LOCUS       NM_001413585            4079 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus prostate transmembrane protein, androgen induced 1
            (Pmepa1), transcript variant 3, mRNA.
ACCESSION   NM_001413585
VERSION     NM_001413585.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4079)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4079)
  AUTHORS   Hirata,H., Xu,X., Nishioka,K., Matsuhisa,F., Kitajima,S.,
            Kukita,T., Murayama,M., Urano,Y., Miyamoto,H., Mawatari,M. and
            Kukita,A.
  TITLE     PMEPA1 and NEDD4 control the proton production of osteoclasts by
            regulating vesicular trafficking
  JOURNAL   FASEB J 35 (2), e21281 (2021)
   PUBMED   33484199
  REMARK    GeneRIF: PMEPA1 and NEDD4 control the proton production of
            osteoclasts by regulating vesicular trafficking.
REFERENCE   3  (bases 1 to 4079)
  AUTHORS   Molstad,D.H.H., Zars,E., Norton,A., Mansky,K.C., Westendorf,J.J.
            and Bradley,E.W.
  TITLE     Hdac3 deletion in myeloid progenitor cells enhances bone healing in
            females and limits osteoclast fusion via Pmepa1
  JOURNAL   Sci Rep 10 (1), 21804 (2020)
   PUBMED   33311522
  REMARK    GeneRIF: Hdac3 deletion in myeloid progenitor cells enhances bone
            healing in females and limits osteoclast fusion via Pmepa1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4079)
  AUTHORS   Xu,X., Hirata,H., Shiraki,M., Kamohara,A., Nishioka,K.,
            Miyamoto,H., Kukita,T. and Kukita,A.
  TITLE     Prostate transmembrane protein androgen induced 1 is induced by
            activation of osteoclasts and regulates bone resorption
  JOURNAL   FASEB J 33 (3), 4365-4375 (2019)
   PUBMED   30557043
  REMARK    GeneRIF: Pmepa1 expression was barely detected in osteoclasts
            formed on plastic surfaces in vitro, but was markedly increased in
            activated osteoclasts formed on calcified matrix. Inhibitors of
            bone resorption suppressed its expression. Pmepa1 protein localized
            to lysosomes in osteoclasts.
REFERENCE   5  (bases 1 to 4079)
  AUTHORS   Funakubo,N., Xu,X., Kukita,T., Nakamura,S., Miyamoto,H. and
            Kukita,A.
  TITLE     Pmepa1 induced by RANKL-p38 MAPK pathway has a novel role in
            osteoclastogenesis
  JOURNAL   J Cell Physiol 233 (4), 3105-3118 (2018)
   PUBMED   28802000
  REMARK    GeneRIF: Pmepa1 is induced by RANK-p38 MAPK pathway signaling.
REFERENCE   6  (bases 1 to 4079)
  AUTHORS   Reichling,T., Goss,K.H., Carson,D.J., Holdcraft,R.W., Ley-Ebert,C.,
            Witte,D., Aronow,B.J. and Groden,J.
  TITLE     Transcriptional profiles of intestinal tumors in Apc(Min) mice are
            unique from those of embryonic intestine and identify novel gene
            targets dysregulated in human colorectal tumors
  JOURNAL   Cancer Res 65 (1), 166-176 (2005)
   PUBMED   15665292
REFERENCE   7  (bases 1 to 4079)
  AUTHORS   Giannini,G., Ambrosini,M.I., Di Marcotullio,L., Cerignoli,F.,
            Zani,M., MacKay,A.R., Screpanti,I., Frati,L. and Gulino,A.
  TITLE     EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a
            conserved gene family and is overexpressed and amplified in breast
            and ovarian cancer
  JOURNAL   Mol Carcinog 38 (4), 188-200 (2003)
   PUBMED   14639658
REFERENCE   8  (bases 1 to 4079)
  AUTHORS   Jolliffe,C.N., Harvey,K.F., Haines,B.P., Parasivam,G. and Kumar,S.
  TITLE     Identification of multiple proteins expressed in murine embryos as
            binding partners for the WW domains of the ubiquitin-protein ligase
            Nedd4
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 557-565 (2000)
   PUBMED   11042109
REFERENCE   9  (bases 1 to 4079)
  AUTHORS   Xu,L.L., Shanmugam,N., Segawa,T., Sesterhenn,I.A., McLeod,D.G.,
            Moul,J.W. and Srivastava,S.
  TITLE     A novel androgen-regulated gene, PMEPA1, located on chromosome
            20q13 exhibits high level expression in prostate
  JOURNAL   Genomics 66 (3), 257-263 (2000)
   PUBMED   10873380
  REMARK    Erratum:[Genomics 2000 Dec 15;70(3):407]
REFERENCE   10 (bases 1 to 4079)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL837509.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.193915.1, AK136450.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AL837509.11        141290-141431       c
            143-193             AL837509.11        135559-135609       c
            194-4079            AL837509.11        131441-135326       c
FEATURES             Location/Qualifiers
     source          1..4079
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 95.85 cM"
     gene            1..4079
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /note="prostate transmembrane protein, androgen induced 1"
                     /db_xref="GeneID:65112"
                     /db_xref="MGI:MGI:1929600"
     exon            1..142
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..715
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /note="isoform 3 is encoded by transcript variant 3; Nedd4
                     WW binding protein 4; transmembrane, prostate androgen
                     induced RNA; transmembrane prostate androgen-induced
                     protein; NEDD4 WW domain-binding protein 4; protein
                     TMEPAI"
                     /codon_start=1
                     /product="protein TMEPAI isoform 3"
                     /protein_id="NP_001400514.1"
                     /db_xref="GeneID:65112"
                     /db_xref="MGI:MGI:1929600"
                     /translation="MMVMVVMITCLLSHYKLSARSFISRHSQARRRDDGLSSEGCLWP
                     SESTVSGGMPEPQVYAPPRPTDRLAVPPFIQRSRFQPTYPYLQHEIALPPTISLSDGE
                     EPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLIDSTMLGGPCPPSSNSGI
                     SATCYSSGGRMEGPPPTYSEVIGHYPGSSFQHQQSNGPSSLLEGTRLHHSHIAPLENK
                     EKEKQKGHPL"
     exon            143..193
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /inference="alignment:Splign:2.1.0"
     exon            194..4079
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1697..1702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /note="hexamer: AATAAA"
     polyA_site      1717
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /note="major polyA site"
     regulatory      4050..4055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
                     /note="hexamer: AATAAA"
     polyA_site      4079
                     /gene="Pmepa1"
                     /gene_synonym="2210418I02Rik; Erg1.2; N4wbp4; Stag1;
                     Tmepai"
ORIGIN      
        1 cgtgcaaatc gtggtcatcg tggtagtgat gatggtgatg gtggttatga ttacgtgcct
       61 gctgagccac tacaagctgt cagcccgctc cttcatcagc cgacacagcc aggccaggag
      121 gagagacgat ggactgtcct cggaaggatg cctctggccc tcagagagta cggtgtcagg
      181 tggaatgccg gagccacagg tctatgcccc gcctcggccc actgaccgac tcgctgtgcc
      241 ccccttcatc cagcggagcc gattccaacc cacctacccc tacctgcagc acgaaattgc
      301 cctgccaccc accatctcac tgtctgatgg ggaggagccc ccaccctacc agggcccctg
      361 caccctccag ctacgggacc ctgagcaaca gctggagctg aaccgggaat ctgtgcgcgc
      421 accccctaac cggaccatct tcgacagtga ccttatagac agcaccatgc tggggggccc
      481 ctgtcccccc agcagtaact cgggcatcag cgccacctgc tacagcagcg gtgggcgcat
      541 ggaggggccg ccccccacct acagcgaggt cattggccac taccctggct cctccttcca
      601 gcaccagcaa agtaacgggc catcctccct gctagagggg acccggctcc atcactcgca
      661 cattgcccca ctggagaaca aggagaagga gaaacagaaa ggtcaccccc tctaggagtg
      721 ggggccgggg cgcctgtagg caaaaccgca aaaaaaaaag aaaggaaaaa aaaacactcc
      781 gcacttctta agagagaaga gagaggaagt caggggacac acaggctgag tggccgtgtg
      841 gtagttctcc tgtctgtgta taaatattta catgttctgt gtggtctgaa tgcagaagct
      901 caaaaagctt gcaaaaaaga aaaaagaaaa tgtttctttg ttgagccgtg tcttgaaggc
      961 aaaagagaaa atgctctact agtctttcct tcattgttct tagttgagct ctgtgcgtga
     1021 atgcttaatt tcttttgttt atgacggttt tacttaactt taaagacata tttgcacaaa
     1081 acctttgttt aagatctgca atattatata tataaatata tatataaaat aagagaactc
     1141 tgtatgtggg agagcaggag tatttttgta ttagaagagg cctattcaaa aaaaaaaaag
     1201 ttgttttctg aactagaaga gaaaaaaaat ggcaattttt tgagtgccaa ctccgaaagt
     1261 gtgtattacc ttgtaaagaa aaaaaaaacc tacaaagcag gggtttagag ctatttatat
     1321 aaatgctgcg attttgcact attttttaat ataatatatc agtgcttgtt tgatggaaac
     1381 ttctagagag tgtgttgaga cttggagaaa tgttgagttt aagtctgaac agagcagcag
     1441 gggtgtgtcc ctccaccccc tgggtctcag agggccccca ctgtgcagga aagccaggct
     1501 cccccagggc cacacagcat gccgcctgca agccaatgga tgcttctgtc cagacaggct
     1561 gtgaacagtt acacattccc tgccgaaggg gacccgtgat gtgtcgtccc tctgggttac
     1621 agctgagtca ggaccgtctc ccccgcaccg ccccccaaca gaggcatcca attccagatg
     1681 cctttcccaa tatgaaaata aactgttacc gaaggaatct tagttttttt ttttttcttc
     1741 ctctttaaaa cacaaaaact atgaaggttc agtgtttggg ggcaaggtgc atccccaaag
     1801 ccaaagcagt ccccgaattt ggtgccaggt ggatacagca gctggcttca tgcagaagcg
     1861 ggttagactc cagtgtccca aggctgggat ctacgcagtt ccaccctggc atgtaggaac
     1921 ggcccagggt gatggctgct tgacctctga ccatgtgttt ccctcaatat tgattttcac
     1981 ttcaagaagc caattaagag tcagcccaag attgaaaggg acaagcccaa gtgttccccc
     2041 aggaagccca aaggggttag gaaagactgc cagcaccagc ggcccgtccc tccatccctc
     2101 cgcctccagc gtaactttcc ttctcctcct ggactctccc ctccgacccg gaaagagttg
     2161 tattagatgt ggtcatctga tcatcattat cacacgttag cgggactggg gtctcatttc
     2221 ccagcatgta attagtatgt aggatgctgg gacccctaga gggcttgctg ttgtgtcttc
     2281 tgtgaataca agagaaagcg gggtgagtgt gtagtgagat ctcttagggt tcagcagcag
     2341 cagaggtatc aggagcagag gtgagtctgc tggaatccct ggagtgaccc cgccacccct
     2401 ccccatccac agggcggtcc tatttcctgc cgaaaacgtt atcatgtaaa tgagagacgg
     2461 taacctggac acagcacctt tttattactt gaaaaccttt tggaggtcag gccaccatgc
     2521 ctgcttatac acatacagtt tttaaaatat aggttaccct gctaccctgc tggatcctga
     2581 gcctggaggc ctgcagatcc atccgggcag aacattccca ggagacctac ttctccagga
     2641 gtggttgacc tgacctctca aagaggattc ttgaaaatat cacgatgtca ctgagatgtc
     2701 ccgtgtttcc ctgtgcgaat aatatccgat gccttaccga ggaagagctc tccctccggg
     2761 ctcagggtgg ggacactccc tacagtgtct cactcttggg gccagtccat caagggctac
     2821 tgctgaagtt caactgtgca cacccctccc cttcccttcc cttccctcag catgcatgta
     2881 ccctgcttgc agaggccccc agctgtccct gcagcctcat ggaatactgc atgtggctcc
     2941 cattcctcta gacaaggaaa ccttatttgt gtctgcggct tcagctgaaa gccaagccaa
     3001 atgaacgtgc ccactgtcct ctggggccaa aatggctgtc cttgctttgt tggatgggtt
     3061 gttgcagggg cttgctgggc tcatttgact taagggcaca cctactcctt tgggtaacaa
     3121 ccctggacta gaaactgggg tcccttggat gtgggttgta ggagcttgaa ggaaaggact
     3181 tgtcaaaggc agggtgtcct gagtgtcagg ctgtcagtcc ctgcaggctg ctggtagtgg
     3241 gaccctgagc tctggccaaa ctctacatgc tgggtccaca ctatctcttc ccatggcaaa
     3301 ttaagcagat cctgggaagt ggctggttgg aaaggaaccg acctggtagg ttgggggggg
     3361 gggcagagat ggggagtcta ttgctccttt cggttctgag aaagggagag ttcttgactc
     3421 cctctgccca cattaccatc tccactgctt gctccagaga ggtcacagcc cctgcagagc
     3481 tccaggctgt gtaaaggcag gaaggctctg ccgagctcca ggctgtgagc cagctttgta
     3541 aagctgggat ctgcatgact ttgcctactg cgcgaaagaa gtctgttgtt ttagcaaaaa
     3601 gttaaaatgt gaccctgtac cctacgtgta acaggaatca gggtcaggca gactccagac
     3661 cctctctgtt caaccgctct ctgttcttgg tcactgttgt gacccgcgtg gccaagttcc
     3721 atgtccctca acttccagaa ccacagaata ttgtaatgat gcgagatgtg ttctcatctg
     3781 tgctctggac ttgagagccc gaaatgccac acctcctttg tcatctgtca cccctccctc
     3841 agcaccctgt ccggctgcac tgctgctcgg ctttggggtg cccttctttg cagctgtccc
     3901 cccaccttct gttcctggtc agcacttggg atttctccgt gcctggagca cccgactgtg
     3961 ggagactgta cccaggcctg aagaagctgt tctctgtgta tctatactct ttggtgccaa
     4021 tgttggcgtt ctgaaaagcc gcaatacaca ataaatttta cagttctttg gagagtgaa
//
