LOCUS       NM_001030305            1364 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus peripheral myelin protein 2 (Pmp2), mRNA.
ACCESSION   NM_001030305
VERSION     NM_001030305.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1364)
  AUTHORS   Hong,J., Garfolo,R., Kabre,S., Humml,C., Velanac,V., Roue,C.,
            Beck,B., Jeanette,H., Haslam,S., Bach,M., Arora,S., Acheta,J.,
            Nave,K.A., Schwab,M.H., Jourd'heuil,D., Poitelon,Y. and Belin,S.
  TITLE     PMP2 regulates myelin thickening and ATP production during
            remyelination
  JOURNAL   Glia 72 (5), 885-898 (2024)
   PUBMED   38311982
  REMARK    GeneRIF: PMP2 regulates myelin thickening and ATP production during
            remyelination.
REFERENCE   2  (bases 1 to 1364)
  AUTHORS   Stettner,M., Zenker,J., Klingler,F., Szepanowski,F., Hartung,H.P.,
            Mausberg,A.K., Kleinschnitz,C., Chrast,R. and Kieseier,B.C.
  TITLE     The Role of Peripheral Myelin Protein 2 in Remyelination
  JOURNAL   Cell Mol Neurobiol 38 (2), 487-496 (2018)
   PUBMED   28447247
  REMARK    GeneRIF: In a sciatic nerve crush model, temporal structural and
            functional changes were found in P2 knock-out animals as compared
            to wild-type.
REFERENCE   3  (bases 1 to 1364)
  AUTHORS   Moruzzo,D., Nobbio,L., Sterlini,B., Consalez,G.G., Benfenati,F.,
            Schenone,A. and Corradi,A.
  TITLE     The Transcription Factors EBF1 and EBF2 Are Positive Regulators of
            Myelination in Schwann Cells
  JOURNAL   Mol Neurobiol 54 (10), 8117-8127 (2017)
   PUBMED   27889898
REFERENCE   4  (bases 1 to 1364)
  AUTHORS   Islam,A., Kagawa,Y., Sharifi,K., Ebrahimi,M., Miyazaki,H.,
            Yasumoto,Y., Kawamura,S., Yamamoto,Y., Sakaguti,S., Sawada,T.,
            Tokuda,N., Sugino,N., Suzuki,R. and Owada,Y.
  TITLE     Fatty Acid Binding Protein 3 Is Involved in n-3 and n-6 PUFA
            transport in mouse trophoblasts
  JOURNAL   J Nutr 144 (10), 1509-1516 (2014)
   PUBMED   25122651
REFERENCE   5  (bases 1 to 1364)
  AUTHORS   Zenker,J., Stettner,M., Ruskamo,S., Domenech-Estevez,E., Baloui,H.,
            Medard,J.J., Verheijen,M.H., Brouwers,J.F., Kursula,P.,
            Kieseier,B.C. and Chrast,R.
  TITLE     A role of peripheral myelin protein 2 in lipid homeostasis of
            myelinating Schwann cells
  JOURNAL   Glia 62 (9), 1502-1512 (2014)
   PUBMED   24849898
  REMARK    GeneRIF: Study results, together with observations that Pmp2 binds
            and transports fatty acids to membranes, uncover a role for Pmp2 in
            lipid homeostasis of myelinating Schwann cells
REFERENCE   6  (bases 1 to 1364)
  AUTHORS   Suresh,S., Wang,C., Nanekar,R., Kursula,P. and Edwardson,J.M.
  TITLE     Myelin basic protein and myelin protein 2 act synergistically to
            cause stacking of lipid bilayers
  JOURNAL   Biochemistry 49 (16), 3456-3463 (2010)
   PUBMED   20334434
REFERENCE   7  (bases 1 to 1364)
  AUTHORS   Narayanan,V., Kaestner,K.H. and Tennekoon,G.I.
  TITLE     Structure of the mouse myelin P2 protein gene
  JOURNAL   J Neurochem 57 (1), 75-80 (1991)
   PUBMED   1711100
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC113990.10.
            
            On Nov 17, 2006 this sequence version replaced NM_001030305.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099520.1, CK795905.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC113990.10        142519-142657       c
            140-312             AC113990.10        141154-141326       c
            313-414             AC113990.10        140893-140994       c
            415-1364            AC113990.10        138623-139572       c
FEATURES             Location/Qualifiers
     source          1..1364
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 2.54 cM"
     gene            1..1364
                     /gene="Pmp2"
                     /gene_synonym="P2"
                     /note="peripheral myelin protein 2"
                     /db_xref="GeneID:18857"
                     /db_xref="MGI:MGI:102667"
     exon            1..139
                     /gene="Pmp2"
                     /gene_synonym="P2"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..465
                     /gene="Pmp2"
                     /gene_synonym="P2"
                     /codon_start=1
                     /product="myelin P2 protein"
                     /protein_id="NP_001025476.1"
                     /db_xref="CCDS:CCDS17236.1"
                     /db_xref="GeneID:18857"
                     /db_xref="MGI:MGI:102667"
                     /translation="MSNKFLGTWKLVSSEHFDDYMKALGVGLANRKLGNLAKPTVIIS
                     KKGDYITIRTESAFKNTEISFKLGQEFDETTADNRKAKSIVTLERGSLKQVQKWDGKE
                     TAIRRTLLDGRMVVECIMKGVVCTRIYEKV"
     exon            140..312
                     /gene="Pmp2"
                     /gene_synonym="P2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..414
                     /gene="Pmp2"
                     /gene_synonym="P2"
                     /inference="alignment:Splign:2.1.0"
     exon            415..1364
                     /gene="Pmp2"
                     /gene_synonym="P2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1342..1347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pmp2"
                     /gene_synonym="P2"
                     /note="hexamer: AATAAA"
     polyA_site      1364
                     /gene="Pmp2"
                     /gene_synonym="P2"
                     /note="major polyA site"
ORIGIN      
        1 ctcatcatct cccaggcatc tgctgcatcc caccaggaac tctactgaac tctctcatct
       61 gtcacaatga gcaacaaatt cctaggcacc tggaagcttg tctccagtga gcacttcgat
      121 gactacatga aagctctagg tgtggggtta gccaacagaa aactgggaaa cttggccaag
      181 cctactgtga tcatcagcaa aaagggggat tatatcacca ttagaacgga aagtgccttt
      241 aaaaatacag agatctcctt caagttgggc caggagtttg atgaaaccac agctgacaac
      301 agaaaagcca agagcatcgt gacactggag agaggctccc tgaagcaagt gcagaagtgg
      361 gatgggaaag agacagccat aaggagaacg ctgctggatg ggagaatggt agtggagtgt
      421 ataatgaagg gtgtggtctg caccagaatt tatgagaaag tctgagaaaa accattggat
      481 catccaaatg atgtttgcta atccaagact ggaaatattc agcatgtcct gaattctctg
      541 tagctggctt gtctggtttc ttctgcactc gtcatactat gttctatagt aaaggtttaa
      601 atgaggatta atctaaaata ttaatttaga tattttccat tttcacccat gtctttacca
      661 tgttaatcct tctgtatgga ctagacaaca gacatcccat aaaaatcttt ggtgcaaagt
      721 gacagcctag gctgtgctca ttctgattta aataatgata agaaggtaag agctttgttc
      781 tgggcagaca gaagtgcctg ggggcctgga cagttcggag gcaggggaat cttaaagaaa
      841 acaaagcaag aggatgagtc gctctaacgg gggtggggtt ccttgtttca gccaacagga
      901 gcagcctcta ttccacttgg ccaaagtttt gtaatgcaca aacagtatga tgcacagctg
      961 ttacagccac taagcatgtt gacaggtgcg tgttcctatg tgcctgccca tcccacctga
     1021 ggcaaacatg gttcctccat cttagcaggc ttcctcatct cactccccag gtaatatcaa
     1081 tccaccagaa gcaaggatgg ttttgatttg gtcctagacg agctttgctt aaaatcgcac
     1141 cagacctcct gtattcattt ctttttacct tttaaaactt agcactatgg ttttcaggtt
     1201 tatccaggtt atcgcatgca gtagtaattt gtttcttttt atcgctgagt attattccat
     1261 tgtataactg catcattata gttatccatc tttctagaca atctgagaca attgggttat
     1321 aaccagtgtt tgtatatgat gaataaagct gctacgttct tgta
//
