LOCUS       NM_178087               5378 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus promyelocytic leukemia (Pml), transcript variant 2,
            mRNA.
ACCESSION   NM_178087
VERSION     NM_178087.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5378)
  AUTHORS   Wani S, Daroszewska A, Salter DM, van 't Hof RJ, Ralston SH and
            Albagha OME.
  TITLE     The Paget's disease of bone risk gene PML is a negative regulator
            of osteoclast differentiation and bone resorption
  JOURNAL   Dis Model Mech 15 (4) (2022)
   PUBMED   35229101
REFERENCE   2  (bases 1 to 5378)
  AUTHORS   Chen IT, Chen HC, Lo YH, Lai PY, Hsieh FY, Wu YH, Shih HM and Lai
            MZ.
  TITLE     Promyelocytic leukemia protein targets MK2 to promote cytotoxicity
  JOURNAL   EMBO Rep 22 (12), e52254 (2021)
   PUBMED   34633746
REFERENCE   3  (bases 1 to 5378)
  AUTHORS   Kon N, Churchill M, Li H, Mukherjee S, Manfredi JJ and Gu W.
  TITLE     Robust p53 Stabilization Is Dispensable for Its Activation and
            Tumor Suppressor Function
  JOURNAL   Cancer Res 81 (4), 935-944 (2021)
   PUBMED   33323382
REFERENCE   4  (bases 1 to 5378)
  AUTHORS   Chiang SY, Wu HC, Lin SY, Chen HY, Wang CF, Yeh NH, Shih JH, Huang
            YS, Kuo HC, Chou SJ and Chen RH.
  TITLE     Usp11 controls cortical neurogenesis and neuronal migration through
            Sox11 stabilization
  JOURNAL   Sci Adv 7 (7) (2021)
   PUBMED   33579706
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5378)
  AUTHORS   Dagher T, Maslah N, Edmond V, Cassinat B, Vainchenker W, Giraudier
            S, Pasquier F, Verger E, Niwa-Kawakita M, Lallemand-Breitenbach V,
            Plo I, Kiladjian JJ, Villeval JL and de The H.
  TITLE     JAK2V617F myeloproliferative neoplasm eradication by a novel
            interferon/arsenic therapy involves PML
  JOURNAL   J Exp Med 218 (2) (2021)
   PUBMED   33075130
  REMARK    GeneRIF: JAK2V617F myeloproliferative neoplasm eradication by a
            novel interferon/arsenic therapy involves PML.
REFERENCE   6  (bases 1 to 5378)
  AUTHORS   Chu CC and Paul WE.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
REFERENCE   7  (bases 1 to 5378)
  AUTHORS   Wang ZG, Delva L, Gaboli M, Rivi R, Giorgio M, Cordon-Cardo C,
            Grosveld F and Pandolfi PP.
  TITLE     Role of PML in cell growth and the retinoic acid pathway
  JOURNAL   Science 279 (5356), 1547-1551 (1998)
   PUBMED   9488655
REFERENCE   8  (bases 1 to 5378)
  AUTHORS   He LZ, Tribioli C, Rivi R, Peruzzi D, Pelicci PG, Soares V,
            Cattoretti G and Pandolfi PP.
  TITLE     Acute leukemia with promyelocytic features in PML/RARalpha
            transgenic mice
  JOURNAL   Proc Natl Acad Sci U S A 94 (10), 5302-5307 (1997)
   PUBMED   9144232
REFERENCE   9  (bases 1 to 5378)
  AUTHORS   Early E, Moore MA, Kakizuka A, Nason-Burchenal K, Martin P, Evans
            RM and Dmitrovsky E.
  TITLE     Transgenic expression of PML/RARalpha impairs myelopoiesis
  JOURNAL   Proc Natl Acad Sci U S A 93 (15), 7900-7904 (1996)
   PUBMED   8755574
REFERENCE   10 (bases 1 to 5378)
  AUTHORS   Goddard AD, Yuan JQ, Fairbairn L, Dexter M, Borrow J, Kozak C and
            Solomon E.
  TITLE     Cloning of the murine homolog of the leukemia-associated PML gene
  JOURNAL   Mamm Genome 6 (10), 732-737 (1995)
   PUBMED   8563172
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028044.1, BB659153.1, U33626.2, AK032799.1, AK137538.1,
            AC160976.2 and BG228200.1.
            
            [WARNING] On Jan 18, 2024 this sequence was replaced by
            NM_178087.5.
            
            On Nov 15, 2007 this sequence version replaced NM_178087.3.
            
            Transcript Variant: This variant (2) represents the longest
            transcript and it encodes the longest protein (isoform 2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028044.1, KJ650238.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AK028044.1         3-7
            6-246               BB659153.1         2-242
            247-1120            U33626.2           144-1017
            1121-3228           AK032799.1         1-2108
            3229-3508           AK137538.1         3172-3451
            3509-4471           AK137538.1         3453-4415
            4472-5053           AC160976.2         115435-116016
            5054-5378           BG228200.1         1-325               c
FEATURES             Location/Qualifiers
     source          1..5378
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.63 cM"
     gene            1..5378
                     /gene="Pml"
                     /gene_synonym="1200009E24Rik; Trim19"
                     /note="promyelocytic leukemia"
                     /db_xref="GeneID:18854"
                     /db_xref="MGI:MGI:104662"
     exon            1..246
                     /gene="Pml"
                     /gene_synonym="1200009E24Rik; Trim19"
                     /inference="alignment:Splign:2.1.0"
     exon            247..710
                     /gene="Pml"
                     /gene_synonym="1200009E24Rik; Trim19"
                     /inference="alignment:Splign:2.1.0"
     exon            711..1291
                     /gene="Pml"
                     /gene_synonym="1200009E24Rik; Trim19"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1386
                     /gene="Pml"
                     /gene_synonym="1200009E24Rik; Trim19"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1524
                     /gene="Pml"
                     /gene_synonym="1200009E24Rik; Trim19"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1783
                     /gene="Pml"
                     /gene_synonym="1200009E24Rik; Trim19"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1836
                     /gene="Pml"
                     /gene_synonym="1200009E24Rik; Trim19"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1987
                     /gene="Pml"
                     /gene_synonym="1200009E24Rik; Trim19"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..5378
                     /gene="Pml"
                     /gene_synonym="1200009E24Rik; Trim19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctctcggga ggcgggctct cctcgggcaa tctctcgctc agttttctgg ctcagatctg
       61 agacccattt cccgccttca cagacctaat caagaaatgg aaactgaacc agtttccgtg
      121 cagaaggtac ctgcaccccc tggatctccc tgtcgacaac aggactctgc cctgaccccc
      181 acgcccacca tgcctccccc agaggaaccc tccgaagact atgaacacag ccaaagccct
      241 gcagagcaag ccatacagga ggaatttcag tttctgcgct gcccgagctg ccaggcccaa
      301 gccaagtgcc ccaaactgct gccttgcctg cacacgctgt gctccggatg cctggaggcg
      361 cctggcctgc agtgccccat ctgcaaggct cctgggcagg ccgatgctaa tggggaggcc
      421 ctggataacg tgttcttcga gagcctgcag cggcgcctgg cggtgttccg gcagatcgtg
      481 gatgctcagg ctgcgtgcac ccgctgcaaa ggcttggccg acttctggtg tttcgagtgt
      541 gaacagctca tttgcagcaa gtgcttcgaa gcacaccagt ggtacctcaa gcatgaggcc
      601 cggcccctgg ctgatctccg cgacaattca gtgagcagct tcctcgacag tacgcgcaag
      661 tccaatatct tctgctccaa taccaaccac cgcaaccctg cgctgactga catctactgc
      721 cgaggctgcg ccaagcctct gtgttgcaca tgcgcgctcc tggaccgcaa ccacagccat
      781 ctccattgcg atattggtga ggagattcag cagtggcatg aggaactagg caccatgaca
      841 cagactctgg aggagcaggg cagaaccttc gacagtgccc atgcacagat gtgctcagct
      901 ataggacagc tggaccacgc acgcgcagac attgagaagc agatccgcgc acgcgtgcgc
      961 caggtggtag actacgtgca ggctcaggag cgcgagctgc tcgaggcggt gaatgaccgc
     1021 taccagcgcg actaccagga aatagctggc cagctgagct gcctggaagc tgtgctgcag
     1081 cgcatccgca ctagtggggc gctggtcaag aggatgaagc tctatgcctc cgaccaggag
     1141 gtgctggata tgcacagctt tctgcgcaag gcactctgta gcttgcgcca ggaggagccc
     1201 cagaaccaga aagtccagct gctcaccaga ggtttcgagg agttcaagct gtgcctgcag
     1261 gacttcatct cctgcatcac ccagaggata aatgcagctg tagccagccc agaggcagcc
     1321 agcaatcaac cagaggcagc cagcactcac ccagtgacaa ccagcacgcc tgaggacctt
     1381 gagcagccca aagaagtgca gagtgtacag gctcaggccc tagagctgtc taagacccaa
     1441 cctgtggcta tggtaaaaac agtgcctgga gcacaccctg taccagtgta tgccttttca
     1501 atgcaaggcc ccacctacag agaggaggct tctcagacag tcggctccat gaagaggaag
     1561 tgctcccacg aagattgctc caggaagatc atcaagatgg agtccacaga ggagaacgag
     1621 gacaggttgg ccacaagctc ccccgagcag tcctggccca gcactttcaa ggccacctcc
     1681 cctccccatc tggatgggac ttccaaccct gagagcaccg tccctgaaaa aaagatcctc
     1741 ctgcccaaca acaatcatgt taccagtgac acaggggaaa cagaggagcg agttgtggtg
     1801 atcagcagct cagaggattc ggacaccgag aatctgtcct cccacgagtt ggacgatagc
     1861 agcagtgagt ccagcagcct gcagctggag ggccccaatt ccctcaaggc cttggatgag
     1921 agcctcgccg aaccccactt agaagacagg accctggttt tctttgacct caagattgac
     1981 aatgaaaccc agaaaattag ccagctggcc gcggtgaacc gggaaagcaa gttccgtgtg
     2041 ctcatccagc ccgaggcctt cagtgtctac tccaaagctg tctccctgga ggcggggctc
     2101 cggcacttcc tcagcttcct caccaccatg caccgtccca tcttggcgtg ttctaggctg
     2161 tgggggccgg gactccccat cttcttccag accctgagtg atattaacaa gctgtgggaa
     2221 ttccaggaca ccatctcagg tttcttggcc gtgctgcccc tcatccggga acgcataccc
     2281 ggcgctagca gcttcaaact tgggaaccta gccaagacct acctggcgag aaacatgagc
     2341 gaacgcagcg ctctggcttc tgtgctggcc atgagggact tgtgctgcct ccttgagatc
     2401 tccccaggac tgccgctggc ccagcatatc tactccttta gtagcttgca gtgttttgct
     2461 tccctgcagc ccctaattca ggccagcgtc ctgccacagt ccgaggcccg cctcttggcc
     2521 ctccacaatg tgagctttgt agagttactg aatgcatatc gcaccaacag gcaagaaggc
     2581 ttgaagaagt atgtccacta tctgagcctg cagaccaccc cgttgtcatc gtcggcttcc
     2641 acccaagttg cccaattcct gcaggctctt agcacccaca tggaaggact gttggaaggc
     2701 catgcccctg ctggggcaga aggcaaagct gaaagtaagg gatgcctggc ctagcggctc
     2761 ggcacagagg gaggggcatc cctgagctaa tccccaccct ccagtacatt cctaggtcct
     2821 ggtcatttag ttcagaacag gtgtcctttc tctgtgacca aacttacttt ctctaaaatt
     2881 cctgcagcag acaccagagg caccccagac ctagacctcc cttctaaaag ccagaaccag
     2941 gaaggcttgc ataaagaagg tgtggcctct gagctctcaa gggccccagt tgccaccaac
     3001 caccaccaca ggtggcctta tggctcttcc tggatgttcg attcatgtaa gtgacctacc
     3061 tgctgatgat ccacaaataa tactttaggg tggcactgac cgctatacca gcagccccat
     3121 gagcactcaa agtgcctttc gaaccataat gccatcttga atttgggtcc tctcggcccc
     3181 aactgaccag aggccaactg tgttcacatt tatttttctt aaagtacttt tgttccaaag
     3241 gggccttgtg gcgccagaga gctaggaact gtggctccgt ccatacccgt ttccacacac
     3301 tgacccttca gagttggttc tttgtttatc aggcctcctg accctccctg cacttagccc
     3361 ttccaaggga catccagtgg agcactggca tctcgagctt gggaaggtct ttagaattag
     3421 gctctctgga gcagggcctg tagtgttaac aagttctctg ggtggttcta ttctgagcac
     3481 ccctgttgcc tctgacgacc ccccccccac caaagggaag cagagaagcc cctggccatg
     3541 cacattgagt atgatgagca aaaggccaga actccagtgt cctgtgagat tggctgaccc
     3601 gagcgaggta ttatctcggt cttcagccgc tggagtttca gggctgggca gcaggttact
     3661 ggagaggcag gcaagaagcg tccttacctt ctctcattcc ccagctctca ttctgagcct
     3721 ttggtccctg accttatggc catcttggag gtcagttgtt ccctgtggtt gactgaactg
     3781 ctgttgctgt ccacattcca ccctgaccca ttccctgctt gcgcctaggg tgttttccag
     3841 atagcccaga gttccagctt tgacagcctg atgacctcca ttttcatatg aatgatgcct
     3901 gcacccccac acctctgact catcctatgg gtgttccaag gcacccaatg ctccaccctt
     3961 taatacagtt tcttatggtt gttgtgaccc ccaaccataa aatcattttg ttgctatttc
     4021 atgtctgtaa ttttgctagt tcatgaactg taatgtaaac atctggtatg aagaatatct
     4081 gatatgcgac tcctatgaaa gggtcgtttg accccacccc caaccccaat tgggtcacga
     4141 acaacaggtt gagaactgct gctctaaggc cttctgtaga agtccattcc tatcacagta
     4201 aggctgaact ctgaaaacta tccattagag ctctggttct gggtggggat aaggatggga
     4261 ggagaaaggt tgagaccttg gtctggctgt actggcaacg cggtgctggg cccatgtctc
     4321 ataccttgcc ctcagcctat ccctgaacta aacaggaccc actgagtccc agcctcagca
     4381 ggctgcttgt cttcagttga tggtggatta atgacagaag gaagccccgc ccctcactgc
     4441 tgtcaaagcc ttcagtaaac atgtgaatcc tgaaacccta acattctgat tgcaatctct
     4501 actcatccct ccttccctag aggagccttt gaggagcctc tttcctgggg acaaaaggct
     4561 ctcctagaca tgagtgagca ggtaatcgcc caacttggct ttggggaaag tcagagtctg
     4621 acagagctga gcattgtctc atccagagct aaggacatga gtcctctatt tcaagtaggg
     4681 aaacccaggt ggactttgct caagatggtt cccaaaatga gaggcaccaa cttcaagaat
     4741 tgcctcctag ggggaggcac gagccagaga ccaggacctg caggtccttt gctgctggga
     4801 actctcccat tttcaggttt ctagagctgt cgataaaatc ctgtgaactg agagcgagga
     4861 gcagtgtagg aaattgcaat gtgtggttca tgcattgtct ttgatatcct agacggagct
     4921 cagcttagaa ctttccaagc gccagtgcac agcgttctag ggaatggtgc tccttggctg
     4981 ggtgagctgc caggcaagtt taaatatgct gtgtgtgcca catttttaaa ttttgtcaag
     5041 gtttacccac acacacacca atcaaaacct tattggtctg gaagttggga ttccgttttt
     5101 ggtagatcgt ggtagatctg gtactcctaa ctccctggtc ctcaggcggc tcctctgtaa
     5161 aatgagaaaa tgtatatttt tttacttcat gagatctttg ctggaaatta atgagaaggg
     5221 tcagtgtttg tgacttatgg gcttatttta cagacaagat gagagttacc actctaagaa
     5281 aacaaacagc aagtctcagc aacataacaa gaatacacat tgtgaggcag atgtatatgc
     5341 agcagcacac tcatacatta aataaataaa attggaaa
//
