LOCUS       NM_172775               8600 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus plexin B1 (Plxnb1), mRNA.
ACCESSION   NM_172775
VERSION     NM_172775.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8600)
  AUTHORS   Huang,Y., Wang,M., Ni,H., Zhang,J., Li,A., Hu,B., Junqueira
            Alves,C., Wahane,S., Rios de Anda,M., Ho,L., Li,Y., Kang,S.,
            Neff,R., Kostic,A., Buxbaum,J.D., Crary,J.F., Brennand,K.J.,
            Zhang,B., Zou,H. and Friedel,R.H.
  TITLE     Regulation of cell distancing in peri-plaque glial nets by
            Plexin-B1 affects glial activation and amyloid compaction in
            Alzheimer's disease
  JOURNAL   Nat Neurosci 27 (8), 1489-1504 (2024)
   PUBMED   38802590
  REMARK    GeneRIF: Regulation of cell distancing in peri-plaque glial nets by
            Plexin-B1 affects glial activation and amyloid compaction in
            Alzheimer's disease.
REFERENCE   2  (bases 1 to 8600)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 8600)
  AUTHORS   Adel,S.S., Pranske,Z.J., Kowalski,T.F., Kanzler,N., Ray,R.,
            Carmona,C. and Paradis,S.
  TITLE     Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic
            synapse formation
  JOURNAL   Mol Cell Neurosci 128, 103920 (2024)
   PUBMED   38331011
REFERENCE   4  (bases 1 to 8600)
  AUTHORS   Chapoval,S.P., Gao,H., Fanaroff,R. and Keegan,A.D.
  TITLE     Plexin B1 controls Treg numbers, limits allergic airway
            inflammation, and regulates mucins
  JOURNAL   Front Immunol 14, 1297354 (2024)
   PUBMED   38259471
  REMARK    GeneRIF: Plexin B1 controls Treg numbers, limits allergic airway
            inflammation, and regulates mucins.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8600)
  AUTHORS   Yang,G., Ullah,H.M.A., Parker,E., Gorsi,B., Libowitz,M.,
            Maguire,C., King,J.B., Coon,H., Lopez-Larson,M., Anderson,J.S.,
            Yandell,M. and Shcheglovitov,A.
  TITLE     Neurite outgrowth deficits caused by rare PLXNB1 mutation in
            pediatric bipolar disorder
  JOURNAL   Mol Psychiatry 28 (6), 2525-2539 (2023)
   PUBMED   37032361
  REMARK    GeneRIF: Neurite outgrowth deficits caused by rare PLXNB1 mutation
            in pediatric bipolar disorder.
REFERENCE   6  (bases 1 to 8600)
  AUTHORS   Aurandt,J., Vikis,H.G., Gutkind,J.S., Ahn,N. and Guan,K.L.
  TITLE     The semaphorin receptor plexin-B1 signals through a direct
            interaction with the Rho-specific nucleotide exchange factor, LARG
  JOURNAL   Proc Natl Acad Sci U S A 99 (19), 12085-12090 (2002)
   PUBMED   12196628
  REMARK    GeneRIF: LARG plays a critical role in plexin-B1 signaling to
            stimulate Rho activation and cytoskeletal reorganization.
REFERENCE   7  (bases 1 to 8600)
  AUTHORS   Giordano,S., Corso,S., Conrotto,P., Artigiani,S., Gilestro,G.,
            Barberis,D., Tamagnone,L. and Comoglio,P.M.
  TITLE     The semaphorin 4D receptor controls invasive growth by coupling
            with Met
  JOURNAL   Nat Cell Biol 4 (9), 720-724 (2002)
   PUBMED   12198496
  REMARK    GeneRIF: binding of Sema 4D to Plexin B1 stimulates the tyrosine
            kinase activity of Met
REFERENCE   8  (bases 1 to 8600)
  AUTHORS   Swiercz,J.M., Kuner,R., Behrens,J. and Offermanns,S.
  TITLE     Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA
            and growth cone morphology
  JOURNAL   Neuron 35 (1), 51-63 (2002)
   PUBMED   12123608
REFERENCE   9  (bases 1 to 8600)
  AUTHORS   Cheng,H.J., Bagri,A., Yaron,A., Stein,E., Pleasure,S.J. and
            Tessier-Lavigne,M.
  TITLE     Plexin-A3 mediates semaphorin signaling and regulates the
            development of hippocampal axonal projections
  JOURNAL   Neuron 32 (2), 249-263 (2001)
   PUBMED   11683995
REFERENCE   10 (bases 1 to 8600)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ173103.1, AB072381.1, BC150701.1 and CJ261396.1.
            
            On Mar 26, 2009 this sequence version replaced NM_172775.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB072381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-423               CJ173103.1         1-423
            424-7276            AB072381.1         268-7120
            7277-8317           BC150701.1         7067-8107
            8318-8600           CJ261396.1         182-464
FEATURES             Location/Qualifiers
     source          1..8600
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.63 cM"
     gene            1..8600
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /note="plexin B1"
                     /db_xref="GeneID:235611"
                     /db_xref="MGI:MGI:2154238"
     exon            1..210
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            211..263
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            264..1376
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1559
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1688
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1789
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1922
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2079
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2188
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2297
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2972
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3095
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3218
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3312
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3485
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..3637
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            3638..3743
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..3880
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            3881..4057
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            4058..4187
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            4188..4430
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            4431..4607
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            4608..4756
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            4757..4857
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            4858..5075
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            5076..5254
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            5255..5321
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            5322..5468
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            5469..5637
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            5638..5741
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            5742..5826
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            5827..5999
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            6000..6160
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            6161..6308
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            6309..6373
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            6374..6449
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            6450..6524
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     exon            6525..8600
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7643..7648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /note="hexamer: ATTAAA"
     polyA_site      7662
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /note="major polyA site"
     regulatory      8574..8579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /note="hexamer: AATAAA"
     polyA_site      8594
                     /gene="Plxnb1"
                     /gene_synonym="2900002G15Rik; mKIAA0407"
                     /note="major polyA site"
ORIGIN      
        1 tttgtctcct ttgttcccag cggaggcagc gccgcggcgg gaggggcggg cggcgggcgc
       61 agttttttcc gcccctcggt ctccgggtaa cagctgcggc tccgccagac ccacctccga
      121 ggggagggaa ggccgccgcg cgcagatctg agctagcccg gagctgcggg cggacgcctc
      181 gccgcgcgca tcccgcagga gggtcgggcg gtgactcctg ctcaggtcat gccgttatct
      241 gctgatccag ccggccctgc caggtgacca tgtctgtcct cggcccagtt cttctccagg
      301 tgttctgggc cgggtgtgtc gtcaccctgc ggtcccctct gccagctgct ttcactgcca
      361 atggcacaca tctacaacac ttggcaaggg accccaccac aggtaccctc tatgtagggg
      421 ccaccaactt cctgttccag ttgagccctg ggctgcagct ggaagccgtg gtgtccacgg
      481 gccctgtgaa tgacagccgg gattgcctgc cacctgtgat acctgatgaa tgtccccaag
      541 cccagcctac taacaaccct aaccagctgc tcctggtgag cccagaggct ctggtggtgt
      601 gtgggagcgt acaccagggc atctgtgagc tacggagcct gggacagatc aggcagctgc
      661 tgctacggcc agagcgacct ggggacaccc agtatgtggc tgcaaatgac cctgcagtca
      721 gtacagtggg gctggtggcc cagggattgg taggggagcc cctcctgttt gtggggcggg
      781 ggtacaccag caggggtgta ggtggtggga ttcctcccat tacaacccga gccctgcgac
      841 caccggaccc ccaagctgcc ttctcttatg aagaaacagc caagttagca gtgggccgcc
      901 tgtccgagta cagccaccac ttcgtgagtg cctttgtacg cggggccagt gcatacttcc
      961 tgttcttgcg gcgagacctg aaggcccctt ctagagcttt ccgtgcctat gtgtctcgag
     1021 tgtgccttca ggaccagcac tactactctt atgtggaatt gcccctggcc tgccagggtg
     1081 gtcgttacgg tcttatccag gctgcagctg tagccacgtc caaggaggtg gcccgtgggg
     1141 acgtactctt tgcagctttc tcctcagtgg ctcctcccac tgtggattgg cccctgtcag
     1201 catctactgg ggcatctgga acctctgtgc tctgtgcctt ccccctggat gaggtagacc
     1261 agcttgctaa ttacactcga gatgcctgtt atactcggga aggccgtgct gagaacggga
     1321 ccaaggttgc tgacattgca tacgatgtcc tttccgactg tgcgcagcta ccagtggaca
     1381 ccccggatgc ttttccatgt ggctctgacc acacacccag tcccatggtc agctgtgtcc
     1441 ctttggaagc cacgccaatt ctggagctac caggggttca gctaacagct gtggctgtca
     1501 ccatggagga tggacacact attgctttcc tgggtgacag tcaaggacag ttgcataggg
     1561 tctacttagg ccctggaaga agtgctgccc catattctaa acagagcatc cagccggggt
     1621 ctcctgtgaa cagagatctt acctttgatg gtacctttga gcatctctat gtagcaactc
     1681 agactactct tgtgaaggtt cctgtggctc cttgtgctca gcatctggac tgtgactctt
     1741 gccttgctca cagggaccct tattgcggat ggtgtgtgct cctgggcagg tgtagtcgcc
     1801 ggtcggagtg ctcaagggac cagggcccag agcagtggct gtggagcttc cagccggaac
     1861 tgggctgtct tcgagtggtg gccgtgagcc ctgccaatat cagtcgggaa gagaggaggg
     1921 aggttttctt gtcagtgcca ggcctgccat ctctctggcc aggggagtca tatttctgct
     1981 actttggaga ccaacagagt cctgctctac tgaccagttc tggtgtgatg tgtccctccc
     2041 cagaccccag tgaggctcca gtgctgcaga gaggagccga ccatatctct gtgaacgtgg
     2101 agctcaggtt tggtgccgtg gtgatcgcca gcacctccct ctccttctat gactgcgtgg
     2161 cagttactgc gtcttcccca tctgcaccgt gccgggcctg tgtgagcagc cgctggggct
     2221 gtaactggtg tgtgtggcag cagctgtgca cacacaaggc ctcgtgtgac gctgggccta
     2281 tggtggcaag ccaacagagc ccactccttc ccctaatccc tcctgcaagg gatgaactca
     2341 cccctttccc acccacagtc ccccaaacca cggtcactcc tacccccaac agcttcccaa
     2401 tagagcctag ggctccctcc acagcctcag atgtcctacc tggggccaag ccttcccggc
     2461 tcagcctctg gggcccatgg gcaggtcctg gccccatact ttcccctact tccacagagt
     2521 cacctcttca tgagaagccc cttcctcctg acccccctac catacctgga accactgtcc
     2581 ctgcccccac tggcttggga ccatcgacca cacctgagga cctcttggcc tcctacccat
     2641 tcccctcaga tgcagctgca gtgtcccctg cagagcctgg ccctgaggct ctgccttcca
     2701 tggtggctct ggaccagccc cctggcactg ttccagacac tactttccca ggggcccctg
     2761 gctccatgaa gcccgttctg gattggctca ccaaaggagg cggcgagctg cccgaggcgg
     2821 atgagtggat ggggggtgac acgcccgcct tctccacttc cacactcctc tcaggtgatg
     2881 gagactcagc agagcacgag ggccctcctg cccccctcat cctcctgtcc agcctcgact
     2941 accagtacga cacccccggg ctctgggagc tgggagaggt gaatcagagg gtgagctcct
     3001 gcccctgtgt ggagaccgtc cagggctcct tgctgatacc ggtccatgtg gaacgcgaag
     3061 tccagcttcg aggcaggaac ctgtggcttt tccaggatgg cccgaggagc agcgagtgtg
     3121 tgctggagct agggagtcgg gaggtggctg tggaggctca ggtggagtgt gcgccgcctc
     3181 cagatgtctg gtgccacatc aagtgccagc agcatcagtt cagctatgaa gctttgaagc
     3241 cagaactgca ggtggggctg ttcctgcgtt gggcaggcgg tctgcgcgtg gacagtgccg
     3301 atgggctgca tgtggtgttg tatgactgct ctgtgggaca tggggactgc agccgctgcc
     3361 aaactgccat gcctcagtac gactgtgtgt ggtgtgaggg ggagcgtccg cgttgtgtgg
     3421 cccgggaagc ctgtaatgaa gccgagactg tggccactca gtgccccgca cctctcattc
     3481 actcggtgga tccactgact ggacctatag atggaggcac ccgtgtcact atcaggggct
     3541 ccaacctggg ccaacatgtg caggatgtcc tggacatggt cagagtggcc ggagttccct
     3601 gcgctgtgga tgctggggag tatgatgtct ctagtagtct tgtgtgcatc actggagcca
     3661 gcggggagga ggtgactggc actgtggcag tggaggtgcc tggaagagga cacggtgtct
     3721 cagagttcag ctttgcctat caggatccaa aagtacactc catcttccca gcccgtggcc
     3781 ctagagctgg aggtacccgc cttaccctgc atggttctaa gctcctgact ggacggctag
     3841 aggacatccg tgtggtggtt ggagaccagc cttgccacct gctcctggag cagcagtctg
     3901 agcagctaca ctgtgagacc ggcccatacc ctgtgcctgc tgaacttcca gtgactgtct
     3961 tgtttggggc cactgagcgg aggcttcagc acggccaatt caagtataca tcagacccca
     4021 atgtcacctc agtgggcccc tccaagagct tcttcagcgg aggacgtgag atatgggtcc
     4081 gcggccagga tcttgatgtg gtacagaggc caagaatccg agtgaccgtg gtcccaagac
     4141 agcatggcca ggggcttgca cagaagcaac acgtggtccc tgagaaattt gaggagccgt
     4201 gtctcgtgaa ctcctcccac ctcctcatgt gccgcactcc cgctctccct ggcccaccct
     4261 gggactctgg ggtccaggtg gagtttatcc tcgacaacat ggtctttgac tttgctgcac
     4321 tgagccccac acccttctcc tatgaggctg atcccaccct gcgttccctg aaccccgagg
     4381 atcccagcac gccgttccgg cacaagccag ggagtgtgtt ctctgtggag ggggagaatc
     4441 tggacctcgc catgtctaaa gaagaggtgg tggccatgat aggggacggg ccctgcgtgg
     4501 taaagacact gacccggaac cacctgtact gtgagccccc tgtggagcag cccctgccac
     4561 atccccatgc cctccgagag gctccagatg ctttgcctga gttcacggta cagatgggca
     4621 acctgcgctt ctccttgggt catgtgcagt acgatggcga gagccccgtg gcttttcctg
     4681 tggcagccca agtgggcttg ggagtgggca cgtctctcct ggctctgggt gtcatcatca
     4741 ttgtcctcat atacaggagg aagagcaagc aggccctgag ggactataag aaagtgcaga
     4801 tccagctgga gaacctggag agcagtgtac gggaccgctg taagaaggag tttacagacc
     4861 tcatgacgga gatgacggat ctcaccagtg acctccttgg cagcggtatc cccttccttg
     4921 actacaaagt gtatgctgag agggtcttct tccctgggta ccgggagtcc cccttgcaca
     4981 gggacctcgg tgtgcctgac agcaggcgac ccaccgtgga acagggcctg gggcagctct
     5041 ccaacctgct aaacagcaag ctcttcctta ccaagttcat ccacacactg gagagtcagc
     5101 gcaccttctc tgctcgggac cgtgcctacg tggcatctct gctcactgtt gcacttcacg
     5161 ggaagcttga atacttcacg gacatactgc ggactctgct cagtgacctg gtagctcagt
     5221 atgttgccaa gaaccccaag ctgatgctgc gcaggacaga gaccgtggta gaaaagctgc
     5281 tcaccaactg gatgtccatc tgcctctaca cctttgtgag ggactctgtg ggagagcctc
     5341 tgtatatgct cttcagaggg attaagcatc aagtggacaa gggtcccgtg gacagtgtga
     5401 ctggcaaagc caaatacact ctgaatgaca accgcctgct cagagaggat gtggagtacc
     5461 gtcccttgac cttgaatgct cttctggctg tggggcctgg ggcaggagaa gcccagtgtg
     5521 tacctgtgaa agtcctggac tgtgacacca tctcccaggc caaggagaag atgctagacc
     5581 agctttacaa gggagtgcct cttgcccagc ggcccgactc ttgcaccttg gatgttgaat
     5641 ggcggtctgg agtggctggg caccttatcc tttctgatga ggacgtcact tccgaactcc
     5701 agggtctgtg gaggcgtctg aatacactgc aacattacaa ggtcccagat ggagcaacgg
     5761 tggcccttgt cccctgcctc accaagcata ttcttaggga aaaccaggat tatgtccctg
     5821 gggaacggac cccaatgctg gaggatgtag atgagggggg catccggccc tggcacctgg
     5881 taaagccgag tgatgaacca gagcctccca ggccgaggag gggcagcctt cggggtgggg
     5941 agcgtgagcg agccaaggct atccctgaga tctacctgac acgcctgcta tccatgaagg
     6001 gcacactgca gaagtttgtg gatgacctgt tccaggtgat tctcagcacc agccgccctg
     6061 tgcctctggc tgtgaagtac ttctttgact tgctggatga acaagctcag cagcatggca
     6121 tctctgatca ggatactatc cacatctgga agaccaacag cctgccgcta aggttctgga
     6181 tcaacatcat caagaaccca cagtttgtgt tcgatgtgca gacttcggat aacatggatg
     6241 ctgtgctcct ggtcattgca cagaccttca tggatgcttg caccctggcc gaccacaagc
     6301 tgggccggga ttctcccatc aacaaacttc tgtatgctcg agatattccc cgttacaaac
     6361 agatggtgga aaggtactat gcagacatca gacagactgt cccggccagt gaccaagaga
     6421 tgaactcagt cttggcggag ctgtcccgga actgctctgc cgaccttggg gcgcgagtgg
     6481 ctctgcatga actctacaag tatatcaaca agtactatga ccagatcatc actgccctgg
     6541 aggaggatgg cactgcccag aagatgcagc tgggctaccg gctccagcag atcgccgctg
     6601 ctgtggaaaa caaggtcacg gatctataag gaccagggag tctttgcctg ctgttgtctc
     6661 tgtacctcct gggcagccct ggaatctcaa gggagaggcc accaccttcg tagatgcctg
     6721 tagtgactga caagcagagt ttaatgaaag gtggctccca gtctcttggt ggcaccagct
     6781 catagcctca gccccattgg acctgccttg taggcctggg acctagtggt tcagtgggta
     6841 gtgctaggcc tgccccaagc ctggtgactc tctgacctac ttcctgggtg acgccagcct
     6901 gcagggagct ggggacttaa ggtttccaga gaatgtctgg taggccctcc aggcccctgg
     6961 ggagactgta ctgttcttga gcactgacct atgtcccatt gggaatcaca gaggaaggaa
     7021 gagaacccgc ccgcccactt cctgtcttct tcatccatcc tccttgacct caagtttcgc
     7081 ttcctttgtc cttgttccct gttgccaatt cccaggagag agagaggggg gggggagaga
     7141 gagagagaga gagagagaga aagagatgca tttctaggct gctgctgcct cagcagggtt
     7201 ggtgcctcag gaccaccctg tcttccaggt ggctggtggg gagggacagc tgcttcaggg
     7261 gagccttggg gagagcagtg acccattgat gctatagctc ttcattaaag gataacacat
     7321 ggtatggact caccagcccc tctgctaaga tagaactggc agctgctggg agatgtgggc
     7381 atcgtgctct gaagggtccc ctgacaccca cggaaggcca ccatgaggtt ggcaagctct
     7441 ctccggctcc taggtagggt ctgccagagg caacactccc cagaaaggag aacttaaagc
     7501 acaataaggc tcagggagag ttggggcctg agatgtgggg ttctgtcccc catctttaag
     7561 gggtccacct tgattgcagg tcgtggtaac tttgccattc atgttccatg aatttttaaa
     7621 agaattgggg aagtatggcg ttattaaagg cgattccagg cagtgtgggt ctcaggtcca
     7681 tgaccctgtt tctggattcc agtttccaca ttgctgtcca tgttaaggta cctgaggcag
     7741 gagctcagag ctactcacct gcctgtgtag tagctacctt gtggtatttt cctgttagaa
     7801 gctacaagtg agcttcaaga ccatggtact gtggtgcact tggcagctgg cggttgagaa
     7861 tgccattggc ttcaccaggc aagggtcgtg gcatcctcag agagctccac cttggctcat
     7921 gtgtatagcc agtgatctgg ccaacctcaa gctcttcccc aagtgtttga agacatgggc
     7981 tgatacaatt ccaagagtcc cttcttgctg tcttttagaa tctttgtctt caagatcgca
     8041 ggagccattt tggttttcat gccaggggta atcacagtga ctatttctgt cagatcccat
     8101 cttccccatg cctgccagat gtggggaacc acagtcacag acggccagca gtcaggccct
     8161 cttttgggag catgtgaact ttagtactaa tgatagttgt cttagttcag attttatcct
     8221 cacgcagaat ggttttgcct cccccagtgg ctactccgac caactatgtt gttgacagtc
     8281 tcagagaaca gggctgacag ggggaatgag gtcttggcta gacttcagac agatacagga
     8341 agggaggcac cttttaagtc aacatggcag ggatggtgac agagacacac ctctgctcca
     8401 ggcttgagct tctgcagtct ttgggagtcc tctgaggcgg taagggttcc tgcagaggaa
     8461 ggccgtgtac ctgcgtgctt gggcgtgtgc tcatgggatg ggcgagtatg gaacgtgctc
     8521 tgagtcactc ctgtctcacc ctcacagaac actgtgatag aagatgtcat gaaaataaaa
     8581 atgttaccac ttcagagagg
//
