LOCUS       NM_013872               1316 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus phosphomannomutase 1 (Pmm1), transcript variant 1,
            mRNA.
ACCESSION   NM_013872
VERSION     NM_013872.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1316)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   2  (bases 1 to 1316)
  AUTHORS   Cano,M. and Ilundain,A.A.
  TITLE     Ontogeny of D-mannose transport and metabolism in rat small
            intestine
  JOURNAL   J Membr Biol 235 (2), 101-108 (2010)
   PUBMED   20523973
  REMARK    GeneRIF: Pmm1 activity in jejunum increased during the early stages
            of life, and it decreased at 1 month old, as does the amount of
            mannose incorporated into glycoproteins, whereas in the ileum, they
            were not affected by age.
REFERENCE   3  (bases 1 to 1316)
  AUTHORS   Veiga-da-Cunha,M., Vleugels,W., Maliekal,P., Matthijs,G. and Van
            Schaftingen,E.
  TITLE     Mammalian phosphomannomutase PMM1 is the brain IMP-sensitive
            glucose-1,6-bisphosphatase
  JOURNAL   J Biol Chem 283 (49), 33988-33993 (2008)
   PUBMED   18927083
  REMARK    GeneRIF: PMM1 is responsible for the degradation of Glc-1,6-P(2) in
            brain
REFERENCE   4  (bases 1 to 1316)
  AUTHORS   Cromphout,K., Vleugels,W., Heykants,L., Schollen,E., Keldermans,L.,
            Sciot,R., D'Hooge,R., De Deyn,P.P., von Figura,K., Hartmann,D.,
            Korner,C. and Matthijs,G.
  TITLE     The normal phenotype of Pmm1-deficient mice suggests that Pmm1 is
            not essential for normal mouse development
  JOURNAL   Mol Cell Biol 26 (15), 5621-5635 (2006)
   PUBMED   16847318
  REMARK    GeneRIF: The normal phenotype of Pmm1-deficient mice suggests that
            Pmm1 is not essential for normal mouse development.
REFERENCE   5  (bases 1 to 1316)
  AUTHORS   Cromphout,K., Keldermans,L., Snellinx,A., Collet,J.F.,
            Grunewald,S., De Geest,N., Sciot,R., Vanschaftingen,E., Jaeken,J.,
            Matthijs,G. and Hartmann,D.
  TITLE     Tissue distribution of the murine phosphomannomutases Pmm1 and Pmm2
            during brain development
  JOURNAL   Eur J Neurosci 22 (4), 991-996 (2005)
   PUBMED   16115222
  REMARK    GeneRIF: Pmm1 immunoreactivity seen in prenatal brain until
            postnatal and adult stage and restricted in neuronal cell bodies.
REFERENCE   6  (bases 1 to 1316)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 1316)
  AUTHORS   Kannan,K., Kaminski,N., Rechavi,G., Jakob-Hirsch,J., Amariglio,N.
            and Givol,D.
  TITLE     DNA microarray analysis of genes involved in p53 mediated
            apoptosis: activation of Apaf-1
  JOURNAL   Oncogene 20 (26), 3449-3455 (2001)
   PUBMED   11423996
REFERENCE   8  (bases 1 to 1316)
  AUTHORS   Heykants,L., Schollen,E., Grunewald,S. and Matthijs,G.
  TITLE     Identification and localization of two mouse phosphomannomutase
            genes, Pmm1 and Pmm2
  JOURNAL   Gene 270 (1-2), 53-59 (2001)
   PUBMED   11404002
REFERENCE   9  (bases 1 to 1316)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 1316)
  AUTHORS   Siu,G., Hedrick,S.M. and Brian,A.A.
  TITLE     Isolation of the murine intercellular adhesion molecule 1 (ICAM-1)
            gene. ICAM-1 enhances antigen-specific T cell activation
  JOURNAL   J Immunol 143 (11), 3813-3820 (1989)
   PUBMED   2479693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX217041.1, AK166999.1 and BI731755.1.
            
            On Aug 15, 2013 this sequence version replaced NM_013872.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004631.1, AK166999.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                CX217041.1         1-67
            68-1293             AK166999.1         3-1228
            1294-1316           BI731755.1         252-274
FEATURES             Location/Qualifiers
     source          1..1316
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.3 cM"
     gene            1..1316
                     /gene="Pmm1"
                     /note="phosphomannomutase 1"
                     /db_xref="GeneID:29858"
                     /db_xref="MGI:MGI:1353418"
     exon            1..216
                     /gene="Pmm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..918
                     /gene="Pmm1"
                     /EC_number="5.4.2.8"
                     /note="isoform 1 is encoded by transcript variant 1; PMM
                     1; Secp53 homolog"
                     /codon_start=1
                     /product="phosphomannomutase 1 isoform 1"
                     /protein_id="NP_038900.1"
                     /db_xref="CCDS:CCDS27678.1"
                     /db_xref="GeneID:29858"
                     /db_xref="MGI:MGI:1353418"
                     /translation="MAVAVEGARRKERILCLFDVDGTLTPARQKIDPEVSAFLQKLRS
                     RVQIGVVGGSDYSKIAEQLGEGDEVIEKFDYVFAENGTVQYKHGRLLSKQTIQNHLGE
                     ELLQDLINFCLSYMALLRLPKKRGTFIEFRNGMLNVSPIGRSCTLEERIEFSELDKKE
                     KIREKFVEALKTEFAGKGLRFSRGGMISFDVFPEGWDKRYCLDSLDEDSFDIIHFFGN
                     ETSPGGNDFEIYADPRTVGHSVVSPQDTVQRCRELFFPETAHEA"
     exon            217..334
                     /gene="Pmm1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..411
                     /gene="Pmm1"
                     /inference="alignment:Splign:2.1.0"
     exon            412..503
                     /gene="Pmm1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..603
                     /gene="Pmm1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..679
                     /gene="Pmm1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..795
                     /gene="Pmm1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1302
                     /gene="Pmm1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1282..1287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pmm1"
                     /note="hexamer: ATTAAA"
     polyA_site      1300
                     /gene="Pmm1"
                     /note="major polyA site"
ORIGIN      
        1 gggagggccg atggccactg ctcctccccg tgctgcgcag ctggccccgc cccggccccg
       61 cccggcctct gtcgcacgcg accctggcgg tggctgcagc gacagcgctt ggcgcgcgga
      121 gctacagcca tggcagtcgc cgtcgagggc gcccgcagga aagagcgcat cctctgcctg
      181 tttgacgtgg acgggaccct cacgccagct cgccagaaaa ttgaccctga ggtatcggcc
      241 ttcctgcaga agctacgaag cagggtacag atcggcgtgg tgggtggctc tgactactct
      301 aagatcgccg agcagctggg agagggggat gaagtcattg agaagtttga ctacgtgttt
      361 gctgagaatg ggacagtgca gtataaacac ggacggctac tctccaaaca gacgatccag
      421 aaccacctgg gggaggagct cctgcaggac ttgatcaact tctgccttag ctacatggcc
      481 ctgctcagac tgcccaagaa gcgtgggacc ttcattgagt tccggaatgg catgctgaac
      541 gtctcgccca ttggccgcag ctgcaccctg gaggagagga tcgagttctc ggaactggac
      601 aagaaggaga agatccggga gaagtttgtg gaagccttga agacagagtt tgctggcaag
      661 gggctgcggt tctcccgagg aggcatgata agcttcgatg tcttccccga gggctgggat
      721 aagcgctact gcctggacag cctggatgaa gacagctttg acatcatcca cttctttgga
      781 aatgagacca gtcctggcgg gaatgacttt gagatctatg cggacccccg gactgtcggc
      841 catagcgtgg tctcccctca ggacactgta cagcgatgcc gtgagctctt cttcccagag
      901 acagcccacg aggcgtgact gggcccacag ctgagcactg ggaccttcaa agagctctga
      961 ccaggcctga agatagaacc attgggtgcc acggttccca tcccactggc ccaacacgta
     1021 gcatcctgtg ggggcactgc agggtcaccc acacaggacc aacgtctgtg tgggaactgt
     1081 ccccagccag gtggctcctg acgagacgca tacctgctct ctaccctgat ggtcctggcc
     1141 tctgatgctg ctggttttgg ggacagaaca ggtctcacca cagggtggca tgggagttgt
     1201 gctatggagc ctgctggcca cagactgaca agggacagaa tggcagagaa ggggcattac
     1261 ttaaaggact ctgtcacaga tattaaagtt cccaagacaa ggaaaaaaaa aaaaaa
//
