LOCUS       NP_032909               1872 aa            linear   ROD 28-APR-2025
DEFINITION  plexin-A3 isoform 1 precursor [Mus musculus].
ACCESSION   NP_032909
VERSION     NP_032909.2
DBSOURCE    REFSEQ: accession NM_008883.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1872)
  AUTHORS   Bsharat,S., Monni,E., Singh,T., Johansson,J.K., Achanta,K.,
            Bertonnier-Brouty,L., Schmidt-Christensen,A., Holmberg,D.,
            Kokaia,Z., Prasad,R.B. and Artner,I.
  TITLE     MafB-dependent neurotransmitter signaling promotes beta cell
            migration in the developing pancreas
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36897571
REFERENCE   2  (residues 1 to 1872)
  AUTHORS   Yan,K., Bormuth,I., Bormuth,O., Tutukova,S., Renner,A., Bessa,P.,
            Schaub,T., Rosario,M. and Tarabykin,V.
  TITLE     TrkB-dependent EphrinA reverse signaling regulates callosal axon
            fasciculate growth downstream of Neurod2/6
  JOURNAL   Cereb Cortex 33 (5), 1752-1767 (2023)
   PUBMED   35462405
REFERENCE   3  (residues 1 to 1872)
  AUTHORS   Lopez-Tello,J. and Sferruzzi-Perri,A.N.
  TITLE     Characterization of placental endocrine function and fetal brain
            development in a mouse model of small for gestational age
  JOURNAL   Front Endocrinol (Lausanne) 14, 1116770 (2023)
   PUBMED   36843585
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1872)
  AUTHORS   Xiao,Z., Liu,S., Li,Z., Cui,J., Wang,H., Wang,Z., Ren,Q., Xia,L.,
            Wang,Z. and Li,Y.
  TITLE     The Maternal Microbiome Programs the m6A Epitranscriptome of the
            Mouse Fetal Brain and Intestine
  JOURNAL   Front Cell Dev Biol 10, 882994 (2022)
   PUBMED   35874829
  REMARK    Erratum:[Front Cell Dev Biol. 2025 Feb 06;13:1553431. doi:
            10.3389/fcell.2025.1553431. PMID: 39981100]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1872)
  AUTHORS   Khdour,H.Y., Kondabolu,K., Khadka,A., Assous,M., Tepper,J.M.,
            Tran,T.S. and Polack,P.O.
  TITLE     Neuropilin 2/Plexin-A3 Receptors Regulate the Functional
            Connectivity and the Excitability in the Layers 4 and 5 of the
            Cerebral Cortex
  JOURNAL   J Neurosci 42 (24), 4828-4840 (2022)
   PUBMED   35534225
REFERENCE   6  (residues 1 to 1872)
  AUTHORS   Takahashi,T., Fournier,A., Nakamura,F., Wang,L.H., Murakami,Y.,
            Kalb,R.G., Fujisawa,H. and Strittmatter,S.M.
  TITLE     Plexin-neuropilin-1 complexes form functional semaphorin-3A
            receptors
  JOURNAL   Cell 99 (1), 59-69 (1999)
   PUBMED   10520994
REFERENCE   7  (residues 1 to 1872)
  AUTHORS   Kuroiwa,A., Watanabe,T., Hishigaki,H., Takahashi,E., Namikawa,T.
            and Matsuda,Y.
  TITLE     Comparative FISH mapping of mouse and rat homologues of twenty-five
            human X-linked genes
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 208-212 (1998)
   PUBMED   9730605
REFERENCE   8  (residues 1 to 1872)
  AUTHORS   Kameyama,T., Murakami,Y., Suto,F., Kawakami,A., Takagi,S.,
            Hirata,T. and Fujisawa,H.
  TITLE     Identification of plexin family molecules in mice
  JOURNAL   Biochem Biophys Res Commun 226 (2), 396-402 (1996)
   PUBMED   8806646
REFERENCE   9  (residues 1 to 1872)
  AUTHORS   Maestrini,E., Tamagnone,L., Longati,P., Cremona,O., Gulisano,M.,
            Bione,S., Tamanini,F., Neel,B.G., Toniolo,D. and Comoglio,P.M.
  TITLE     A family of transmembrane proteins with homology to the
            MET-hepatocyte growth factor receptor
  JOURNAL   Proc Natl Acad Sci U S A 93 (2), 674-678 (1996)
   PUBMED   8570614
REFERENCE   10 (residues 1 to 1872)
  AUTHORS   Rivella,S., Tamanini,F., Bione,S., Mancini,M., Herman,G.,
            Chatterjee,A., Maestrini,E. and Toniolo,D.
  TITLE     A comparative transcriptional map of a region of 250 kb on the
            human and mouse X chromosome between the G6PD and the FLN1 genes
  JOURNAL   Genomics 28 (3), 377-382 (1995)
   PUBMED   7490070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807376.4 and CJ192479.1.
            
            On Jan 30, 2007 this sequence version replaced NP_032909.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86950.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.0 cM"
     Protein         1..1872
                     /product="plexin-A3 isoform 1 precursor"
                     /note="plexin 3"
                     /calculated_mol_wt=205982
     sig_peptide     1..19
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P70208.2)"
                     /calculated_mol_wt=1996
     mat_peptide     20..1872
                     /product="Plexin-A3. /id=PRO_0000411104"
                     /note="propagated from UniProtKB/Swiss-Prot (P70208.2)"
                     /calculated_mol_wt=205982
     Region          22..490
                     /region_name="Sema_plexin_A3"
                     /note="The Sema domain, a protein interacting module, of
                     Plexin A3; cd11273"
                     /db_xref="CDD:200534"
     Site            60
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P70208.2)"
     Site            order(77,79..80,139,176..178,204..206,213..215,369,372,
                     374,377..381,391..392,394)
                     /site_type="other"
                     /note="putative Semaphorin binding site [polypeptide
                     binding]"
                     /db_xref="CDD:200534"
     Region          491..>528
                     /region_name="PSI"
                     /note="Plexin repeat; pfam01437"
                     /db_xref="CDD:396154"
     Region          547..637
                     /region_name="TIG_plexin"
                     /note="TIG domain; pfam17960"
                     /db_xref="CDD:465588"
     Site            549
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P70208.2)"
     Region          638..685
                     /region_name="PSI"
                     /note="Plexin repeat; pfam01437"
                     /db_xref="CDD:396154"
     Region          691..785
                     /region_name="TIG_2"
                     /note="TIG domain found in plexin; pfam18020"
                     /db_xref="CDD:465619"
     Region          789..838
                     /region_name="PSI"
                     /note="Plexin repeat; pfam01437"
                     /db_xref="CDD:396154"
     Region          841..935
                     /region_name="IPT_plexin_repeat1"
                     /note="First repeat of the IPT domain of Plexins and Cell
                     Surface Receptors (PCSR) . Plexins are involved in the
                     regulation of cell proliferation and of cellular adhesion
                     and repulsion receptors. In general, there are three
                     copies of the IPT domain present...; cd01180"
                     /db_xref="CDD:238585"
     Region          936..1022
                     /region_name="IPT_plexin_repeat2"
                     /note="Second repeat of the IPT domain of Plexins and Cell
                     Surface Receptors (PCSR) . Plexins are involved in the
                     regulation of cell proliferation and of cellular adhesion
                     and repulsion receptors. In general, there are three
                     copies of the IPT domain present...; cd01179"
                     /db_xref="CDD:238584"
     Region          1024..1124
                     /region_name="IPT_plexin_repeat3"
                     /note="Third repeat of the IPT domain of Plexins and Cell
                     Surface Receptors (PCSR) . Plexins are involved in the
                     regulation of cell proliferation and of cellular adhesion
                     and repulsion receptors. In general, there are three
                     copies of the IPT domain present...; cd01181"
                     /db_xref="CDD:238586"
     Region          1126..1209
                     /region_name="IPT_PCSR"
                     /note="IPT domain of Plexins and Cell Surface Receptors
                     (PCSR) and related proteins . This subgroup contains IPT
                     domains of plexins, receptors, like the
                     plasminogen-related growth factor receptors, the
                     hepatocyte growth factor-scatter factors, and the...;
                     cd00603"
                     /db_xref="CDD:238337"
     Site            1163
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P70208.2)"
     Site            1221..1241
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70208.2)"
     Region          1294..1837
                     /region_name="Plexin_cytopl"
                     /note="Plexin cytoplasmic RasGAP domain; pfam08337"
                     /db_xref="CDD:462434"
     Site            1597
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51805; propagated from
                     UniProtKB/Swiss-Prot (P70208.2)"
     CDS             1..1872
                     /gene="Plxna3"
                     /gene_synonym="mKIAA4078; PlexA3; Plxa3; Plxn3; Plxn4;
                     SEX"
                     /coded_by="NM_008883.2:178..5796"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS30228.1"
                     /db_xref="GeneID:18846"
                     /db_xref="MGI:MGI:107683"
ORIGIN      
        1 mptvcllpll fftiggclgs srpfrtfvvt dttlthlavh rvtgevfvga vnrvfklapn
       61 ltelrahvtg piednarcyp ppsmrvcshr lvpvdnvnkl llidyaarrl vacgsiwqgi
      121 cqflrlddlf klgephhrke hylsgaqepd smagviveqv qgpsklfvgt avdgkseyfp
      181 tlssrklidd edsgdmfslv yqdefvssqi kipsdtlsly pafdiyyiyg fvsasfvyfl
      241 tlqldtqqtl ldtagekfft skivrmcagd sefysyvefp igcswrgvey rlvqsahlak
      301 pglllaqalg vpadedvlft ifsqgqknra npprqtilcl ftlssinahi rrriqscyrg
      361 egtlalpwll nkelpcintp lqingnfcgl vlnqplgglh vieglpllad stdgmasvaa
      421 ytyhqhsvvf igtrsgnlkk vrvdgsqdaq lyetvsvvqg spilrdllfs pdhrhiylls
      481 ekqvsqlpve tceqylscaa clgsgdphcg wcvlqhrccr egacpgasap hgfaeelskc
      541 iqvrvrpnnv svtssgvqlt vamrnvpdls vgvscsfeev teseaillps gelrcpspsl
      601 qelqtltrgh gathtvrlql lsmetgvrfa gvdfvfyncs alqscmscvg spypchwcky
      661 rhvctshphe csfqegrvhs pegcpeilpq gdllipvgvm qpltlraknl pqpqsgqkny
      721 ecvvrvqgrq hrvpavrfns ssvqcqnasy fyegdefgdt eldfsvvwdg dfpidkppsf
      781 rallykcwaq rpscglclka dprfncgwci sehrcqlrah cpapksnwmh psqkgarcsh
      841 pritqihplt gpkeggtrvt ivgenlglts revglrvagv rcnsipteyv saerivceme
      901 eslvpspppg paelcvgdcs adfrtqsqql ysfvtptfdr vspsrgpasg gtrltisgis
      961 ldagsrvtvi irdgecqfvr rdaeaivcis pvstlgpsqs pitlaidhan isntgviyty
     1021 tqdptvthle ptwsiingst sitvsgthll tvqeprvrak yrgiettntc qvindtamlc
     1081 kapgiflghp qpraqgehpd efgflldhvq aarslnrssf tyypdpsfep lgpsgvldvk
     1141 pgshvvlkgk nlipaaagss rlnytvligg qpcaltvsdt qllcdspsqt grqpvmvlvg
     1201 glefwlgtlh itadraltlp amvglaaggg llllaitvvl vaykrktqda drtlkrlqlq
     1261 mdnlesrval eckeafaelq tdineltnhm dgvqipfldy rtyavrvlfp gieahpvlke
     1321 ldtppnveka lrlfgqllhs raflltfiht leaqssfsmr drgtvasltm valqsrldya
     1381 tgllkqllad lieknleskn hpklllrrte svaekmltnw ftfllhkflk ecageplfll
     1441 ycaikqqmek gpidaitgea ryslsedkli rqqidyktlt lhcvcpeseg saqvpvkvln
     1501 cdsitqakdk lldtvykgip ysqrpkaedm dlewrqgrma riilqdedit tkiecdwkrv
     1561 nslahyqvtd gslvalvpkq vsaynmansf tftrslsrye sllraasspd slrsrapmlt
     1621 pdqeagtklw hlvrnhdhtd hregdrgskm vseiyltrll atkgtlqkfv ddlfetvfst
     1681 ahrgsalpla ikymfdflde qadqrqisdp dvrhtwksnc lplrfwvnvi knpqfvfdih
     1741 knsitdacls vvaqtfmdsc stsehrlgkd spsnkllyak dipnykswve ryyrdiakma
     1801 sisdqdmday lveqsrlhan dfnvlsalse lyfyvtkyrq eiltsldrda scrkhklrqk
     1861 leqiitlvss ss
//
