LOCUS       NM_032398               2033 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus plasmalemma vesicle associated protein (Plvap), mRNA.
ACCESSION   NM_032398
VERSION     NM_032398.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2033)
  AUTHORS   Lehtonen,H., Jokela,H., Hofmann,J., Tola,L., Mehmood,A.,
            Ginhoux,F., Becher,B., Greter,M., Yegutkin,G.G., Salmi,M., Gerke,H.
            and Rantakari,P.
  TITLE     Early precursor-derived pituitary gland tissue-resident macrophages
            play a pivotal role in modulating hormonal balance
  JOURNAL   Cell Rep 44 (2), 115227 (2025)
   PUBMED   39841599
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2033)
  AUTHORS   Lettieri,A., Oleari,R., van den Munkhof,M.H., van Battum,E.Y.,
            Verhagen,M.G., Tacconi,C., Spreafico,M., Paganoni,A.J.J.,
            Azzarelli,R., Andre',V., Amoruso,F., Palazzolo,L., Eberini,I.,
            Dunkel,L., Howard,S.R., Fantin,A., Pasterkamp,R.J. and Cariboni,A.
  TITLE     SEMA6A drives GnRH neuron-dependent puberty onset by tuning median
            eminence vascular permeability
  JOURNAL   Nat Commun 14 (1), 8097 (2023)
   PUBMED   38062045
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2033)
  AUTHORS   Sui,Y., Kou,S., Ge,K., Cao,J., Liu,C. and Zhang,H.
  TITLE     Expression analysis of plvap in mouse heart development,
            homeostasis and injury
  JOURNAL   Gene Expr Patterns 50, 119343 (2023)
   PUBMED   37774966
  REMARK    GeneRIF: Expression analysis of plvap in mouse heart development,
            homeostasis and injury.
REFERENCE   4  (bases 1 to 2033)
  AUTHORS   Feng,W., Bais,A., He,H., Rios,C., Jiang,S., Xu,J., Chang,C.,
            Kostka,D. and Li,G.
  TITLE     Single-cell transcriptomic analysis identifies murine heart
            molecular features at embryonic and neonatal stages
  JOURNAL   Nat Commun 13 (1), 7960 (2022)
   PUBMED   36575170
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2033)
  AUTHORS   Darche,M., Verschueren,A., Belle,M., Boucherit,L., Fouquet,S.,
            Sahel,J.A., Chedotal,A., Cascone,I. and Paques,M.
  TITLE     Three-dimensional characterization of developing and adult ocular
            vasculature in mice using in toto clearing
  JOURNAL   Commun Biol 5 (1), 1135 (2022)
   PUBMED   36302949
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2033)
  AUTHORS   Hnasko,R., Frank,P.G., Ben-Jonathan,N. and Lisanti,M.P.
  TITLE     PV-1 is negatively regulated by VEGF in the lung of caveolin-1, but
            not caveolin-2, null mice
  JOURNAL   Cell Cycle 5 (17), 2012-2020 (2006)
   PUBMED   16969073
  REMARK    GeneRIF: The PV-1 protein is negatively regulated in pulmonary
            endothelial cells by VEGF-R2 signaling.
REFERENCE   7  (bases 1 to 2033)
  AUTHORS   Cachaco,A.S., Chuva de Sousa Lopes,S.M., Kuikman,I., Bajanca,F.,
            Abe,K., Baudoin,C., Sonnenberg,A., Mummery,C.L. and
            Thorsteinsdottir,S.
  TITLE     Knock-in of integrin beta 1D affects primary but not secondary
            myogenesis in mice
  JOURNAL   Development 130 (8), 1659-1671 (2003)
   PUBMED   12620989
REFERENCE   8  (bases 1 to 2033)
  AUTHORS   Stan,R.V., Arden,K.C. and Palade,G.E.
  TITLE     cDNA and protein sequence, genomic organization, and analysis of
            cis regulatory elements of mouse and human PLVAP genes
  JOURNAL   Genomics 72 (3), 304-313 (2001)
   PUBMED   11401446
REFERENCE   9  (bases 1 to 2033)
  AUTHORS   Straub,V., Ettinger,A.J., Durbeej,M., Venzke,D.P., Cutshall,S.,
            Sanes,J.R. and Campbell,K.P.
  TITLE     epsilon-sarcoglycan replaces alpha-sarcoglycan in smooth muscle to
            form a unique dystrophin-glycoprotein complex
  JOURNAL   J Biol Chem 274 (39), 27989-27996 (1999)
   PUBMED   10488149
REFERENCE   10 (bases 1 to 2033)
  AUTHORS   Hallmann,R., Mayer,D.N., Berg,E.L., Broermann,R. and Butcher,E.C.
  TITLE     Novel mouse endothelial cell surface marker is suppressed during
            differentiation of the blood brain barrier
  JOURNAL   Dev Dyn 202 (4), 325-332 (1995)
   PUBMED   7626790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI225679.1, AF348403.1, AC127416.7, AV003733.1 and BM898788.1.
            
            On Aug 6, 2009 this sequence version replaced NM_032398.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF369900.1, AF348403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AI225679.1         1-38
            39-881              AF348403.1         10-852
            882-995             AC127416.7         170423-170536       c
            996-1909            AF348403.1         967-1880
            1910-2015           AV003733.1         166-271
            2016-2033           BM898788.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2033
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.43 cM"
     gene            1..2033
                     /gene="Plvap"
                     /gene_synonym="MECA32; Pv1"
                     /note="plasmalemma vesicle associated protein"
                     /db_xref="GeneID:84094"
                     /db_xref="MGI:MGI:1890497"
     exon            1..419
                     /gene="Plvap"
                     /gene_synonym="MECA32; Pv1"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1370
                     /gene="Plvap"
                     /gene_synonym="MECA32; Pv1"
                     /note="plasmalemma vesicle protein 1; MECA-32 antigen"
                     /codon_start=1
                     /product="plasmalemma vesicle-associated protein"
                     /protein_id="NP_115774.2"
                     /db_xref="CCDS:CCDS22396.1"
                     /db_xref="GeneID:84094"
                     /db_xref="MGI:MGI:1890497"
                     /translation="MGLSMDRSPYARTGDQQRGCWYYLRYFFLFVSLIQFLIILGLVL
                     FMIYGNVHATTESSLRATEIRADSLYSQVVGLSASQANLSKQLNISLLVKETVMQQLL
                     TTRREMERINASFRQCQGDLITYINYNRFIAAIILSEKQCQEQLKEVNKTCEALLFKL
                     GEKVKTLEMEVAKEKAVCSKDKESLLAGKRQAEEQLEACGKARERQQQEQQVTEENLR
                     KVQSLCIPLDQEKFQADVLSAWRDSLIYRTLETLPYHYQLMPEYASLRRTCESLPGIM
                     TTKIEELARGLRAGIERVTRENAELRRQKLELERAAQAAQEARARAGTEAQARETQLR
                     AECARQTQLALEEKAALRAQRDNLERELEARKRELEQLRTEVDVRISALDTCVKAKSL
                     PAVPPRVSGPPPNPPPIDPASLEEFKKRILESQRLPVVNPAAQPSG"
     exon            420..516
                     /gene="Plvap"
                     /gene_synonym="MECA32; Pv1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..1223
                     /gene="Plvap"
                     /gene_synonym="MECA32; Pv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1281
                     /gene="Plvap"
                     /gene_synonym="MECA32; Pv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1363
                     /gene="Plvap"
                     /gene_synonym="MECA32; Pv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..2016
                     /gene="Plvap"
                     /gene_synonym="MECA32; Pv1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1982..1987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plvap"
                     /gene_synonym="MECA32; Pv1"
                     /note="hexamer: AATAAA"
     polyA_site      2004
                     /gene="Plvap"
                     /gene_synonym="MECA32; Pv1"
                     /note="major polyA site"
ORIGIN      
        1 agatctggcc aggcagacaa cgccagacag tgcgccctgt ggacactgcg caaatggggc
       61 tctccatgga ccgcagccca tacgcccgca cgggggacca gcagcgcggc tgctggtact
      121 acctgcgcta tttcttcctc ttcgtgtcgc tcattcagtt cctcatcatc ctgggcctgg
      181 tcctcttcat gatctatggc aatgtgcacg ccaccactga gtccagcctg cgcgccacgg
      241 agatccgcgc cgacagcctg tacagccagg tggttggact atctgcctca caggctaacc
      301 tgagcaaaca gctgaacatc agcttgcttg tcaaggaaac agtcatgcag caactgttga
      361 ctacgcgacg tgagatggag cgcatcaacg ccagcttccg ccagtgccaa ggcgacctga
      421 tcacctacat aaactataat cgcttcatcg ccgctatcat cctgagcgag aagcagtgcc
      481 aggaacagct gaaggaggtc aacaagacct gcgaagcttt actcttcaag ctgggagaaa
      541 aagttaagac actggagatg gaggtggcca aggagaaggc agtgtgctcc aaggacaagg
      601 agagcctgct ggcaggaaag cggcaggcgg aagagcagct ggaggcctgt ggcaaagcac
      661 gcgaaaggca acagcaggag cagcaggtga ccgaggagaa cctgcgcaag gtgcagtccc
      721 tgtgcatccc actggaccag gagaagttcc aggcggacgt gctgagtgcg tggcgggact
      781 cgctgatcta ccgtaccttg gaaaccctgc cctaccacta ccagctgatg ccggagtacg
      841 cgtccctccg tcggacctgc gagagcctgc ccgggatcat gaccaccaag atagaagagc
      901 tggcccgcgg gctgcgcgcc ggcattgagc gcgtgacccg tgagaatgca gaactgcggc
      961 gccagaagtt ggagctagag cgcgcggcac aggcggcgca ggaggcgcgg gcgcgcgccg
     1021 ggaccgaggc gcaggcgcga gaaacccagc tacgggcgga gtgcgcgcgc cagacgcagc
     1081 tggctctgga ggagaaggcg gcgctgcgcg cgcagcggga caacctagag cgcgaactgg
     1141 aggcgcgtaa gcgggagctg gagcaactgc gcaccgaggt ggatgtgcgc attagcgcgc
     1201 tggacacctg cgtcaaggcc aagtcgctgc cagccgtccc gccgagagtc tcaggcccac
     1261 ccccgaaccc tccacccatt gatccagcta gcctggagga attcaagaaa aggatcctgg
     1321 agtctcagcg gctccctgta gtcaaccctg ctgcccaacc cagcggttga ggacccagct
     1381 gccgcaggac gctgggtgcc agaatcgccc acctgtggat gggggcagcc aggtgcccac
     1441 agtgctggac acccgccgtg cctgccggca gcctccaccc ccacgccttc tctggcaccc
     1501 cttcactgtc ccctgcatcc ccgccattcc ccagacactg gatttaaggc acacacagct
     1561 gtgagatgac ttcacatcga ccccttgtgc agtgacccgg atggtgcccc acccacacat
     1621 gaagcaccca cagctcagct gccaccctag gcaactcctc cggtttccta tcactctgct
     1681 cctgacccgg gaggtgagaa caggaagccc agccttcagc tcccttggga gtttccagcc
     1741 tccctcttaa aggccactag ggtttccaga tcctatttga gagtctccag gcctcccctg
     1801 aagggttcta gccaccacgc ccacaggatt cccattaggt tttaaagtct tttccagagt
     1861 ccgctggttc ccctcctcct cacaaggaag ggcctcaatt gtagatgagc gttccgggtg
     1921 gatcttagag ccctagaggg aggcttttgc ttgtagcccc ctaaagatat tactggcaca
     1981 taataaatat gaaagtcctt tgaagactgg tttgtaaaaa aaaaaaaaaa aaa
//
