LOCUS       NM_001413590            4655 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus prostate transmembrane protein, androgen induced 1
            (Pmepa1), transcript variant 1, mRNA.
ACCESSION   NM_001413590 XM_006499991
VERSION     NM_001413590.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4655)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4655)
  AUTHORS   Hirata,H., Xu,X., Nishioka,K., Matsuhisa,F., Kitajima,S.,
            Kukita,T., Murayama,M., Urano,Y., Miyamoto,H., Mawatari,M. and
            Kukita,A.
  TITLE     PMEPA1 and NEDD4 control the proton production of osteoclasts by
            regulating vesicular trafficking
  JOURNAL   FASEB J 35 (2), e21281 (2021)
   PUBMED   33484199
  REMARK    GeneRIF: PMEPA1 and NEDD4 control the proton production of
            osteoclasts by regulating vesicular trafficking.
REFERENCE   3  (bases 1 to 4655)
  AUTHORS   Molstad,D.H.H., Zars,E., Norton,A., Mansky,K.C., Westendorf,J.J.
            and Bradley,E.W.
  TITLE     Hdac3 deletion in myeloid progenitor cells enhances bone healing in
            females and limits osteoclast fusion via Pmepa1
  JOURNAL   Sci Rep 10 (1), 21804 (2020)
   PUBMED   33311522
  REMARK    GeneRIF: Hdac3 deletion in myeloid progenitor cells enhances bone
            healing in females and limits osteoclast fusion via Pmepa1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4655)
  AUTHORS   Xu,X., Hirata,H., Shiraki,M., Kamohara,A., Nishioka,K.,
            Miyamoto,H., Kukita,T. and Kukita,A.
  TITLE     Prostate transmembrane protein androgen induced 1 is induced by
            activation of osteoclasts and regulates bone resorption
  JOURNAL   FASEB J 33 (3), 4365-4375 (2019)
   PUBMED   30557043
  REMARK    GeneRIF: Pmepa1 expression was barely detected in osteoclasts
            formed on plastic surfaces in vitro, but was markedly increased in
            activated osteoclasts formed on calcified matrix. Inhibitors of
            bone resorption suppressed its expression. Pmepa1 protein localized
            to lysosomes in osteoclasts.
REFERENCE   5  (bases 1 to 4655)
  AUTHORS   Funakubo,N., Xu,X., Kukita,T., Nakamura,S., Miyamoto,H. and
            Kukita,A.
  TITLE     Pmepa1 induced by RANKL-p38 MAPK pathway has a novel role in
            osteoclastogenesis
  JOURNAL   J Cell Physiol 233 (4), 3105-3118 (2018)
   PUBMED   28802000
  REMARK    GeneRIF: Pmepa1 is induced by RANK-p38 MAPK pathway signaling.
REFERENCE   6  (bases 1 to 4655)
  AUTHORS   Reichling,T., Goss,K.H., Carson,D.J., Holdcraft,R.W., Ley-Ebert,C.,
            Witte,D., Aronow,B.J. and Groden,J.
  TITLE     Transcriptional profiles of intestinal tumors in Apc(Min) mice are
            unique from those of embryonic intestine and identify novel gene
            targets dysregulated in human colorectal tumors
  JOURNAL   Cancer Res 65 (1), 166-176 (2005)
   PUBMED   15665292
REFERENCE   7  (bases 1 to 4655)
  AUTHORS   Giannini,G., Ambrosini,M.I., Di Marcotullio,L., Cerignoli,F.,
            Zani,M., MacKay,A.R., Screpanti,I., Frati,L. and Gulino,A.
  TITLE     EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a
            conserved gene family and is overexpressed and amplified in breast
            and ovarian cancer
  JOURNAL   Mol Carcinog 38 (4), 188-200 (2003)
   PUBMED   14639658
REFERENCE   8  (bases 1 to 4655)
  AUTHORS   Jolliffe,C.N., Harvey,K.F., Haines,B.P., Parasivam,G. and Kumar,S.
  TITLE     Identification of multiple proteins expressed in murine embryos as
            binding partners for the WW domains of the ubiquitin-protein ligase
            Nedd4
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 557-565 (2000)
   PUBMED   11042109
REFERENCE   9  (bases 1 to 4655)
  AUTHORS   Xu,L.L., Shanmugam,N., Segawa,T., Sesterhenn,I.A., McLeod,D.G.,
            Moul,J.W. and Srivastava,S.
  TITLE     A novel androgen-regulated gene, PMEPA1, located on chromosome
            20q13 exhibits high level expression in prostate
  JOURNAL   Genomics 66 (3), 257-263 (2000)
   PUBMED   10873380
  REMARK    Erratum:[Genomics 2000 Dec 15;70(3):407]
REFERENCE   10 (bases 1 to 4655)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL837520.26 and AL837509.11.
            
            On Nov 3, 2022 this sequence version replaced XM_006499991.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI692342.1, ERR3765653.692595.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               AL837520.26        28373-28821         c
            450-563             AL837520.26        23852-23965         c
            564-718             AL837509.11        141290-141444       c
            719-769             AL837509.11        135559-135609       c
            770-4655            AL837509.11        131441-135326       c
FEATURES             Location/Qualifiers
     source          1..4655
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 95.85 cM"
     gene            1..4655
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /note="prostate transmembrane protein, androgen induced 1"
                     /db_xref="GeneID:65112"
                     /db_xref="MGI:MGI:1929600"
     exon            1..449
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..1291
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /note="isoform 1 is encoded by transcript variant 1; Nedd4
                     WW binding protein 4; transmembrane, prostate androgen
                     induced RNA; transmembrane prostate androgen-induced
                     protein; NEDD4 WW domain-binding protein 4; protein
                     TMEPAI"
                     /codon_start=1
                     /product="protein TMEPAI isoform 1"
                     /protein_id="NP_001400519.1"
                     /db_xref="GeneID:65112"
                     /db_xref="MGI:MGI:1929600"
                     /translation="MGVNGTAAAAAGQPNVSCACNCQRSLFPSMEIRNPEEGTLLPPA
                     RETAVRDQCITVDSHHSHHGHPVLYSAELEFVQIVVIVVVMMVMVVMITCLLSHYKLS
                     ARSFISRHSQARRRDDGLSSEGCLWPSESTVSGGMPEPQVYAPPRPTDRLAVPPFIQR
                     SRFQPTYPYLQHEIALPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPN
                     RTIFDSDLIDSTMLGGPCPPSSNSGISATCYSSGGRMEGPPPTYSEVIGHYPGSSFQH
                     QQSNGPSSLLEGTRLHHSHIAPLENKEKEKQKGHPL"
     exon            450..563
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /inference="alignment:Splign:2.1.0"
     exon            564..718
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /inference="alignment:Splign:2.1.0"
     exon            719..769
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /inference="alignment:Splign:2.1.0"
     exon            770..4655
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2273..2278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /note="hexamer: AATAAA"
     polyA_site      2293
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /note="major polyA site"
     regulatory      4626..4631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /note="hexamer: AATAAA"
     polyA_site      4655
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
ORIGIN      
        1 gtcagaccgt ctgcctgcct ccgaccgcgg gcgcgcggcg caacccgatc tccttggact
       61 tgaatgagga gcgggcggcg gcgctcagct gcggatcggc cggcgcgcag gctgagcccg
      121 gcggccccgt gccccggccg cccgcccgtg ccccgcacgc cgcccgcggc cacggcccgc
      181 cgccccgggg ctcccgctcg gcggccgggg gacccagctc gcctcgggga cctcggcggc
      241 gccccgagcc cgcgccgcgc tgctcgctgt atgcggggcc cgagccccgc gcgccggccg
      301 gagccgcccc cgcgccccgc gcctcgcgcc ccgcgccgcc cgtgaccgct tgatgggggt
      361 caacggcacc gccgccgccg ccgccgggca gcccaatgtc tcctgcgcgt gcaactgcca
      421 gcgctctttg ttccccagca tggagatcag gaaccccgaa gaaggtacct tgcttccccc
      481 cgcccgggaa acagctgtca gagaccagtg tatcacggtt gacagccacc acagtcacca
      541 cggtcaccct gtgttgtact cagcggagct ggagttcgtg caaatcgtgg tcatcgtggt
      601 agtgatgatg gtgatggtgg ttatgattac gtgcctgctg agccactaca agctgtcagc
      661 ccgctccttc atcagccgac acagccaggc caggaggaga gacgatggac tgtcctcgga
      721 aggatgcctc tggccctcag agagtacggt gtcaggtgga atgccggagc cacaggtcta
      781 tgccccgcct cggcccactg accgactcgc tgtgcccccc ttcatccagc ggagccgatt
      841 ccaacccacc tacccctacc tgcagcacga aattgccctg ccacccacca tctcactgtc
      901 tgatggggag gagcccccac cctaccaggg cccctgcacc ctccagctac gggaccctga
      961 gcaacagctg gagctgaacc gggaatctgt gcgcgcaccc cctaaccgga ccatcttcga
     1021 cagtgacctt atagacagca ccatgctggg gggcccctgt ccccccagca gtaactcggg
     1081 catcagcgcc acctgctaca gcagcggtgg gcgcatggag gggccgcccc ccacctacag
     1141 cgaggtcatt ggccactacc ctggctcctc cttccagcac cagcaaagta acgggccatc
     1201 ctccctgcta gaggggaccc ggctccatca ctcgcacatt gccccactgg agaacaagga
     1261 gaaggagaaa cagaaaggtc accccctcta ggagtggggg ccggggcgcc tgtaggcaaa
     1321 accgcaaaaa aaaaagaaag gaaaaaaaaa cactccgcac ttcttaagag agaagagaga
     1381 ggaagtcagg ggacacacag gctgagtggc cgtgtggtag ttctcctgtc tgtgtataaa
     1441 tatttacatg ttctgtgtgg tctgaatgca gaagctcaaa aagcttgcaa aaaagaaaaa
     1501 agaaaatgtt tctttgttga gccgtgtctt gaaggcaaaa gagaaaatgc tctactagtc
     1561 tttccttcat tgttcttagt tgagctctgt gcgtgaatgc ttaatttctt ttgtttatga
     1621 cggttttact taactttaaa gacatatttg cacaaaacct ttgtttaaga tctgcaatat
     1681 tatatatata aatatatata taaaataaga gaactctgta tgtgggagag caggagtatt
     1741 tttgtattag aagaggccta ttcaaaaaaa aaaaagttgt tttctgaact agaagagaaa
     1801 aaaaatggca attttttgag tgccaactcc gaaagtgtgt attaccttgt aaagaaaaaa
     1861 aaaacctaca aagcaggggt ttagagctat ttatataaat gctgcgattt tgcactattt
     1921 tttaatataa tatatcagtg cttgtttgat ggaaacttct agagagtgtg ttgagacttg
     1981 gagaaatgtt gagtttaagt ctgaacagag cagcaggggt gtgtccctcc accccctggg
     2041 tctcagaggg cccccactgt gcaggaaagc caggctcccc cagggccaca cagcatgccg
     2101 cctgcaagcc aatggatgct tctgtccaga caggctgtga acagttacac attccctgcc
     2161 gaaggggacc cgtgatgtgt cgtccctctg ggttacagct gagtcaggac cgtctccccc
     2221 gcaccgcccc ccaacagagg catccaattc cagatgcctt tcccaatatg aaaataaact
     2281 gttaccgaag gaatcttagt tttttttttt ttcttcctct ttaaaacaca aaaactatga
     2341 aggttcagtg tttgggggca aggtgcatcc ccaaagccaa agcagtcccc gaatttggtg
     2401 ccaggtggat acagcagctg gcttcatgca gaagcgggtt agactccagt gtcccaaggc
     2461 tgggatctac gcagttccac cctggcatgt aggaacggcc cagggtgatg gctgcttgac
     2521 ctctgaccat gtgtttccct caatattgat tttcacttca agaagccaat taagagtcag
     2581 cccaagattg aaagggacaa gcccaagtgt tcccccagga agcccaaagg ggttaggaaa
     2641 gactgccagc accagcggcc cgtccctcca tccctccgcc tccagcgtaa ctttccttct
     2701 cctcctggac tctcccctcc gacccggaaa gagttgtatt agatgtggtc atctgatcat
     2761 cattatcaca cgttagcggg actggggtct catttcccag catgtaatta gtatgtagga
     2821 tgctgggacc cctagagggc ttgctgttgt gtcttctgtg aatacaagag aaagcggggt
     2881 gagtgtgtag tgagatctct tagggttcag cagcagcaga ggtatcagga gcagaggtga
     2941 gtctgctgga atccctggag tgaccccgcc acccctcccc atccacaggg cggtcctatt
     3001 tcctgccgaa aacgttatca tgtaaatgag agacggtaac ctggacacag caccttttta
     3061 ttacttgaaa accttttgga ggtcaggcca ccatgcctgc ttatacacat acagttttta
     3121 aaatataggt taccctgcta ccctgctgga tcctgagcct ggaggcctgc agatccatcc
     3181 gggcagaaca ttcccaggag acctacttct ccaggagtgg ttgacctgac ctctcaaaga
     3241 ggattcttga aaatatcacg atgtcactga gatgtcccgt gtttccctgt gcgaataata
     3301 tccgatgcct taccgaggaa gagctctccc tccgggctca gggtggggac actccctaca
     3361 gtgtctcact cttggggcca gtccatcaag ggctactgct gaagttcaac tgtgcacacc
     3421 cctccccttc ccttcccttc cctcagcatg catgtaccct gcttgcagag gcccccagct
     3481 gtccctgcag cctcatggaa tactgcatgt ggctcccatt cctctagaca aggaaacctt
     3541 atttgtgtct gcggcttcag ctgaaagcca agccaaatga acgtgcccac tgtcctctgg
     3601 ggccaaaatg gctgtccttg ctttgttgga tgggttgttg caggggcttg ctgggctcat
     3661 ttgacttaag ggcacaccta ctcctttggg taacaaccct ggactagaaa ctggggtccc
     3721 ttggatgtgg gttgtaggag cttgaaggaa aggacttgtc aaaggcaggg tgtcctgagt
     3781 gtcaggctgt cagtccctgc aggctgctgg tagtgggacc ctgagctctg gccaaactct
     3841 acatgctggg tccacactat ctcttcccat ggcaaattaa gcagatcctg ggaagtggct
     3901 ggttggaaag gaaccgacct ggtaggttgg gggggggggc agagatgggg agtctattgc
     3961 tcctttcggt tctgagaaag ggagagttct tgactccctc tgcccacatt accatctcca
     4021 ctgcttgctc cagagaggtc acagcccctg cagagctcca ggctgtgtaa aggcaggaag
     4081 gctctgccga gctccaggct gtgagccagc tttgtaaagc tgggatctgc atgactttgc
     4141 ctactgcgcg aaagaagtct gttgttttag caaaaagtta aaatgtgacc ctgtacccta
     4201 cgtgtaacag gaatcagggt caggcagact ccagaccctc tctgttcaac cgctctctgt
     4261 tcttggtcac tgttgtgacc cgcgtggcca agttccatgt ccctcaactt ccagaaccac
     4321 agaatattgt aatgatgcga gatgtgttct catctgtgct ctggacttga gagcccgaaa
     4381 tgccacacct cctttgtcat ctgtcacccc tccctcagca ccctgtccgg ctgcactgct
     4441 gctcggcttt ggggtgccct tctttgcagc tgtcccccca ccttctgttc ctggtcagca
     4501 cttgggattt ctccgtgcct ggagcacccg actgtgggag actgtaccca ggcctgaaga
     4561 agctgttctc tgtgtatcta tactctttgg tgccaatgtt ggcgttctga aaagccgcaa
     4621 tacacaataa attttacagt tctttggaga gtgaa
//
