LOCUS       NM_008881               9045 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus plexin A1 (Plxna1), mRNA.
ACCESSION   NM_008881
VERSION     NM_008881.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9045)
  AUTHORS   Thowfeequ,S., Fiorentino,J., Hu,D., Solovey,M., Ruane,S.,
            Whitehead,M., Zhou,F., Godwin,J., Mateo-Otero,Y.,
            Vanhaesebroeck,B., Scialdone,A. and Srinivas,S.
  TITLE     An integrated approach identifies the molecular underpinnings of
            murine anterior visceral endoderm migration
  JOURNAL   Dev Cell 59 (17), 2347-2363 (2024)
   PUBMED   38843837
REFERENCE   2  (bases 1 to 9045)
  AUTHORS   Lu,Y., Cheng,D., Pang,J., Peng,Y., Jin,S., Zhang,X., Li,Y. and
            Zuo,Y.
  TITLE     Chronic stress promotes gastric cancer progression via the
            adrenoceptor beta 2/PlexinA1 pathway
  JOURNAL   Cell Stress Chaperones 29 (1), 201-215 (2024)
   PUBMED   38331165
  REMARK    GeneRIF: Chronic stress promotes gastric cancer progression via the
            adrenoceptor beta 2/PlexinA1 pathway.
REFERENCE   3  (bases 1 to 9045)
  AUTHORS   Prieur,D.S., Francius,C., Gaspar,P., Mason,C.A. and Rebsam,A.
  TITLE     Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to
            Position and Target Retinal Ganglion Cell Axons
  JOURNAL   J Neurosci 43 (32), 5769-5778 (2023)
   PUBMED   37344233
  REMARK    GeneRIF: Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous
            Manner to Position and Target Retinal Ganglion Cell Axons.
REFERENCE   4  (bases 1 to 9045)
  AUTHORS   Yan,K., Bormuth,I., Bormuth,O., Tutukova,S., Renner,A., Bessa,P.,
            Schaub,T., Rosario,M. and Tarabykin,V.
  TITLE     TrkB-dependent EphrinA reverse signaling regulates callosal axon
            fasciculate growth downstream of Neurod2/6
  JOURNAL   Cereb Cortex 33 (5), 1752-1767 (2023)
   PUBMED   35462405
REFERENCE   5  (bases 1 to 9045)
  AUTHORS   Pinskey,J.M., Hoard,T.M., Zhao,X.F., Franks,N.E., Frank,Z.C.,
            McMellen,A.N., Giger,R.J. and Allen,B.L.
  TITLE     Plexins promote Hedgehog signaling through their cytoplasmic GAP
            activity
  JOURNAL   Elife 11, e74750 (2022)
   PUBMED   36169302
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9045)
  AUTHORS   Shimizu,M., Murakami,Y., Suto,F. and Fujisawa,H.
  TITLE     Determination of cell adhesion sites of neuropilin-1
  JOURNAL   J Cell Biol 148 (6), 1283-1293 (2000)
   PUBMED   10725340
REFERENCE   7  (bases 1 to 9045)
  AUTHORS   Tamagnone,L., Artigiani,S., Chen,H., He,Z., Ming,G.I., Song,H.,
            Chedotal,A., Winberg,M.L., Goodman,C.S., Poo,M., Tessier-Lavigne,M.
            and Comoglio,P.M.
  TITLE     Plexins are a large family of receptors for transmembrane,
            secreted, and GPI-anchored semaphorins in vertebrates
  JOURNAL   Cell 99 (1), 71-80 (1999)
   PUBMED   10520995
  REMARK    Erratum:[Cell 2001 Jan 26;104(2):following 320]
REFERENCE   8  (bases 1 to 9045)
  AUTHORS   Takahashi,T., Fournier,A., Nakamura,F., Wang,L.H., Murakami,Y.,
            Kalb,R.G., Fujisawa,H. and Strittmatter,S.M.
  TITLE     Plexin-neuropilin-1 complexes form functional semaphorin-3A
            receptors
  JOURNAL   Cell 99 (1), 59-69 (1999)
   PUBMED   10520994
REFERENCE   9  (bases 1 to 9045)
  AUTHORS   Kameyama,T., Murakami,Y., Suto,F., Kawakami,A., Takagi,S.,
            Hirata,T. and Fujisawa,H.
  TITLE     Identification of a neuronal cell surface molecule, plexin, in mice
  JOURNAL   Biochem Biophys Res Commun 226 (2), 524-529 (1996)
   PUBMED   8806667
REFERENCE   10 (bases 1 to 9045)
  AUTHORS   Kameyama,T., Murakami,Y., Suto,F., Kawakami,A., Takagi,S.,
            Hirata,T. and Fujisawa,H.
  TITLE     Identification of plexin family molecules in mice
  JOURNAL   Biochem Biophys Res Commun 226 (2), 396-402 (1996)
   PUBMED   8806646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ111942.1, BC138023.1, AK220460.1 and CF734847.1.
            
            On Jul 10, 2009 this sequence version replaced NM_008881.1.
            
            Sequence Note: An in-frame AUG is located 18 codons upstream of the
            annotated translation start site but is not being annotated as a
            start site since it would disrupt the signal peptide on
            NP_034907.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86948.1, SRR14777535.2690377.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               CJ111942.1         1-208
            209-6012            BC138023.1         1-5804
            6013-9025           AK220460.1         4253-7265
            9026-9045           CF734847.1         319-338
FEATURES             Location/Qualifiers
     source          1..9045
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.91 cM"
     gene            1..9045
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /note="plexin A1"
                     /db_xref="GeneID:18844"
                     /db_xref="MGI:MGI:107685"
     exon            1..207
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..1468
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..5965
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /note="plex 1; plexin-1"
                     /codon_start=1
                     /product="plexin-A1 precursor"
                     /protein_id="NP_032907.1"
                     /db_xref="CCDS:CCDS20344.1"
                     /db_xref="GeneID:18844"
                     /db_xref="MGI:MGI:107685"
                     /translation="MPLPPLSSRTLLLLLLLLLRGVWIAISSPPAGLGPQPAFRTFVA
                     SDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQSC
                     PHGLGSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSS
                     VREAGSMAGVLIAGPPGQGQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVY
                     QDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSPDAAGEHFF
                     TSKIVRLCVNDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGQALAKQLGLAEDEEV
                     LFTVFAQGQKNRVKPPKESALCLFTLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELG
                     CINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKEDGLTAVAAYDYQGRTVVFAGT
                     RSGRIRKILVDLANPSGRPALAYESVVAQEGNPILRDLVLSPNRQYLYAMTEKQVTQV
                     PVESCVQYTSCELCLGSRDPHCGWCVLHSICSRQDACERAEEPQRFASDLLQCVQLTV
                     QPRNVSVTMSQVPLVLQAWNVPDLSAGVNCSFEDFTETESILEDGRIHCHSPSAREVA
                     PITQGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQSCLACVNGSFPCHWCKYRH
                     VCTNNAADCAFLEGRVNMSEDCPQILPSTHIYVPVGVVKPITLAARNLPQPQSGQRGY
                     ECLFHIPGSPARVTALRFNSSSLQCQNSSYSYEGNDVSDLPVNLSVVWNGNFVIDNPQ
                     NIQAHLYKCPALRQSCGLCLKADPRFECGWCVAERRCSLRHHCPADSPASWMHAHHGS
                     SRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVHVGKVLCSPVESEYIS
                     AEQIVCEIGDASTLRAHDALVEVCVRDCSLHYRALSPKRFTFVTPTFYRVSPSRGPLS
                     GGTWIGIEGSHLNAGSDVAVSIGGRPCSFSWRNSREIRCLTPPGHTPGSAPIVININR
                     AQLSNPEVKYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRIRAKYGGIER
                     ENSCMVYNDTTMVCRAPSIDNPKRSPPELGERPDEIGFIMDNVRTLLVLNSSSFLYYP
                     DPVLEPLSPTGLLELKPSSPLILKGRNLLPPAPGNSRLNYTVLIGSTPCILTVSETQL
                     LCEAPNLTGQHKVTVRAGGFEFSPGMLQVYSDSLLTLPAIVGIGGGGGLLLLVIVAVL
                     IAYKRKSRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIHELTSDLDGAGIPFL
                     DYRTYAMRVLFPGIEDHPVLKEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQRS
                     FSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAE
                     KMLTNWFTFLLYKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQ
                     QIDYKTLTLNCVNPEHENAPEVPVKGLNCDTVTQVKEKLLDAVYKGVPYSQRPKAGDM
                     DLEWRQGRMARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNISN
                     SSTFTKSLSRYESMLRTASSPDSLRSRTPMITPDLESGTKLWHLVKNHDHLDQREGDR
                     GSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADK
                     HQIHDSDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCST
                     SEHKLGKDSPSNKLLYAKDIPNYKSWVERYYADIAKMPAISDQDMSAYLAEQSRLHLS
                     QFNSMSALHEIYSYIAKYKDEILVALEKDEQARRQRLRSKLEQVVDTMALSS"
     exon            1469..1651
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1792
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1893
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2017
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2171
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2271
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2386
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2587
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2684
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2878
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3030
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3151
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3288
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3289..3456
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3550
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3790
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3791..3934
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3935..4169
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4170..4312
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4313..4569
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4570..4636
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4637..4783
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4784..4943
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4944..5047
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            5048..5144
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            5145..5335
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            5336..5505
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            5506..5718
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            5719..5869
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     exon            5870..9028
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9010..9015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /note="hexamer: ATTAAA"
     polyA_site      9028
                     /gene="Plxna1"
                     /gene_synonym="2600013D04Rik; mKIAA4053; NOV; PlexA1;
                     Plxn1"
                     /note="major polyA site"
ORIGIN      
        1 ggggcggcga gagcgaggcc ggtccgcagc cgcgcggagc tcagcgcccc attcatgctg
       61 ggcagcggcg acgcagccac gcagcggagc ggagcccggg cgcggcggcc tcggcctggg
      121 cggcctgcgc ggcgtgggcg gccccgcaga ggggcgagcg gcggggcgca acgatggcca
      181 gcggcgggac gcgcccgggg ttggcggggc caagaaaccc aatcccatga tgctcgcccc
      241 tataggacct gaatactttg gcttgaggcc ccagcccacc atgccactgc cacctctgag
      301 ctctcggaca ctgctgctgc tgctcttgct gctgctgagg ggtgtgtgga tagccatcag
      361 ctcgccccca gctggtttgg gtccacaacc tgccttccgc acctttgtgg ccagtgactg
      421 gggcctcact cacctggtgg ttcacgaaca gacaggagag gtatatgttg gcgctgtgaa
      481 ccgtatttac aagctgtcgg ggaacctaac cctgcttcgg gcccatgtga caggccctgt
      541 agaagacaat gagaaatgct acccaccccc cagtgtacag tcctgcccac atggtctggg
      601 cagcacagac aacgtcaaca agcttctact gctggactat gcagccaacc gcctgttggc
      661 ctgtggcagt gcctcacagg gcatctgcca gttcctgagg ttggacgatc tcttcaagct
      721 gggcgagccg caccaccgca aggaacacta cctgtccagt gttcgagagg ctggcagcat
      781 ggcgggagtg ctcattgctg ggccacccgg ccagggccag gccaagctct tcgtgggcac
      841 acccatcgat ggcaaatcag aatacttccc cactctgtcc agtcgccggc tcatggccaa
      901 cgaggaagat gctgacatgt ttggctttgt gtaccaggat gagtttgtgt catctcagct
      961 caagatccct tcagacacat tgtccaagtt cccagccttt gacatctact atgtgtacag
     1021 tttccgcagc gagcagttcg tatactacct caccctgcag ctagacacgc agcttacctc
     1081 gcccgacgcc gctggcgagc acttcttcac ctccaagatt gtgcggctgt gcgtgaatga
     1141 ccccaagttc tactcttacg tggagttccc cattggctgc gagcaggctg gcgtggagta
     1201 tcggctggtg caggacgcct acctgagccg gccgggacag gccctggcca aacagctggg
     1261 cctggctgag gatgaggagg tgttgttcac tgtgttcgca cagggccaga agaaccgcgt
     1321 gaagccaccc aaggagtcgg cgctgtgcct gttcacactg agggccatca aggagaaaat
     1381 caaggagcgc atccaatcct gctaccgtgg agaaggaaag ctctccctgc cttggctgct
     1441 caacaaggag ctgggctgca tcaactcgcc cctgcagatt gatgacgact tctgcgggca
     1501 ggatttcaac cagccactgg gtggcacggt caccatcgag ggcacacccc tttttgtcga
     1561 caaggaagat ggcctgactg ctgtggctgc ctatgactac caaggccgca ccgtggtttt
     1621 tgctggcact cgcagcggcc gcatccgcaa gattctggtg gaccttgcaa accccagcgg
     1681 caggccggcc ctggcttatg aaagtgtggt ggctcaggag ggcaacccta tcctgcgtga
     1741 cctggtcctc agccccaacc gccagtacct ctatgctatg acggagaagc aggtgacgca
     1801 ggtgcctgtg gaaagctgtg tccagtatac ttcctgtgag ctgtgcctgg ggtctcggga
     1861 cccccactgt ggctggtgtg tcctgcacag catctgctct aggcaggatg cctgtgagcg
     1921 ggcagaagag ccccagcgtt ttgcctctga cctgctgcag tgtgtgcagt taactgtcca
     1981 gccgcgcaat gtgtcagtca ccatgtccca ggtgccgctc gtgctgcagg cttggaatgt
     2041 gcctgacctc tcagctggtg tcaactgctc ctttgaggac ttcacggaga ctgagagcat
     2101 cctggaagat ggccgcatcc attgccactc accttctgcc cgggaagtgg cgcccatcac
     2161 acagggtcag ggagaccagc gggtggtgaa gctctacctc aagtccaagg agacagggaa
     2221 gaagtttgca tctgtggact ttgtcttcta taactgcagt gttcaccagt cctgcctggc
     2281 atgtgtcaac ggctccttcc cctgccattg gtgcaaatac cgccatgttt gcaccaacaa
     2341 tgcggctgac tgcgcctttc tggaaggccg agtcaacatg tctgaggact gcccacagat
     2401 cctgccttct acccacatct atgtgccagt gggtgtggtg aagcccatca ccctggctgc
     2461 acggaacctg ccgcagccac agtcgggtca gcgagggtac gagtgccttt tccacatccc
     2521 aggcagcccg gcccgagtca ctgcactgcg cttcaacagc tccagcctgc agtgccagaa
     2581 ctcctcgtac tcctatgagg ggaatgatgt cagcgatctg cctgtgaacc tgtcggttgt
     2641 gtggaatggc aactttgtca ttgacaaccc ccagaacatc caggcccacc tctacaagtg
     2701 cccagccttg cgccagagtt gtggcctctg cctcaaggca gacccacgct ttgagtgcgg
     2761 ctggtgcgta gctgagcgcc gctgttccct tcgtcaccac tgcccagctg actcaccagc
     2821 ctcctggatg catgcccacc atggcagcag ccgctgcaca gaccccaaga ttctcaagct
     2881 gtccccagag acaggccctc ggcagggagg gactcgacta accatcaccg gtgagaatct
     2941 gggcctccgg tttgaggatg tgcggctagg cgtgcacgtg ggcaaggtgc tttgcagccc
     3001 tgtggagagc gagtacatca gcgcagaaca gattgtctgc gagattggag atgccagcac
     3061 gctgcgggcc catgatgccc tggtggaggt gtgtgtgcgg gactgctccc tccactaccg
     3121 agcgctgtcc cctaaacgct tcacttttgt gacaccgacc ttctaccgtg tgagcccctc
     3181 ccgtgggcct ctgtctggag gtacctggat tggcatcgaa gggagccatc tgaatgctgg
     3241 cagtgatgta gctgtgtcca ttggcggtcg gccctgctcc ttctcctgga gaaactcacg
     3301 agagatccgc tgcctgacac cgcccgggca cactcctggc agcgccccta ttgttatcaa
     3361 catcaatcgt gcccagctct ccaaccccga ggtgaagtac aactatactg aagaccctac
     3421 tatcctgagg atcgaccctg agtggagcat caatagtggt gggaccctcc taacagtcac
     3481 gggcaccaac ctggccactg tccgtgaacc tcgaatccgc gccaagtatg gaggcattga
     3541 gagggaaaat agctgcatgg tgtacaatga caccaccatg gtgtgccggg cgccgtctat
     3601 agacaaccca aagcgcagcc cgccagaact gggagagcgg ccagatgaga ttggtttcat
     3661 catggacaat gtgcgcacgc tgctggtact caacagctcc tccttcctct actacccgga
     3721 ccctgtactg gagccactta gccctactgg gctcttggag ctgaagccca gctccccgct
     3781 catcctcaag gggcggaatc tcctgccacc tgctcctggc aattcccggc tcaactacac
     3841 ggtgctcatc ggctccacac cttgtatcct caccgtgtct gagacacagc tgctgtgtga
     3901 agcacccaac ctcacggggc agcacaaagt cacggtgcgg gccgggggct tcgagttctc
     3961 acctgggatg ctgcaggtgt attcggacag cctgctgaca ctgccggcca ttgtgggtat
     4021 cggtggtggg ggtggcctct tgctgctggt catcgtggct gtgctcatcg cctacaaacg
     4081 caaatcccgg gatgctgacc gtaccctcaa gcggctgcag ctccagatgg acaacctgga
     4141 gtcacgggtg gccctcgagt gcaaggaagc ttttgcagag ctacagacgg acatccatga
     4201 gctgaccagt gacctggatg gtgctggcat ccccttcctt gactaccgca catatgccat
     4261 gcgagtgctg tttcctggga ttgaggacca tcctgtactg aaggagatgg aggtgcaggc
     4321 caatgtggag aagtcgctga cactgttcgg acagctgttg accaagaagc atttcctgct
     4381 aaccttcatc cgcacactag aggcccagcg tagcttctcc atgcgtgacc gtgggaacgt
     4441 ggcctcactc atcatgacag ccctgcaggg tgagatggag tatgccacag gagtgctaaa
     4501 gcagttgctg tctgacctca tcgagaaaaa cctagaaagc aagaaccacc ccaagctcct
     4561 gttacggagg accgaatcag tggcagagaa gatgttgacc aactggttca ccttcctttt
     4621 gtataagttc ctcaaggagt gtgctgggga gccgctcttt atgctgtact gtgccatcaa
     4681 gcagcagatg gagaagggcc ctattgacgc catcacaggg gaggcccgct actctctgag
     4741 cgaagacaag ctcattcggc agcagattga ctacaagacc ctgaccctga actgcgtgaa
     4801 ccctgaacat gagaatgcgc ccgaggttcc tgtgaagggg ctgaactgtg acaccgtgac
     4861 ccaggtcaag gagaagctcc tggatgctgt gtacaagggt gtgccttact cacagcggcc
     4921 gaaggccggg gacatggacc tggagtggcg ccagggtcgc atggcacgca tcatccttca
     4981 ggacgaggac gtcaccacta aaattgacaa tgactggaag aggctgaaca cactagctca
     5041 ctatcaggtg acggatgggt catcggtggc actagtaccc aagcagacat cggcctacaa
     5101 catctccaac tcctctacct tcactaagtc cctcagcaga tacgagagca tgctgcgtac
     5161 agccagtagc cccgacagcc tacgctcacg aacacccatg atcacgccag acctggaaag
     5221 tggaacaaaa ctgtggcacc tggtgaagaa ccacgaccac ctggaccaac gtgaaggcga
     5281 ccgtggcagc aagatggtct ctgagatcta cctaaccagg ctgctggcca ccaagggaac
     5341 actacaaaag ttcgtggatg acctgttcga gaccatcttc agcacggcgc accgtggctc
     5401 agccctacct ctggccatca agtacatgtt tgacttctta gatgagcagg ccgacaagca
     5461 tcagatccac gactcagatg tgcgccatac ctggaagagc aattgcctgc ctctgcgctt
     5521 ctgggtgaat gtgattaaga accctcagtt cgtgttcgac atccacaaga acagcataac
     5581 agatgcctgc ctctcagtgg tagcgcagac cttcatggac tcctgctcta catcagagca
     5641 caagctgggc aaagactcac cctccaacaa gttgctctat gccaaggaca tccccaacta
     5701 caagagctgg gttgaaaggt actatgctga cattgccaag atgcctgcaa tcagtgacca
     5761 agacatgagc gcctacctgg cagagcagtc ccggctgcat ctcagccagt tcaacagcat
     5821 gagtgccctg cacgagatct actcctacat cgccaagtac aaggacgaga ttctggtggc
     5881 tctggagaaa gatgaacagg ctcgaaggca gcggcttcga agcaaactgg agcaggtggt
     5941 ggacacaatg gccctgagca gctgagccct ggaagtgccc acccagcagg aggcagagca
     6001 ggagggcagc agaggaccca ggagacagcc cttggcccac ctgtaccaag tccaggtgtg
     6061 ggggctgtgg ttgggtcctg gccctcgcct tcctctccct gccatgcagg gccaattctt
     6121 atcgctgtgg atgtaagggt tcctgctgag ccgcctctgt gcctggggct tgctgccgtg
     6181 gggcaaggat agcacagcgt ggctggttct gcccagggat atttgctgct tggcaagagc
     6241 tgctagtggt tttcctgaga gagaggtggc ctctgagggg ccgagataga aggccaggcc
     6301 ctccagaagg agggcagcag gacaaggggc tggaccaatt cacatttctt ggcttcttca
     6361 gctgctacca gcaggcagag tctgagggag aggtgagata cccaaggcta ggccacataa
     6421 gtcacagcct ggggctgtcc caccagcctc tactctagca ccctgtgctt gccaccaccc
     6481 tcagattcac cgcgtgctct gcgcggccaa ggctggagtg ccacatcctt ctgctgggga
     6541 gagaggcccc actcccctcc tatggagggc ctgcagaccc cacttccaag tgacatgtgg
     6601 acaatggcta ggcgaaccct tctctgtcct cagggctgtg cctctgggag ctcctggtcc
     6661 tggggctcca gtcagagtgc atgttcccgt tatttattcc ccgcctcctg ctcctatcgc
     6721 agcccaccac ggagctctgg aggataacag gccaccgtcc caccatcctt tatcctcccc
     6781 tcccctgatg ttcccggtgg cttccagtct ggcctctcaa cggtgtcctg gcccctctgc
     6841 agtgggacat ctgggtactg cttttaaggg aacaagaaat cctgtggtat tttgccctgg
     6901 ggatgtgggg ggcatttctg ccaccctgct gaccatgggc agtgacccaa gggactggag
     6961 gtcaactgtg tccacctctg ccctcaagga gcaacagtac gtttttaatg gaccctgtac
     7021 atatatatat gtatgtatgt gtatatatat atatgtgtgt gtggccctgg ccccaatggg
     7081 gtgctgtaca attatttgag ggaagagaca cggaaaggca attcaggagg aacccaggtg
     7141 gaagagagca aaaccaaggg ccctggagct gccatctgat gtggcctcta cttcccccag
     7201 atggaagaag ccgctgccca cgattccgtg ccccgagctt tgggtgcaga gctgtggacc
     7261 tgcatgactg tgctagcgtt tagtctgagt tgatcttttc aaactgcaag tgttgaatac
     7321 tagaggtggt tagacccttt ttttaaatgt ttttttttta attagtcatt ggaaaagcaa
     7381 gcaagcggcc tactcccttt tcaagttcac ctttttgatg gtactaaaga ttataatgga
     7441 ttttaaggga cagctaactg tggccaggac cattatcagt gctggggaca gcacacccca
     7501 catccatggg ctgctagtct tgtggtccct cacactccaa gctagggagc cgatgggaca
     7561 gggtggaggt cagattagag ctgcaccttt attagctatg gggcaggtac aaggactcag
     7621 ggagcaactc ctctgtggta gtcatgagcc tagacaccct gggccatgaa ttctggtcag
     7681 actcccaccc caactctttg gctcattccc tgggctgata ctagggtcag agcctggata
     7741 tagccgtttc tcagaagccc ctgttgttgc ctggggtttt acccatggat atacccctct
     7801 cttccttctg atgcctccag gctgtgcctg ggtgggagcc tcagtttccc ctaaagtctt
     7861 ccctggttgt aggcttcaga tggaagcccc cagttcttcc agctctgcct ggaacacgca
     7921 cagcttctag gctcaatgcc ttcactatcc agccccacgt ccccaggctc cctcagaata
     7981 ggccagcctc actttgtcct acaggccacc ttgcccatgt gggtgtcagg taggaggtga
     8041 ggtggcctgg agcagcttcc cagggtgttt gttcgcaagc actttagcat ttctgtttac
     8101 atgcgaactg ccctagctgt tcttaccacg catcttctcg gcacagccat cagggccagg
     8161 cctcatttcc ctgctacttc tggactgggc tctgacatct gcttgtcctt ggtcttctag
     8221 agccatccat ctctgtggta tcctgcaaag ggttccgttt cagcctcaat atggcttggg
     8281 gttggagcca actgcacact gggtggtgga tgctcagagc caccctctac aggcctaggg
     8341 cccagggagg tgggcaagca ctactccagc cagcctggcc ctaacactct tggtactgcc
     8401 gtcctgccat gggccccatc ccccttcctg cctggtcttt ccctttgcac ctggactcag
     8461 gagtgcctgg gccattccaa gctgggcctg ggtgcctggc ctccacatgc cttgggctgg
     8521 ctctgctctc cagctgcccc actctcttat ggttggacag ctagacagag cagcaggggt
     8581 gagggccttg atgtgtcccc aagagacact gcattgagtc caggcacagg ccagcaacct
     8641 ctgttggttc agaggggtcc gactgccacc ctctactcca gtttccccag ttggatctgg
     8701 tggctcacat cggtgctaca caagctagag tagatatatt tagagagaga aagatatttt
     8761 taaggtgaag cccatgatta gctgtccttt aatgccgcag aacactccct cttaccccct
     8821 tcctcccacc cccacccaaa aaaaatccct ggtcatttgg atggtctgag tagaccaggc
     8881 ctcggccatt gcttctctgg aagcggcaga gccaatacgc tcagccatca gatgtgtaaa
     8941 tatacggcta tttcctattt tacggttctt cagatttagt acttgtaaat aaacacacat
     9001 taaggagaga ttaaacattt ttgctaaaaa aaaaaaaaaa aaaaa
//
