LOCUS       NM_029971                748 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus pro-melanin-concentrating hormone (Pmch), mRNA.
ACCESSION   NM_029971
VERSION     NM_029971.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 748)
  AUTHORS   Zhang,Q., Liu,X., Ma,Q. and Zhang,J.
  TITLE     Melanin concentrating hormone regulates the JNK/ERK signaling
            pathway to alleviate influenza A virus infection-induced
            neuroinflammation
  JOURNAL   J Neuroinflammation 21 (1), 259 (2024)
   PUBMED   39390522
  REMARK    GeneRIF: Melanin concentrating hormone regulates the JNK/ERK
            signaling pathway to alleviate influenza A virus infection-induced
            neuroinflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 748)
  AUTHORS   Spencer,C.D., Miller,P.A., Williams-Ikhenoba,J.G., Nikolova,R.G.
            and Chee,M.J.
  TITLE     Regulation of the Mouse Ventral Tegmental Area by
            Melanin-Concentrating Hormone
  JOURNAL   J Neurosci 44 (27), e0790232024 (2024)
   PUBMED   38806249
  REMARK    GeneRIF: Regulation of the Mouse Ventral Tegmental Area by
            Melanin-Concentrating Hormone.
            Erratum:[J Neurosci. 2024 Oct 16:e1832242024. doi:
            10.1523/JNEUROSCI.1832-24.2024. PMID: 39414378]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 748)
  AUTHORS   Payant,M.A., Spencer,C.D., Ly,N.K.K. and Chee,M.J.
  TITLE     Inhibitory actions of melanin-concentrating hormone in the lateral
            septum
  JOURNAL   J Physiol 602 (14), 3545-3574 (2024)
   PUBMED   38874572
  REMARK    GeneRIF: Inhibitory actions of melanin-concentrating hormone in the
            lateral septum.
REFERENCE   4  (bases 1 to 748)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 748)
  AUTHORS   Viale,A., Ortola,C., Hervieu,G., Furuta,M., Barbero,P.,
            Steiner,D.F., Seidah,N.G. and Nahon,J.L.
  TITLE     Cellular localization and role of prohormone convertases in the
            processing of pro-melanin concentrating hormone in mammals
  JOURNAL   J Biol Chem 274 (10), 6536-6545 (1999)
   PUBMED   10037747
REFERENCE   6  (bases 1 to 748)
  AUTHORS   Mantzoros,C.S., Qu,D., Frederich,R.C., Susulic,V.S., Lowell,B.B.,
            Maratos-Flier,E. and Flier,J.S.
  TITLE     Activation of beta(3) adrenergic receptors suppresses leptin
            expression and mediates a leptin-independent inhibition of food
            intake in mice
  JOURNAL   Diabetes 45 (7), 909-914 (1996)
   PUBMED   8666142
REFERENCE   7  (bases 1 to 748)
  AUTHORS   Hervieu,G., Segretain,D. and Nahon,J.L.
  TITLE     Developmental and stage-dependent expression of
            melanin-concentrating hormone in mammalian germ cells
  JOURNAL   Biol Reprod 54 (6), 1161-1172 (1996)
   PUBMED   8724342
REFERENCE   8  (bases 1 to 748)
  AUTHORS   Qu,D., Ludwig,D.S., Gammeltoft,S., Piper,M., Pelleymounter,M.A.,
            Cullen,M.J., Mathes,W.F., Przypek,R., Kanarek,R. and
            Maratos-Flier,E.
  TITLE     A role for melanin-concentrating hormone in the central regulation
            of feeding behaviour
  JOURNAL   Nature 380 (6571), 243-247 (1996)
   PUBMED   8637571
  REMARK    GeneRIF: This study showed increased expression of MCH mRNA with
            fasting and in mice lacking leptin. It also demonstrated that
            administration of MCH in the lateral ventricle leads to increased
            feeding.
REFERENCE   9  (bases 1 to 748)
  AUTHORS   Breton,C., Presse,F., Hervieu,G. and Nahon,J.L.
  TITLE     Structure and regulation of the mouse melanin-concentrating hormone
            mRNA and gene
  JOURNAL   Mol Cell Neurosci 4 (3), 271-284 (1993)
   PUBMED   19912933
REFERENCE   10 (bases 1 to 748)
  AUTHORS   Parkes,D. and Vale,W.
  TITLE     Secretion of melanin-concentrating hormone and neuropeptide-EI from
            cultured rat hypothalamic cells
  JOURNAL   Endocrinology 131 (4), 1826-1831 (1992)
   PUBMED   1327720
  REMARK    GeneRIF: Rat prepro-MCH is processed into three neuropeptides:
            melanin-concentrating hormone, neuropeptide-glutamic
            acid-isoleucine (NEI), and Neuropeptide-glycine-glutamic acid
            (NGE).
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK138363.1 and BB169239.1.
            
            On Feb 27, 2007 this sequence version replaced NM_029971.1.
            
            Summary: This gene encodes a preproprotein that is cleaved to
            produce three mature peptides: melanin concentrating hormone,
            neuropeptide-glutamic acid-isoleucine (NEI), and
            neuropeptide-glycine-glutamic acid (NGE). The proprotein is
            processed differently depending on the tissue where it is
            expressed. Melanin concentrating hormone is involved in the
            regulation of food intake, energy homeostasis, and sleep-wake
            behavior. Disruption of this gene is associated with resistance to
            diet-induced obesity. [provided by RefSeq, May 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048534.1, AK138363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-745               AK138363.1         4-748
            746-748             BB169239.1         243-245
FEATURES             Location/Qualifiers
     source          1..748
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 43.7 cM"
     gene            1..748
                     /gene="Pmch"
                     /gene_synonym="A230109K23Rik"
                     /note="pro-melanin-concentrating hormone"
                     /db_xref="GeneID:110312"
                     /db_xref="MGI:MGI:97629"
     exon            1..314
                     /gene="Pmch"
                     /gene_synonym="A230109K23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..563
                     /gene="Pmch"
                     /gene_synonym="A230109K23Rik"
                     /note="pro-MCH; neuropeptide-glutamic acid-isoleucine
                     (NEI); neuropeptide-glycine-glutamic acid (NGE)"
                     /codon_start=1
                     /product="pro-MCH preproprotein"
                     /protein_id="NP_084247.1"
                     /db_xref="CCDS:CCDS24105.1"
                     /db_xref="GeneID:110312"
                     /db_xref="MGI:MGI:97629"
                     /translation="MAKMTLSSYMLMLAFSLFSQGILLSASKSIRNLEDDIVFNTFRM
                     GKAFQKEDTAERSVVAPSLEQYKNDESGFMNDDDNKNSKNTGSKQNLVTHGLPLSLAV
                     KPYLALKGSVAFPAENGVQNAESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYR
                     PCWQV"
     exon            315..513
                     /gene="Pmch"
                     /gene_synonym="A230109K23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            514..748
                     /gene="Pmch"
                     /gene_synonym="A230109K23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      723..728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pmch"
                     /gene_synonym="A230109K23Rik"
     polyA_site      744
                     /gene="Pmch"
                     /gene_synonym="A230109K23Rik"
ORIGIN      
        1 ggcagagtgt gaaagttttc atccaatgca ctcttgtttg gctttatgca agcatcaaac
       61 taaggatggc aaagatgact ctctcttcct acatgttaat gctggctttt tctttgtttt
      121 ctcaaggtat tttactttca gcttccaagt ccataaggaa tttggaagat gacatagtat
      181 ttaatacatt tcgaatgggg aaagcctttc agaaggaaga tactgcagaa agatccgttg
      241 tcgccccttc tctggaacaa tacaaaaacg acgagagcgg tttcatgaac gatgatgaca
      301 ataagaattc aaagaacaca ggctccaaac agaatcttgt aactcacggg ctgccactga
      361 gtctggctgt aaaaccttac ctcgctctga aaggatccgt agccttccca gctgagaatg
      421 gagttcagaa tgctgagtcc acacaggaaa agagagaaat tggggatgaa gaaaactcag
      481 ctaaatttcc cataggaagg agagattttg acatgctcag gtgtatgctg ggaagagtct
      541 accgaccatg ttggcaagtc tgatacctgc tggtccgcaa catccttaca gaagaaaaca
      601 attcattgca agcggggaga aaagcccttg atgttgctat aacttgtgca ttatgtaaat
      661 gtctgtttta aaaggacctg gttaagatat gtaataatgt aagcgatatg cttgacgtgt
      721 gcattaaacc tcacaaaagt tctgcata
//
