LOCUS       NM_175750              12602 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus plexin A4 (Plxna4), mRNA.
ACCESSION   NM_175750 XM_910622 XM_921693 XM_921705
VERSION     NM_175750.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12602)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12602)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 12602)
  AUTHORS   Lettieri,A., Oleari,R., van den Munkhof,M.H., van Battum,E.Y.,
            Verhagen,M.G., Tacconi,C., Spreafico,M., Paganoni,A.J.J.,
            Azzarelli,R., Andre',V., Amoruso,F., Palazzolo,L., Eberini,I.,
            Dunkel,L., Howard,S.R., Fantin,A., Pasterkamp,R.J. and Cariboni,A.
  TITLE     SEMA6A drives GnRH neuron-dependent puberty onset by tuning median
            eminence vascular permeability
  JOURNAL   Nat Commun 14 (1), 8097 (2023)
   PUBMED   38062045
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12602)
  AUTHORS   James,R.E., Hamilton,N.R., Huffman,L.N., Pasterkamp,J., Goff,L.A.
            and Kolodkin,A.L.
  TITLE     Semaphorin 6A in Retinal Ganglion Cells Regulates Functional
            Specialization of the Inner Retina
  JOURNAL   bioRxiv (2023)
   PUBMED   38014224
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12602)
  AUTHORS   Guo,Q., Wang,Y., Wang,Q., Qian,Y., Jiang,Y., Dong,X., Chen,H.,
            Chen,X., Liu,X., Yu,S., Zhu,J., Shan,S., Wu,B., Zhou,W. and Wang,H.
  TITLE     In the developing cerebral cortex: axonogenesis, synapse formation,
            and synaptic plasticity are regulated by SATB2 target genes
  JOURNAL   Pediatr Res 93 (6), 1519-1527 (2023)
   PUBMED   36028553
REFERENCE   6  (bases 1 to 12602)
  AUTHORS   Yaron,A., Huang,P.H., Cheng,H.J. and Tessier-Lavigne,M.
  TITLE     Differential requirement for Plexin-A3 and -A4 in mediating
            responses of sensory and sympathetic neurons to distinct class 3
            Semaphorins
  JOURNAL   Neuron 45 (4), 513-523 (2005)
   PUBMED   15721238
REFERENCE   7  (bases 1 to 12602)
  AUTHORS   Perala,N.M., Immonen,T. and Sariola,H.
  TITLE     The expression of plexins during mouse embryogenesis
  JOURNAL   Gene Expr Patterns 5 (3), 355-362 (2005)
   PUBMED   15661641
REFERENCE   8  (bases 1 to 12602)
  AUTHORS   Suto,F., Murakami,Y., Nakamura,F., Goshima,Y. and Fujisawa,H.
  TITLE     Identification and characterization of a novel mouse plexin,
            plexin-A4
  JOURNAL   Mech Dev 120 (3), 385-396 (2003)
   PUBMED   12591607
  REMARK    GeneRIF: plexin-A4 was expressed in the developing nervous system
            with a pattern different to that of other members of the plexin-A
            subfamily (plexin-A1, plexin-A2 and plexin-A3)
REFERENCE   9  (bases 1 to 12602)
  AUTHORS   Cheng,H.J., Bagri,A., Yaron,A., Stein,E., Pleasure,S.J. and
            Tessier-Lavigne,M.
  TITLE     Plexin-A3 mediates semaphorin signaling and regulates the
            development of hippocampal axonal projections
  JOURNAL   Neuron 32 (2), 249-263 (2001)
   PUBMED   11683995
REFERENCE   10 (bases 1 to 12602)
  AUTHORS   Kuroiwa,A., Suto,F., Fujisawa,H. and Matsuda,Y.
  TITLE     Chromosome assignment of four plexin A genes (Plxna1, Plxna2,
            Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster
  JOURNAL   Cytogenet Cell Genet 92 (1-2), 127-129 (2001)
   PUBMED   11306810
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158678.6, AB073228.1, AC153629.3 and BF456700.1.
            
            On Apr 1, 2008 this sequence version replaced NM_175750.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB073228.1, BC141298.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-889               AC158678.6         44661-45549
            890-2954            AB073228.1         889-2953
            2955-3068           AC153629.3         102277-102390       c
            3069-7023           AB073228.1         3068-7022
            7024-12492          AC153629.3         12421-17889         c
            12493-12602         BF456700.1         1-110               c
FEATURES             Location/Qualifiers
     source          1..12602
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.9 cM"
     gene            1..12602
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /note="plexin A4"
                     /db_xref="GeneID:243743"
                     /db_xref="MGI:MGI:2179061"
     exon            1..889
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            890..2159
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     CDS             975..6656
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /codon_start=1
                     /product="plexin-A4 precursor"
                     /protein_id="NP_786926.2"
                     /db_xref="CCDS:CCDS19985.2"
                     /db_xref="GeneID:243743"
                     /db_xref="MGI:MGI:2179061"
                     /translation="MKAMPWNWTCLLSHLLVVGMGSSTLLPRQPPQLSQKPSFVTFRG
                     EPAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQT
                     CNEPLASTNNVNKMLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPFHKKEHYLS
                     GVNESGSVFGVIVSYSNFDDKLFIATAVDGKPEYFPTISSRKLTKNSEADGMFAYVFH
                     DEFVASMIKIPSDTFTVIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYT
                     SKLVRLCKEDTAFNSYVEVPIGCERNGVEYRLLQAAYLSKAGAVLGRTLGVRPDDDLL
                     FTVFSKGQKRKMKSLDESALCIFILKQINDRIKDRLQSCYRGEGTLDLAWLKVKDIPC
                     SSALLTIDDNFCGLDMNAPLGVSEMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFVGTK
                     SGKLKKIRVDGPKGNALQYETVQVVDSGPVLRDMAFSKDHEQLYIMSERQLTRVPVES
                     CGQYRSCGECLGSGDPHCGWCVLHNTCTRKERCERSREPRRFASEMKQCVRLTVHPNN
                     ISVSQYNVLLVLETYNVPELSAGVNCTFEDLSEMDGLVIGNQIQCYSPAAKEVPRIIT
                     ENGDHHVVQLQLKSKETGMTFASTSFVFYNCSVHNSCLSCVESPYRCHWCKYRHVCTH
                     DPNTCSFQEGRVKLPEDCPQLLRVDKILVPVEVIKPITLKAKNLPQPQSGQRGYECIL
                     NIQGIEQRVPALRFNSSSVQCQNTSYSYEGMEINNLPVELTVVWNGHFNIDNPAQNKV
                     YLYKCGAMRESCGLCLKADPDFECGWCQSPGQCTLRQHCPAHESRWLELSGANSKCTN
                     PRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIV
                     CEMGEAKPSQHAGFVEICVAVCRPEFMARSSQLYYFMTLTLADLKPNRGPMSGGTQVT
                     ITGTNLNAGSNVVVMFGSQPCLFHRRSPSYIICNTTSSEEVLDMKVTVQVDRARIRQD
                     LVFQYVEDPTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINICEVL
                     NATEMTCQAPALALGPDHQSDLTERPEEFGFILDNVQSLLILNKTNFTYYPNPVFEAF
                     SPSGILELKPGTPIILKGKNLIPPVAGGNVKLNYTVLVGEKPCTVTVSDVQLLCESPN
                     LIGRHKVMARVGGMEYSPGMVYIAPDSPLSLPAIVSIAVAGGLLIIFIVAVLIAYKRK
                     SRESDLTLKRLQMQMDNLESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTYT
                     MRVLFPGIEDHPVLRDLEVPGYRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFS
                     MRDRGNVASLIMTVLQSKLEYATDVLKQLLADLIDKNLESKNHPKLLLRRTESVAEKM
                     LTNWFTFLLYKFLKECAGEPLFSLFCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQI
                     EYKTLVLSCVSPDNVNSPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPKAADMDL
                     EWRQGSGARMILQDEDITTKIENDWKRLNTVAHYQVPDGSVVALVSKQVTAYNAVNNS
                     TVSRTSASKYENMIRYTGSPDSLRSRTPMITPDLESGVKLWHLVKNHEHGDQKEGDRG
                     SKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKH
                     GIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTS
                     EHRLGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNE
                     FNTMSALSEIFSYVGKYSEEILGPLDHDDQCGKQKLAYKLEQVITLMSLDS"
     exon            2160..2342
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2474
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2575
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2699
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2853
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..2953
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3068
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3269
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3366
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3557
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3709
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..3827
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..3964
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            3965..4129
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            4130..4223
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4463
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            4464..4610
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            4611..4845
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            4846..4988
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            4989..5257
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            5258..5324
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            5325..5471
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            5472..5631
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            5632..5735
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            5736..5835
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            5836..6026
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            6027..6196
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            6197..6409
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            6410..6560
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     exon            6561..12602
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8017..8022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /note="hexamer: ACTAAA"
     polyA_site      8036
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
     polyA_site      12517
                     /gene="Plxna4"
                     /gene_synonym="9330117B14; mKIAA1550; Plxa4"
                     /note="major polyA site"
ORIGIN      
        1 gcgagccgcg gcggcagcag gcagcccggg agctccggcg gcggccgagc cagcggcggc
       61 cccgctccct gccccctgca aactttgcga gcagcccgcc cggggggccg gggacgcgcc
      121 tgggaggctc ggcttggact acggccgcgc tcttggccgc cgcagcgcta gccgccgccg
      181 tcgctgctac caccgcagct ccgcgcctcc ccggggagct gccggcggct tccgaggccc
      241 cccagccccg gcccctgggc actgcccggc tagtccccgg ccagggttgg gggcgacagc
      301 ggcgcagcca gccccgggct gccagggggt ggccgtcact gcccagggag gcgcgcagag
      361 gatcggagag cgctccccgg cgggtcccca acgtactcgc cgccgcgccc gggcagcggc
      421 ccgacccggc tagcatgggc ggcgcggagt gacgccgccg tgcccgcttg gcatcaagga
      481 cattcagccc gcgggggtgg ggacgaaggg gggcagcccc gcgtcgccgc cgcagcccct
      541 gagagccacc gctgtcgctg cttgggctcc ggggctggat ggaagctagg ggtgcttgga
      601 attgatcttc atttcctgac ctttttgttg gacattacgc ccaccttgga cgctgcaaga
      661 ggagctgtca agcccggcag gctctgattt ggccccctcc gtttttctct gctgctcgtg
      721 gcttccccgt gcctcggtgg agtatttgcg ttcggggctg gggctggagg aggcagccac
      781 acgcgcgcac acgcacacgt tcagaggagg gcgagaggca gcggtacagg caccatctgc
      841 agtgtcaatg cggcgctggg gctgaaggag ggaaacgccg cgcttccagg ggagacagcc
      901 ctgctgagtc ctggcccccg cgaagggaca gttgtgctgg agtgctgctg tgtctgcgag
      961 gacctgtgtc tgagatgaaa gccatgccct ggaactggac ttgcctgctc tcccacctgc
     1021 tggtggtagg gatgggctcc tccactctgc ttccacgaca gccaccccag ctgtctcaga
     1081 agccttcctt tgtgacattc cgaggggagc ctgctgaggg cttcaatcac cttgtggtgg
     1141 atgagaggac agggcacatt tatttggggg ctgtcaacag aatctacaaa ctctctagtg
     1201 acctcaaagt cttggtgact catcagacag ggccagatga ggacaacccc aagtgttacc
     1261 cacctcggat tgttcagacc tgcaatgagc ctctggccag caccaataac gtcaacaaga
     1321 tgctgcttat agactacaaa gaaaacaggc tgatcgcgtg tgggagcctg taccagggta
     1381 tctgcaagct cctgaggcta gaggacctct tcaagttggg agagcccttt cacaagaagg
     1441 aacattatct ctcgggggtt aacgagagtg gctcagtctt tggggtgatt gtttcctaca
     1501 gcaactttga tgataaactc tttattgcca cagcagtgga tggcaaacct gaatattttc
     1561 ctaccatctc cagcaggaag ctgactaaga actctgaggc cgatggcatg tttgcttacg
     1621 ttttccatga tgaatttgtg gcctctatga ttaagatccc ttcagacact ttcacggtta
     1681 tccccgactt tgacatctac tacgtctatg gcttcagcag tggcaatttt gtctactttt
     1741 tgacccttca gccagagatg gtgtctcccc caggctccac gacaaaggag caggtgtaca
     1801 cctcaaagct tgtgaggctt tgcaaagagg acacagcctt taactcctac gtagaggtgc
     1861 ccattggctg tgagcgcaat ggggtggagt atcgcttgtt acaggctgcc tacttgtcta
     1921 aagctggtgc agtgcttggc cggaccctag gagtccgccc agatgacgac ctcctcttca
     1981 ccgtcttctc caagggccag aagcggaaga tgaaatctct ggatgagtct gccctgtgca
     2041 tcttcatctt gaagcagatc aatgatcgca ttaaggaccg cctgcagtcc tgttataggg
     2101 gtgagggaac actagacctg gcctggctca aggtgaagga catcccttgc agcagtgcgc
     2161 tccttactat tgatgacaac ttctgtggcc tggatatgaa tgctcctctg ggagtttccg
     2221 aaatggtgcg tggcattcca gtcttcacag aagacaggga ccgcatgact tctgtcatcg
     2281 cctatgtcta caagaaccac tcactggcct tcgtgggcac caaaagtggc aagctgaaga
     2341 agatccgggt tgatgggccc aagggaaatg ccctccaata tgagactgtg caggtggtgg
     2401 actcaggacc agtcctccgg gacatggcct tttccaagga ccacgagcaa ctctacatca
     2461 tgtcagaaag gcagcttacc agagttcctg tggagtcctg tgggcagtac cggagctgtg
     2521 gcgagtgtct tggctcaggt gacccccatt gtggctggtg tgtgctccac aacacgtgca
     2581 cccggaagga acggtgtgaa cgctccagag aaccccgaag gtttgcctca gagatgaagc
     2641 agtgtgtccg gctgacggtc catcccaaca acatctctgt ctctcagtac aacgtgctgc
     2701 tggtcctaga gacatacaat gtcccggagc tgtcagcagg tgtcaactgt acctttgaag
     2761 atctgtcaga gatggatggg ctggtaatag gcaatcagat ccagtgctac tcccctgcag
     2821 ccaaggaagt gccccggatc atcacagaaa atggggacca tcatgttgtc cagctgcaac
     2881 tcaagtcaaa ggagactggg atgaccttcg ccagcaccag ctttgtcttc tacaactgca
     2941 gtgtccacaa ttcatgcctg tcctgtgtgg agagcccgta ccgttgccac tggtgtaaat
     3001 accggcatgt ttgtactcac gaccccaaca catgctcctt ccaggaaggc cgagtgaagc
     3061 tacctgagga ctgcccccag ctgctgcgag tggacaagat cctcgttcca gtagaggtga
     3121 tcaagcccat cactctgaag gctaagaacc tcccacagcc tcagtcggga cagagaggct
     3181 acgagtgcat cttgaacatc cagggcatcg agcagagggt acctgctctg cgcttcaaca
     3241 gctccagtgt gcagtgtcag aacacctcct attcctatga aggaatggag atcaacaacc
     3301 tgccagtgga gttgacagtc gtgtggaatg gacacttcaa cattgacaac ccagctcaga
     3361 ataaagttta cctctacaag tgtggagcca tgcgcgagag ctgtgggctg tgcctcaagg
     3421 ccgacccgga tttcgagtgt ggctggtgtc agagcccagg ccagtgtacc ctgcgccagc
     3481 actgccctgc ccatgagagc cggtggttgg aactgtcggg ggccaacagc aagtgcacca
     3541 accctcgtat cacagagatc atcccagtga cgggccctcg agaagggggc accaaggtca
     3601 ccatccgagg ggagaacttg ggcctggaat tccgtgacat tgcatcacac gtgaaagtgg
     3661 ctggtgtgga atgcagcccc ttggtggatg gctacatccc agctgaacag atcgtgtgtg
     3721 agatgggtga ggccaagcct agccagcatg caggctttgt ggagatctgt gtggctgtgt
     3781 gtcggcctga gttcatggcc cgctcttcgc agctctatta cttcatgact ctgaccctcg
     3841 cagatctgaa gcccaaccga ggacccatgt ctggggggac acaggttacc atcacaggta
     3901 ccaacttgaa tgcaggcagc aatgttgtgg tgatgttcgg gagccagccc tgcctcttcc
     3961 acaggcgctc tccatcctac attatctgta acactacatc ctcagaggag gtgctggaca
     4021 tgaaggtgac tgtgcaggtg gacagggcca ggatccgcca ggacctggtc tttcagtacg
     4081 tggaggaccc caccattgtg cggattgaac cagaatggag cattgtcagt gggaacacac
     4141 ctattgctgt ctggggaact cacctggacc tcatacagaa cccacagatc cgtgccaagc
     4201 atggaggaaa agaacacatc aacatctgtg aggtcctaaa tgctacagag atgacctgcc
     4261 aggctccagc ccttgccctg ggtcccgacc accagtcaga tctcactgag aggcctgaag
     4321 aatttggttt catcctggac aatgtccagt ctctgctaat tctcaacaag accaacttca
     4381 cctattatcc taaccccgtg tttgaggctt tcagtccctc gggaatcctg gagctcaagc
     4441 cgggcacccc cattatccta aagggcaaga acttgatccc gcctgtggcc ggaggcaatg
     4501 tgaagctgaa ctacaccgtg ctggttgggg agaaaccatg caccgtgaca gtatcagatg
     4561 tgcagctgct ctgcgagtct cccaacctca tcggcaggca caaagtgatg gcacgggtgg
     4621 gtggcatgga gtattcccct gggatggtat acatcgcccc agacagcccg ctcagcctgc
     4681 ccgccattgt cagcatcgcg gtggctggtg gcctcctcat catcttcatc gtggccgtac
     4741 tcatcgccta caaacgcaaa tcccgagaaa gtgacctcac gctgaagagg ttgcagatgc
     4801 agatggacaa ccttgagtcc cgtgtggcgc tggagtgcaa ggaagctttt gccgagctgc
     4861 agacagatat ccatgagctt accagtgacc tggatggagc tgggattccc tttctggact
     4921 acagaaccta taccatgcgg gtgctgttcc cagggattga agaccaccct gtgctacgag
     4981 accttgaggt cccaggctac cggcaggagc gtgtggagaa aggactcaag ctcttcgccc
     5041 agctcatcaa caacaaggtg ttcctgctct ctttcatccg cactctggag tctcagcgca
     5101 gtttttccat gcgcgaccga ggtaacgtgg cctccctcat catgacggta cttcagagca
     5161 agctagagta tgccactgac gtgctgaagc agctactggc tgacctcatt gataagaacc
     5221 tggagagcaa gaaccacccc aagctgctgc tcaggaggac ggagtcggtg gccgagaaga
     5281 tgttgactaa ttggttcact ttcctcctct acaagttcct caaggagtgt gctggggagc
     5341 cactcttctc cctgttctgt gccatcaagc agcagatgga gaagggcccc attgatgcca
     5401 tcaccggaga ggcccgctac tcgctaagtg aggacaaact catccgacag cagattgaat
     5461 ataaaacctt ggtcctgagc tgtgtcagtc cagataatgt taacagccca gaggtcccag
     5521 tgaagatcct caactgtgac accatcactc aggtcaaaga gaagatccta gatgccatct
     5581 tcaagaatgt cccgtgctcc cataggccca aagctgcaga catggatcta gagtggcgac
     5641 aaggaagtgg ggcgaggatg atcctgcagg acgaagatat caccaccaag atcgagaatg
     5701 attggaagag actcaacaca gtagcccact accaggtacc agatggttct gtggtggctt
     5761 tagtgtccaa gcaagtgaca gcctacaatg cagtgaacaa ctccactgtc tccaggactt
     5821 cagcaagtaa atatgagaac atgatccggt acacaggcag ccctgacagc ctccgttccc
     5881 ggacacccat gatcacccct gacctggaaa gcggggtcaa gctttggcat ctggtgaaga
     5941 accatgaaca tggagaccag aaggaggggg accgggggag caagatggtg tctgagatct
     6001 atctgacacg actattggcc acaaagggca cactgcagaa gtttgtggat gacctattcg
     6061 agaccatctt cagtacggcc caccgtggct ccgctctgcc gctagccatc aagtacatgt
     6121 ttgacttcct cgatgagcag gctgataagc acggcatcca tgacccgcac gtccgccaca
     6181 cctggaagag caactgcctg cccctacggt tttgggtgaa tatgatcaag aaccctcagt
     6241 ttgtgtttga catccataag aacagcatca cggatgcctg tctctctgtg gtggcccaga
     6301 ccttcatgga ctcctgctcc acttcggagc accgactggg caaggattcc ccctccaaca
     6361 agctgctcta tgccaaggac atccccagct acaagaactg ggtagagagg tattattcag
     6421 acattgggaa gatgccggca ataagtgacc aggacatgaa tgcatacctg gccgagcagt
     6481 cgcggatgca catgaatgag ttcaatacga tgagtgcgct ctcagagatc ttctcctatg
     6541 tgggcaaata cagtgaggag atccttggac ccctggacca tgatgaccag tgtggaaagc
     6601 agaaactggc ttacaaacta gaacaagtca taactctcat gagcttagac agctgagaac
     6661 tgtccttcca gggccatcct ggagggaggg acacaccaag ccgtgcctca gtctagatta
     6721 tcatctttac caagtgcaag ttccgacagg catcagcagc aatccccaag cagcgccgtc
     6781 tctcctttca tttctctgcc tcttctgtct ctccctcctt ccggagcccc atctctttca
     6841 gttgctctgc cagcgggatt ggaccacacc actgaccctc catcagttta gggatggcca
     6901 ggccatagtg aggtacctga ccagatctca gagtcaggct ccctcccagc tgctcctggc
     6961 cccatgcatc aatggcaggg ctcagaaagg atgaggagct gaggacagaa cattcctatg
     7021 ctgctacttc acctttgctt tgagaatctc cactgtggtc caaaacctgg cttcaggaag
     7081 caactgtgag ctcagtatta tctgaagtag gagatatcac tcggatctcc cgttcaacac
     7141 actcaacaac aagaggccag gcagtaggcc tgggtgcttt gtaactgtga gataaaggcc
     7201 ttgcctccta ctgatgttgg actggggacc agtggaaatt taaagatgct ctctcagggg
     7261 ccgctgccta cctgtttgat gtccagcagc cttctgtccc cttctaatat ccttggaggc
     7321 cttccaaatg tccatacaga ccttcctccc tttcctgtga aaagtcagac aggaaagcta
     7381 acagttacat tccaccatgg agatgctcct acgttaccta acctggttcc taatagcaga
     7441 aatgtaatac ggagagagag aagaggaaaa agaatatcat ctatgccaga agcaacaatg
     7501 agttgttctc tattcacccc aagttcaaat gcatcatgac catagtcaaa ggtccattgc
     7561 cagagccttg tgtgttgtct agagaaggca tctccacgct cctttgtcac catcaccaac
     7621 actcaccgtg aaatgcagag tgcgtcaagg agattctacc tccagccgtc tccaaggctc
     7681 cattccccac tgtctttgag aactccatag acggccaggg cagagggccc agcccttgtc
     7741 cctcctgcag aatctggtgc cattgctatg cagatgactt tgtcactaga gtgtccagac
     7801 ctctgtggga attgtttcat caacatctca gctgtccttt cagtggttct tcctccttat
     7861 cctttctgaa gtcatccacc attggaagaa acatacttac acacagcctc accaagacaa
     7921 aacaagatgc cagcagcctc agccaacagc ttgtgcctgg aagggactgg agagctgagt
     7981 gagggacctg gatggatatg gagaacagta cataccacta aaccacggtc ttgacagtta
     8041 tgtctccatt gtgtctttcc atctttggat acagcatttt gttttagcca gtcaggcaaa
     8101 tgtgtacaca gaaatgtacc aagtggttat gccaagaggt ggtctattgg tgggtcctgg
     8161 gaacctacag tcttgcaggg atcttagata cttagtgatc cagtctccac cataagcaag
     8221 aatctctttt ggcttgttgt tgtcccacac tcatggagac aagagaggca ctggagaagg
     8281 aggtgttaat agcattccac agtctcgcct tccttcattc tccatgcata gcatgccatt
     8341 acttttcatc actaaaatga gcctcacatg gggcaaagtc cgcctgtcat cctgcacctg
     8401 taaggacact gagtcccttt gcatacgaga gaacagggtt gggggaggca cctaggaaca
     8461 tgcaaggatt tcttatccca tgtaggatgc tgagacagtc cccttctctc tcccctggct
     8521 catctgtcca gtcttcagtg tcagtatact tcactgagtg gtagtgtata cggtaagaac
     8581 attcttctat ccacagcaaa tcatgatgtt acctaccaag gctgaactgt ggaatcagag
     8641 cagaaggccc catgtggtgt tgctgtagac aaacagcaaa gacacgccaa tgtagcaaac
     8701 aagaagaaga ggctggggaa agatgcattg gaatcgggga ggggtaatga aaaacaaaaa
     8761 ccaaaaacca aaggttttgg caaatcaatt gccaggtgga gacatgtaaa atttctatca
     8821 ctgcgtattg ttttcttcca tgaagccacg ggagctggca ggctttaggg tgaatgtggg
     8881 agttcagcag gaggagcacc tcagctgcaa aggtcttttt acacgtgtga agggttgggg
     8941 aggagagaga caggaaccta tttaatagag acttgcagac agacagaagc tgtgtgtgtg
     9001 tgtgtgtgtg tgtgtgtgtg tacatgcatg agtgagagag atttgattta agttttgcac
     9061 agttagaaaa ttatgaacaa gcagcagaag agcttgtgac tttgctgacc tttttttttt
     9121 ttttactgga tgattttatt gttattatta ttttgtcggt acagattttt tttcatcatt
     9181 ttttttttgt tgttgttgtt gttacaagca gaacttcaaa cacctcagag aaatacacat
     9241 atcaggaaga aagaggccag gacagtcaca tttccagggt ctcctcattt ctcttgaggg
     9301 aggggcttta gttagatatt ttacttagtt ggcacttcat aggcagtcct gatggcctgc
     9361 ttggggaact cagaagttga ggcccatgtt gcctgtaaaa accttccctt tttgctgctt
     9421 gtttgtttgt ttacttccca tttcttccat ttgctttttg gtgcaagtgt gatacattta
     9481 aaagcaagta taggcaatgt tgtccaaaat ctgtcaaacc ctcccattta ttcttatcca
     9541 actcctactt ggggttttct agttcctctt agctgccagg gaccctggtg gtctgtgagc
     9601 ttccagagaa ctaaatcaga gaagctaggc catgcaatcc agtggtgcct tgtgctcttt
     9661 ccagagttca tttgcagggt gttgcagagc tgtcaaaggt ggaaccgtta tttatcccct
     9721 ggagtttgtt cagagggtat gtggcgggcg ggcgataggt agtctctctc tcacctctca
     9781 ttcacctcta catcttccta ttcctgacac cactggtcaa aatggtactg atcccacatc
     9841 caaaatatct ggctaggtga ggatttgaat cttgtaggcc gattagcaag gagctcaatg
     9901 gggtcctgaa tgcaaaagaa tatgtagaag aaaccaagga aagtatctgc aggctggttg
     9961 tttctctgtg gcctatgtct ctttaggtgt gggcatggtc tggtcatgtc ttcctccttg
    10021 gctaaaagga gacaccctaa tgtgtcttgg tgccatgaag tcaagttagc cttggagttg
    10081 gttacttcct caggaaaata ctttcttgcc ttcttctttc aatacagttt taaacttggg
    10141 gatggaggat aaacagagga tttccccaga ccaaggtact ttgcaaccct gtgaaccatg
    10201 catggccaga gccagcccct ggagcctcca tgcagggagt ccacagccct ggagtaagcg
    10261 tgtggtgcct caatggggcc aagtttgcaa agagagacac ttgtaattca ttttgcattt
    10321 ccaggcagag tatccaggtc aattcccagg aagcacaagc tactcacaga caaaatcttt
    10381 ctgtgctccc accctcaact cctgctccca ccgggttaat attgatatag tgcccagctc
    10441 atccagcacc ctaaggttct aaggtgttta tttcccaccc cacccctata ctcccacccc
    10501 caagtgcatg tctgtctact gactataccc caccctggca gctagcttcc tccttgttcc
    10561 tccttgaacc tcctgtacaa ggagcctctc caaggctaag tactgattct gatatgggag
    10621 ttgctcagaa ctttagtccg ttagtagtca gtgccgtcct gacccagctt tggctgcttc
    10681 cctgagtgat ggggtcatcc tcccccagcc aacaccctgt gggtcgtcca ccagaggagc
    10741 cacaagcaat gatctccaag atacgagtgt ctgacacact ttccaggacc ctgggtgatg
    10801 ctgctgctgt ggtcccttat ggcccaagca cctctctctg atagaaataa gagagcctcc
    10861 ttcctgccat gtctcctagg acaccccatt gacttcacca gacagcaaat aaatgcatca
    10921 tcttgagaag ggccaatact cctgtcatca ggaacaaatt atcctgattg catagaacca
    10981 actcaagcat catgcttaca attgagcagc tgaggtacca tcgcagatgg aggtaaaggg
    11041 gcagctcctg agaaagaggc tgggaccacc atgcaagctt accccagagc tctgatgggg
    11101 gccacaccct ctctcccatt tagaaagcaa tcactacagg aaacatttca aatattagga
    11161 gagacttttt tgttgttgtc gttttgctac agatcattgc tcttcaataa tattgcttta
    11221 aaaaaaaaaa aagagggagc atccaagttt aaaaaaactt ttttcagttg aaaagacaga
    11281 atgtcttacc ctgatggaat cccttgagta gactgatggc tattagaaag ttgagcagaa
    11341 caagcagttc ccaaggagta aagagaaggt catgttcttg ctcctcacag agatggtgag
    11401 ggctctaagt agtggggtct ttggttagga atctcaagtc ccttctccct cctccctcct
    11461 tcctcctccc tcctccctcc tccctcctcc ttgggctgcc cctggaattt ctgaatcctt
    11521 caaatttctt ctcggcttcc ttcaaacttc actgaaactg attttagggg aacccaagct
    11581 ccctgtcccc cacaataaca caaaaacaag tggacactca attagccagt ttcttcctct
    11641 tctgcccgtt tgttttgtct atatctttaa agttaagact caagcacatg ttggaagggc
    11701 tcccttatga gagtggagtt caaaacagag ggtacagtta agcagcaccc caaaacaaaa
    11761 actttgaagc agagaccact ccagcaaaca gaacgaagga acattcctgt gcagagatca
    11821 gttcaattct atccaagcaa gaggtaaaga ggggctgcgt cctcatctgt ccctctgtcc
    11881 cttccctggc attcttgtca gcttgttgct gtattaaacc ttctgttctt taaaagcaaa
    11941 agctagttta cctcaaagaa ttgtacttcc atttggaaac caatgacagg gcttgagaat
    12001 ggatgatatt cctcgtacct ctccctacct gggcctggtg tccttgggca cgtggtctta
    12061 gcttagtcct gagttaggtg ctctaagcag gcaccaggtc cccaggtctg cgatgggaag
    12121 aaaggattgt atgcagcctt tctccctgct tagcatgtag ggaacaaaca gcctctgtct
    12181 cttccatcag ggtcttgtca agttaccata gcaaccagca actccaggta ccacaaaaga
    12241 caatgagctg aggtgtgaga gagagcatgg gcttctggcc tggtcagagg acccagaatt
    12301 aaggcccaga tgctaagagg gcaaagggag gagggatcga actggatgca tgaatgggtg
    12361 aagaagaagc tgcaagaggc cttgtgagtc agagagaagc cactggcaga gctaggacag
    12421 atcgcttctg tttccctcac cgcttaccct tctccagcct gccccacctc tattccaaac
    12481 actctcacct tgaataccaa ccttttgaaa gaagaaagca aaatatgcct ttagacgaca
    12541 gtgttaccct ggccgccagg acaggaggat gggatctctg aaagaaaaaa aaaaaaaaaa
    12601 aa
//
