LOCUS       NM_019938               3398 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus polyamine modulated factor 1 binding protein 1
            (Pmfbp1), mRNA.
ACCESSION   NM_019938
VERSION     NM_019938.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3398)
  AUTHORS   Xu,W., Yao,Z., Li,Y., Wang,K., Kong,S., Wang,Y., Xiang,M., Zhu,F.,
            Wang,F. and Zhang,H.
  TITLE     Loss of PMFBP1 Disturbs Mouse Spermatogenesis by Downregulating
            HDAC3 Expression
  JOURNAL   J Assist Reprod Genet 40 (8), 1865-1879 (2023)
   PUBMED   37423931
  REMARK    GeneRIF: Loss of PMFBP1 Disturbs Mouse Spermatogenesis by
            Downregulating HDAC3 Expression.
REFERENCE   2  (bases 1 to 3398)
  AUTHORS   Zhang,Y., Liu,C., Wu,B., Li,L., Li,W. and Yuan,L.
  TITLE     The missing linker between SUN5 and PMFBP1 in sperm head-tail
            coupling apparatus
  JOURNAL   Nat Commun 12 (1), 4926 (2021)
   PUBMED   34389728
  REMARK    GeneRIF: The missing linker between SUN5 and PMFBP1 in sperm
            head-tail coupling apparatus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3398)
  AUTHORS   Romanov,R.A., Tretiakov,E.O., Kastriti,M.E., Zupancic,M.,
            Haring,M., Korchynska,S., Popadin,K., Benevento,M., Rebernik,P.,
            Lallemend,F., Nishimori,K., Clotman,F., Andrews,W.D.,
            Parnavelas,J.G., Farlik,M., Bock,C., Adameyko,I., Hokfelt,T.,
            Keimpema,E. and Harkany,T.
  TITLE     Molecular design of hypothalamus development
  JOURNAL   Nature 582 (7811), 246-252 (2020)
   PUBMED   32499648
REFERENCE   4  (bases 1 to 3398)
  AUTHORS   Sha,Y.W., Wang,X., Xu,X., Ding,L., Liu,W.S., Li,P., Su,Z.Y.,
            Chen,J., Mei,L.B., Zheng,L.K., Wang,H.L., Kong,S.B., You,M. and
            Wu,J.F.
  TITLE     Biallelic mutations in PMFBP1 cause acephalic spermatozoa
  JOURNAL   Clin Genet 95 (2), 277-286 (2019)
   PUBMED   30298696
  REMARK    GeneRIF: our data indicate that PMFBP1 is necessary for sperm
            morphology in both humans and mice, and that biallelic truncating
            mutations in PMFBP1 cause acephalic spermatozoa
REFERENCE   5  (bases 1 to 3398)
  AUTHORS   Zhu,F., Liu,C., Wang,F., Yang,X., Zhang,J., Wu,H., Zhang,Z., He,X.,
            Zhang,Z., Zhou,P., Wei,Z., Shang,Y., Wang,L., Zhang,R.,
            Ouyang,Y.C., Sun,Q.Y., Cao,Y. and Li,W.
  TITLE     Mutations in PMFBP1 Cause Acephalic Spermatozoa Syndrome
  JOURNAL   Am J Hum Genet 103 (2), 188-199 (2018)
   PUBMED   30032984
  REMARK    GeneRIF: Mutations in PMFBP1 are an important cause of infertility
            in men with acephalic spermatozoa syndrome.
REFERENCE   6  (bases 1 to 3398)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   7  (bases 1 to 3398)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   8  (bases 1 to 3398)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   9  (bases 1 to 3398)
  AUTHORS   Ohuchi,J., Arai,T., Kon,Y., Asano,A., Yamauchi,H. and Watanabe,T.
  TITLE     Characterization of a novel gene, sperm-tail-associated protein
            (Stap), in mouse post-meiotic testicular germ cells
  JOURNAL   Mol Reprod Dev 59 (4), 350-358 (2001)
   PUBMED   11468771
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123838.4 and AC125162.4.
            
            On Jul 31, 2009 this sequence version replaced NM_019938.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB029919.1, BC138246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC123838.4         12220-12300         c
            82-142              AC123838.4         11372-11432         c
            143-298             AC123838.4         6788-6943           c
            299-547             AC125162.4         19016-19264
            548-769             AC125162.4         22227-22448
            770-940             AC125162.4         28659-28829
            941-1051            AC125162.4         29406-29516
            1052-1178           AC125162.4         33570-33696
            1179-1336           AC125162.4         33795-33952
            1337-1577           AC125162.4         36063-36303
            1578-1767           AC125162.4         38635-38824
            1768-1921           AC125162.4         38968-39121
            1922-2089           AC125162.4         40119-40286
            2090-2227           AC125162.4         40546-40683
            2228-2392           AC125162.4         44295-44459
            2393-2560           AC125162.4         45035-45202
            2561-2728           AC125162.4         45520-45687
            2729-2832           AC125162.4         46424-46527
            2833-2907           AC125162.4         47082-47156
            2908-3143           AC125162.4         50122-50357
            3144-3398           AC125162.4         50871-51125
FEATURES             Location/Qualifiers
     source          1..3398
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.05 cM"
     gene            1..3398
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /note="polyamine modulated factor 1 binding protein 1"
                     /db_xref="GeneID:56523"
                     /db_xref="MGI:MGI:1930136"
     exon            1..81
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            82..142
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            143..298
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            299..547
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            548..769
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            770..940
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1051
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1178
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1336
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1577
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1767
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1921
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2089
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2227
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2392
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2560
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2728
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2832
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..2907
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3143
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3398
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3370..3375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /note="hexamer: AATAAA"
     polyA_site      3397
                     /gene="Pmfbp1"
                     /gene_synonym="1700016D22Rik; F77; Stap"
                     /note="major polyA site"
ORIGIN      
        1 gcttatatta gggatggggg atgtagctta tcacaaagaa tgagtatttg gtggcttctc
       61 attcttggaa ccattctgca ggtttacaaa aatgctaaag cttaaaggag aattacgaac
      121 tgccaaggga ctgaagaatg aggctgggga gagagacagg gatgtcagca atctaaacag
      181 caagctcttg agcctacaac tggacatcaa gaatctccac gatgtctgca agaggcaggg
      241 gaagaccttg caagagaacc agctctgcgt ggaggaagcg atgctgaaag ccaaccacaa
      301 caagaagcaa gcccagacgt tagtattcac ggacaaccag atggacttcc gggtcaataa
      361 gcaataccat ctcaggcaac tccagcaact gaagaagaag ctgctgaccc tccagcagga
      421 actggagttc cgtacccagg agctccaggc ttcctactgc tctctcctgc agtaccagtc
      481 gatcctggag aagcagactt ccgaccttct tgttcttcac cgtcactgca aacttaagga
      541 agatgaggtc attctctacg aggaggagat gggaaatcat agtaagagca cgggggagaa
      601 actccatctg gcgcaagagc agcttgcctt ggcgggggac aagatcctct ccctagaaag
      661 gagcctaaac ctctacaggg acaagtacca gacttccctg agcaacatag agttactgga
      721 gtgccaagtg aagatgctgg agggggaact cagcggactc attggtcagg accctgagaa
      781 caaaggagac cacccgaagg ttcgaatcta cacttctccg tgcgtgattc aagagcatca
      841 ggagacccta aagcgactgt ctgaagtctg gcaaaaggtt tctgaacagg atgacctaat
      901 ccaggagctt cggaataaac tggcctgcag caactctttg gtcctggagc gtgaggaggc
      961 gttgataaaa ttacaagctg agtttgcttc ctacacagcc acccaccggc atccccctac
     1021 ctcctcagaa gactgtgaag acatcacaaa gatcctgaag cacctgcaag agcagaaaga
     1081 cagccagtgc ctgcacgtgg aggagtacca gaaccttgtg aaggacctgc gcatggagct
     1141 ggaagctgtg tcagaacaga agaaaaagat catgaaggac atgatgaagc tggagctaga
     1201 tctacatggg ctgcgggaag agacgtcctg cgtcatcgag aagaaggaca aggagactgt
     1261 cttcctgcag taccggctgc aagatctgca gcaacagtac acagagtcac agaagctgtc
     1321 cctgaagaag gacaagttgc tccaagacaa ggatgagagg ctgcacgagc tggagaagaa
     1381 tctgatgcag gtgcagaaca gcctcagaga gaaagaggca gagctggaga agctacagtg
     1441 tacaaccaaa gaactggaca ccagcctcca agaagctagg caaagcacat ccaaaataga
     1501 ctgcgaggcc ctgcgggccg agatccagaa gctcaaggat agcctcgagg aggccaggga
     1561 gcagctgaag gtgtcagatc agaatctaac ccagagtaag gaggaagcgc acctctctgc
     1621 cagcagccta gaggatgctc atcggaaaat cgagaactgc cttctccagg acaagcagaa
     1681 ggaagaggtc attaaggatc tgcagagcca gttgcataag ctacagaagg agtcttcgaa
     1741 aattgaggag gaacgaaaac acaacaggca acggttacag gagctgagct cggaactctc
     1801 tgaaggccag agaaggcttt cgaatgcaga gaaggaaaag tcgctgcttc agaagacact
     1861 ggatgaagac gagaaaaaga tagatgagct atttcacagc acccaagtct ctgagcaaaa
     1921 gcaaagggag ctaacaaact ccataaggaa gctagaggag gaacttctgg agataaaagg
     1981 gctcttggag gagaaacgag agcaactgaa gaagagtaag gaacaggaga aggcactgga
     2041 ggaagagatc gaggctttgc gacaagaagc gaaaaggaaa gagaagatgg cgaaggaaca
     2101 tttgagaaag ctggatgaag agaaggagaa cctgcaggct gagttgacct cccgttcctc
     2161 acacctggac tcctctctca acaaatacaa ctcctcccag aaagtcatcc aagagctcaa
     2221 cgcggagata gcccgccaga aggattccat catgattctg cagacacagc tggattcggc
     2281 tatccagaaa gagaagaact gtttccagaa catggttagt aaagaagctt atgaggaact
     2341 tgtgcggaag tcgggcaact gccaggacga cctgacacag gccctggaga agctcactca
     2401 ggcaacctca gagacaaaga gcctgaatcg ctccttgcaa cagacccagg agaggaaagc
     2461 tcaactggaa gatgaaatcg cggcttatga ggaaaggatg aaaaagctca atatggagtt
     2521 aaaaaaactg cagggcttcc aacagcagag cgagcaagag gtgcacaact ttgacaagaa
     2581 gctggaggag atgagcaacc aggtgttgca gtggcagagg cagcaccaga gtgaccttaa
     2641 gatgttggca gctaaggagt cgcagctccg agaattccag gaggaaatgg cgaccctaag
     2701 agagagcctc cttgcagatg agaaggagcc gtactccccg cctgcaaagc taacccccaa
     2761 agaaacctgc aggcaccacc gggagaatga ccagattatg aacaacgtgg aacaatgggc
     2821 aaaggagcag aagattgcca atgagaagtt gggaaacaag ctgagagagc aggttaaata
     2881 cattgccaag ttgactggcg aaaaggacca cctccacaat gtaatggtcc acctgcagca
     2941 ggagaacaaa aagctgaaga acgagataga agagaagaag ctaaaggccg ggaacccgag
     3001 gatctgtgtc aaggcctttc ccccaaacaa actggagcct tcccaaaagg gaaagctatg
     3061 ctgtgccctg ggctggagag ggatacccca ggacctgaca ccgaaaacgg accacaagta
     3121 catggggtta cctcactcct caggctcctc ctactgctag aatcggctct tcacccaaag
     3181 cgtcactgct acacgttttc agaggacatt gagtccccac ccctctttct tgaccggaac
     3241 cagctcctac agtggtccat caaggcccct gtctagtttg caagaagtta tgctttgctg
     3301 agttttgtct acctcctgaa gtagagttgt aagaccccac tccccccagc ctccgggccc
     3361 agactctgaa ataaagatac aaacaacaag gcctccat
//
