LOCUS       NM_021882               2016 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus premelanosome protein (Pmel), mRNA.
ACCESSION   NM_021882
VERSION     NM_021882.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2016)
  AUTHORS   Chen,Y., Li,H., Wang,J., Yang,S., Su,Z., Wang,W., Rao,C. and Hou,L.
  TITLE     The Ednrb-Aim2-AKT axis regulates neural crest-derived melanoblast
            proliferation during early development
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39555938
REFERENCE   2  (bases 1 to 2016)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2016)
  AUTHORS   Jacob,T., Annusver,K., Czarnewski,P., Dalessandri,T., Kalk,C.,
            Levra Levron,C., Campama Sanz,N., Kastriti,M.E., Mikkola,M.L.,
            Rendl,M., Lichtenberger,B.M., Donati,G., Bjorklund,A.K. and
            Kasper,M.
  TITLE     Molecular and spatial landmarks of early mouse skin development
  JOURNAL   Dev Cell 58 (20), 2140-2162 (2023)
   PUBMED   37591247
REFERENCE   4  (bases 1 to 2016)
  AUTHORS   Escobar,G., Tooley,K., Oliveras,J.P., Huang,L., Cheng,H.,
            Bookstaver,M.L., Edwards,C., Froimchuk,E., Xue,C., Mangani,D.,
            Krishnan,R.K., Hazel,N., Rutigliani,C., Jewell,C.M., Biasco,L. and
            Anderson,A.C.
  TITLE     Tumor immunogenicity dictates reliance on TCF1 in CD8+ T cells for
            response to immunotherapy
  JOURNAL   Cancer Cell 41 (9), 1662-1679 (2023)
   PUBMED   37625402
REFERENCE   5  (bases 1 to 2016)
  AUTHORS   Wilkinson,E.L., Brennan,L.C., Harrison,O.J., Crane-Smith,Z.,
            Gautier,P., Keighren,M.A., Budd,P., Swaminathan,K., Machesky,L.M.,
            Allinson,S.L., Jackson,I.J. and Mort,R.L.
  TITLE     Genetically engineered multicistronic allele of Pmel yielding
            highly specific CreERT2-mediated recombination in the melanocyte
            lineage
  JOURNAL   Pigment Cell Melanoma Res 36 (1), 71-77 (2023)
   PUBMED   36412082
REFERENCE   6  (bases 1 to 2016)
  AUTHORS   Orlow,S.J., Hearing,V.J., Sakai,C., Urabe,K., Zhou,B.K.,
            Silvers,W.K. and Mintz,B.
  TITLE     Changes in expression of putative antigens encoded by pigment genes
            in mouse melanomas at different stages of malignant progression
  JOURNAL   Proc Natl Acad Sci U S A 92 (22), 10152-10156 (1995)
   PUBMED   7479744
REFERENCE   7  (bases 1 to 2016)
  AUTHORS   Ozeki,H., Ito,S., Wakamatsu,K. and Hirobe,T.
  TITLE     Chemical characterization of hair melanins in various coat-color
            mutants of mice
  JOURNAL   J Invest Dermatol 105 (3), 361-366 (1995)
   PUBMED   7665913
REFERENCE   8  (bases 1 to 2016)
  AUTHORS   Sango,K., Johnson,O.N., Kozak,C.A. and Proia,R.L.
  TITLE     beta-1,4-N-Acetylgalactosaminyltransferase involved in ganglioside
            synthesis: cDNA sequence, expression, and chromosome mapping of the
            mouse gene
  JOURNAL   Genomics 27 (2), 362-365 (1995)
   PUBMED   7558008
REFERENCE   9  (bases 1 to 2016)
  AUTHORS   Kwon,B.S., Chintamaneni,C., Kozak,C.A., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N., Barton,D., Francke,U., Kobayashi,Y. and
            Kim,K.K.
  TITLE     A melanocyte-specific gene, Pmel 17, maps near the silver coat
            color locus on mouse chromosome 10 and is in a syntenic region on
            human chromosome 12
  JOURNAL   Proc Natl Acad Sci U S A 88 (20), 9228-9232 (1991)
   PUBMED   1924386
REFERENCE   10 (bases 1 to 2016)
  AUTHORS   Swank,R.T., Reddington,M., Howlett,O. and Novak,E.K.
  TITLE     Platelet storage pool deficiency associated with inherited
            abnormalities of the inner ear in the mouse pigment mutants muted
            and mocha
  JOURNAL   Blood 78 (8), 2036-2044 (1991)
   PUBMED   1912584
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117232.3 and AC131081.7.
            
            On Jun 2, 2022 this sequence version replaced NM_021882.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012808.1, BC082555.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC117232.3         191834-191934
            102-212             AC117232.3         199621-199731
            213-359             AC117232.3         199858-200004
            360-494             AC117232.3         200797-200931
            495-656             AC117232.3         201103-201264
            657-1280            AC117232.3         201503-202126
            1281-1397           AC117232.3         203327-203443
            1398-1482           AC117232.3         203634-203718
            1483-1688           AC117232.3         204174-204379
            1689-1776           AC131081.7         59734-59821
            1777-2016           AC131081.7         60719-60958
FEATURES             Location/Qualifiers
     source          1..2016
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 77.13 cM"
     gene            1..2016
                     /gene="Pmel"
                     /gene_synonym="D10H12S53E; D12S53Eh; gp100; gp87; Pmel17;
                     Si; Silv"
                     /note="premelanosome protein"
                     /db_xref="GeneID:20431"
                     /db_xref="MGI:MGI:98301"
     exon            1..101
                     /gene="Pmel"
                     /gene_synonym="D10H12S53E; D12S53Eh; gp100; gp87; Pmel17;
                     Si; Silv"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1909
                     /gene="Pmel"
                     /gene_synonym="D10H12S53E; D12S53Eh; gp100; gp87; Pmel17;
                     Si; Silv"
                     /note="silver locus protein; melanocyte protein pmel 17"
                     /codon_start=1
                     /product="melanocyte protein PMEL precursor"
                     /protein_id="NP_068682.2"
                     /db_xref="CCDS:CCDS36091.1"
                     /db_xref="GeneID:20431"
                     /db_xref="MGI:MGI:98301"
                     /translation="MGVQRRSFLPVLVLSALLAVGALEGSRNQDWLGVPRQLVTKTWN
                     RQLYPEWTEVQGSNCWRGGQVSLRVINDGPTLVGANASFSIALHFPGSQKVLPDGQVI
                     WANNTIINGSQVWGGQPVYPQEPDDACVFPDGGPCPSGPKPPKRSFVYVWKTWGKYWQ
                     VLGGPVSRLSIATGHAKLGTHTMEVTVYHRRGSQSYVPLAHASSTFTITDQVPFSVSV
                     SQLQALDGETKHFLRNHPLIFALQLHDPSGYLAEADLSYTWDFGDGTGTLISRALDVT
                     HTYLESGSVTAQVVLQAAIPLVSCGSSPVPGTTDGYMPTAEAPGTTSRQGTTTKVVGT
                     TPGQMPTTQPSGTTVVQMPTTEVTATTSEQMLTSAVIDTTLAEVSTTEGTGTTPTRPS
                     GTTVAQATTTEGPDASPLLPTQSSTGSISPLLDDTDTIMLVKRQVPLDCVLYRYGSFS
                     LALDIVQGIESAEILQAVPFSEGDAFELTVSCQGGLPKEACMDISSPGCQPPAQRLCQ
                     SVPPSPDCQLVLHQVLKGGSGTYCLNVSLADANSLAVASTQLVVPGQDGGLGQAPLLV
                     GILLVLVAVVLASLIHRHRLKKQGSVSQMPHGSTHWLRLPPVFRARGLGENSPLLSGQ
                     QV"
     exon            102..212
                     /gene="Pmel"
                     /gene_synonym="D10H12S53E; D12S53Eh; gp100; gp87; Pmel17;
                     Si; Silv"
                     /inference="alignment:Splign:2.1.0"
     exon            213..359
                     /gene="Pmel"
                     /gene_synonym="D10H12S53E; D12S53Eh; gp100; gp87; Pmel17;
                     Si; Silv"
                     /inference="alignment:Splign:2.1.0"
     exon            360..494
                     /gene="Pmel"
                     /gene_synonym="D10H12S53E; D12S53Eh; gp100; gp87; Pmel17;
                     Si; Silv"
                     /inference="alignment:Splign:2.1.0"
     exon            495..656
                     /gene="Pmel"
                     /gene_synonym="D10H12S53E; D12S53Eh; gp100; gp87; Pmel17;
                     Si; Silv"
                     /inference="alignment:Splign:2.1.0"
     exon            657..1280
                     /gene="Pmel"
                     /gene_synonym="D10H12S53E; D12S53Eh; gp100; gp87; Pmel17;
                     Si; Silv"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1397
                     /gene="Pmel"
                     /gene_synonym="D10H12S53E; D12S53Eh; gp100; gp87; Pmel17;
                     Si; Silv"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1482
                     /gene="Pmel"
                     /gene_synonym="D10H12S53E; D12S53Eh; gp100; gp87; Pmel17;
                     Si; Silv"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1688
                     /gene="Pmel"
                     /gene_synonym="D10H12S53E; D12S53Eh; gp100; gp87; Pmel17;
                     Si; Silv"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1776
                     /gene="Pmel"
                     /gene_synonym="D10H12S53E; D12S53Eh; gp100; gp87; Pmel17;
                     Si; Silv"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..2016
                     /gene="Pmel"
                     /gene_synonym="D10H12S53E; D12S53Eh; gp100; gp87; Pmel17;
                     Si; Silv"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1997..2002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pmel"
                     /gene_synonym="D10H12S53E; D12S53Eh; gp100; gp87; Pmel17;
                     Si; Silv"
                     /note="hexamer: AATAAA"
     polyA_site      2016
                     /gene="Pmel"
                     /gene_synonym="D10H12S53E; D12S53Eh; gp100; gp87; Pmel17;
                     Si; Silv"
                     /note="major polyA site"
ORIGIN      
        1 acctttggct gctggcaaga ggaccactat gggtgtccag agaaggagct tccttcccgt
       61 gcttgtgctg agtgctctgc tggctgtggg ggccctagaa ggatccagga atcaggactg
      121 gcttggtgtc ccaagacaac ttgtaactaa aacctggaac aggcagctgt accccgagtg
      181 gacagaggtg caggggtcta actgctggag aggtggccag gtatctctga gggtcattaa
      241 tgatgggcct acactggttg gtgcaaatgc ctccttttcc attgccctgc acttccctgg
      301 aagtcaaaag gtactaccgg atggtcaggt tatctgggcc aacaacacca tcatcaatgg
      361 gagccaggtg tggggaggac agccagtgta tccacaggag cctgatgatg cctgtgtctt
      421 ccctgacggt ggaccctgcc catctggtcc taaacctccg aagagaagct ttgtttatgt
      481 ttggaagacc tggggaaaat actggcaagt tctggggggt ccagtgtcca ggctgagcat
      541 tgctacgggc cacgcaaagc tgggcacaca cacaatggaa gtgactgtct accaccgacg
      601 gggttcccag agctacgtgc cccttgctca cgccagttca accttcacca ttactgacca
      661 ggtacctttc tccgtgagtg tgtcccagct acaggccttg gacggagaga ccaagcactt
      721 cctgagaaat catcctctca tctttgccct tcagctccac gaccccagtg gttatttggc
      781 cgaggccgac ctctcctaca catgggactt tggagatggt actgggaccc tgatctctcg
      841 ggcacttgat gtcactcaca cttacctgga gtcgggctca gtcactgccc aggtggtact
      901 gcaggctgcc attcctcttg tttcctgtgg ttcctcccca gtcccgggta ccacagatgg
      961 ctacatgcca actgcagaag cacctggaac cacatctagg caaggaacca ctacaaaagt
     1021 tgtgggtact acacctggcc agatgccaac tacacagccc tctggaacca cagttgtaca
     1081 aatgccaacc acagaggtca cagctactac atctgagcag atgctgacct cagcggtcat
     1141 agataccaca ctggcagagg tgtcaactac agagggtaca ggtaccacac ccacaaggcc
     1201 ttctggaacc accgttgcac aagcaacaac cacagagggt ccagatgcca gcccattgct
     1261 gcccacacaa agttctacag ggtccattag ccctctactg gatgacaccg acaccataat
     1321 gcttgtgaag agacaagttc ccctggactg tgttctatat cgatatggtt ctttctccct
     1381 cgccctggac attgtccagg gtattgaaag tgctgagatc ctgcaggctg tgccattcag
     1441 tgaaggggat gcatttgagc tgactgtgtc ctgccaaggc gggctaccca aggaagcctg
     1501 tatggacatt tcatcaccag ggtgccagcc ccctgcccag aggctgtgcc agtctgttcc
     1561 accgagccca gactgccagc tggttctaca ccaagtgctg aaaggtggct cagggacata
     1621 ttgcctcaat gtgtctttgg ctgacgccaa cagcctggca gtggccagca cccaacttgt
     1681 tgttcctggt caagacggtg gccttgggca ggctcccttg cttgtaggta tcttgctggt
     1741 gttggtggct gtggtccttg catctctgat acataggcat agacttaaga agcagggctc
     1801 agtttcccaa atgccacatg gtagcactca ctggctgcgc ctgcctccgg tcttccgcgc
     1861 ccgcggcctt ggagaaaaca gcccgctcct cagtggacag caggtctgat cattctcaag
     1921 gcaccgtgga tttcctgggg ttgacagcag tgcctgtgtt ttctgcagtc ttcccttcga
     1981 gactaccaat atctgaaata aattctcaga accttg
//
