctgctg
      481 acagcaaagg cttggacact gtggtggatc tgttggctga tgtggttctg cacccccgac
      541 tgacagatga agaaattgag atgacgagga tggctgtgca gtttgaacta gaggacctga
      601 acatgagacc tgacccagag ccactgctca ccgagatgat tcatgaagct gcttttaggg
      661 agaacacagt gggtctgcac cggttctgcc ctgtagagaa catagcgaag atcgatcggg
      721 aagtgctgca ctcctaccta aagaactact acacccctga ccgcatggtg cttgctgggg
      781 tgggcgtgga gcatgagcac ctagtagaat gtgccagaaa gtacctcgtg ggagccgagc
      841 ctgcctgggg agcccctgga acggtggacg ttgacagatc agtggcacag tacactgggg
      901 ggatcatcaa ggtggaaaga gacatgtcaa atgtcagcct tggcccaacc ccaattccag
      961 agctcacaca catcatggtg ggactggaga gctgttcctt cctggaggac gacttcatcc
     1021 cctttgctgt gctgaatatg atgatgggag gagggggctc cttctcagct ggagggcctg
     1081 gcaaaggcat gttctccagg ctctacctca atgtgctcaa tcggcaccac tggatgtaca
     1141 atgcaacctc ctaccaccac agctatgaag atacaggcct cctgtgcatt catgccagcg
     1201 cagacccaag acaagttcga gaaatggtag aaatcatcac aaaggagttt atcttgatgg
     1261 gcaggacggt ggatttggtg gagctagagc gggccaagac acagctcatg tccatgctca
     1321 tgatgaacct ggagtccagg cctgtgattt ttgaggatgt ggggaggcag gtgttggcta
     1381 cacattcaag aaagctgccc cacgagctat gtacactcat tcgcaacgtg aagccagaag
     1441 atatcaagag ggttgcttcc aagatgctcc gtggcaagcc tgctgtggct gccctgggtg
     1501 atttgactga cctacccacc tatgagcaca tccaggcagc gctgtccagc agaaatggac
     1561 acctgcccag atcataccgg ctgttccggt agagtccctt agagctggct gtagagtgct
     1621 tgtgtgcatg ttactgttgg tgtagacact gcataaggct agctagctgt gtgaacagtg
     1681 ccaacagtga aactctggaa acttgaatga aagttactgt tgccactgca cttttgtgtc
     1741 tttcaaacac aagtggctta tttttcatct aacaagtatt tttcctgagt atctgccaaa
     1801 gcaggtgctg tctggccact agatgtttct ggagcaagga aggctgggaa agattagaaa
     1861 gtcttgggac tctagggaga caaagcgcca cactctgaaa gcacacaggg cctacccatt
     1921 ggtagaacca ctggcataaa ttgtactcat ttttttcccc ttcaaatagg atctcacagt
     1981 aaaaccctga gtggcttgag acttgatata agatatactc atctcaaact cagagaccct
     2041 cctgcctctg cctcccaggt gctaaaatta taggcaagtg ctaccacacc tggcctcatt
     2101 tctaaagctt aagttcttta acaagcctaa aggtatttca caatcttctc ctttgttttt
     2161 tgagataaaa tactaattag ccctggctgg cctcacagtg agcttgtctt tgcctcagtt
     2221 actggtcttt ctagtaagag tcaccatgcc agttgtatct cacaattatt tacaagtcca
     2281 gttttaattt cccacttcat ctgcactagt ttacgtgttt aacttttcca actgaaatgc
     2341 cctctaaatg taaaggctat ctaaatgtaa attgctatgg ctgtactttg ccccccgacc
     2401 cctaagactt tatgatcttg atcttgggcc aaactgggaa gttccaggat tacctcagtc
     2461 ttttctaagg tgccagagaa tgtccacaaa gaagcaccaa actgctgggc tgtggtagtg
     2521 cacgccttta atcccagcat tcaggaggca gaagcaggtg gttctccaag ttcgaggcca
     2581 gcctggtcta cagagagttc caggacagcc ggggctacag agaaacctgt ctggaactct
     2641 taccacatca aaccttattc aagccaggaa tagttgaggc aggattatga agtccagggc
     2701 agcctgtctg ggagagaaaa ggctgtcttc ccagtagaat ttgcagttca cagtggttta
     2761 ttgaagcagg tgactttcca tattggagaa gctgatgctg ttgagtttca ccttattcgt
     2821 tggtttatta tggttcactg gagtcccaag tcgtcacttt ttccagctat tgctgcttct
     2881 ggctgtgagc agggacagta cctagcagaa agacctggga tgggactgag tagcaggtga
     2941 cagctgagac caaatgtttg gcctttgact tctatgtcct tttaaaaccc tggggtgtcc
     3001 tgaggcccca agatgcatgc agacttcttc caaggttcac tctttggcca gaaagagttt
     3061 acaattgaat atatccttat ttatttaaaa atataaatat ggaaaaataa atgatttaga
     3121 agact
//
