LOCUS       NM_028199               2901 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus plexin domain containing 1 (Plxdc1), transcript
            variant 2, mRNA.
ACCESSION   NM_028199
VERSION     NM_028199.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2901)
  AUTHORS   Hu,J., Chen,X., Zhang,X., Yuan,X., Yang,M., Dai,H., Yang,W.,
            Zhou,Q., Wen,W., Wang,Q., Qin,W. and Zhao,A.
  TITLE     A fusion-protein approach enabling mammalian cell production of
            tumor targeting protein domains for therapeutic development
  JOURNAL   Protein Sci 27 (5), 933-944 (2018)
   PUBMED   29500915
  REMARK    GeneRIF: A novel fusion expression system based on mouse TEM7
            (tumor endothelial marker 7), which could facilitate protein
            expression.
REFERENCE   2  (bases 1 to 2901)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   3  (bases 1 to 2901)
  AUTHORS   Negishi-Koga,T., Shinohara,M., Komatsu,N., Bito,H., Kodama,T.,
            Friedel,R.H. and Takayanagi,H.
  TITLE     Suppression of bone formation by osteoclastic expression of
            semaphorin 4D
  JOURNAL   Nat Med 17 (11), 1473-1480 (2011)
   PUBMED   22019888
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2901)
  AUTHORS   Gaultier,A., Simon,G., Niessen,S., Dix,M., Takimoto,S.,
            Cravatt,B.F. 3rd and Gonias,S.L.
  TITLE     LDL receptor-related protein 1 regulates the abundance of diverse
            cell-signaling proteins in the plasma membrane proteome
  JOURNAL   J Proteome Res 9 (12), 6689-6695 (2010)
   PUBMED   20919742
  REMARK    GeneRIF: Studies identify Plxdc1, Sema4D, and neuropilin-1 as novel
            LRP1-regulated cell-signaling proteins.
REFERENCE   5  (bases 1 to 2901)
  AUTHORS   Miller,S.F., Summerhurst,K., Runker,A.E., Kerjan,G., Friedel,R.H.,
            Chedotal,A., Murphy,P. and Mitchell,K.J.
  TITLE     Expression of Plxdc2/TEM7R in the developing nervous system of the
            mouse
  JOURNAL   Gene Expr Patterns 7 (5), 635-644 (2007)
   PUBMED   17280871
REFERENCE   6  (bases 1 to 2901)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   7  (bases 1 to 2901)
  AUTHORS   Lee,H.K., Seo,I.A., Park,H.K. and Park,H.T.
  TITLE     Identification of the basement membrane protein nidogen as a
            candidate ligand for tumor endothelial marker 7 in vitro and in
            vivo
  JOURNAL   FEBS Lett 580 (9), 2253-2257 (2006)
   PUBMED   16574105
REFERENCE   8  (bases 1 to 2901)
  AUTHORS   Wang,X.Q., Sheibani,N. and Watson,J.C.
  TITLE     Modulation of tumor endothelial cell marker 7 expression during
            endothelial cell capillary morphogenesis
  JOURNAL   Microvasc Res 70 (3), 189-197 (2005)
   PUBMED   16202431
  REMARK    GeneRIF: TEM7 is a novel protein whose cell surface expression is
            essential during endothelial cell capillary morphogenesis
REFERENCE   9  (bases 1 to 2901)
  AUTHORS   Nanda,A., Buckhaults,P., Seaman,S., Agrawal,N., Boutin,P.,
            Shankara,S., Nacht,M., Teicher,B., Stampfl,J., Singh,S.,
            Vogelstein,B., Kinzler,K.W. and St Croix,B.
  TITLE     Identification of a binding partner for the endothelial cell
            surface proteins TEM7 and TEM7R
  JOURNAL   Cancer Res 64 (23), 8507-8511 (2004)
   PUBMED   15574754
REFERENCE   10 (bases 1 to 2901)
  AUTHORS   Carson-Walter,E.B., Watkins,D.N., Nanda,A., Vogelstein,B.,
            Kinzler,K.W. and St Croix,B.
  TITLE     Cell surface tumor endothelial markers are conserved in mice and
            humans
  JOURNAL   Cancer Res 61 (18), 6649-6655 (2001)
   PUBMED   11559528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591209.17, AK153684.1, BB129646.2 and AI848450.1.
            
            On Jul 28, 2009 this sequence version replaced NM_028199.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF378760.1, AK153684.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL591209.17        67152-67167         c
            17-729              AK153684.1         4-716
            730-730             AL591209.17        35586-35586         c
            731-2414            AK153684.1         718-2401
            2415-2457           BB129646.2         628-670
            2458-2901           AI848450.1         1-444               c
FEATURES             Location/Qualifiers
     source          1..2901
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.31 cM"
     gene            1..2901
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /note="plexin domain containing 1"
                     /db_xref="GeneID:72324"
                     /db_xref="MGI:MGI:1919574"
     exon            1..209
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1633
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; plexin domain-containing protein 1; TEM7
                     related"
                     /codon_start=1
                     /product="plexin domain-containing protein 1 isoform 2
                     precursor"
                     /protein_id="NP_082475.3"
                     /db_xref="CCDS:CCDS25333.1"
                     /db_xref="GeneID:72324"
                     /db_xref="MGI:MGI:1919574"
                     /translation="MRAQLWLLQLLLLRGAARALSPATPAGHNEGQDSAWTAKRTRQG
                     WSRRPRESPAQVLKPGKTQLSQDLGGGSLAIDTLPDNRTRVVEDNHNYYVSRVYGPGE
                     KQSQDLWVDLAVANRSHVKIHRILSSSHRQASRVVLSFDFPFYGHPLRQITIATGGFI
                     FMGDMLHRMLTATQYVAPLMANFNPGYSDNSTVAYFDNGTVFVVQWDHVYLQDREDRG
                     SFTFQAALHRDGRIVFGYKEIPMAVLDISSAQHPVKAGLSDAFMILNSSPEVPASQRR
                     TIFEYHRVELDSSKITTTSAVEFTPLPTCLQHQSCDTCVSSNLTFNCSWCHVLQRCSS
                     GFDRYRQEWLTYGCAQEAEGKTCEDFQDDSHYSASPDSSFSPFNGDSTTSSSLFIDSL
                     TTEDDTKLNPYAEGDGLPDHSSPKSKGPPVHLGTIVGIVLAVLLVAAIILAGIYISGH
                     PNSNAALFFIERRPHHWPAMKFHNHPNHSTYTEVEPSGHEKEGFVEAEQC"
     exon            210..388
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /inference="alignment:Splign:2.1.0"
     exon            389..532
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /inference="alignment:Splign:2.1.0"
     exon            533..602
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /inference="alignment:Splign:2.1.0"
     exon            603..725
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /inference="alignment:Splign:2.1.0"
     exon            726..844
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /inference="alignment:Splign:2.1.0"
     exon            845..944
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1040
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1122
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1183
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1316
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1352
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1513
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..2884
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2862..2867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /note="hexamer: AATAAA"
     polyA_site      2883
                     /gene="Plxdc1"
                     /gene_synonym="2410003I07Rik; Tem7"
                     /note="major polyA site"
ORIGIN      
        1 ccaaggccgc agcgccgtgc ttcgctcgcc ctgcccgctc cgctcccgct ccccgctcgc
       61 ccagcccggg gctgctccct ctgcagccgc cgccgccgcc gcgcagaccc ggaggtcgtc
      121 cgcgcccacc atgcgagctc agctctggtt gctgcagttg ctgctactcc gcggggccgc
      181 gcgcgcgctc agtcccgcaa cacccgcagg tcacaatgaa ggtcaagact ctgcatggac
      241 tgccaagagg accaggcaag gctggagtcg gagaccccga gagagccccg cgcaggtgtt
      301 gaagccaggc aagacccagc taagccagga cttgggtggg ggctccctgg ccatcgacac
      361 acttccggac aacaggactc gggtggtgga ggacaaccat aactactacg tgtcccgtgt
      421 ctacggccct ggtgagaaac aaagccagga tctgtgggtg gacctggctg tggccaaccg
      481 gagtcatgtg aagatccaca ggatcctctc cagttctcac cgacaggctt caagagtggt
      541 cttgtccttt gatttccctt tctatgggca tcctctgcgg cagatcacca tagcaaccgg
      601 aggcttcatc ttcatggggg acatgctcca ccggatgctc acagctacgc agtatgtggc
      661 acccctgatg gccaacttca accccggcta ctctgacaac tccacggttg cttactttga
      721 caatgggacc gtttttgtgg ttcagtggga tcatgtttac ctccaggacc gggaggacag
      781 gggcagcttc accttccagg cggccctaca ccgagatggc cgcattgtct tcggctacaa
      841 agagatcccc atggctgtcc tggatatcag ctctgcccag caccctgtca aggcaggcct
      901 gtccgacgct ttcatgattc tcaattcatc cccagaggtg ccagcgtctc agagacggac
      961 cattttcgaa taccaccgtg tggaactgga ctccagcaag atcaccacca cctcggccgt
     1021 ggagttcacc ccgttgccaa cctgcctcca gcatcagagt tgcgacacct gcgtgtcctc
     1081 gaatctaacc ttcaactgca gctggtgcca tgtcctgcag aggtgttcca gtggctttga
     1141 ccgataccgc caagaatggc tgacctacgg ctgtgcccag gaggcagaag gcaagacatg
     1201 cgaggacttc caggatgata gccactactc agcctcccct gacagctcct tcagcccctt
     1261 taatggcgac tccactacct cttcctccct cttcattgac agcctcacca cagaagatga
     1321 caccaagttg aatccctacg cagaaggaga cggccttccg gaccactcat ctccgaagtc
     1381 caagggtcct cccgtgcacc tgggcaccat cgtgggtatc gtgcttgctg tactcctggt
     1441 agcggccatc atcctggctg ggatttacat cagtggccac cctaattcca atgctgcact
     1501 cttcttcatc gagcggagac ctcaccactg gccagccatg aagttccata accaccccaa
     1561 ccactctacc tacaccgagg tagagccctc cgggcacgag aaggaaggct tcgtggaggc
     1621 cgagcagtgc tgagagagca tcgggccaga gacctggaga tggcatgaaa gacaagtcac
     1681 agcacagaga agtgattttt tttcctggct tcctcggagc tggccctggg ccaggaagac
     1741 aagacaacag cttgtggtgc caacactaca gtttggtctg cacaccccat ttaaaggggg
     1801 ctcagtaata caactgcgaa ggctccttgg ggaacactga cctcaagagt tccctgtttc
     1861 aatgggagga ggcttcgttt ggggtctctc agtggtctgc agctatggcg gagcccctgc
     1921 ccactggaga cagcctcctg tgttcctcct gctcactgaa gcccacactg ggccattgca
     1981 ttccggggtc tatagattca agagctggtc ttgctagcta tggagtcagt gcccttggct
     2041 ccaaactttg tggcttagaa gcctgaagaa ggggatccct tccctccgag agcgcttaac
     2101 cctgagatgc gctaacagag agaaaagtaa ccttggggaa cttgcatttt tctggccttg
     2161 gtcctttgct tcattgtttt ttttgcagag gccggggcca acatccgagc actgtagcct
     2221 gcagctcatt ctgtaccctg ccctgccctg cccctcagcc tccaccctgc aagctggtct
     2281 tgcatggctg ccagtaatga gtggggccct tactgtgcca tgtgtctggt gcctgcatta
     2341 ctcgttaacc tgttctgtta tcaacggcag tagtttcctt caaagagggg gacaatttac
     2401 ctggctcctg ttttaacttg gctgaccaga gtcgagttct tgtaaccatt aaaaacaact
     2461 agggggccgg gtgtggtggt gctcacactc aggaggctga gctctgagat caaggccagc
     2521 ctggtctaca gagagagcct gtcttgaaga aacaagacaa atggggggct agaggtttcc
     2581 ctgagacacc cctgccttag caaggggctc cagttggatc ccgttgaagc acggtggccg
     2641 cgaaggtagg gcagagaaat ctggtatggg agggagagac cttgacctgg aaagcggcct
     2701 ccatctctcc agctctgcaa agagctttgg gaactgggag ttgacgttcc cacactcagc
     2761 ctggttttaa gggacttctg tccccgtggt ggaccaggac ggcttctaaa ggacaatgaa
     2821 aacctagagc tcaccttcat cccaaagaag cgtcatcagc aaataaataa ggtatagccc
     2881 tcacaaaaaa aaaaaaaaaa a
//
