LOCUS       NM_021451               2654 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus phorbol-12-myristate-13-acetate-induced protein 1
            (Pmaip1), mRNA.
ACCESSION   NM_021451
VERSION     NM_021451.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2654)
  AUTHORS   Lin,Y., Tang,W., Huang,P., Wang,Z., Duan,L., Jia,C., Sun,R., Liu,L.
            and Shen,J.
  TITLE     Denticleless E3 ubiquitin protein ligase (DTL) maintains the
            proliferation and differentiation of epidermis and hair follicles
            during skin development
  JOURNAL   Dev Dyn 253 (7), 635-647 (2024)
   PUBMED   38131461
REFERENCE   2  (bases 1 to 2654)
  AUTHORS   Sepulveda-Rincon,L.P., Wang,Y.F., Whilding,C., Moyon,B.,
            Ojarikre,O.A., Maciulyte,V., Hamazaki,N., Hayashi,K., Turner,J.M.A.
            and Leitch,H.G.
  TITLE     Determining the potency of primordial germ cells by injection into
            early mouse embryos
  JOURNAL   Dev Cell 59 (6), 695-704 (2024)
   PUBMED   38359835
REFERENCE   3  (bases 1 to 2654)
  AUTHORS   Valverde-Lopez,J.A., Li-Bao,L., Sierra,R., Santos,E.,
            Giovinazzo,G., Diaz-Diaz,C. and Torres,M.
  TITLE     P53 and BCL-2 family proteins PUMA and NOXA define competitive
            fitness in pluripotent cell competition
  JOURNAL   PLoS Genet 20 (3), e1011193 (2024)
   PUBMED   38489392
  REMARK    GeneRIF: P53 and BCL-2 family proteins PUMA and NOXA define
            competitive fitness in pluripotent cell competition.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2654)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2654)
  AUTHORS   Li,N., Liu,H., Xue,Y., Zhu,Q. and Fan,Z.
  TITLE     The chromatin remodeling protein BRG1 contributes to liver
            ischemia-reperfusion injury by regulating NOXA expression
  JOURNAL   Life Sci 334, 122235 (2023)
   PUBMED   37926300
  REMARK    GeneRIF: The chromatin remodeling protein BRG1 contributes to liver
            ischemia-reperfusion injury by regulating NOXA expression.
REFERENCE   6  (bases 1 to 2654)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 2654)
  AUTHORS   Villunger,A., Michalak,E.M., Coultas,L., Mullauer,F., Bock,G.,
            Ausserlechner,M.J., Adams,J.M. and Strasser,A.
  TITLE     p53- and drug-induced apoptotic responses mediated by BH3-only
            proteins puma and noxa
  JOURNAL   Science 302 (5647), 1036-1038 (2003)
   PUBMED   14500851
  REMARK    GeneRIF: Puma and Noxa are critical mediators of the apoptotic
            responses induced by p53 and other agents
REFERENCE   8  (bases 1 to 2654)
  AUTHORS   Shibue,T., Takeda,K., Oda,E., Tanaka,H., Murasawa,H., Takaoka,A.,
            Morishita,Y., Akira,S., Taniguchi,T. and Tanaka,N.
  TITLE     Integral role of Noxa in p53-mediated apoptotic response
  JOURNAL   Genes Dev 17 (18), 2233-2238 (2003)
   PUBMED   12952892
  REMARK    GeneRIF: Noxa(-/-) mice showed resistance to X-ray
            irradiation-induced gastrointestinal death, accompanied with
            impaired apoptosis.
REFERENCE   9  (bases 1 to 2654)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   10 (bases 1 to 2654)
  AUTHORS   Oda,E., Ohki,R., Murasawa,H., Nemoto,J., Shibue,T., Yamashita,T.,
            Tokino,T., Taniguchi,T. and Tanaka,N.
  TITLE     Noxa, a BH3-only member of the Bcl-2 family and candidate mediator
            of p53-induced apoptosis
  JOURNAL   Science 288 (5468), 1053-1058 (2000)
   PUBMED   10807576
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC100212.8.
            
            On Nov 17, 2006 this sequence version replaced NM_021451.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB041230.1, BC050821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC100212.8         52052-52260
            210-365             AC100212.8         54291-54446
            366-2654            AC100212.8         56718-59006
FEATURES             Location/Qualifiers
     source          1..2654
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 39.52 cM"
     gene            1..2654
                     /gene="Pmaip1"
                     /gene_synonym="Noxa"
                     /note="phorbol-12-myristate-13-acetate-induced protein 1"
                     /db_xref="GeneID:58801"
                     /db_xref="MGI:MGI:1930146"
     exon            1..209
                     /gene="Pmaip1"
                     /gene_synonym="Noxa"
                     /inference="alignment:Splign:2.1.0"
     exon            210..365
                     /gene="Pmaip1"
                     /gene_synonym="Noxa"
                     /inference="alignment:Splign:2.1.0"
     exon            366..2654
                     /gene="Pmaip1"
                     /gene_synonym="Noxa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2618..2623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pmaip1"
                     /gene_synonym="Noxa"
                     /note="hexamer: AATAAA"
     regulatory      2631..2636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pmaip1"
                     /gene_synonym="Noxa"
                     /note="hexamer: ACTAAA"
     polyA_site      2640
                     /gene="Pmaip1"
                     /gene_synonym="Noxa"
                     /note="major polyA site"
     polyA_site      2651
                     /gene="Pmaip1"
                     /gene_synonym="Noxa"
                     /note="major polyA site"
ORIGIN      
        1 ggattccagc gctggtgctg cctactgaag ctcggtgcgt ctggctcgcg gcactcgcga
       61 ttcatcttgc gcagcccgag tcttggggga gccccagagc ccagattggg gaccttagtc
      121 tcccgtgcgc agcggagatc gccgcggcgt ttctgagatg cccgggagaa aggcgcgtcg
      181 gaacgcgcca gtgaacccaa cgcgggcaga gctaccacct gagttcgcag ctcaactcag
      241 gaagatcgga gacaaagtgt attgcacgtg gagtgcaccg gacataactg tggttctggc
      301 gcagatgcct gggaagtcgc aaaagagcag gatgaggagc ccaagcccaa cccgggtgcc
      361 agcagacttg aaggacgagt gtgctcaact ccggaggatt ggagacaaag tgaatttacg
      421 gcagaaactt ctgaatttga tttccaagct cttcaattta gtaacctgag ttcttccaaa
      481 gcttttgcaa gaagggacct cccaggaagg aagttccgcc ggttgatgga aatgcctggt
      541 attggatgga ttgtgatgtg atgagagaaa cgctcgcttg cttttggttc cctgagcagg
      601 gatgatgaag gagataggaa tgagtttctt tcggaaagtt ttcagaaatc gttctttgag
      661 ctgtgataac gtgaaaccac acttgttttt acttttatta ttattttttt gaagagtcgt
      721 ggagctaggg aagtaactag taataatcta tctttttaga gttgttctgg ttgtttttgc
      781 caaaggttgt tgtcaagaat aatagacggg gtatggctag tggttacatt gtatgggggc
      841 agtcgtttgg gattgctttt tgacaactgc agagcaatgt actatataac actgaatgtt
      901 ctagtgaaaa ctgatttcat aggtcactac aagcttaact ggattgtgtc tgtttagatg
      961 actcttacgt gtgttattgt aagcattaac tggagagtat aaagagacta ccaagtaagt
     1021 agaggaaatt gaaaatatag taaggtcagt aggtgccagt caaactctta cagattgaat
     1081 agtatgtgat aaaaacagag tttggatttt atataatccg agaaaggttt aaaaacaaac
     1141 ttttaaaagt tgacacaatt aaaacttagt aaaagattca tgagaagttt ctaaaatttt
     1201 gtaacctgtc acaggtattt catagagtat tttcccttca cctcctctca cttgtttttg
     1261 ttttttggag acagggttcc tttcctctgt gtagccctgg ccatcctgga actccctctg
     1321 tagaccaggc tggcctcaaa ctccacctgc cttgcctccc gggtgctggg attaaaggca
     1381 agtgccagca tcactgggtt taaagtttca tttttaattt ggtctataaa tgtgacactc
     1441 agactgctta atagcaaatc agtcctggtt aacagagaga ggcaagaaac ttgagtagac
     1501 attcccaaaa ggcaggtggc cagcagatac gtgattcaga gtaaatgaaa accatcatac
     1561 gatgatctta tattctctag gtttgcctgt tactggaagc gaaagctaac acgcagagta
     1621 aggacttttt tgtatatttt tattagtact gtaacgtagg actgttcttt tgtaaaacgg
     1681 ttctttaata gataagaaat gaaccacctt aaatccagct gtcccactcc tgggaaagta
     1741 cacaaaggtg ttgatctgtc tgctgaaggg acatctgtac ttctgggttg tttgttttgt
     1801 tttgtttttt actctgtatc agccaagaca tggaaacaag caatcaaggg ctgaagggat
     1861 tttcaaagtg agaacagaaa cagaattgag ctttaaaagg cgggaaatgg tattttatca
     1921 aaaacatgga tattacatat cccaggtgcc tctctttatt ttgaccaaag tcaaaaccaa
     1981 tgggggaggg gggtgggaga tgagaaaagg gccaatctgt tttagggtga aaaccagaaa
     2041 ttagttctgt tctttcccac cgtaaagcga ctacaattga tgtatatatg actacaactg
     2101 aacggatgtt gcctgttctg accacaaggt cttgatgcct accagaagtg atgggatatg
     2161 caaataactg tgatctttcc ccggggtgtc catgtattga aactaagccc ataaacacgt
     2221 ttgatttgtc agttgactaa aactaaaaac tatcccaaaa tttttttgag aaagaatctc
     2281 acgattaagt tttaccagga ataatattta tttttaccta tttatacttt aaatattttt
     2341 gtttactttc agcatgtgta tccgtttcat ttttgtttgg agacaagggt cccttgtgac
     2401 cgtgggaagg gtgtcatatg gcttgtcgct ttggatgaag ttacctcagt agctagtggg
     2461 cctcagcatt aaggttgttt actttaaagt ttttttgttt tgttttgttt tggttttgtt
     2521 ttcctgaaag tagatatctt gcccaatggg tatttatggt ctgtgactat atttatatgt
     2581 atgcttctga agactgatat tgtagccgca actattaaat aaaagttgat actaaagtaa
     2641 ctattgaaaa atgc
//
