LOCUS       NM_001416431            6685 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus plexin B2 (Plxnb2), transcript variant 10, mRNA.
ACCESSION   NM_001416431 XM_036159125
VERSION     NM_001416431.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6685)
  AUTHORS   Borrelli,C., Roberts,M., Eletto,D., Hussherr,M.D., Fazilaty,H.,
            Valenta,T., Lafzi,A., Kretz,J.A., Guido Vinzoni,E., Karakatsani,A.,
            Adivarahan,S., Mannhart,A., Kimura,S., Meijs,A., Baccouche
            Mhamedi,F., Acar,I.E., Handler,K., Ficht,X., Platt,R.J.,
            Piscuoglio,S. and Moor,A.E.
  TITLE     In vivo interaction screening reveals liver-derived constraints to
            metastasis
  JOURNAL   Nature 632 (8024), 411-418 (2024)
   PUBMED   39048831
  REMARK    GeneRIF: In vivo interaction screening reveals liver-derived
            constraints to metastasis.
REFERENCE   2  (bases 1 to 6685)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6685)
  AUTHORS   Casden,N., Belzer,V., El Khayari,A., El Fatimy,R. and Behar,O.
  TITLE     Astrocyte-to-microglia communication via Sema4B-Plexin-B2 modulates
            injury-induced reactivity of microglia
  JOURNAL   Proc Natl Acad Sci U S A 121 (22), e2400648121 (2024)
   PUBMED   38781210
  REMARK    GeneRIF: Astrocyte-to-microglia communication via Sema4B-Plexin-B2
            modulates injury-induced reactivity of microglia.
REFERENCE   4  (bases 1 to 6685)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 6685)
  AUTHORS   Adel,S.S., Pranske,Z.J., Kowalski,T.F., Kanzler,N., Ray,R.,
            Carmona,C. and Paradis,S.
  TITLE     Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic
            synapse formation
  JOURNAL   Mol Cell Neurosci 128, 103920 (2024)
   PUBMED   38331011
REFERENCE   6  (bases 1 to 6685)
  AUTHORS   Worzfeld,T., Puschel,A.W., Offermanns,S. and Kuner,R.
  TITLE     Plexin-B family members demonstrate non-redundant expression
            patterns in the developing mouse nervous system: an anatomical
            basis for morphogenetic effects of Sema4D during development
  JOURNAL   Eur J Neurosci 19 (10), 2622-2632 (2004)
   PUBMED   15147296
REFERENCE   7  (bases 1 to 6685)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   8  (bases 1 to 6685)
  AUTHORS   Swiercz,J.M., Kuner,R., Behrens,J. and Offermanns,S.
  TITLE     Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA
            and growth cone morphology
  JOURNAL   Neuron 35 (1), 51-63 (2002)
   PUBMED   12123608
REFERENCE   9  (bases 1 to 6685)
  AUTHORS   Cheng,H.J., Bagri,A., Yaron,A., Stein,E., Pleasure,S.J. and
            Tessier-Lavigne,M.
  TITLE     Plexin-A3 mediates semaphorin signaling and regulates the
            development of hippocampal axonal projections
  JOURNAL   Neuron 32 (2), 249-263 (2001)
   PUBMED   11683995
REFERENCE   10 (bases 1 to 6685)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160538.8 and AC113069.10.
            
            On Feb 2, 2023 this sequence version replaced XM_036159125.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.15499.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               AC160538.8         153216-153605
            391-440             AC113069.10        192073-192122       c
            441-489             AC113069.10        191575-191623       c
            490-1576            AC113069.10        187947-189033       c
            1577-1759           AC113069.10        187590-187772       c
            1760-1888           AC113069.10        187372-187500       c
            1889-1989           AC113069.10        186912-187012       c
            1990-2116           AC113069.10        186709-186835       c
            2117-2270           AC113069.10        186253-186406       c
            2271-2385           AC113069.10        185426-185540       c
            2386-2494           AC113069.10        185219-185327       c
            2495-2596           AC113069.10        185018-185119       c
            2597-2689           AC113069.10        184284-184376       c
            2690-2771           AC113069.10        183929-184010       c
            2772-2932           AC113069.10        183693-183853       c
            2933-3081           AC113069.10        183453-183601       c
            3082-3190           AC113069.10        183257-183365       c
            3191-3327           AC113069.10        182992-183128       c
            3328-3498           AC113069.10        182681-182851       c
            3499-3631           AC113069.10        182230-182362       c
            3632-3859           AC113069.10        181891-182118       c
            3860-4036           AC113069.10        181613-181789       c
            4037-4176           AC113069.10        181374-181513       c
            4177-4277           AC113069.10        181167-181267       c
            4278-4507           AC113069.10        180779-181008       c
            4508-4689           AC113069.10        180467-180648       c
            4690-4756           AC113069.10        180233-180299       c
            4757-4903           AC113069.10        179965-180111       c
            4904-5060           AC113069.10        179633-179789       c
            5061-5161           AC113069.10        179431-179531       c
            5162-5246           AC113069.10        179242-179326       c
            5247-5401           AC113069.10        178907-179061       c
            5402-5562           AC113069.10        178641-178801       c
            5563-5710           AC113069.10        178398-178545       c
            5711-5775           AC113069.10        178192-178256       c
            5776-5851           AC113069.10        177999-178074       c
            5852-5926           AC113069.10        177504-177578       c
            5927-6056           AC113069.10        177262-177391       c
            6057-6685           AC113069.10        176555-177183       c
FEATURES             Location/Qualifiers
     source          1..6685
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.68 cM"
     gene            1..6685
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /note="plexin B2"
                     /db_xref="GeneID:140570"
                     /db_xref="MGI:MGI:2154239"
     exon            1..390
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            391..440
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..489
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            490..1576
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             503..6031
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 10; differentially expressed in brain tumors"
                     /codon_start=1
                     /product="plexin-B2 isoform 1 precursor"
                     /protein_id="NP_001403360.1"
                     /db_xref="GeneID:140570"
                     /db_xref="MGI:MGI:2154239"
                     /translation="MALPLWALTFLGLTGLGLSLRSRKPESFRSETELNHLAVDEVTG
                     VVYVGAVNALYQLSADLHVQQHVVTGPFMDNKKCTPPIEASQCHEAVLTDNFNQLLLL
                     DPPGKRLVECGSLFKGICALRAMSNISVRLFYEDGSGEKSFVASNDERVATVGLVTST
                     RPDGERVLFVGKGNGPHDNGIIVSTRLLDRAEGREAFEAYSDHTTFKAGYLSTNTQQF
                     VAAFEDDFYVFFVFNHQDKHPAKNRTLLARMCKDDPSYYSYVEMDLQCQDPSDPQDSA
                     FGTCLAASVATSGAGRALYAVFSRDGRSTGGPGAGLCVFPLDKVREKIEANRNACYTG
                     AREAGRTIFYKPFHGEIQCGGHLIGASESFPCGSEHLPYPLGSRDGLVATAVLHRGGL
                     NLTAVTVTAENDHTVAFLGTSDGRILKVYLAPDGTSAEYGSIPVDINKKIKQDLALSG
                     NLSSLYAMTQDKVFRLPVQECLSYVTCAQCRDSQDPYCGWCVIEGRCTRKSECSRAEE
                     TGHWLWSREKSCVAITDAFPQNMSRRAQGEVRLSVSPLPTLTEDDELLCLFGDSPPHP
                     ARVEDDTVICNSPSSIPSTPPGQDHVDVSIQLLLKSGSVFLTSHQYPFYDCREAMSLV
                     ENLPCISCASNRWTCQWDLQYYECREASPNPEEGIIRAHMEDNCPQFLAPDPLVIPMN
                     HETEVTFQGKNLETVKVSSLYVGSELLNFEETVTMHESDTFSFRTPKLSHDGNETLPL
                     HLYVKSFGKNIDSKLQVTLYNCSFGRSDCSLCLAADPAYRCVWCRGQNRCVYEALCSN
                     VTSECPPPVITRIQPETGPLGGGILVTIHGSNLGVKADDVKKITVAGQNCAFEPRGYS
                     VSTRIVCAIEASEMPFTGGIEVDVNGKLGHSPPHVQFTYQQPQPLSVEPRQGPQAGGT
                     TLTINGTHLDTGSKEDVRVTLNDVPCEVTKFGAQLQCVTGQQLAPGQVTLEIYYGGSR
                     VPSPGISFTYCENPMIRAFEPLRSFVSGGRSINVTGQGFSLIQKFAMVVIAEPLRSWR
                     RRRREAGALERVTVEGMEYVFYNDTKVVFLSPAVPEEPEAYNLTVLIRMDGHCAPLRT
                     EAGVFEYVADPTFENFTGGVKKQVNKLIHARGTNLNKAMTLEEAEAFVGAERCIMKTL
                     TETDLYCEPPEVQPPPKRRQKRDTAHNLPEFIVKFGSREWVLGRVEYDTRASDVPLSL
                     ILPLVMVPMVFIIVVSIYCYWRKSQQAEREYEKIKSQLEGLEESVRDRCKKEFTDLMI
                     EMEDQTNDVHEAGIPTLDYKTYTDRVFFLPSKDGDKDVMITGKLDIPESRRPIVEQAL
                     YQFSNLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTDIMRTLFL
                     ELMEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKHQV
                     EKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGIDAIPVKVLNCDTISQV
                     KEKIIDQVYRTQPCSCWPKPDSVVLEWRPGSTAQILSDLDLTSQREGRWKRINTLMHY
                     NVRDGATLILSKVGVSQQPEDSQQDLPGERHALLEEENRVWHLVRPTDEVDEGKSKRG
                     SMKEKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQ
                     AEKHDIRDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDA
                     CTRTEHKLSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRA
                     HTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAALENKVTDL
                     "
     exon            1577..1759
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1888
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1989
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2116
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2270
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2385
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2494
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2596
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2689
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2771
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2932
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2933..3081
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3190
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3327
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3498
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            3499..3631
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..3859
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            3860..4036
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            4037..4176
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            4177..4277
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            4278..4507
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            4508..4689
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            4690..4756
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            4757..4903
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            4904..5060
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            5061..5161
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            5162..5246
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            5247..5401
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            5402..5562
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            5563..5710
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            5711..5775
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            5776..5851
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            5852..5926
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            5927..6056
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            6057..6685
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6662..6667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /note="hexamer: AATACA"
     polyA_site      6685
                     /gene="Plxnb2"
                     /gene_synonym="Debt; plexin-B2"
                     /note="major polyA site"
ORIGIN      
        1 gctttccttc cccggctgga aggacttagg taggtaatgg ccggtcctgc tttcggctgt
       61 ttctgatacc aggttagcaa cgcaaggaaa cggctctaga cttttgacag ttgcctctgc
      121 tgtcattgtc acccgaggtt gggctcccat ctacccatcg ccttgtgagc ttccctggtg
      181 aggctcgcgc caaaagctca gtccacgtgt tccctctagg tgtgcgctgg ggtgcagggc
      241 caaaatgtgg aagcagacct gaatagagcg cggggggcgg tgggggggca tccctaggtt
      301 ccaggaccgt gggcgtggcc aggtccctag gggagcttcg gccgcgcgtc ctagcccacc
      361 tctggggtcc gcctccggtg cagttcccag atggggaaat gaggcacaga gacattaact
      421 tgcccaaggt cacacagcta cgagtcctga tgccagccta aaacagagac ggagaccact
      481 ggagccttga gttctggggg caatggctct gccactctgg gccctgacct ttctaggtct
      541 cacgggccta gggttgagcc tgcggtcccg aaagccggag agtttccgca gtgagacaga
      601 gctgaaccac ctggctgtgg atgaggtcac aggtgtggtg tatgtcgggg cagtgaacgc
      661 gctctaccag ctgagtgccg acctgcacgt ccagcagcac gtggtcacag gccccttcat
      721 ggataacaag aagtgcacac cacccattga ggccagccag tgccacgaag cggtgctcac
      781 tgacaacttc aaccagctgc tgctgctcga cccaccgggg aaacgcctgg tggagtgcgg
      841 cagcctcttc aagggcatct gtgccctgcg cgccatgagc aacatctcgg tgcgcctctt
      901 ctacgaggat ggcagcggcg agaagtcctt cgtggccagc aatgacgaga gagtggccac
      961 cgtggggctg gtgacctcca cgcgccccga cggcgagcgc gtgctgtttg tgggcaaagg
     1021 caatgggccg cacgacaatg gtatcatcgt gagcacccgc ctgctggaca gggctgaggg
     1081 ccgggaggcc tttgaggcct actctgacca caccaccttc aaggccggct acctgtccac
     1141 gaatactcag cagtttgtcg cagcctttga ggatgatttc tatgtcttct tcgtctttaa
     1201 ccatcaagac aagcatcctg ctaagaaccg cacgctgctg gcgcgcatgt gcaaagacga
     1261 cccctcctac tattcctatg tagagatgga cctgcagtgt caggatccca gtgaccccca
     1321 agactctgcc tttggcacct gcctagccgc ttctgtagcc acatcgggtg ctggcagagc
     1381 actttatgct gtcttcagca gagatggccg gagcactggg ggacctggcg cgggcctctg
     1441 tgtgttcccg ctagataaag tccgtgagaa gatagaagcc aaccgtaacg cctgctacac
     1501 aggtgcccga gaggcaggcc gcactatctt ctacaagccc ttccacggag aaatccagtg
     1561 tggcggccat ctgataggtg ccagcgagag cttcccatgc ggctcggagc atctgcccta
     1621 tccactgggc agtcgtgatg gactcgtcgc cacagccgtg ctgcaccgcg ggggcctgaa
     1681 tctgacagca gtgacagtaa ctgccgagaa tgaccacact gttgcgttcc tgggcacctc
     1741 agatggccgg atccttaagg tgtaccttgc tccagacggc acttctgcag agtatggttc
     1801 tatcccagta gacatcaata agaaaatcaa gcaggacctg gcactgtctg gaaacctgtc
     1861 cagtctgtat gctatgaccc aggacaaggt gttccggctc ccagtacaag aatgcctgag
     1921 ctatgtaacc tgcgctcagt gtcgtgactc ccaagatccc tactgtggct ggtgtgtcat
     1981 cgagggacga tgcaccagga agtccgagtg ctcacgggcc gaggaaaccg gacactggct
     2041 gtggagccgg gagaagtcct gtgtggccat cactgatgcc tttccacaga acatgagccg
     2101 gcgggcccaa ggagaggtac gcctgtctgt cagccccctg cccaccctga ctgaggacga
     2161 tgagttactg tgcctctttg gtgactcacc accccaccct gcccgggtag aggacgatac
     2221 cgtcatctgt aattccccaa gcagcatccc tagtacaccg ccaggccaag accatgttga
     2281 cgtgagcatc cagctcctct taaaaagcgg cagtgtcttc ctcacctccc accagtatcc
     2341 cttctatgac tgccgtgagg ccatgagcct ggtggagaac ctgccgtgca tctcttgtgc
     2401 tagcaaccgc tggacttgcc aatgggacct gcagtactac gagtgtcggg aggcttcgcc
     2461 caacccagag gagggaatca tacgtgccca catggaggac aactgccccc agttcctggc
     2521 ccctgaccct ttggtcatcc ccatgaacca tgagacagag gtgaccttcc agggcaagaa
     2581 cttggagact gtgaaggttt cttccctgta tgtgggcagt gagctgctga attttgaaga
     2641 gactgtgacc atgcatgaat cagacacctt ctcttttagg accccaaagc tatcccatga
     2701 tggtaatgag acactgcctc ttcacctgta tgttaagtcc tttggcaaga acattgacag
     2761 caagctacaa gtgactctct acaactgctc ctttggccgc agtgactgta gcctgtgtct
     2821 ggctgccgat cctgcctaca ggtgtgtgtg gtgccgtggg cagaaccggt gcgtgtacga
     2881 agctctgtgc agcaatgtca cttctgagtg cccaccacca gttatcacta ggatccagcc
     2941 tgagacgggc ccgctgggtg ggggcatcct ggtcactatc catgggtcca atctgggtgt
     3001 caaagcagat gacgtcaaga agataactgt ggctggccag aactgtgcct ttgaaccaag
     3061 agggtactcc gtatccaccc ggattgtgtg tgcaattgag gcttcggaga tgcccttcac
     3121 aggaggcatt gaggtggatg ttaatggaaa actcggccat tcaccgccac acgtccagtt
     3181 cacttatcaa caaccccagc ctctcagtgt ggagccacga caggggccac aggcaggtgg
     3241 caccacattg accatcaatg gcactcacct ggacacaggc tccaaggagg atgtgcgggt
     3301 gacactcaat gacgtccctt gtgaagtgac aaagtttgga gcacagctac agtgtgtcac
     3361 aggtcaacag ttggctccag gccaggtgac actagaaatc tactatgggg gctccagagt
     3421 gcccagcccc ggcatctctt tcacctactg cgagaacccc atgatacgag cctttgagcc
     3481 attgagaagc tttgtcagtg gtggccggag catcaacgtt actggccagg gcttcagcct
     3541 catccagaag tttgccatgg ttgtcatcgc tgagcccttg cggtcctgga ggcggcggcg
     3601 gcgggaggct ggagccctgg agcgtgtgac ggtcgagggc atggagtacg tgttctacaa
     3661 cgacaccaag gtcgtcttct tgtctcctgc tgtccccgaa gagcccgagg cttacaacct
     3721 caccgtgctg atacggatgg acggtcactg tgccccgctc aggaccgaag ccggagtctt
     3781 tgagtatgtg gcagacccca cctttgagaa cttcacgggt ggcgtcaaaa agcaggtcaa
     3841 caagctcatc cacgcccggg gaaccaatct gaacaaagcc atgactctgg aggaggcaga
     3901 ggcatttgtg ggtgctgagc gttgcattat gaagacgctg accgagacgg acctgtactg
     3961 cgagccccca gaggtgcagc ctccacccaa gcggcggcag aagcgagaca cggcacacaa
     4021 cctacctgag ttcattgtga agtttggctc ccgagagtgg gtgctaggcc gagtggagta
     4081 cgacacgcgt gcgagtgacg tgccgctcag tctcatcctg cctctggtca tggtacccat
     4141 ggtgtttatc atcgtggtct ccatctactg ctactggagg aagagccagc aggccgagcg
     4201 cgagtacgag aagatcaaat cccagctcga gggcttggag gagagcgtgc gtgaccgctg
     4261 caagaaggaa ttcacagacc tgatgatcga gatggaggac cagacgaatg acgtgcatga
     4321 ggcaggcatc cccacgctgg actacaagac ctacaccgac cgcgtattct tcctgccatc
     4381 caaggatggt gacaaggatg tgatgatcac cggcaagcta gacatccctg agtcacggcg
     4441 gcccattgtg gagcaagccc tctaccagtt ctccaacctg cttaatagca agtccttcct
     4501 catcaatttc atccacaccc tggagaatca gcgtgagttc tcagctcggg ccaaggtcta
     4561 ctttgcatca ctgctgactg tggccctgca cgggaagctg gagtactaca cggacatcat
     4621 gcgcacgctc ttcctggagc tcatggagca gtatgtggtg gccaagaacc ccaagctaat
     4681 gctgcgcagg tctgagacag tggtggagag gatgctgtcc aactggatgt ccatctgtct
     4741 gtaccagtac ctcaaggata gtgcagggga gcctctctac aagctcttca aggccatcaa
     4801 acaccaggtg gaaaaggggc ccgtggatgc tgtgcagaag aaggccaagt acaccctcaa
     4861 tgacacaggc ctgctcgggg acgatgttga gtatgcgcct ctgaccgtga gcgtgattgt
     4921 tcaggatgaa gggatcgatg ccatcccggt taaggtcctc aactgtgaca ccatctctca
     4981 ggtcaaagag aagatcatcg accaagtgta ccgtactcag ccctgctcct gctggcccaa
     5041 gccagacagt gtggtgcttg aatggcgtcc tgggtccacg gcccagattc tgtctgactt
     5101 ggaccttacc tcccagcggg agggccggtg gaagcgcatc aacaccctga tgcactacaa
     5161 cgtccgggat ggagccaccc tcatcctgtc taaggtggga gtctcccagc agccagaaga
     5221 cagccaacag gacttgccag gggagcgcca tgcccttctg gaagaggaaa accgcgtgtg
     5281 gcacttggtg cggccaacag atgaggtaga tgaaggcaag tccaagcgcg gcagcatgaa
     5341 ggagaaagag cggactaagg ccatcacaga gatctacctg acgcggctac tctccgtcaa
     5401 gggcacactg cagcagtttg tggacaactt cttccaaagc gtgctggcgc ctgggcatgc
     5461 ggtgccaccc gccgtcaagt acttcttcga tttcttggac gagcaggcag agaagcatga
     5521 catccgagat gaggatacca tccatatctg gaaaaccaac agtttaccac ttcggttctg
     5581 ggtgaacatc ctgaagaacc ctcatttcat ctttgatgtc cacgtccacg aagtggtgga
     5641 cgcctccctg tcagtcatcg cacagacctt catggacgcc tgtactcgca cggagcacaa
     5701 gctgagccga gactctccca gcaacaagct gttgtatgct aaggagatct ctacctacaa
     5761 gaagatggtg gaggactact acaagggcat cagacagatg gtgcaggtca gcgaccagga
     5821 catgaatacg cacttggcag agatttcccg ggctcacaca gactccctga acacactcgt
     5881 ggccctacac cagctctacc aatacacaca gaagtactat gatgagatca tcaatgctct
     5941 ggaggaggac cctgcagccc aaaagatgca actggccttc cgcctacagc agattgctgc
     6001 tgcgcttgag aataaggtta cagacctctg accgtcaatg ccgcctcagg atgcagtaga
     6061 ggatgcaccc aaggcatctg gagtgggtgt ggtgaaccca cctcttgtag actgtagcgt
     6121 ctttctcctg agcaatactg cccgggcgcc cgagtcagca ccagctcctt ccaatggcac
     6181 cagcatcggg tgttctctgt gttgtctcct gagcaattcg caaatgtgcc ttacaaagcc
     6241 acactgggcc actgggggcg gtggaggcat ggcctcccct tcccacgcac cagcagccca
     6301 gccgcctcag atgccctggg tttggcctgt agctcccaca gccggttcct ggactgtaac
     6361 tgtctgccag acggaaggag aagaaaaagc ggtacaatgc cttcctgacc tcacctggcc
     6421 ctcctcgtgg ggcgcaggca ctccaggtgg gcttgagggt catcactggc tccacctcta
     6481 aggtcaagct ggacgtcaga cgtcagggcc caggtggccg ccagagggac ccagaaaact
     6541 gaggtccttg tctcagctgt taaacaggct gtcctggagg ccctgcctgg atctgggggt
     6601 gctggagcag catctccccc caggaccacc cacccttttt gtaaatcgtg attgtaaatc
     6661 caatacagtt gtctttttca ctctc
//
